Browsing by Author "Kara M.I."

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    Thymoquinone accelerates new bone formation in the rapid maxillary expansion procedure
    (2012) Kara M.I.; Erciyas K.; Altan A.B.; Ozkut M.; Ay S.; Inan S.
    Objective: The aim of this study was to evaluate the effect of systemic thymoquinone (TQ) in a rat rapid maxillary expansion (RME) study. Design: Thirty-two Wistar albino rats were divided into 4 equal groups: only-expansion (OE), expansion plus TQ (TQ1 group, TQ given to the rats during their nursery phase and during the expansion and retention period), expansion plus TQ (TQ2 group, TQ given to the rats only during the retention period), and control group (no procedure done). Expansion appliances were placed on the maxillary incisors of all animals for 5 days. The appliance was deactivated during the 12 day retention period. The rats were sacrificed at the end of the retention period. Histomorphometric evaluation was carried out in order to compare the number of osteoclasts, osteoblasts, and capillaries, as well as the intensities of inflammatory cells, and new bone formation amongst the groups. Results: New bone formation, number of capillaries and the ratio of intensities of inflammatory cells in maxillary sutures was higher in the TQ groups than in the other groups. Statistical analysis also demonstrated that osteoblast and osteoclast numbers were also highest in the TQ1 group. Conclusion: Histomorphometric analysis demonstrated that systemic use of thymoquinone may be effective in accelerating new bone formation in the RME procedure and that TQ may be beneficial in preventing relapse following the RME procedure. © 2011 Elsevier Ltd. All rights reserved.
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    Effects of Ginkgo biloba on experimental rapid maxillary expansion model: A histomorphometric study
    (2012) Kara M.I.; Altan A.B.; Sezer U.; Erdoan M.Ş.; Inan S.; Ozkut M.; Nalcac R.
    Objective: We aimed to investigate the effect of systemic Ginkgo biloba in rapid maxillary expansion (RME). Study Design: We randomly divided 24 rats into 3 groups: expansion only (EO), expansion plus Ginkgo biloba (GB), and no expansion (NE). Expansion appliances were affixed to the maxillary incisors. After a 5-day expansion period, there was a consolidation period of 15 days, following which the rats were killed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries, the number and intensity of inflammatory cells, and new bone formation. Results: New bone formation, number of capillaries, and the ratio of inflammatory cells in maxillary sutures were higher in the GB group than in the other groups. Statistical analysis demonstrated that the GB group had more osteoblasts and osteoclasts than the other groups. Conclusions: GB may hasten new bone regeneration in RME and prevent relapse after RME. © 2012 Elsevier Inc.