Browsing by Author "Karadag B."

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    Reliability and validity of the Cystic Fibrosis Questionnaire-Revised for children and parents in Turkey: Cross-sectional study
    (Kluwer Academic Publishers, 2013) Yuksel H.; Yilmaz O.; Dogru D.; Karadag B.; Unal F.; Quittner A.L.
    Purpose: The purpose of study was to translate Cystic Fibrosis Questionnaire-Revised (CFQ-R) into Turkish for children with cystic fibrosis (CF) and evaluate its reliability and validity. This is the first CF-specific health-related quality of life (HRQOL) measure validated in a Muslim country. Methods: Fifty-one children aged 6-13 years treated at four centers in Turkey and 30 parents participated in this cross-sectional study. Demographic characteristics and disease severity parameters were recorded for all participants. All participants completed the parent or child versions of CFQ-R and KINDL questionnaires at enrollment. Reliability and construct validity analysis were carried out. Results: Both children and parents endorsed a range of responses, with no evidence of floor or ceiling effects. Item-to-total correlations indicated that most items were more highly correlated with their intended scale than competing scales. Good internal consistency was found for majority of child and parent scales. CFQ-R scales correlated significantly with clinical indices of disease severity. Good evidence of convergent validity with a generic HRQOL scale was found. Conclusion: Turkish versions of CFQ-R Child and Parent instruments have demonstrated adequate reliability and validity and can be utilized in clinical trials or integrated into clinical evaluation and follow-up of Turkish children with CF. © 2012 Springer Science+Business Media B.V.
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    Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey
    (Frontiers Media S.A., 2021) Karbuz A.; Akkoc G.; Bedir Demirdag T.; Yilmaz Ciftdogan D.; Ozer A.; Cakir D.; Hancerli Torun S.; Kepenekli E.; Erat T.; Dalgic N.; Ilbay S.; Karaaslan A.; Erdeniz E.H.; Aygun F.D.; Bozdemir S.E.; Hatipoglu N.; Emiroglu M.; Sahbudak Bal Z.; Ciftci E.; Bayhan G.I.; Gayretli Aydin Z.G.; Ocal Demir S.; Kilic O.; Hacimustafaoglu M.; Sener Okur D.; Sen S.; Yahsi A.; Akturk H.; Cetin B.; Sutcu M.; Kara M.; Uygun H.; Tural Kara T.; Korukluoglu G.; Akgun O.; Üstündağ G.; Demir Mis M.; Sali E.; Kaba O.; Yakut N.; Kılıc O.; Kanik M.K.; Cetin C.; Dursun A.; Cicek M.; Kockuzu E.; Sevketoglu E.; Alkan G.; Guner Ozenen G.; İnce E.; Baydar Z.; Ozkaya A.K.; Ovali H.F.; Tekeli S.; Celebi S.; Cubukcu B.; Bal A.; Khalilova F.; Kose M.; Hatipoglu H.U.; Dalkiran T.; Turgut M.; Basak Altas A.; Selcuk Duru H.N.; Aksay A.; Saglam S.; Sari Yanartas M.; Ergenc Z.; Akin Y.; Duzenli Kar Y.; Sahin S.; Tuteroz S.K.; Bilen N.M.; Ozdemir H.; Senoglu M.C.; Pariltan Kucukalioglu B.; Besli G.E.; Kara Y.; Turan C.; Selbest Demirtas B.; Celikyurt A.; Cosgun Y.; Elevli M.; Sahin A.; Bahtiyar Oguz S.; Somer A.; Karadag B.; Demirhan R.; Turk Dagi H.; Kurugol Z.; Taskin E.C.; Sahiner A.; Yesil E.; Ekemen Keles Y.; Sarikaya R.; Erdem Eralp E.; Ozkinay F.; Konca H.K.; Yilmaz S.; Gokdemir Y.; Arga G.; Ozen S.; Coksuer F.; Vatansever G.; Tezer H.; Kara A.
    Objectives: The aim of this study is to identify the epidemiological, clinical, and laboratory features of coronavirus disease 2019 (COVID-19) in children. Methods: A retrospective study was conducted by pediatric infectious disease specialists from 32 different hospitals from all over Turkey by case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, and June 15, 2020 were included. Case characteristics including age, sex, dates of disease onset and diagnosis, family, and contact information were recorded. Clinical data, including the duration and severity of symptoms, were also collected. Laboratory parameters like biochemical tests and complete blood count, chest X-ray, and chest computed tomography (CT) were determined. Results: There were 1,156 confirmed pediatric COVID-19 cases. In total, male cases constituted 50.3% (n = 582) and females constituted 49.7% (n = 574). The median age of the confirmed cases was 10.75 years (4.5–14.6). Of the total cases, 90 were younger than 1 year of age (7.8%), 108 were 1–3 years of age (9.3%), 148 were 3–6 years of age (12.8%), 298 were 6–12 years of age (25.8%), 233 were 12–15 years of age (20.2%), and 268 cases were older than 15 years of age (23.2%). The most common symptom of the patients at the first visit was fever (50.4%) (n = 583) for a median of 2 days (IQR: 1–3 days). Fever was median at 38.4°C (38.0–38.7°C). The second most common symptom was cough (n = 543, 46.9%). The other common symptoms were sore throat (n = 143, 12.4%), myalgia (n = 141, 12.2%), dyspnea (n = 118, 10.2%), diarrhea (n = 112, 9.7%), stomachache (n = 71, 6.1%), and nasal discharge (n = 63, 5.4%). When patients were classified according to disease severity, 263 (22.7%) patients were asymptomatic, 668 (57.7%) patients had mild disease, 209 (18.1%) had moderate disease, and 16 (1.5%) cases had severe disease. One hundred and forty-nine (12.9%) cases had underlying diseases among the total cases; 56% of the patients who had severe disease had an underlying condition (p < 0.01). The need for hospitalization did not differ between patients who had an underlying condition and those who do not have (p = 0.38), but the need for intensive care was higher in patients who had an underlying condition (p < 0.01). Forty-seven (31.5%) of the cases having underlying conditions had asthma or lung disease (38 of them had asthma). Conclusions: To the best of our knowledge, this is one of the largest pediatric data about confirmed COVID-19 cases. Children from all ages appear to be susceptible to COVID-19, and there is a significant difference in symptomatology and laboratory findings by means of age distribution. © Copyright © 2021 Karbuz.
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    Pediatric dysphagia overview: best practice recommendation study by multidisciplinary experts
    (Zhejiang University School of Medicine Children's Hospital, 2022) Umay E.; Eyigor S.; Giray E.; Karadag Saygi E.; Karadag B.; Durmus Kocaaslan N.; Yuksel D.; Demir A.M.; Tutar E.; Tikiz C.; Gurcay E.; Unlu Z.; Celik P.; Unlu Akyuz E.; Mengu G.; Bengisu S.; Alicura S.; Unver N.; Yekteusaklari N.; Uz C.; Cikili Uytun M.; Bagcier F.; Tarihci E.; Akaltun M.S.; Ayranci Sucakli I.; Cankurtaran D.; Aykın Z.; Aydın R.; Nazli F.
    Background: Currently, there is no comprehensive and multidisciplinary recommendation study covering all aspects of pediatric dysphagia (PD). This study aimed to generate PD management recommendations with methods that can be used in clinical practice to fill this gap in our country and in the world, from the perspective of experienced multidisciplinary experts. Methods: This recommendation paper was generated by a multidisciplinary team, using the seven-step process and a three-round modified Delphi survey via e-mail. First, ten open-ended questions were created, and then detailed recommendations including management, diagnosis, treatment, and follow-up were created with the answers from these questions. Each recommendation item was voted on by the experts as overall consensus (strong recommendation), approaching consensus (weak recommendation) and divergent consensus (not recommended). Results: In the 1st Delphi round, a questionnaire of 414 items was prepared based on the experts’ responses to ten open-ended questions. In the 2nd Delphi round, 59.2% of these items were accepted as pre-recommendation. In the 3rd Delphi round, 62.6% of 246 items were accepted for inclusion in the proposals. The final version recommendations consisted of 154 items. Conclusions: This study includes comprehensive and detailed answers for every problem that could be posed in clinical practice for the management of PD, and recommendations are for all pediatric patients with both oropharyngeal and esophageal dysphagia. © 2022, Children's Hospital, Zhejiang University School of Medicine.
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    Childhood interstitial lung disease survivors in adulthood: a European collaborative study
    (2025) Manali E.D.; Griese M.; Nathan N.; Uzunhan Y.; Borie R.; Michel K.; Schwerk N.; Fijolek J.; Radzikowska E.; Chua F.; Pabary R.; Mogulkoc N.; McCarthy C.; Kallieri M.; Papaioannou A.I.; Kiper N.; Koziar Vasakova M.; Lacina L.; Molina-Molina M.; Torrent-Vernetta A.; Tsiligiannis T.; Karadag B.; Kokosi M.; Renzoni E.A.; van Moorsel C.H.M.; Campo I.; Bendstrup E.; Prior T.S.; Prasse A.; Bonella F.; Cottin V.; Diesler R.; Froidure A.; Kolilekas L.; Fotis L.; Douros K.; Kaditis A.G.; Jeny F.; Chauveau S.; Nunes H.; Dahbia A.; Mariani F.; van der Vis J.J.; Groen K.; Erdem Eralp E.; Gokdemir Y.; Kocakaya D.; Olgun Yildizeli S.; Yalçın E.; Emiralioğlu N.; Nayir Buyuksahin H.; O'Brien H.; Karcıoglu O.; Can D.; Ezircan A.; Kartal Ozturk G.; Ocal N.; Yuksel H.; Narin Tongal S.; Safrankova M.; Kourtesi K.; Louvrier C.; Kannengiesser C.; Fabre A.; Legendre M.; Crestani B.; Pohunek P.; Bush A.; Papiris S.A.
    BACKGROUND: Interstitial lung disease is rarer in children than adults, but, with increasing diagnostic awareness, more cases are being discovered. The prognosis of childhood interstitial lung disease is often poor, but increasing numbers are now surviving into adulthood. AIM: To characterise childhood interstitial lung disease survivors and identify their impact on adult interstitial lung disease centres. METHODS: This was a European study (34 adult and childhood interstitial lung disease centres) reporting incident/prevalent cases of childhood interstitial lung disease survivors from January to July 2023. Epidemiological, clinical, physiological and genetic data were collected. RESULTS: 244 patients were identified with a median (interquartile range) age at diagnosis of 12.5 years (6-16 years) and age at study inclusion of 25 years (22-33 years), with 51% male, 86% nonsmokers and a median (interquartile range) % predicted forced vital capacity of 70% (47-89%) and diffusing capacity of the lungs for carbon monoxide of 48% (32-75%). 32% were prescribed long-term oxygen and 227 (93%) were followed up in adult centres whereas 17 (7%) never transitioned. The commonest diagnoses (82%) were childhood interstitial lung disease category B1 (sarcoidosis, hemosiderosis, connective tissue disorders, vasculitis) at 35%, A4 (surfactant-related) at 21%, B2 (bronchiolitis obliterans, hypersensitivity pneumonitis) at 14% and Bz (unclassified interstitial lung disease) at 13%. Bz patients had the worst functional status. 60% of all patients were still being prescribed corticosteroids. Re-specification of diagnosis and treatment were made after transition for 9.8% and 16% of patients, respectively. Not all childhood interstitial lung disease diagnoses were recognised in adult interstitial lung disease classifications. CONCLUSION: Childhood interstitial lung disease survivors are seen in most adult interstitial lung disease centres and only a minority continue follow-up in paediatric centres. Survivors have a significant loss of lung function. The heterogeneity of their aetiologies and therapeutic requirements has a real impact on adult interstitial lung disease centres. Re-specification of diagnosis and treatment may contribute to precision and personalisation of management. Copyright ©The authors 2025. For reproduction rights and permissions contact permissions@ersnet.org.