Browsing by Author "Karadag A.S."

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    Internalized stigma in psoriasis: A multicenter study
    (Blackwell Publishing Ltd, 2017) Alpsoy E.; Polat M.; FettahlıoGlu-Karaman B.; Karadag A.S.; Kartal-Durmazlar P.; YalCın B.; Emre S.; Didar-Balcı D.; Bilgic-Temel A.; Arca E.; Koca R.; Gunduz K.; Borlu M.; Ergun T.; Dogruk-Kacar S.; Cordan-Yazici A.; Dursun P.; Bilgic O.; Gunes-Bilgili S.; Sendur N.; Baysal O.; Halil-Yavuz I.; Yagcioglu G.; Yilmaz E.; Kavuzlu U.; Senol Y.
    Internalized stigma is the adoption of negative attitudes and stereotypes of the society regarding a person's illness. It causes decreased self-esteem and life-satisfaction, increased depression and suicidality, and difficulty in coping with the illness. The primary aim of this study was to investigate the internalized stigma state of psoriatic patients and to identify the factors influencing internalized stigma. The secondary aim was to identify the correlation of internalized stigma with quality of life and perceived health status. This multicentre, cross-sectional study comprised 1485 patients. There was a significant positive correlation between mean values of Psoriasis Internalized Stigma Scale (PISS) and Psoriasis Area and Severity Index, Body Surface Area, Dermatological Life Quality Index and General Health Questionnaire-12 (P < 0.001 in all). Lower percieved health score (P = 0.001), early onset psoriasis (P = 0.016), family history of psoriasis (P = 0.0034), being illiterate (P < 0.001) and lower income level (P < 0.001) were determinants of high PISS scores. Mean PISS values were higher in erythrodermic and generalized pustular psoriasis. Involvement of scalp, face, hand, genitalia and finger nails as well as arthropathic and inverse psoriasis were also related to significantly higher PISS scores (P = 0.001). Our findings imply that psoriatic patients experience high levels of internalized stigma which are associated with psoriasis severity, involvement of visible body parts, genital area, folds or joints, poorer quality of life, negative perceptions of general health and psychological illnesses. Therefore, internalized stigma may be one of the major factors responsible from psychosocial burden of the disease. © 2017 Japanese Dermatological Association
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    The effect of personal, familial, and environmental characteristics on acne vulgaris: A prospective, multicenter, case controlled study
    (Edizioni Minerva Medica, 2019) Karadag A.S.; Balta I.; Saricaoglu H.; Kiliç S.; Kelekçi K.H.; Yildirim M.; Arica D.A.; Ozturk S.; Karaman G.; Çerman A.A.; Bilgili S.G.; Turan E.; Demirci M.M.; Uzunçakmak T.K.; Guvenç S.C.; Ataseven A.; Ferahbaş A.; Aksoy B.; Çolgeçen E.; Ekiz O.; Demir F.T.; Bilgiç O.; Çakmak S.; Uçmak D.; Ozuguz P.; Konkuralp Y.K.; Ermertcan A.T.; Gokdemir G.; Başkan E.B.; Alyamaç G.; Şanli H.
    BACKGROUND: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. METHODS: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. RESULTS: A total of 3826 patients and 759 control patients were involved in this study. Mild acne was the most common type of acne, and most of the lesions were localized on face followed by the trunk. The severity of acne was worse in patients who had a positive family history of acne. The most common triggering factor was psychological stress. We found a positive correlation with chocolate, bread, green tea, milk, white sugar, ripe banana, ice cream, apple, orange, and red meat consumption. As we compare the acne severity according to geographical features we detected mild- moderate acne was more common in Mediterranean region and severe acne was more common in East Anatolian region. Family history positivity was more common in Aegean region and least common in Central Anatolian region. There was statistically significant relationship as we compare acne severity and dietary factors such as chocolate, dairy products such as milk, sunflower seed consumption within the geographical regions. CONCLUSIONS: This study presents the demographic and clinical characteristics of acne patients in Asian and the European parts of Turkey. We believe that this study will provide a useful overview of acne in Turkey. © 2017 EDIZIONI MINERVA MEDICA.
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    Systemic comorbidities associated with rosacea: a multicentric retrospective observational study
    (Blackwell Publishing Ltd, 2019) Aksoy B.; Ekiz Ö.; Unal E.; Ozaydin Yavuz G.; Gonul M.; Kulcu Cakmak S.; Polat M.; Bilgic Ö.; Baykal Selcuk L.; Unal I.; Karadag A.S.; Kilic A.; Balta I.; Kutlu Ö.; Uzuncakmak T.K.; Gunduz K.
    Background: Once considered a disorder limited to the skin, rosacea is now known to be associated with systemic disorders. The aim of this study was to determine what systemic comorbidities accompany rosacea and to determine the relationship between the type, severity, and duration of rosacea, and the presence of and type of systemic comorbidities. Methods: This retrospective multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Thirteen dermatology clinics throughout Turkey participated in the study. A structured physician-administered questionnaire was used to collect patient demographics, clinical findings, and lifestyle data. The principal rosacea subtype, physician global assessment of severity, and duration of rosacea were recorded. Physicians recorded each participant's medical history, including current and past comorbidities, duration of any such comorbidity, and the use of medications to treat any comorbidities. Results: The study included 1,195 rosacea patients and 621 controls without rosacea aged 18–85 years. As compared to the controls, more of the rosacea patients had respiratory tract, gastrointestinal system, and metabolic and hepatobiliary system disorders in a rosacea's severity- and duration-dependent manner. Conclusion: Clinicians must be aware of the potential for systemic comorbidities in rosacea patients, which becomes more likely as disease duration and severity increase. © 2018 The International Society of Dermatology
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    Internalized stigma in pediatric psoriasis: A comparative multicenter study
    (Korean Dermatological Association, 2020) Alpsoy E.; Polat M.; Yavuz I.H.; Kartal P.; Balci D.D.; Karadag A.S.; Bilgic A.; Arca E.; Karaman B.F.; Emre S.; Adisen E.; Sendur N.; Bilgic O.; Yazici A.C.; Yalcin B.; Koca R.; Gunduz K.; Borlu M.M.; Ergun T.; Dursun P.; Bilgili S.G.; Adanir A.S.; Gulekon A.; Yagcioglu G.; Yilmaz E.; Kavuzlu U.; Senol Y.
    Background: Internalized stigma, adoption of negative attitudes and stereotypes of the society regarding persons' illness, has not been studied previously in pediatric psoriasis patients. Objective: We aimed to investigate the internalized stigma in pediatric psoriasis patients and to determine differences according to factors affecting internalized stigma compared to adult psoriasis patients. Methods: This multicenter, cross-sectional, comparative study included 125 pediatric (55 female, 70 male; mean age±standard deviation [SD], 14.59±2.87 years) and 1,235 adult psoriasis patients (577 female, 658 male; mean age±SD, 43.3±13.7 years). Psoriasis Internalized Stigma Scale (PISS), Dermatology Life Quality Index (DLQI), Perceived Health Status (PHS), and the General Health Questionnaire (GHQ)-12 were the scales used in the study. Results: The mean PISS was 58.48±14.9 in pediatric group. When PISS subscales of groups were compared, the pediatric group had significantly higher stigma resistance (p=0.01) whereas adult group had higher scores of alienation (p=0.01) and stereotype endorsement (p=0.04). There was a strong correlation between mean values of PISS and DLQI (r=0.423, p=0.001). High internalized stigma scores had no relation to either the severity or localization of disease in pediatric group. However, poor PHS (p=0.007) and low-income levels (p=0.03) in both groups, and body mass index (r=0.181, p=0.04) in the pediatric group were related to high PISS scores. Conclusion: Internalized stigma in pediatric patients is as high as adults and is related to poor quality of life, general health, and psychological illnesses. Unlike adults, internalized stigma was mainly determined by psoriasis per se, rather than disease severity or involvement of visible body parts, genitalia or folds. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology.
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    Clinical characteristics, quality of life and risk factors for severity in palmoplantar pustulosis: a cross-sectional, multicentre study of 263 patients
    (John Wiley and Sons Inc, 2022) Sarıkaya Solak S.; Kara Polat A.; Kilic S.; Oguz Topal İ.; Saricaoglu H.; Karadag A.S.; Canpolat F.; Kartal S.P.; Deveci B.N.; Kacar N.; Polat Ekinci A.; Guner R.; Polat M.; Dogan G.; Guler Ozden M.; Bulbul Baskan E.; Ozaydin Yavuz G.; Adisen E.; Gulekon A.; Tanribilir M.E.; Yilmaz O.; Akman Karakas A.; Ozturk P.; Didar Balci D.; Gonulal M.; Yondem H.; Turel Ermertcan A.; Sendur N.; Topyildiz H.; Korkmaz S.; Alpsoy E.
    Background: Palmoplantar pustulosis (PPP) is a rare, chronic, inflammatory skin disease characterized by sterile pustules on palmar or plantar areas. Data on PPP are scarce. Aim: To investigate the clinical characteristics and risk factors for disease severity in a large cohort of Turkish patients with PPP. Methods: We conducted a cross-sectional, multicentre study of patients with PPP recruited from 21 tertiary centres across Turkey. Results: In total, 263 patients (165 women, 98 men) were evaluated. Most patients (75.6%) were former or current smokers. The mean Palmoplantar Pustulosis Area and Severity Index (PPPASI) was 8.70 ± 8.06 and the mean Dermatology Life Quality Index (DLQI) score was 6.87 ± 6.08, and these scores were significantly correlated (r = 0.52, P < 0.001). Regression analysis showed that current smoking was significantly associated with increased PPPASI (P = 0.03). Coexisting psoriasis vulgaris (PsV) was reported by 70 (26.6%) patients. Male sex prevalence, PPP onset incidence, disease duration, DLQI, and prevalence of nail involvement and psoriatic arthritis (PsA) were significantly increased among patients with PPP with PsV. Of the 263 patients, 18 (6.8%) had paradoxical PPP induced by biologic therapy, and these patients had significantly increased mean DLQI and prevalence of PsA (r = 0.03, P = 0.001). Conclusion: Our data suggest that smoking is a risk factor for both PPP development and disease severity. Patients with PPP with PsV present distinct clinical features and patients with biologic therapy-induced paradoxical PPP have reduced quality of life and are more likely to have PsA. © 2021 British Association of Dermatologists.
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    Clinical Features and Natural Course of Hidradenitis Suppurativa in Turkey: A Multicenter Study
    (S. Karger AG, 2024) Alpsoy E.; Fettahlloglu Karaman B.; Demirseren D.D.; Clnar S.L.; Kacar N.; Türel Ermertcan A.; Bulbul Baskan E.; Ucmak D.; Mammadli K.; Klllnc F.; Yazici S.; Temiz S.A.; Özkök Akbulut T.; Ataseven A.; Şikar Aktürk A.; Sarlcaoǧlu H.; Türkmen M.; Gülbaşaran F.; Engin B.; Kaya Özden H.; Durmaz K.; Güler Özden M.; Özdemir H.; Çevirgen Cemil B.; Sarlkaya Solak S.; Bilgili S.G.; Yavuz I.H.; Özaydln Yavuz G.; Güven M.; Polat Ekinci A.; Atcl T.; Didar Balci D.; Oztürk A.; Klvanç Altunay I.; Özkur E.; Ugurer E.; Karadag A.S.; Kalkan G.; Klllc S.; Erdoǧan B.; Yayli S.; Baykal Selçuk L.; Dönmez L.; Bilgic A.
    Introduction: The natural history, the progression of a disease process in an individual over time, has not yet been fully elucidated in hidradenitis suppurativa (HS). In this large multicenter study, we aimed to investigate the natural history of HS and its gender differences. Methods: This cross-sectional study included 827 patients. The chronological order of the clinical manifestations for each patient was recorded retrospectively. Sociodemographic characteristics, triggering factors, clinical, treatment, and prognostic featureswere also evaluated. Results: The mean age of disease onset was significantly younger in women than in men (22.42 ± 9.28 vs. 27.06 ± 20.56, p < 0.001) and those with a family history (p < 0.0001). The mean disease duration was 91.17 ± 83.64 months. The most common symptom was purulent discharge (81%). The mean duration of abscess was shorter in women than in men (3.11 ± 2.65 vs. 3.75 ± 3.75, p = 0.01). The axilla was the most common onset area followed by the inguinal and gluteal regions. The disease ran a more severe course in men. Abscess/inflammatory nodule was defined in the last 6 months in 88.6% of the patients; however, the first 5 years of the disease were the most active disease period in 67.5% of the patients. Multivariate analysis revealed being male, older age, family history, involvement of the axillary, inguinal, and perianal regions independently associated with HS severity. While antibiotic use was the most important factor in improving the disease symptoms, stress was themost common aggravating factor. Biological therapy in men, laser epilation and pregnancy in women were significant alleviating factors, whereas weight gain was a more common aggravating factor for women. Conclusion: HS shows a relentlessly progressive course with inflammatory attacks, but the first years of the disease are the most active period. This study confirms that environmental and hormonal factors may play an important role in the disease course, probably with other endogenous or exogenous factors. © 2024 S. Karger AG, Basel.