Browsing by Author "Kalayci, F"
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Item Reliability and Validity of the Turkish Version of the Burden Assessment ScaleAydemir, Ö; Dikici, DS; Akdeniz, F; Kalayci, FBackground: In this study, it is aimed to evaluate the reliability and validity of the Turkish version of the Burden Assessment Scale. Methods: The study was carried out on 100 volunteers who were caregivers of in-or outpatients at a university hospital, department of psychiatry. The diagnoses of the patients were schizophrenia (25%), bipolar disorder (22%), major depressive disorder (24%), and anxiety disorder (29%). The mean duration of the illness was 8.2 +/- 8.7 years. For the concurrent validity, the Perceived Family Burden Scale and the Zarit Caregiver Burden Scale were used. In the statistical analyses, internal consistency, item-total score correlation, explorative factor analysis, correlation with other scales were calculated. Results: The Turkish version of the Burden Assessment Scale was prepared after the translation and back-translation of the original scale and after the consensus on the translated form. In the internal consistency analysis, Cronbach alpha coefficient was found to be 0,894 and item-total score correlation coefficients were between 0.297 and 0.742. In the explorative factor analysis, a five-factor solution explaining 67.2% of the total variance was obtained and the conceptual themes of the factors were limitations in daily life, negative emotions, worry for the patient, losses of the caregiver, and disruption in activities. The correlation of the Burden Assessment Scale with the Perceived Family Burden Scale was r=0.485 and with the Zarit Caregiver Burden Scale was r=0.610. Conclusion: It is demonstrated that the Turkish version of the Burden Assessment Scale which is convenient in the milder forms of psychiatric disorders and which is developed for the assessment burden of patients on their caregivers is reliable and valid. (Archives of Neuropsychiatry 2012; 49: 276-280)Item Multicenter Evaluation of the Indirect Nitrate Reductase Assay for the Rapid Detection of Multidrug-Resistant TuberculosisÇoban, AY; Tastekin, B; Uzun, M; Kalayci, F; Ceyhan, I; Biçmen, C; Albay, A; Sig, AK; Özkütük, N; Sürücüoglü, S; Ozkütük, A; Esen, N; Albayrak, N; Aslantürk, A; Saribas, Z; Alp, AMultidrug-resistant tuberculosis (MDR-TB) is defined as resistance to at least isoniazid (INH) and rifampicin (RIF), and it complicates the implementation of tuberculosis control programmes. The rapid detection of MDR-TB is crucial to reduce the transmission of disease. The nitrate reductase assay (NRA) is one of the colorimetric susceptibility test methods for rapid detection of MDR-TB and based on the ability of reduction of nitrate to nitrite by Mycobacterium tuberculosis. The aim of this study was to evaluate the performance of the NRA for the rapid detection of MDR-TB. A total of 237 M.tuberculosis complex (MTC) isolates that were identified by the same method (BD MGIT (TM) TBc Identification Test, USA) from nine different medical centers in Turkey were included in the study. The susceptibility results of the isolates against INH and RIF obtained by reference test (Bactec MGIT (TM) 960, BD, USA) were then compared with NRA. In order to ensure consistency between centers, Lowenstein-Jensen (LJ) medium with antibiotics and without antibiotics (growth control) and Griess reagent solution were prepared in a single center (Ondokuz Mayis University School of Medicine, Medical Microbiology Department) and sent to all participant centers with the standardized test procedure. After the inoculation of bacteria into the test tubes, the tubes were incubated at 37 degrees C, and after seven days of incubation, 500 mu l Griess reagent was added to the LJ medium without antibiotics. If a color change was observed, an equal volume of Griess reagent was added to test LJ media with antibiotics. When a color change was observed in LJ media with antibiotics, it was considered that the isolate was resistant to tested antibiotics. Among 237 MTC isolates, 16 were resistant only to INH and nine were resistant only to RIF; 93 isolates (39.2%) were resistant (MDR) and 119 isolates (50.2%) were susceptible to both of the drugs determined with the reference susceptibility test. In the study, five INH-resistant isolates determined with reference method were found susceptible with NRT and eight INH-susceptible isolates determined with reference method were found resistant with NRT. In contrast, one RIF-resistant isolate determined with reference method was found susceptible with NRT and three RIF-susceptible determined isolates were found resistant with NRT. Accordingly, the concordance rate between the reference method and NRA were estimated as 94.5% for INH and 98.3% for RIF. The sensitivity, specificity, positive and negative predictive values of NRA were detected as 95.4%, 93.7%, 92.8% and 96% for INH, and 99%, 97.8%, 97.1% and 99.2% for RIF, respectively. The results of the 111 isolates were obtained on the seventh day, while the rest of the results were obtained between 10-14 days. In conclusion, the data of this multicenter study showed that NRA is a reliable, relatively inexpensive and practical method to perform for the rapid detection of MDR-TB.Item Reliability and validity of Turkish version of biological rhythms interview of assessment in neuropsychiatryAydemir, O; Akkaya, C; Altinbas, K; Kora, K; Dikici, DS; Akdeniz, F; Kalayci, F; Oral, ET; Vahip, SItem Reliability and validity of Turkish version of Biological Rhythms Interview of Assessment in NeuropsychiatryAydemir, Ö; Akkaya, C; Altinbas, K; Kora, K; Sücüllüoglu, DS; Akdeniz, F; Kalayci, F; Oral, ET; Vahip, SObjective: In this study, it is aimed to perform the validity and reliability of the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry. Methods: The study was performed with 79 bipolar type-I disorder, 26 bipolar type-II disorder and 42 major depressive disorder patients attending to mood disorder clinics of three university hospitals and one state training hospital as well as 116 university students consisting healthy control subjects. The mean duration of the illness was 15.1 years for the bipolar groups and 9,3 years for the depressive group. For concurrent validity, Pittsburgh Sleep Quality Index was used. In the statistical analyzes, internal consistency coefficient, item-total score correlations, exploratory and confirmatory factor analyzes, correlation with the other scale and ROC curve were calculated. Results: The forward and back translation of the Biological Rhythms Interview of Assessment in Neuropsychiatry was performed, and linguistic equivalence was obtained with the scale prepared. In internal consistency, the Cronbach's alpha coefficient was found to be 0.899 and item-total correlation coefficients were between 0.239 and 0.747. In the exploratory factor analysis, a total of three factors representing 56.5% of the total variance were obtained and the themes of the factors were daily activities, sleep and eating habits and interpersonal relations. In the confirmatory factor analysis, confirmatory fit index was 0.932 and root mean square of approximation was 0.065. The correlation between Biological Rhythms Interview of Assessment in Neuropsychiatry and Pittsburgh Sleep Quality Index was found to be r=0.238. In the sensitivity and specificity analysis, the area under the ROC curve was 0.876. The scale discriminated mood disorder groups from the healthy control group. Conclusion: It is shown that the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry which is used in the assessment of circadian rhythm and functionality is reliable and valid.Item Reliability and Validity Study of the Turkish Version of Hypomania Checklist-32-RevisedVahip, S; Aydemir, Ö; Akkaya, C; Altinbas, K; Kora, K; Dikici, D; Akdeniz, F; Kalayci, F; Oral, T; Vahip, I; Alkan, M; Angst, JObjective: In this study, it is aimed to evaluate the reliability and validity of the Turkish version of Hypomania Checklist-32-Revised. Method: The study was carried out with 80 patients diagnosed with bipolar I disorder, 26 patients diagnosed with bipolar II disorder and 42 patients diagnosed with major depressive disorder attending the out- and in-patient psychiatry departments of three university hospitals and one training hospital, and 116 healthy volunteers consisting of university students. Mean duration of illness was 15,1 years for the bipolar disorder group, and 9,3 years for the major depressive disorder group. For concurrent validity, Mood Disorder Questionnaire was used. In the statistical analysis, internal consistency coefficient, item-total score correlation coefficients, exploratory factor analysis, correlation with concurrent scale and ROC curve were calculated. Results: Translation into Turkish and back-translation into English of Hypomania Checklist-32-Revised were performed and thus the semantic harmony of the scale was obtained. In the internal consistency, Cronbach alpha coefficient was 0,914 and item-total score correlations were between 0,235-0.743. Solely the coefficient of item #23 was found as 0,110. In factor analysis, six factors were obtained but a two-factor solution representing 44,5% of the total variance was accepted and first factor represents overactivity and being expansive, second factor represents impulsivity and risky behaviors. Correlation of Hypomania Checklist-32-R with Mood Disorder Questionnaire was r=0,379. In the ROC analysis, the cut off point of the scale was calculated as 14 with a sensitivity of 71,0 and specificity of 69,8. The scale discriminates well between the bipolar group, and depressive and control groups. Conclusion: Hypomania Checklist-32-Revised developed for screening hypomania is reported to be reliable and valid in Turkish after cutting out item #23.