Browsing by Author "Kader, S"

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    Change in quality of life, anxiety and depressive symptoms with asthma severity in children
    Yilmaz, Ö; Sögüt, A; Kader, S; Taskin, O; Yüksel, H
    Objective: The aim of this study was to evaluate the change in anxiety-depression symptoms with the change in asthma related symptom score and quality of life in children. Materials and Methods: Thirty five children with asthma aged 6 to 16 years were enrolled in this cohort. Symptom scores were recorded and all children filled in Pediatric Asthma Quality of Life Questionnaire (PAQLQ), Hospital Anxiety Depression Scale (HADS) and Center for Epidemiologic Studies Depression Scale (CES-D). They were called in again four months later to evaluate for change in all parameters. Results: When initial presentation and follow-up values were compared, significant decrease in symptom score, number of exacerbations and number of emergency visits was detected (p< 0.001, p= 0.001 and p= 0.004 respectively). Similarly, HADS anxiety and depression scores as well as CES-D score improved significantly at follow-up when compared to the initial presentation (p< 0.001, p= 0.001 and p< 0.001 respectively). Change in symptom score was significantly correlated with changes in CES-D score as well as PAQLQ symptom, emotion and total scores (r= 0.39 p= 0.04, r= -0.57 p< 0.001, r= -0.66 p< 0.001, r= -0.66 p< 0.001 respectively). Change in PAQLQ total score demonstrated significant negative correlation with the change in HADS anxiety score (r= -0.42, p= 0.02). Conclusion: Improvement in asthma symptoms and QoL is associated with improvement in depression-anxiety symptoms.
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    GASTROESOPHAGEAL REFLUX OR ASTHMA: WHICH COMES FIRST IN ATOPIC AND NONATOPIC CHILDREN?
    Yilmaz, O; Kasirga, E; Kader, S; Alkan, S; Yuksel, H
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    Diagnostic Yield of Upper Gastrointestinal Endoscopy in the Evaluation of Iron Deficiency Anemia in Older Children and Adolescents
    Gulen, H; Kasirga, E; Yildirim, SA; Kader, S; Sahin, G; Ayhan, S
    Iron deficiency anemia (IDA) is frequent in childhood. Inadequate nutrition and gastrointestinal malabsorption are the frequent causes of IDA in children. But reduced iron absorption and insidious blood loss from the gastrointestinal tract has been identified as the most frequent causes of IDA in older children and adolescents. Therefore the authors evaluated the frequency and etiologies of the upper gastrointestinal system pathologies causing IDA in older pediatric population. Patients with known hematological or chronic diseases, heavy menstrual flow, and obvious blood loss were excluded from the study. Forty-four children between the ages of 9.5 and 17.5 years and diagnosed with IDA were enrolled. They underwent upper gastrointestinal endoscopy and biopsy from esophagus, stomach, and duodenum. Mean age and hemoglobin (Hb) levels of study group (32 boys, and 12 girls) were 14.6 +/- 2.0 years and 7.9 +/- 1.8 g/dL, respectively. Only 1 patient had a positive serology testing with anti-tissue transglutaminase and small bowel biopsy correlating with celiac disease. Endoscopy revealed abnormal findings in 25 (56.8%) patients (21 endoscopic antral gastritis, 2 active duodenal ulcers, and 2 duodenal polyps). Helicobacter pylori (HP) infection was identified by using antral histopathological evaluation in 19 of 44 children (43.2%). In 2 of duodenal samples, one patient had celiac disease, and the other one was diagnosed as giardiasis. In conclusion, there are different etiologies resulting in IDA in older children and adolescents. When older children and adolescents are found to have iron deficiency, HP infection and other gastrointestinal pathologies should be ruled out before iron deficiency treatment.
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    Gastroesophageal reflux disease in asthmatic children and its relation with atopy
    Yilmaz, Ö; Kasirga, E; Kader, S; Alkan, S; Yüksel, H
    Objective: The aim of this study was to determine frequency of gastroesophegeal reflux disease (GERD) and influence of GERD treatment on respiratory findings in atopic and nonatopic children with asthma. Materials and Methods: Thirty two nonatopic, 24 atopic children with asthma were enrolled in this retrospective study. GERD related respiratory symptoms and asthma severity parameters six months prior to and after pH monitoring were recorded. 24 hour pH monitoring results were also recorded. Results: Frequency of proximal GERD was 71.9% in atopic and 70.8% in nonatopic group (p=0.93). Distal GERD frequencies were similar (66.7% and 68.8% in atopic and nonatopic groups respectively, p=0.87). All parameters improved in nonatopic children after GERD treatment (p=0.01). However, only respiratory symptoms and hospitalization improved in atopic children (p=0.002 and p=0.007 respectively). Conclusion: Similar frequencies of GERD in atopic and nonatopic children may suggest role of asthma in development of GERD. However, improvement in all clinical parameters in nonatopic but not in atopic children might indicate that gastroesophageal reflux is the causal event in the association of asthma and GER in nonatopic children whereas it is the result in atopic ones. These findings need to be supported by further prospective cohort studies.
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    Is Obesity Related to Worse Control in Children with Asthma?
    Yilmaz, O; Sögüt, A; Bozgül, A; Türkeli, A; Kader, S; Yüksel, H
    Introduction: Asthma and obesity are related diseases however the influence of obesity on asthma severity is not clear yet. Therefore, the aim of our study was to evaluate the association between obesity and asthma control evaluated on the basis of symptoms and asthma control questionnaire (ACQ). Materials and Methods: We enrolled 98 children with asthma aged 4 to 14 years consecutively and recorded their disease characteristics and severity parameters as well as the symptom scores. All children filled in the ACQ. Children were classified as obese and non-obese according to body mass index. Obesity was defined as body mass index over 90th percentile. Results: Mean age of the children in the obese group (n=27) was 8.1 +/- 2.6 while that in the non-obese group (n=71) was 8.6 +/- 2.9 (p=0.41). Asthma symptom score in obese and non-obese groups were not significantly different (p=0.73). Children in the obese group had lower ACQ scores when compared to the non-obese group (1.2 +/- 0.9 vs 1.7 +/- 1.0, p=0.04) however this significance was lost when controlled for age and gender in the regression model. Conclusion: The results of this study suggest that obesity is not significantly associated with worse asthma control when adjusted for age and gender.
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    Caffeine use in preterm neonates: national insights into Turkish NICU practices
    Unal, S; Beken, S; Ince, DA; Turan, O; Toygar, AK; Ecevit, A; Akcan, AB; Akin, MA; Aktas, S; Ciftdemir, NA; Altuncu, E; Altunhan, H; Arcagok, BC; Armangil, D; Ozer, EA; Aydin, B; Bezirganoglu, H; Bilgin, L; Calisici, E; Calkavur, S; Celik, K; Celik, Y; Cetinkaya, B; Cetinkaya, M; Demirel, A; Demirel, G; Dogan, NN; Dogan, P; Durukan, M; Engur, D; Ercan, TE; Gokmen, Z; Varal, IG; Gulasi, S; Gunlemez, A; Gursoy, T; Toptan, HH; Hamitoglu, S; Isleyen, F; Iyigun, I; Kader, S; Kahvecioglu, D; Kayki, G; Kostu, M; Kurnaz, D; Mammadaliyev, T; Akin, IM; Narli, N; Okulu, E; Okur, N; Olukman, O; Ovali, F; Ozcan, B; Ozdemir, A; Ozdemir, O; Ozkan, H; Sandal, G; Sarici, D; Sivrikaya, C; Bilgin, BS; Sundus, S; Onay, OS; Simsek, H; Tandircioglu, UA; Tanriverdi, S; Tekgunduz, KS; Terek, D; Tunc, G; Tunc, T; Tutak, E; Tufekcioglu, E; Erdogan, FT; Ulu, E; Isik, DU; Uras, N; Uslu, SI; Unal, I; Yilmaz, FH; Moniri, A
    Objective: Caffeine is a proven medication used for the prevention and treatment of apnea in premature infants, offering both short- and long-term benefits. International guidelines provide a range of recommendations regarding the preterm population eligible for caffeine prophylaxis, including the timing, dosage, and duration of treatment. Our national guidelines, published prior to the most recent updates of the international guidelines, recommend the use of caffeine citrate starting from the first day after delivery for preterm infants with a gestational age of <28 weeks. For infants up to 32 weeks, if positive pressure ventilation is required, the decision should be made on an individual basis. This study aims to describe the variability in caffeine usage across neonatal intensive care units in our country. Methods: An online survey was sent to neonatologist who are members of the Turkish Neonatology Society to describe the variability in caffeine usage in neonatal intensive care units in our country. Results: We collected responses from 74 units. Prophylactic caffeine usage was observed as; GA <= 27(6/7): 98.6%, GA 28(0/7)-28(6/7): 89.0%, GA 29(0/7)-29(6/7): 75.3%, GA 30(0/7)-31(6/7): 53.4%. 62.2% of units reported administering loading dose within the first two hours. The initial maintenance dose was 5 mg/kg in 64.8% of units, 10 mg/kg in 32.4% of units, and intermediate dose in 5.3% of units. 47.3% of units reported no routine dose adjustment. The postmenstrual age that caffeine treatment was stopped was found to be 34 (min-max; 32-36) weeks for infants without apnea and respiratory support, 36 (min-max; 34-52) weeks for infants without apnea but any respiratory support. The time to discharge after treatment cessation was found as; 1-4 days: 37.8%, 5-7 days: 68.9%. Among the 56 units with multiple responsible physicians, 32.1% reported intra-unit variations. Conclusion: The significant differences in caffeine usage characteristics between and within units highlight the need for clear recommendations provided by standardized guidelines.