Browsing by Author "Kara Ö."

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    Guideline on pregnancy and diabetes by the society of specialists in perinatology (PUDER), Turkey
    (Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2020) Bayram M.; Asyali Biri A.; Esim Büyükbayrak E.; Daglar H.K.; Ercan F.; Gürsoy Erzincan S.; Çorbacioglu Esmer A.; Inan C.; Kanit H.; Kara Ö.; Katlan D.C.; Nas T.; Öcal E.; Sagsöz N.; Sanhal C.Y.; Sahin G.; Timur H.; Turhan U.; Gençosmanoglu Türkmen G.; Türkyilmaz G.; Bilgin Yanik F.F.; Yüksel M.A.
    Diabetes mellitus (DM) is the most common endocrinologic problem in pregnancy. In Turkey, the reported prevalance is between 1.9-27.9%, with an average of 7.7%. While some of these cases are pregestational diabetes (PGDM), about 90% are detected during the pregnancy for the first time and diagnosed as gestational diabetes (GDM). Diabetes in pregnancy confers serious risks regarding the fetus, newborn and the mother. Therefore, we offer GDM screening for all pregnant women preferantially between 24-28 weeks of gestation. Either one-step 75-g oral glucose tolerance test (OGTT) or two-step 50-g glucose challenge test and 100-g OGTT may be used for the screening and diagnosis. In pregnancies with high-risk for DM, screening should be performed earlier, if possible, in the first antenatal visit. When GDM is diagnosed, maternal glycemic control is tried to be achieved by diet and exercise program, and if necessary, by using insulin. The use of metformin or glyburide in pregnancy is also possible. In women with the diagnosis of DM before pregnancy, preconceptional control of plasma glucose levels is of utmost importance in order to prevent adverse pregnancy outcomes. In pregnancies with GDM regulated by diet and exercise, pregnancy follow-up may be performed as in the low risk group without any pregnancy complications. If maternal or fetal distress is not observed, delivery is planned between 39+0 -40+6 weeks. Although caesarean section is recommended when estimated fetal weight is 4500 g or more, the mode of delivery may be decided more appropriately on a case-by-case basis. Copyright © 2020 by Türkiye Klinikleri.
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    SARcopenia Assessment in Hypertension
    (Lippincott Williams and Wilkins, 2023) Kara M.; Kara Ö.; Ceran Y.; Kaymak B.; Kaya T.C.; Çıtır B.N.; Durmuş M.E.; Durmuşoğlu E.; Razaq S.; Doğan Y.; Shehab D.; Alkandari S.A.; Abdulsalam A.J.; Ata A.M.; Koyuncu E.G.; Coşkun E.; Turan G.; Dilek B.; Culha M.A.; Yıldırım P.; Mezian K.; Doğu B.; Kılıç G.; Ünlü Z.; Barbosa J.; Pinho S.; Analay P.; Palamar D.; Güvener O.; Ocak H.; Malas F.Ü.; Baday M.; Çakır B.; Özçakar L.
    Objectives: The aims of the study were to investigate the relationship between sarcopenia and renin-angiotensin system-related disorders and to explore the effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on muscle mass/function and physical performance. Design: This multicenter, cross-sectional study was performed using ISarcoPRM algorithm for the diagnosis of sarcopenia. Results: Of the 2613 participants (mean age = 61.0 ± 9.5 yrs), 1775 (67.9%) were hypertensive. All sarcopenia-related parameters (except chair stand test in males) were worse in hypertensive group than in normotensive group (all P < 0.05). When clinical/potential confounders were adjusted, hypertension was found to be an independent predictor of sarcopenia in males (odds ratio = 2.403 [95% confidence interval = 1.514-3.813]) and females (odds ratio = 1.906 [95% confidence interval = 1.328-2.734], both P < 0.001). After adjusting for confounding factors, we found that all sarcopenia-related parameters (except grip strength and chair stand test in males) were independently/negatively related to hypertension (all P < 0.05). In females, angiotensin-converting enzyme inhibitors users had higher grip strength and chair stand test performance values but had lower anterior thigh muscle thickness and gait speed values, as compared with those using angiotensin II receptor blockers (all P < 0.05). Conclusions: Hypertension was associated with increased risk of sarcopenia at least 2 times. Among antihypertensives, while angiotensin-converting enzyme inhibitors had higher muscle function values, angiotensin II receptor blockers had higher muscle mass and physical performance values only in females. © 2022 Wolters Kluwer Health, Inc.
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    The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study
    (Springer, 2024) Kara M.; Kara Ö.; Durmuş M.E.; Analay P.; Şener F.E.; Çıtır B.N.; Korkmaz G.O.; Ünlü Z.; Tiftik T.; Gürçay E.; Mülkoğlu C.; Yalçınkaya B.; Bağcıer F.; Aksakal M.F.; Erdoğan K.; Sertçelik A.; Çakır B.; Kaymak B.; Özçakar L.
    We aimed to investigate the relationship among probable sarcopenia, osteoporosis (OP) and supraspinatus tendon (SSP) tears in postmenopausal women. Postmenopausal women screened/followed for OP were recruited. Demographic data, comorbidities, exercise/smoking status, and handgrip strength values were recorded. Probable sarcopenia was diagnosed as handgrip strength values < 20 kg. Achilles and SSP thicknesses were measured using ultrasound. Among 1443 postmenopausal women, 268 (18.6%) subjects had SSP tears. Unilateral tears were on the dominant side in 146 (10.1%) and on the non-dominant side in 55 women (3.8%). In contrast to those without, women with SSP tears had older age, lower level of education, thinner SSP and lower grip strength (all p < 0.05). In addition, they had higher frequencies of hypertension, hyperlipidemia, DM, OP and probable sarcopenia, but lower exercise frequency (all p < 0.05). Binary logistic regression modeling revealed that age [odds ratio (OR): 1.046 (1.024–1.067 95% CI)], hypertension [OR: 1.560 (1.145–2.124 95% CI)], OP [OR: 1.371 (1.022–1.839 95% CI)] and probable sarcopenia [OR: 1.386 (1.031–1.861 95% CI)] were significant predictors for SSP tears (all p < 0.05). This study showed that age, presence of hypertension, probable sarcopenia and OP were related with SSP tears in postmenopausal women. To this end, although OP appeared to be related to SSP tears, SSP tear/thickness evaluation can be recommended for OP patients, especially those who have other risk factors such as older age, higher BMI, hypertension, and probable sarcopenia. © The Author(s) 2024.