Browsing by Author "Ilkgül, Ö"

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    Effect of polyethylene glycol 4000 on adhesion formation following thyroid surgery in rats
    Sakarya, A; Ilkgül, Ö; Aydede, H; Erhan, Y; Içöz, G; Kapkaç, M; Alkanat, M; Kara, E
    Background & objectives: Difficulties in dissection encountered during. reoperative thyroid surgery could be minimised by preventing formation of adhesions in the,operative field. We studied the prevention of adhesion formation in rats after thyroid surgery by using polyethylene glycol 4000 (PEG 4000). Methods: Twenty two rats in two equal groups were studied. Right hemithyroidectomy was performed in both groups with 0.9 per cent saline being instilled in. the operative field in the control group and PEG 4000 solution in the study group. After 10 days, all rats were re-explored and the remaining thyroid tissue of the right lobe was excised. The specimens were scored according to the thickness of the connective tissue over the remainder of the thyroid gland. Results: The connective tissue thickness over the remaining tissue of the thyroid gland in the control and study groups was 272.04 +/- 77.10 and 172.90 +/- 48.92 mum respectively. The decrease of the connective tissue thickness over, the remainder of thyroid gland in the study group Was significant (P<0.05). Interpretation & conclusion: In this animal model although application of PEG 4000 did not completely prevent adhesion formation, a significantly decreased amount of adhesions was found.
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    Late diagnosis of a lateral abdominal wall hematoma presenting with nonspecific findings
    Ilkgül, Ö; Özden, S; Özsoy, Y; Yoleri, L; Erhan, Y; Aydede, H
    We report a case with a late diagnosis of posttraumatic lateral abdominal wall hematoma. The patient was admitted with a giant hematoma presenting with pleural effusion, anemia and weight loss on postoperative 30th day after a blunt trauma. Computerized tomography analysis revealed a hematoma extending from axilla to the gluteus. Fine-needle aspiration revealed an exudative fluid and five liters of fluid collection was drained. Misdiagnosed lateral abdominal wall hematomas can be diagnosed with nonspecific findings as in this case.
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    Value of P53 protein expression and its relationship with short-term prognosis in colorectal cancer
    Erhan, Y; Korkut, MA; Kara, E; Aydede, H; Sakarya, A; Ilkgül, Ö
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    Perforation of the stomach due to chest tube complication in a patient with latrogenic diaphragmatic rupture
    Icoz, G; Kara, E; Ilkgül, Ö; Yetgin, S; Tunçyürek, R; Korkut, MA
    Diagnosis of diaphragmatic injury is difficult. A case of iatrogenic diaphragmatic rupture is reported in which perforation of a herniated stomach occurred following left lobectomy and partial resection of the diaphragm for lung cancer. On the second postoperative day, bile-stained fluid coming out from the chest tube revealed gastrointestinal leakage. This rare complication of chest tube insertion, early diagnosis and treatment are emphasized.
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    The protective mechanisms of defibrotide on liver ischaemia-reperfusion injury
    Aydemir, EO; Var, A; Uyanik, BS; Ilkgül, Ö; Aydede, H; Sakarya, A
    During some surgical interventions, temporary occlusion of the hepatic blood supply may cause ischaemia-reperfusion (I/R) injury and hepatic dysfunction. In this study the protective effect of defibrotide (DEF) was evaluated in a rat model of liver I/R injury. Four groups of rats were subjected to the following protocols: saline infusion without ischaemia, DEF infusion without ischaemia, DEF infusion with hepatic I/R, and saline infusion with hepatic I/R. After a midline laporatomy, liver ischaemia was induced by 45 min of portal occlusion. DEF 175 mg/kg(-1) was infused before ischaemia in 10 ml of saline. The same volume of saline was infused into the control animals. At the end of the 45-min reperfusion interval, the animals were sacrified. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities were determined in haemolysates, and malondialdehyde (MDA) level in the liver tissue was measured. Tissue MDA levels were significantly higher in the I/R plus saline group compared to the sham operation control groups (p < 0.01 and p < 0.05, respectively). Tissue MDA levels decreased in the DEF plus I/R group compared to the I/R plus saline group (p < 0.05), but DEF could not reduce tissue lipid peroxidation to the levels of the control sham operation groups. SOD and GSH-Px enzyme activities were significantly higher in DEF-treated animals than in the other groups (p < 0.05). These results suggest that DEF protects liver against I/R injury by increasing the antioxidant enzyme levels. Copyright (C) 2003 John Wiley Sons, Ltd.
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    Effect of mesh and its localisation on testicular flow and spermatogenesis in patients with groin hernia
    Aydede, H; Erhan, Y; Sakarya, A; Kara, E; Ilkgül, Ö; Can, M
    In this study, the long-term effects of mesh and its localisation (i.e. anterior or posterior) on testicular perfusion and testicular function were evaluated in groin hernia patients. Testicular function has been evaluated with spermiogram and testicular perfusion with colour Doppler ultrasonography. Group I : consisted of 30 posterior preperitoneal mesh repair patients Group 11 : consisted of 30 anterior tension-free repair patients. The operation types were randomised with a systematic sampling method. There was no statistically significant difference between pre-operative and postoperative spermiogram results for both groups. No statistically significant difference was found between the two groups in terms of Doppler flow parameters (PSV, EDV, RI and PI) for pre-operative, early and late postoperative periods. When Doppler flow parameters were compared for group I, statistically significant differences were found between preoperative and early postoperative values. No statistically significant difference was found between pre-operative and late postoperative values. This is also true for early postoperative values versus late postoperative values. When Doppler flow parameters were compared for group II, statistically significant differences were found between pre-operative and early postoperative values. No statistically significant difference was found between pre-operative and late postoperative values. This is also true for early postoperative values versus late postoperative values. These results support the idea that inguinal mesh application is still a safe procedure in patients with no children or who are undergoing infertility treatment, where testicular function is important.
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    Primary omental pregnancy on the gastrocolic ligament
    Karaer, Ö; Ilkgül, Ö; Oruç, S
    Omental pregnancy is an extremely rare form of abdominal pregnancy. Only 16 cases had been reported in the literature, and most were secondary omental pregnancies. We presented a case of primary omental pregnancy located on gastrocolic ligament diagnosed at surgical operation. The aim of this presentation is to remember that pregnancy can exist in unusual localizations, so abdominal observation and examination is very important during operations.