Browsing by Author "Kabay S.C."

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    The role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis
    (Elsevier B.V., 2024) Taşkıran E.; Terzi M.; Helvacı E.M.; Eser M.Z.; Avcı B.; Ömer Faruk T.; Yetkin M.F.; Çilingir V.; Bir L.S.; Kabay S.C.; Bilge N.; Poyraz T.; Demir C.F.; Dündar D.K.; Ocak Ö.; Çam M.; Mavioğlu H.; Altun Y.; Karaibrahimoğlu A.
    Background/aim: Multiple sclerosis (MS) is an inflammatory demyelinating central nervous system (CNS) disease. Among the paraclinical tests, brain and spinal Magnetic Resonance Imaging (MRI) is primarily involved in the diagnosis process, and cerebrospinal fluid (CSF) analysis is fundamental in diagnosing MS and the differential diagnosis. A positive relationship was demonstrated between oligoclonal band (OCB) positivity, CSF band number and immunoglobulin G(IgG) index. The study aimed to evaluate whether the number of OCB can predict disease activity and determine a correlation with the IgG index. Methods: Our study included 401 MS patients who had relapsing-remitting multiple sclerosis (RRMS), primary progressive multiple sclerosis (PPMS), secondary progressive multiple sclerosis (SPMS), clinic isolated syndrome (CIS), radiologic isolated syndrome (RIS), Neuromyelitis optica spectrum disorder (NMOSD) and Acute disseminated encephalomyelitis (ADEM) with OCB number groups of 2–4, 4–8, 8–12, and 12 and above. Results: No significant correlation was observed between IgG index, pre-and post-treatment EDSS (Expanded Disability Status Scale Scores) and disease-modifying therapies (DMT). Drug response was better in the patient group with band number between 2 and 8 and post-treatment EDSS scores were lower (1.62±0.44). Conclusion: The study results suggested that band number may be as valuable as the IgG index and a predictive biomarker for disease activity. © 2023
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    Other primary headache disorders: Data from the HEAD-MENA-A study in Africa, Asia, and the Middle East
    (Elsevier B.V., 2024) Atalar A.Ç.; Genç H.; Ur Özçelik E.; Bolay H.; Uluduz D.; Unal-Cevik, I; Kissani N.; Luvsannorov O.; Togha M.; Ozge A.; Baykan B.; Cakan M.; Ak A.K.; Celik F.; Orun M.O.; Seker D.; Kucuk A.; Ozkan S.; Kiraz M.; Sirin T.C.; Ocal R.; Hakyemez H.A.; Yener M.O.; Serim V.A.; Cınar N.; Unal E.D.; Domac F.M.; Ates M.F.; Turkoglu B.G.; Gursoy G.; Cekic S.; Aslan S.K.; Agırcan D.; Oktar A.C.; Demirel E.A.; Gelener P.; Ibrahim E.A.A.E.; Evlice A.; Gorken G.; Sanlı Z.S.; Bayır B.R.H.; Tepe N.; Okluoglu T.; Demir T.G.; Badr M.Y.; Vurallı D.; Jafari E.; Polat B.; Ermis A.; Khanmammadov E.; Yolcu O.; Kul B.; Sakadi F.; Ulutas S.; Akturk T.; Ketema T.M.; Lala S.; Cedric A.P.S.A.; Velioglu S.K.; Kırbasoglu O.; Moustafa R.R.; Nowar A.G.; Kabay S.C.; Gumanovna V.K.; Yifru Y.M.; Nasergivehchi S.; Azizova I.; Kizek O.; Ekizoglu E.; Orhan E.K.; Melka D.; Alemayehu B.
    Objective: Other primary headache disorders (OPHD) are under-investigated compared to frequent primary headache types like migraine, tension-type headache, and trigeminal autonomic cephalalgias. Knowledge of the distribution and characteristics of OPHD subtypes is crucial for their recognition. We aimed to determine the prevalence at the hospital and headache clinics and clinical characteristics of OPHDs in patients from 13 countries. Methods: We analyzed a large dataset from the cross-sectional study Head-MENA-A (Middle East, North Africa, Asia). Consecutive patients over 10 years of age presenting with headaches were included from outpatient, inpatient, and emergency settings. A structured questionnaire addressing demographics, headache characteristics, accompanying symptoms, and triggers was administered. Headache subtypes were diagnosed according to the ICHD-3 criteria. Results: Among patients complaining of headaches (n = 3722), 106 (2.9%) were diagnosed with OPHD. Fifty-two patients (1.4% of all headache patients) had only OPHD, while 54 (1.5%) had both OPHD and a co-existing primary headache (mostly migraine). All OPHDs were more common in females. The most frequent subtypes were new daily persistent headache and primary stabbing headache (0.2% each among all admitted patients). Photophobia and phonophobia were the most frequent accompanying symptoms, while physical activity (28.8%), stress (15.4%), and the Valsalva maneuver (15.4%) were the most common triggering factors. The majority of triggering factors were more pronounced in patients with both migraine and OPHD. Conclusions: Other primary headaches are rare and heterogeneous. Their high co-existence with migraine suggests shared predisposing factors, hinting at a “headache continuum” concept for primary headaches. © 2024 Elsevier B.V.
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    Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein
    (Galenos Publishing House, 2024) Koç S.; Şen S.; Terzi Y.; Kızılay F.; Demir S.; Aksoy D.B.; Kurtuluş F.; Bilge N.; Idilman E.; Uzunköprü C.; Güngör S.; Çilingir V.; Ethemoğlu Ö.; Boz C.; Gümüş H.; Kılıç A.K.; Kısabay A.; Bir L.S.; Turan Ö.F.; Soysal A.; Köseoğlu M.; Uzuner G.T.; Bayındır H.; Kabay S.C.; Çam M.; Yayla V.; Tan H.; Özcan A.; Taşkapıoğlu Ö.; Korkmaz M.; Tamam Y.; İnanç Y.; Efendi H.; Kotan D.; Yetkin M.F.; Bilgiç A.B.; Saçmacı H.; Demirci S.; Çelik Y.; Poyraz T.; Terzi M.
    Background: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz Mayıs University’s Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and 43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG. © Author(s).
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    Corrigendum to “The role of oligoclonal band count and IgG index in treatment response and disease activity in multiple sclerosis” [Multiple Sclerosis and Related Disorders 83 (2024) 105391] (Multiple Sclerosis and Related Disorders (2024) 83, (S2211034823008908), (10.1016/j.msard.2023.105391))
    (Elsevier B.V., 2025) Taşkıran E.; Terzi M.; Helvacı E.M.; Eser M.Z.; Avcı B.; Faruk T.Ö.; Yetkin M.F.; Çilingir V.; Bir L.S.; Kabay S.C.; Bilge N.; Poyraz T.; Demir C.F.; Dündar D.K.; Deveci E.E.; Çam M.; Mavioğlu H.; Altun Y.; Karaibrahimoğlu A.
    The authors regret Esra Taşkıran1, Murat Terzi2, Elif Merve Helvacı3, Meltem Zeycan Eser4, Bahattin Avcı5, Turan Ömer Faruk6, Mehmet Fatih Yetkin7, Vedat Çilingir8, Levent Sinan Bir9, Sibel Canbaz Kabay10, Nuray Bilge11, Turan Poyraz12, Caner Feyzi Demir13, Dilcan Kotan Dündar14,Emrah Emre Deveci15, Mustafa Çam16, Hatice Mavioğlu17, Yaşar Altun18, Adnan Karaibrahimoğlu19 1 Antalya Training and Research Hospital Neurology Clinic, Antalya 2 Ondokuz Mayıs University Faculty of Medicine Department of Neurology, Samsun 3 Ondokuz Mayıs University Graduate School of Education Department of Neurosciences, Samsun 4 Ondokuz Mayıs University Department of Biochemistry, Samsun 5 Ondokuz Mayıs University Department of Biochemistry, Samsun 6 Uludag University Faculty of Medicine Department of Neurology, Bursa 7 Erciyes University Faculty of Medicine, Kayseri 8 Van Yüzüncüyıl University Faculty of Medicine, Van 9 Pamukkale University Faculty of Medicine, Denizli 10 Dokuz Eylul University Faculty of Medicine, İzmir 11 Atatürk University Faculty of Medicine, Erzurum 12 Private Medifema Hospital, İzmir 13 Firat University Faculty of Medicine, Elazığ 14 Sakarya University Faculty of Medicine, Sakarya 15 Muğla Sıtkı Koçman University Faculty of Medicine, Muğla 16 Çanakkale University Faculty of Medicine, Çanakkale 17 Celal Bayar University Faculty of Medicine, Manisa 18 Adıyaman University Faculty of Medicine, Adıyaman 19 Süleyman Demirel University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Isparta Unfortunately, due to oversight, an author-related error occurred in the article. In order to facilitate the requested change of author, I have previously forwarded to the editorial manager the necessary documentation, including the signatures of the authors involved. The authors would like to apologise for any inconvenience caused. © 2025 Elsevier B.V.