Browsing by Author "Karaboga B."

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    Community-acquired pneumonia in patients with chronic obstructive pulmonary disease requiring admission to the intensive care unit: Risk factors for mortality
    (2013) Cilli A.; Erdem H.; Karakurt Z.; Turkan H.; Yazicioglu-Mocin O.; Adiguzel N.; Gungor G.; Bilge U.; Tasci C.; Yilmaz G.; Oncul O.; Dogan-Celik A.; Erdemli O.; Oztoprak N.; Samur A.A.; Tomak Y.; Inan A.; Karaboga B.; Tok D.; Temur S.; Oksuz H.; Senturk O.; Buyukkocak U.; Yilmaz-Karadag F.; Ozcengiz D.; Karakas A.; Savasci U.; Ozgen-Alpaydin A.; Kilic E.; Elaldi N.; Bilgic H.
    Purpose: The aims of this study are to identify factors predicting mortality in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia (CAP) requiring intensive care unit (ICU) admission and to examine whether noninvasive ventilation treatment reduces mortality. Materials and Methods: An analysis was performed on data from patients with CAP hospitalized in the ICUs of 19 different hospitals in Turkey between October 2008 and January 2011. Predictors of mortality were assessed by both univariate and multivariate statistical analyses. Results: Two hundred eleven patients with COPD and CAP were included. The overall ICU mortality was 23.9%. Noninvasive ventilation treatment (odds ratio [OR], 0.12; 95% confidence interval [CI], 0.03-0.49; P = .003), hypertension (OR, 0.13; 95% CI, 0.02-0.93; P = .042), bilateral infiltration (OR, 13.92; 95% CI, 2.94-65.84; P = .001), systemic corticosteroid treatment (OR, 0.19; 95% CI, 0.35-0.96; P = .045), length of ICU stay (OR, 0.65; 95% CI, 0.47-0.89; P = .007), and duration of invasive mechanical ventilation (OR, 1.11; 95% CI, 1.01-1.22; P = .032) were independent factors related to mortality. Conclusion: Noninvasive ventilation, hypertension, systemic corticosteroid treatment, and shorter ICU stay are associated with reduced mortality, whereas bilateral infiltration and longer duration of invasive mechanical ventilation are associated with increased risk of mortality in patients with COPD and CAP requiring ICU admission. © 2013 Elsevier Inc.
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    Relation between vascular endothelial markers and right ventricular function in the children with asthma
    (Tehran University of Medical Sciences, 2017) Cetin M.; Karaboga B.; Yilmaz O.; Yilmaz M.; Yuksel H.; Coskun S.
    Objectives: The aim of the study was to evaluate the possible relationship of clinical severity during asthmatic exacerbation with the ventricular functions and the levels of vascular endothelial-related biomarkers endothelin-1 (ET-1) and platelet-derived growth factor-BB (PDGF-BB) in the condensed breathing air in the children with asthma. Methods: The study included a total of 80 children with acute asthmatic episode; of these, 28 had a mild, 26 had a moderate, and 26 had a severe attack. Samples of condensed breathing air were obtained for being analyzed for ET-1 and PDGF-BB levels during the study. All patients were evaluated by echocardiography at the beginning of the study and two weeks after the treatment of asthmatic episode. Results: Before treatment, mPAP in moderate and severe asthma groups was significantly higher than in mild asthma group (21.6 ± 7.3, 30.1 ± 9.8 and 32.7 ± 7.8; P < 0.01, P < 0.001, respectively). After treatment, no significant difference was detected between the asthma groups (P > 0.05). Am and Em waves, and IVRT, IVCT, ET and RV MPI during the asthmatic attack and after treatment did not change significantly between the groups; pre- and post-treatment values of these parameters also did not show significant differences. In exhaled air samples of the group with severe asthma exacerbation ET-1 and PDGF-BB were higher than those in the moderate and mild group (0.80 ± 0.42, 0.58 ± 0.30, 0.50 ± 0.15; P = 0.002 and 281.7 ± 253.2, 167.3 ± 148.1, 135.9 ± 74.9; P = 0.008 respectively). Conclusions: Ourstudy resultsshowedthatmPAPin direct proportion with the increasedinflammatory cytokineswassignificantly higher in asthma attacks and levels of ET-1 and PDGF-BB were significantly increased with severity of asthma, indicating a vascular response. © 2017, Iranian Journal of Pediatrics.
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    Evaluation of cardiac autonomic functions in children with thalassemia trait, iron deficiency anemia and iron deficiency
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2018) Cetin M.; Moumin N.; Karaboga B.; Coskun S.; Gulen H.
    Distruption of cardiac autonomic functions during diseases associated with anemia were reported in multiple studies previously. Objective in this study is to investigate heart rate variability (HRV) for evaluation of cardiac autonomic functions in children patients with Thalassemia trait (TT), iron deficiency anemia (IDA) and iron deficiency (ID) without anemia. Twenty-five patients with TT, 25 patients with IDA, 25 patients with ID, and 25 healthy controls were assessed with 24-hour ambulatory electrocardiography recordings. The following time-domain indices were calculated; standard deviation values of all normal sinus R-R intervals for 24 hours (SDNN), standard deviation levels of all mean normal sinus R-R interspaces over each 5-minute strip in the 24-hour enrollments (SDANN), the square root of the mean of the sum of squares of differences between adjacent RR intervals (RMSSD), percentage of difference between adjacent normal R -R intervals that are greater than 50 ms computed for the overall 24-hour ECG recording (pNN50). Re-evaluation regarding HRV were done in children with IDA after 4 months of treatment. Although reduction in HRV parameters was detected in IDA group compared to ID, TT, and control groups, it wa s statistically not significant. The pNN50 was significantly low only in the IDA group (p=0.042). When ID group and TT group were compared with control group, it was found that HRV parameters were not affected. In IDA group, SDNN, SDANN, RMSSD and pNN50 index were significantly higher after trea tment (p=0.002, p=0.005, p=0.005, p=0.010, respectively). Our results indicate that cardiac autonomic activity are affected in IDA and improvement occurs after treatment. HRV parameters were found to be especially associated with hemoglobin and hematocrit values. © 2018, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.