Browsing by Author "Karaca S."

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    Assessment of the effectiveness of postmenopausal tibolone therapy on neural functions by measuring visual evoked potentials: A placebo-controlled study
    (Elsevier Ireland Ltd, 2001) Laçin S.; Oruç S.; Karaca S.; Kusçu K.; Koyuncu F.; Uyar Y.; Çaglar H.
    Objective: To assess the effect of hormone replacement therapy on neural transmission in postmenopausal women using tibolone by a non-invasive, objective way. Study design: In a randomised, 3 cycle, placebo-controlled study, neurovisual transmission in optic pathways were evaluated by measuring visual evoked potentials (VEP). After neuroophtalmologic examination, eligible subjects were randomised into two groups. Treatment group (n = 38) were given tibolone 2.5 mg daily continuously for 3 months and control group (n = 20) were treated with placebo. A baseline VEP measurement before the treatment and then at the end of first, second and third month were obtained by the EMG-evoked system in the Department of Neurology, University of Celal Bayar, Manisa, Turkey. Results: Data from 31 women from treatment group and 16 from control group were available for evaluation. The mean P 100 latency values, which indicate the transition time period between the optic stimuli and electrical change recorded on the occipital area by the skin electrodes, have showed a significant decrease for the study group (from 100.39 ± 0.58 to 97.90 ± 0.65 ms, P < 0.01) at the end of the first month of treatment according to the baseline values. This difference between two groups has remained constant during the study period. Conclusion: The change in latency measurements of VEP, reflecting the functional status in optic pathways from retina to occipital cortex were significantly different in the treatment group than in that of control. We concluded that a facilitating effect of tibolone was observed on neurovisual transmission. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
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    Voice analysis and videolaryngostroboscopy in patients with Parkinson's disease
    (Springer Verlag, 2002) Yücetürk A.; YIlmaz H.; Eǧrilmez M.; Karaca S.
    Parkinson's disease (PD) is clinically characterized by a resting tremor, bradykinesia, cogwheel phenomenon, rigidity, disorder of postural reflexes and especially changes in voice and speech. We studied 30 PD patients who were treated with dopamine and 20 normal subjects as the control group. The parameters of vocal fold edges, glottal closure, vertical levels of cords, amplitude of vibration, mucosal wave, vibratory behavior, phase symmetry, ventricular folds and movements, periodicity, arytenoids and thick mucous were evaluated by videolaryngostroboscopy. The Unified Parkinson's Disease Rating Scale was applied to the patient group. The voices of the patients were evaluated by the Dr. Speech-4 and Spectra-PRO computer programs. Maximum phonation time, fundamental frequency, amplitude and the harmonic-to-noise ratio were recorded and compared with those of the control group. The abnormal videolaryngostroboscopic findings were more frequent in the PD group (70% versus 45%; P<0.05). Voice analysis showed significant differences in the parameters such as maximum phonation time, maximum fundamental frequency, the frequency range and the harmonic-to-noise ratio. We thought that these methods and parameters yielded sufficient information for diagnosis and follow-up of vocal function in patients with PD.
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    An alternative biphasic nutrient medium for the diagnosis of cutaneous leishmaniasis; [Kutanöz Leyşmanyazis Tanisinda Alternatif Bifazik Nutrient Besiyeri]
    (Ankara Microbiology Society, 2015) Aksoy Gökmen A.; Öncel K.; Özdemir O.A.; Pektaş B.; Çavuş I.; Güngör S.; Uzun B.; Kaya S.; Karaca S.; Yula E.; Demirci M.; Özbilgin A.
    Cutaneous leishmaniasis (CL) caused by the Leishmania spp. parasites, is a disease characterized by nodulo-ulcerative lesions in the skin. CL is transmitted to humans by infected sandflies during blood sucking, and is endemic in about 98 countries over the world. The demonstration of amastigotes via microscopic examination, and the growth of promastigotes in NNN (Novy-MacNeal-Nicolle) medium are gold standard methods for laboratory diagnosis. The aim of this study was to compare the biphasic NNN medium that is frequently used in routine laboratories with the biphasic nutrient medium that can be prepared easily in microbiology laboratories, for the growth of promastigotes. In the study, the aspiration fluid sample was used as clinical sample which was obtained from the skin lesion of a 47-year-old female patient admitted to izmir Katip Celebi Ataturk Education and Research Hospital dermatology outpatient clinic and pre-diagnosed as CL. The aspirate sample taken from the lesion was evaluated with microscopy, cultivation in two different media and real-time polymerase chain reaction (Rt-PCR) methods. In microscopic examination Leishmania amastigotes were observed in Ciemsa-stained smears prepared from the aspiration fluid. In Rt-PCR performed by using specific primers and probes targeting ITS1 region of Leishmania parasite, a melting-curve compatible with L.tropica was detected. For cultivation, triple inoculations of the aspirate sample into NNN (NNN + RPMI 1640 + 10% fetal calf serum) and nutrient media (nutrient agar + nutrient broth + 10% fetal calf serum) were used. The cultures were incubated at 27°C for 10 days, and the number of propagated promastigotes were counted on the third, seventh and tenth days. The growth of Leishmania promastigotes was detected in both media on the third day. The number of promastigotes grown in NNN medium on the third, seventh and tenth days were 105/ml, 106/ml and 108/ml, respectively. Those values in nutrient medium were 106/ml, 107/ml and 108/ml on the third, seventh and tenth days, respectively. Although the number of promastigotes on the third and seventh days were higher in nutrient medium than NNN medium, the number of cultivated promastigotes were equal on the tenth day. As a result, nutrient medium is considered to have an impact in the diagnosis of CL, by providing an alternative to the routine medium used and can readily be available in microbiology and parasitology laboratories with long shelf-life. It was concluded that biphasic nutrient medium could be used as a supplementary medium for diagnosis in laboratories in the absence of NNN medium or can not be provided.
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    Comparison of the mental symptoms in peritoneal dialysis and haemodialysis patients
    (A. CARBONE Editore, 2015) Pakyuz S.C.; Karaca S.; Bahcebasi Z.B.
    Introduction: Although dialysis has become a life-prolonging therapy for patients with end-stage renal disease, dialysis patients deal with serious problems. Dialysis patients face major mental problems such as depression, anxiety and stress and paranoia. The aim of this study was to evaluate and compare mental symptoms in chronic haemodialysis and peritoneal dialysis patients. Materials and methods: One hundred twenty-nine haemodialysis and 100 peritoneal dialysis patients were included in this study. The Brief Symptom Inventory (BSI) was used for the mental symptoms evaluation. Statistical analysis was performed using chisquare, t-test and Pearson's correlation analysis. Results: Although the BSI and its subscales such as the mean global severity index, somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety and paranoid ideation scores of the haemodialysis and peritoneal dialysis patients were similar, hostility, phobic anxiety and psychosis scores were significantly higher in the peritoneal dialysis patients than in haemodialysis patients. The BSI subscales such as anxiety, hostility and psychosis were negatively correlated with age in the haemodialysis patients, and hostility was negatively correlated with age in the peritoneal dialysis patients. In the peritoneal dialysis patients, paranoid ideation scores of female were higher than the scores of male. In the haemodialysis patients, hostility scores of male were higher than the scores of female. Conclusion: The results of this study indicate that hostility, phobic anxiety and psychosis are higher in peritoneal dialysis patients compared to haemodialysis patients. We suggest that dialysis patients especially on peritoneal dialysis and younger dialysis patients should be evaluated for mental symptoms and supported as needed.