Browsing by Author "Kürsat S."

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    Hypokalemic rhabdomyolysis aggravated by diuretics complicating Conn's syndrome without acute renal failure [1]
    (Dustri-Verlag Dr. Karl Feistle, 2002) Özgür B.; Kürsat S.
    [No abstract available]
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    Effect of ultrafiltration on blood pressure variability in hemodialysis patients
    (Dustri-Verlag Dr. Karl Feistle, 2003) Kürsat S.; Özgü B.; Alici T.
    Aim: Increased blood pressure variability (BPV) in end-stage renal disease (ESRD) patients is proved to be a risk factor for cardiovascular disease [Tozawa et al. 1999]. The effect of ultrafiltration (UF) on BPV in hemodialysis (HD) patients has not been reported in the literature. This study was undertaken to define the effect of a single UF on BPV in HD patients. Methods: Prior and after HD with UF, 24-hour ambulatory BP monitoring (ABPM) was applied to each patient and then diurnal and nocturnal BP and BPV parameters (both before and after UF) were compared and correlated with UF values Results: Increase in BPV after single UF in all groups was statistically significant (p < 0.05). Only the daytime systolic (DS) BPV increase (median 42.4%) was in positive correlation with δ body weight (body wt) (median 3.07%) or UF amount (r = 0.649, p < 0.01). Conclusions: Large volume depletions and sympathetic hyperreactivity could explain the increase in BPV. Increased interdialytic weight gain requires more UF and subsequently BPV, morbidity and mortality also increase. Thus, considerable efforts must be made to prevent great interdialytic weight gain in HD patients.
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    Hand function assessment in patients receiving haemodialysis
    (SMW supporting association, 2003) Duruöz M.T.; Cerrahoglu L.; Dincer-Turan Y.; Kürsat S.
    Objective: To assess the usefulness of Duruöz's Hand Index (DHI) in patients undergoing haemodialysis. Methods: Patients receiving haemodialysis for more than 2 months were recruited randomly. Demographic, clinical and functional characteristics of patients were evaluated. Functional assessment was performed with DHI, Hand Functional Index (HFI), Health Assessment Questionnaire (HAQ), Purdue Pegboard, grip strength and 3 kinds of pinch strengths. DHI was correlated (Spearman's) with the other functional parameters in assessing the convergent validity and with non-functional parameters in assessing the divergent validity. Results: Sixty patients with a mean age of 50.05 were recruited. The average duration of haemodialysis was 55.02 months. DHI is significantly correlated with HAQ, HFI, Purdue Pegboard scores, grip strength and 3 types of pinch strengths while no significant correlation was found with non-functional parameters. Conclusions: DHI is a practical scale which is efficient in assessing accurately the functional disability of the hand in patients receiving haemodialysis.
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    Correlation between intestinal colony numbers and inflammation markers (TNF-Alpha, IL-6, high-sensitive CRP) following the use of sevelamer in rats with kidney failure; [Böbrek Yetmezlikli Ratlarda Sevelamer Kullanımı Sonrası İnflamasyon Belirteçleri (TNF-Alfa, IL-6, Hassasiyeti Yüksek CRP) ile Baǧırsak Koloni Sayısı Arasındaki İlişki]
    (Turkiye Klinikleri, 2012) Kürsat S.; Çolak H.; Yilmaz O.; Kolatan E.; Ulman C.; Kurutepe S.; Özyurt B.
    Our aim was to investigate anti-inflammatory effect of sevelamer in experimentally induced renal failure (RF) and whether this effect was related to a decrease in Escherichia coli colony counts in feces. Material and Methods: Eighteen female Wistar albino rats weighted 200-250 g were divided into three groups. RF was induced by 5/6 nephrectomy. Group 1 was the control group. Group 2 rats were those with induced RF receiving a high phosphate diet. Group 3 contained rats with induced RF receiving a high phosphate diet + sevelamer. E.coli count in feces, plasma creatinine, high-sensitive C-reactive protein (hsCRP), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) concentrations were determined at the beginning and at the end of 1st, 3rd and 6th weeks in all rats. Results: In Group 2 and 3, creatinine concentrations were found to be increased (p=0.03, p=0.02) in the 1st week. In Group 2, there was an increase in number of E. coli colony count in the 3rd week (p=0.05). In group 3, E. coli colony count and levels of inflammatory markers (IL-6, CRP, TNF-alfa) significantly were increased in comparison to the basal values (p=0.042, p=0.021, p=0.042, respectively) in the 1st week. In group 3, in the sixth week, E. coli colony count (p=0.02) and levels of inflammatory markers (IL-6, hsCRP, TNF-alpha) (p<0.05) were found to be significantly decreased in comparison to the 1st week levels. Conclusion: Anti-inflammatory effects of sevelamer might be explained by its effects on the bacterial colonization in colon. © 2012 by Türkiye Klinikleri.