Browsing by Author "Kandiloǧlu A.R."

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    Effects of extracorporeal shockwave lithotripsy at different stages of pregnancy in the rabbit
    (Mary Ann Liebert Inc., 1997) Gümüş B.; Lekili M.; Kandiloǧlu A.R.; Işisaǧ A.; Temeltaş G.; Nazli O.; Büyüksu C.
    Although SWL is now the most common treatment modality for urinary tract stone disease, it is not regarded as a safe method for pregnant patients because of its potential harmful effects on fetus. Using a rabbit model, we investigated whether SWL might cause fetal injury when administered at various developmental stages. Two groups of pregnant rabbits were given 1000 shockwaves either early or late in the gestational period. Time-matched controls did not receive shockwaves. After spontaneous labor, all newborn rabbits were counted, weighted, and measured, and specimens were taken from organs and examined histopathologically. The numbers, weights, and diameters of the newborns in each group were similar. There was no notable histopathologic finding in the heart and brain specimens of any of the newborns, whereas noticeable congestion and multiple focal intraparanchymal microhemorrhages were found in lungs, livers, and kidneys of the animals that had been exposed to shockwaves early in gestation. In conclusion, this study shows that SWL is not a safe treatment in early pregnancy.
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    The effects of extensive vas mobilization on testicular histology during orchiopexy
    (Akademiai Kiado Rt., 1998) Lekili M.; Gümüş B.; Kandiloǧlu A.R.; Işisaǧ A.; Müezzinoǧlu T.; Büyüksu C.
    We were aware that extensive mobilization of vas deferens during orchiopexy could cause secondary infertility due to testicular damage and/or functional obstruction of the vas deferens. We decided to perform this experimental study in order to document the effects of this procedure on the testis. Thirty adult fertility-proven New Zealand white rabbits were randomly divided into 3 groups. Ten rabbits underwent extensive mobilization of the vas deferens and the other 10 rabbits had vasectomy on the left side. The remaining 10 rabbits were explored on the left side only and were considered sham controls. Four weeks later all rabbits underwent bilateral orchiectomy. Mean seminiferous tubular diameters and Johnsen's testicular biopsy scores were noted. Comparison of the three groups showed that vas mobilization and vasectomies cause no effect on the viability of testis, however, significant testicular histological changes, which were different from the controls and contralateral testis, were observed. We concluded that during any surgical intervention involving the inguinal canal, vascular and neural supports of the vas deferens should be preserved as much as possible in order to avoid iatrogenic damages to the testis.
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    Giant mucinous cystadenocarcinoma: A case report
    (2003) Kuşcu N.K.; Çaǧlar H.; Íshakoǧlu M.; Kandiloǧlu A.R.; Keleş G.T.
    We present a mucinous cystadenocarcinoma weighing 10 kg in a postmenopausal woman and the way how we managed the case.
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    Col IV and Fn Distribution in Prostatic Adenocarcinoma and Correlation of 67LR, MMP-9 and TIMP-1 Expression with Gleason Score
    (2003) Işisaǧ A.; Neşe N.; Ermete M.; Lekili M.; Ayhan S.; Kandiloǧlu A.R.
    OBJECTIVE: To assess the immunoreactivity of 5 proteins related to basement membrane (BM) and extracellular matrix in order to investigate whether any of them correlates with differentiation of prostatic adenocarcinoma (PAc). Two of these markers are collagen type IV (Col IV), the collagenous component of basement membrane, and fibronectin (Fn), an adhesion protein in extracellular matrix. Others are matrix metalloproteinase-9 (MMP-9), a type IV collagenase, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), which has a high affinity for MMP-9, and 67-kd laminin receptor (67LR), which belongs to the non-integrin laminin binding receptor family. STUDY DESIGN: Forty-three PAc cases with Gleason scores ranging between 5 and 10 and 10 benign prostatic hyperplasia (BPH) cases, the control group, were included in the study. Formalin-fixed and paraffin-embedded tissue slides from each case were immunostained with the avidin-biotin-peroxidase method. Immunoreactivity was determined by means of a scoring system similar to the Gleason scoring system. RESULTS: Overexpression of Col IV, Fn, 67LR and MMP-9 was detected in PAc as compared with BPH, whereas no difference was determined in TIMP-1 expression. Among these, only 67LR correlated statistically with Gleason score. CONCLUSION: Expression of 67LR in tumor cells was significantly increased in parallel to tumor grade. This may be useful in microscopic evaluation of PAc.
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    Acrodermatitis continua of Hallopeau: Was it an outcome of a surgical trauma or initially misdiagnosed as onychomycosis? [8]
    (2003) Şahin M.T.; Öztürkcan S.; Türel A.; Kandiloǧlu A.R.
    [No abstract available]
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    Does asymptomatic inflammation increase PSA? A histopathological study comparing benign and malignant tissue biopsy specimens
    (2004) Gümüs B.H.; Neşe N.; Gündüz M.I.; Kandiloǧlu A.R.; Ceylan Y.; Büyüksu C.
    Aim: To determine the effect of inflammation on postage-specific antigen (PSA) levels in patients who were performed transrectal ultrasonography (TRUSG) guided prostate biopsy because of high PSA levels. Materials and method: 376 tissue specimens of 47 patients with BPH and 176 tissue specimens of 22 patients with prostate adenocancer were analysed histopathologically. Digital rectal examination, TRUSG, and PSA measurements were performed to all the patients before biopsy. Sextant biopsy was performed. Two pathologists examined all the biopsy specimens in blinded fashion. Inflammation pattern was categorized as glandular, periglandular, stromal and perivascular and intensity of inflammation graded from 1 to 3. Results: The mean age of the patients was 66.2 years. The mean serum PSA level of the initial biopsy was 8.7 ng/ml in the BPH and 13.4 ng/ml in the prostate Ca. No relation was found between the serum total PSA levels and prostate volume or patient's age in BPH patients (P =0.258). In BPH patients stromal, periglandular, glandular inflammations did not increase PSA levels. Perivascular inflammation increased PSA levels significantly. Conclusion: The inflammation in perivascular field increases serum PSA levels (P =0.007). Although high serum PSA levels shows correlation with cancer in biopsy, there is no such significant relation with rebiopsy results and PSA levels at last studies. Because of this, these patients' biopsy samples must be reinspected for infection findings and atipic biopsy or high grade PIN. The result of our study showed that histological perivascular infection within the prostatic gland is a significant factor to serum PSA levels in BPH. If you have negative biopsy sample, pathology must indicate the place of the infection. Follow up of this patient and rebiopsy time are decided according to the result of this negative biopsy sample. © 2004 Kluwer Academic Publishers.
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    Nested variant of transitional cell carcinoma with osseous metaplasia of the urinary bladder: A case report and review of published reports
    (2007) Neşe N.; Kandiloǧlu A.R.; Atesçi Y.Z.
    Nested variant of transitional cell carcinoma (NV-TCC) of the bladder is a rare and relatively new entity. The tumor is aggressive contrasted by its benign histopathologic appearance, and characterized by irregular urothelial nests and/or tubules. Herewith, a case with exceptional osseous metaplasia is presented emphasizing its diagnostic difficulties, because it can be confused with benign diseases or conventional TCC. © 2007 The Japanese Urological Association.
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    The effects of transparenchymal suture material and fibrine-a tissue adhesive-on the contralateral testis
    (Turkiye Klinikleri, 2008) Dilşen Ç.; Şencan A.; Neşe N.; Kandiloǧlu A.R.; Yilmaz Ö.; Günşar C.; Genç A.; Taneli C.; Mir E.
    Objective: Experimental studies showed that fibrin glue (FG) which was used in orchidopexy and testicular torsion caused less tissue damage in the ipsilateral testis when compared with the transparenchymal suture materials. However, whether the usage of the FG in testis fixation causes any histological changes in the contralateral testis is not known. The aim of this study was to compare the effects of FG and other suture materials on the contralateral testis where no surgical procedure is performed. Material and Methods: Fifty prepubertal rats were randomly divided into 5 groups and the tunica vaginalis of all the right testes were longitudinally incised. In group 1, the incision line was closed with FG, whereas silk, catgut and polypropylene were used respectively in the groups 2, 3 and 4. Group 5 was the control group and no surgical procedure was performed on the left testes. The rats were sacrificed 3 weeks later and the diameters of the right and left testes were measured. Testes were evaluated by means of inflammation, seminiferous tubular diameter (STD), spermatogenetic activity and epididymal inflammation. Result: In group 2, 3 and 4, spermatogenetic activity, STD and the testis diameter of the ipsilateral testes decreased, whereas testicular and epidydimal inflammation increased. When the contralateral testis was evaluated, STD of the FG group decreased and FG had no extra benefit on testicular histology when compared to other suture materials. Conclusion: Surgical procedures performed on the ipsilateral testis cause only a decrease in the contralateral STD, which is observed by light microscope, but this decrease seems to have no effect on the spermatogenetic activity. Besides, the usage of FG instead of other materials in testis fixation has no extra benefit. However, it must be kept in mind that these results might vary when ultrastructural and immunological evaluations are performed. Copyright © 2008 by Türkiye Klinikleri.
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    Primary squamous cell carcinoma of the breast: A case report and immunohistochemical features for differential diagnosis; [Memenin primer skuamöz hücreli karsinomu: Olgu sunumu ve Ayırıcı tanı açı;sından İmmunohistokimyasal özellikleri]
    (Ekin Tibbi Yayincilik, 2010) Temiz P.; Kandiloǧlu A.R.; Şimşek G.; Coşkun T.; Göktan C.
    We present a 68-year-old postmenopausal woman with a rapidly growing right breast mass. It was diagnosed as "invasive ductal carcinoma" on tru-cut biopsy owing to infiltrative pattern and c-erbB-2 (HER2/neu) and progesterone receptor positivities. Partial response was obtained after four cure chemotherapy (adriamycin and cyclophosphamide). Then, she underwent a modified radical mastectomy with axillary lymph node dissection (level III). Grossly, a white-tan, solid, ill-defined tumor with 5 cm diameter located in the upper inner and outer quadrant of the breast was detected. Central portion of the tumor showed necrotic and hemorrhagic changes. Microscopic examination revealed poorly differentiated squamous cell carcinoma (SCC) having intraductal epithelial hyperplasia with squamous cell metaplasia and multiple small tumor foci at the periphery. The tumor had patchy necrotic, hemorrhagic and fibrotic areas representing regressive changes due to chemotherapy effect. Immunohistochemically, the tumor stained diffusely with CK7, CK8, CK19, HMW-CK and E-cadherin, whereas focally with CEA. Estrogenand progesterone receptors and c-erbB-2 were negative in the tumor. Five out of 20 lymph nodes dissected from the specimen were metastatic. Clinically, other organs were ruled out as the originating site of the tumor. She had taken oral chemotherapy (capecitabine) after surgery and has been living healthy for one year. © Medical Journal of Trakya University.
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    Leptin expression in proliferative, secretory and hyperplastic endometrial tissues; [Proliferatif, sekretuar ve hiperplazik endometrial dokuda leptin ekspresyonu]
    (2011) Özler A.; Kuşçu N.K.; Temiz P.; Kandiloǧlu A.R.; Koyuncu F.M.
    Objective: The goal of this study was to detect endometrial leptin expression in proliferative and secretory phases and then to compare the results with that of hyperplastic endometrium. Material and Methods: Seventeen proliferative, 23 secretory phase and 18 hyperplastic endometrial tissues diagnosed in our hospital between 2002 and 2007 were included in the study. These samples were stained with leptin antibody using an immunohistochemical method. Endometrial glandular and surface epithelium and stroma were evaluated for staining distribution and intensity. Conclusion: Staining intensity seen in early proliferative phase samples (2.33±0.51) increased significantly throughout the middle (2.40±0.54) and late phases (2.83±0.40) (p<0.05). Early secretory phase samples had the least staining intensity (1.42±0.53), while it increased significantly in later periods (2.38±0.51) (p<0.05). There was no difference in staining intensity among proliferative, secretory and hyperplastic tissues (p>0.05). Conclusion: Although endometrial leptin expression was observed in a differential manner throughout the whole menstrual period, no difference was seen in endometrial hyperplasia. We consider that leptin does not play a role in hyperplastic transformation of the endometrium. © 2011 by the Turkish-German Gynecological Education and Research Foundation.