Browsing by Author "Kalkan, S"

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    The effects of gender and menopause on serum lidocaine levels in smokers
    Oztekin, S; Mavioglu, O; Elar, Z; Guven, H; Kalkan, S; Gurpinar, T
    it has been established that human cytochrome P450 (CYP) enzymatic activity is affected by gender, or by hormonal factors such as the menopause in women. Gender differences have a more pronounced effect on cytochrome (CYP) 3A4 isoenzyme activity, whereas cytochrome (CYP) 1A2 isoenzyme activity is mainly induced by chronic smoking. Lidocaine is frequently used in the treatment of hemodynamic changes following laryngoscopy and tracheal intubation during general anesthesia, and is metabolized by CYP3A4 and CYP1A2 isoenzymes in the liver. The aim of this study was investigate the effects of gender and menopause on serum lidocaine levels in smokers under general anesthesia. Six men, six premenopausal women and six postmenopausal women were enrolled in the study and received i.v. lidocaine (1 mg/kg) 1 minute before they underwent general anesthesia. Serum lidocaine concentrations were measured using the EMITO method at 1, 5, 10, 20, 40 and 60 minutes post-administration. Statistical analyses were performed using the Mann-Whitney U-test. No statistically significant differences were found regarding the area under curve (AUC((0-60)) mu g/mL/min), elimination half-life (t(1)/(2) [min]) of lidocaine and in the measured levels of serum lidocaine at any time point between the study groups (p > 0.05). These results suggest that gender and menopause may have no significant effect on serum lidocaine levels in smokers.
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    Importance of Inhaler Device Use Status in the Control of Asthma in Adults: The Asthma Inhaler Treatment Study
    Yildiz, F; Erbagci, A; Demirel, YS; Akcali, SD; Ekici, A; Dursunoglu, N; Ediger, D; Erdinc, M; Cemri, SC; Kalyoncu, AF; Guclu, SZ; Aktogu, S; Gurler, BB; Bayram, M; Akgun, M; Mirici, A; Akyildiz, L; Celik, P; Guven, AO; Camsari, G; Ozseker, F; Cimen, F; Kurutepe, M; Senyigit, A; Bektas, Y; Ozbudak, O; Saylan, B; Baslilar, S; Polatli, M; Cagatay, T; Kalkan, S; Ozer, A
    BACKGROUND: Proper education and training in correct inhalation technique has been reported to have a substantial role in the achievement of optimal therapeutic benefit and asthma control. The present study was designed to evaluate inhaler technique and the role of education in relation to asthma control among patients with persistent asthma in Turkey. METHODS: A total of 572 patients with persistent asthma (mean +/- SD age 42.7 +/- 12.2 y, 76% females) were included in this non-interventional, observational, registry study conducted across Turkey. Data on the effective and correct use of inhaler devices were collected via the Ease of Use for the Inhaler Device Questionnaire to patients and physicians. RESULTS: Asthma control (overall 61.5% at baseline, and increased to 87.3% during follow-up) was better, with significant improvement in technique and decrease in basic errors to the range 0-1, regardless of the inhaler type. Overall, the most common basic error associated with inhalation maneuvers was failure to exhale before inhaling through the device (18.9%). There was concordance between the patients and physicians in the ratio of correct inhaler technique only for spray-type inhalers. CONCLUSIONS: Close follow-up with repeated checking of the patient's inhaler technique and correction of errors each time by a physician seem to be associated with a significant decrease in the percent of patients who make basic errors in inhalation maneuvers and device-independent errors, and with better control of persistent asthma.