Browsing by Author "Karaca Ö."

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Prevalence of fetal malnutrition and relationship between fetal malnutrition and fetal acidemia; [Fetal malnütrisyonun sikliǧi ve fetal asidemi ile olan i̇lişkisi]
    (2012) Tanriverdi S.; Karaboǧa B.; Karaca Ö.; Baytur Y.
    Objective: The aim of this study is determining prevalence of fetal malnutrition and relationship between fetal malnutrition and fetal acidemia at term newborn infants. Material and Methods: This study was performed on 121 term newborn infants who were born at the Department of Gynecology and Obstetrics, between September 2010 and May 2011. Fetal malnutrition was diagnosed using [Clinical Assessment of Fetal Nutritional Status Scoring (CANSCORE)] within 12 hours after birth and umblical artery blood-gas analysis was performed at birth. Results: Mean value of CANSCORE was 27.6±3.5 (18-44) at term newborn infants. CANSCORE score was determined as 24 and less in 12 (9.9%) infants who were evaluated as having fetal malnutrition. CANSCORE score was above 24 in other 109 (90.1%) infants. Ten of the 12 newborn infants with fetal malnutrition were [small for gestational age (SGA)]. There was no relationship between fetal malnutrition and low CANSCORE (P=0.000). The mean value of pH was 7.30±0.07 (7.01-7.41) at umblical artery blood-gas analysis. Fetal acidemia (pH<7.15) was observed in 8 (6.6%) infants. There was no significant relationship between the presence of fetal malnutrition and fetal acidemia (p=0.735). Conclusion: No relationship between fetal malnutrition and fetal acidemia was observed in this study. Copyright © 2012 by Türkiye Klinikleri.
  • No Thumbnail Available
    Item
    Does having an asthmatic sibling affect the quality of life in children?
    (Turkish Journal of Pediatrics, 2017) Yılmaz Ö.; Türkeli A.; Karaca Ö.; Yüksel H.
    Chronic illness in a family member leads to deterioration of quality of life in other members of that family. We aimed to investigate the influence of having an asthmatic sibling on a child’s quality of life (QoL). We enrolled 2-12 year aged healthy children with an asthmatic sibling in the study group and healthy children with a healthy sibling in the control group of this cross-sectional study. Sociodemographic characteristics of children and disease severity characteristics of asthmatic siblings were recorded. All parents filled in Turkish generic PedsQL™ short form appropriate for the child’s age group. Study and control groups had 114 children each. Total PedsQL™ scores were not significantly different in any of the age groups (p=0.23, p=0.13, p= 0.11 respectively). Emotional PedsQL™ sub-scores in children with an asthmatic sibling were significantly worse (83.0±16.5 vs 91.6±10.9 in the 2-4 year age group, 72.0±17.8 vs 92.2±11.6 in the 5-7 year age group, 73.7±24.1 vs 88.7±14.8 in the 8-12 year age group respectively, p≤0.002 for all). Similarly, psychosocial sub-score was significantly lower in the 2-4 and 5-7-year-olds but not the 8-12 year old groups (p=0.01, p=0.01, p=0.08 respectively). In conclusion, healthy children with asthmatic siblings have significantly lower emotional QoL and this needs to investigated for other chronic diseases in further research. © 2017, Turkish Journal of Pediatrics. All rights reserved.
  • No Thumbnail Available
    Item
    Safety of once-or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: A NOAC-TR study
    (Association of Basic Medical Sciences of FBIH, 2018) Emren S.V.; Zoghi M.; Berilgen R.; Özdemir İ.H.; Çelik O.; Çetin N.; Enhoş A.; Köseoğlu C.; Akyüz A.; Doğan V.; Levent F.; Dereli Y.; Doğan T.; Başaran Ö.; Karaca I.; Karaca Ö.; Otlu Y.Ö.; Özmen Ç.; Coşar S.; Sümerkan M.; Gürsul E.; İnci S.; Onrat E.; Ergene O.
    Once-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) may increase patient adherence to treatment but may also be associated with a higher risk of bleeding. In this study, we investigated the adherence to once-or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September 2015 and 28 February 2016, included 2214 patients receiving NOACs for at least 3 months, due to NVAF. Patients receiving once-daily or twice-daily NOAC doses were 1:1 propensity score matched for baseline demographic characteristics and the presence of other diseases. The medication adherence was assessed by the 8-item Morisky Medication Adherence Scale. Risk factors were investigated in relation to minor and major bleeding. The mean age of patients was 71 ± 10 years, and 53% of the patients were women. The medication adherence was lower in patients receiving twice-daily NOAC doses compared to once-daily-dose group (47% versus 53%, p = 0.001), and there was no difference between the groups in terms of minor (15% versus 16%, p = 0.292) and major bleeding (3% versus 3%, p = 0.796). Independent risk factors for bleeding were non-adherence to medication (OR: 1.62, 95% CI: 1.23–2.14, p = 0.001), presence of 3 or more other diseases (OR: 10.3, 95% CI: 5.3–20.3, p < 0.001), and HAS-BLED (Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile INR, Elderly, Drugs or alcohol) score (OR: 4.84, 95% CI: 4.04–5.8, p < 0.001). In summary, the once-daily dose of NOACs was associated with increased patient adherence to medication, while it was not associated with bleeding complications. © 2018 ABMSFBIH.
  • No Thumbnail Available
    Item
    Optic neuritis in Turkish children and adolescents: A multicenter retrospective study
    (Elsevier B.V., 2024) Direk M.Ç.; Besen Ş.; Öncel İ.; Günbey C.; Özdoğan O.; Orgun L.T.; Sahin S.; Cansu A.; Yıldız N.; Kanmaz S.; Yılmaz S.; Tekgül H.; Türkdoğan D.; Ünver O.; Thomas G.Ö.; Başıbüyük S.; Yılmaz D.; Kurt A.N.; Gültutan P.; Özsoy Ö.; Yiş U.; Kurul S.H.; Güngör S.; Özgör B.; Karadağ M.; Dündar N.O.; Gençpınar P.; Bildik O.; Orak S.A.; Kabur Ç.Ç.; Kara B.; Karaca Ö.; Canpolat M.; Gümüş H.; Per H.; Yılmaz Ü.; Karaoğlu P.; Ersoy Ö.; Tosun A.; Öztürk S.B.; Yüksel D.; Atasoy E.; Gücüyener K.; Yıldırım M.; Bektaş Ö.; Çavuşoğlu D.; Yarar Ç.; Güngör O.; Mert G.G.; Sarıgeçili E.; Edizer S.; Çetin İ.D.; Aydın S.; Diler B.; Özdemir A.A.; Erol İ.; Okuyaz Ç.; Anlar B.
    Background: Various etiologies may underlie optic neuritis, including autoantibody-mediated disorders described in the last decade. We re-examined demographic, clinical, laboratory features and prognostic factors in pediatric patients with autoimmune optic neuritis according to current knowledge. Methods: Cases of pediatric ON from 27 centers in Türkiye diagnosed between 2009 and 2022 were included for retrospective evaluation. Results: The study included 279 patients, 174 females and 105 males, with a female-to-male ratio of 1.65. The average age at onset was 12.8 ± 3.4 years, and mean follow-up, 2.1 years (range: 1–12.1 years). Patients <10 years old were grouped as "prepubertal" and those ≥10 years old as "others”. The diagnoses made at the end of follow-up were multiple sclerosis associated optic neuritis (n = 90, 32.3 %), single isolated optic neuritis (n = 86, 31 %), clinically isolated syndrome (n = 41, 14.7 %), myelin oligodendrocyte glycoprotein antibody associated optic neuritis (n = 22, 7.9 %), and relapsing isolated optic neuritis (n = 18, 6.5 %). Predominant diagnoses were myelin oligodendrocyte glycoprotein antibody associated optic neuritis and acute disseminated encephalomyelitis associated optic neuritis in the prepubertal group and multiple sclerosis associated optic neuritis in the older group. Recurrences were observed in 67 (24 %) patients, including 28 with multiple sclerosis associated optic neuritis, 18 with relapsing isolated optic neuritis, 11 with myelin oligodendrocyte glycoprotein antibody associated optic neuritis, 8 with aquaporin-4 antibody related optic neuritis, and 2 with chronic relapsing inflammatory optic neuropathy. Recurrences were more common among female patients. Findings supporting the diagnosis of multiple sclerosis included age of onset ≥ 10 years (OR=1.24, p = 0.027), the presence of cranial MRI lesions (OR=26.92, p<0.001), and oligoclonal bands (OR=9.7, p = 0.001). Treatment in the acute phase consisted of intravenous pulse methylprednisolone (n = 46, 16.5 %), pulse methylprednisolone with an oral taper (n = 212, 76 %), and combinations of pulse methylprednisolone, plasmapheresis, or intravenous immunoglobulin (n = 21, 7.5 %). Outcome at 12 months was satisfactory, with 247 out of 279 patients (88.5 %) demonstrating complete recovery. Thirty-two patients exhibited incomplete recovery and further combination treatments were applied. Specifically, patients with relapsing isolated optic neuritis and aquaporin-4 antibody related optic neuritis displayed a less favorable prognosis. Conclusion: Our results suggest optic neuritis is frequently bilateral in prepubertal and unilateral in peri‑ or postpubertal patients. Age of onset 10 or older, presence of oligoclonal bands, and brain MRI findings reliably predict the development of multiple sclerosis. The risk of developing multiple sclerosis increases mostly during the second and third years of follow-up. Relapsing isolated optic neuritis remains a separate group where the pathogenesis and outcome remain unclear. Investigation of predisposing and diagnostic biomarkers and long follow-up could help to define this group. © 2023 Elsevier B.V.