Browsing by Author "Istifli E.S."

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    Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey
    (Elsevier B.V., 2021) Sarikurkcu C.; Ozer M.S.; Istifli E.S.; Sahinler S.S.; Tepe B.
    Sideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in α-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and α-amylase inhibitory agent. © 2021 SAAB