Browsing by Author "Karakas, B"

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Cognitive functions in idiopathic intracranial hypertension
    Ak, AK; Saritas, AS; Batum, M; Gemici, YI; Karakas, B; Çelebisoy, N
    Objective Cognitive problems in idiopathic intracranial hypertension (IIH) is generally overlooked in the presence of disabling headache and threat to visual function. The aim of this study was to search for cognitive deficits in patients with IIH using neuropsychologic tests in addition to P300 potential recordings to assess cognition related brain activity. Methods Fifty IIH patients were examined using Montreal Cognitive Assessment Test, Stroop Test and Visual Aural Digit Span Test to measure different domains of cognition at the time of diagnosis. P300 potentials were recorded by using an oddball paradigm. Hospital Anxiety and Depression Scale was used to determine anxiety and depression. Quality of life (QoL) was assessed by SF-36. The results were compared with fifty healthy controls with matching age, gender and body mass index. Results Neuropsychologic tests revealed wide cognitive impairment including attention, working memory, executive function, naming, language, delayed recall and orientation in IIH patients. In addition, quality of life was affected in the sub-parameters of general health perceptions, emotional role functioning, vitality, mental health and bodily pain. P300 potential latencies were long and the amplitudes were reduced indicating deficits in attention and working memory. Anxiety scores were high, and health-related QoL was low mainly involving vitality, emotional and mental health. Cognitive dysfunction was not correlated with the levels of anxiety and the correlation with headache severity was mild. Conclusion A multidomain cognitive decline mainly involving attention and working memory was recorded in IIH patients. It was not correlated with anxiety and only a mild correlation with headache severity was present which may indicate a casual relationship between raised intracranial pressure and cognitive deficits. Screening is important as neuropsychological rehabilitation might be relevant in these patients.
  • No Thumbnail Available
    Item
    Calcitonin gene-related peptide (CGRP) levels in peripheral blood in patients with idiopathic intracranial hypertension and migraine
    Ak, AK; Gemici, YI; Batum, M; Karakas, B; Özmen, EY; Gökçay, F; Çelebisoy, N
    Background: Calcitonin gene-related peptide (CGRP) plays a dominant role in migraine. This prospective study was designed to investigate CGRP levels in patients with idiopathic intracranial hypertension (IIH) and compare the results of migraine patients and healthy controls (HC). As a second objective, CGRP levels obtained from IIH patients defining sustained headache after the resolution of papilledema were compared with those not defining post-IIH headache. Methods: Thirty-six patients with IIH, 36 with episodic migraine (EM), 18 with chronic migraine (CM), and 36 HC were included in the study. CGRP levels were studied from blood samples obtained from the antecubital vein by using a commercial ELISA kit. Results: Serum CGRP levels of the patient groups were significantly higher than the HC (p < 0.001). As compared with controls, both CM (p Adj<0.001) and IIH (p Adj=0.039) had significantly increased levels of CGRP. Levels recorded from EM patients did not differ from the HC (p Adj=0.661). In 16 IIH patients, persistent headache was reported after the normalization of intracranial pressure (ICP). Twenty patients did not report post-IIH headaches. Comparison of serum CGRP levels of these two groups revealed significantly higher CGRP levels in patients with sustained headaches obtained from blood samples both at the initial and control visit (p Adj <0.001). Conclusions: CGRP levels of the patient groups were higher than the HC. High levels recorded in patients with IIH indicates the role of CGRP in IIH related headache and even higher levels in patients with sustained headache after normalization of ICP strengthens this finding.
  • No Thumbnail Available
    Item
    Cognıtıve functıons in idiopathic intracranial hypertensıon
    Ak, AK; Saritas, AS; Batum, M; Gemici, YI; Karakas, B; Celebisoy, N
    ObjectiveCognitive problems in idiopathic intracranial hypertension (IIH) is generally overlooked in the presence of disabling headache and threat to visual function. The aim of this study was to search for cognitive deficits in patients with IIH using neuropsychologic tests in addition to P300 potential recordings to assess cognition related brain activity.MethodsFifty IIH patients were examined using Montreal Cognitive Assessment Test, Stroop Test and Visual Aural Digit Span Test to measure different domains of cognition at the time of diagnosis. P300 potentials were recorded by using an oddball paradigm. Hospital Anxiety and Depression Scale was used to determine anxiety and depression. Quality of life (QoL) was assessed by SF-36. The results were compared with fifty healthy controls with matching age, gender and body mass index.ResultsNeuropsychologic tests revealed wide cognitive impairment including attention, working memory, executive function, naming, language, delayed recall and orientation in IIH patients. In addition, quality of life was affected in the sub-parameters of general health perceptions, emotional role functioning, vitality, mental health and bodily pain. P300 potential latencies were long and the amplitudes were reduced indicating deficits in attention and working memory. Anxiety scores were high, and health-related QoL was low mainly involving vitality, emotional and mental health. Cognitive dysfunction was not correlated with the levels of anxiety and the correlation with headache severity was mild.ConclusionA multidomain cognitive decline mainly involving attention and working memory was recorded in IIH patients. It was not correlated with anxiety and only a mild correlation with headache severity was present which may indicate a casual relationship between raised intracranial pressure and cognitive deficits. Screening is important as neuropsychological rehabilitation might be relevant in these patients.
  • No Thumbnail Available
    Item
    Evaluation of predictive factors of idiopathic intracranial hypertension in different clinics
    Karakas, B; Saritas, AS; Kisabay, AKA
    Purpose: Idiopathic Intracranial Hypertension (IIH) is marked by elevated intracranial pressure without an identifiable cause. This study aimed to compare predictive factors between two IIH groups: those experiencing remission (single attack) and those developing migrainous headaches, in order to identify factors influencing the disease's progression. Methods: This retrospective study was conducted after obtaining ethics committee approval. It involved 118 patients diagnosed with IIH who were followed up in the Neuro-ophthalmology outpatient clinic between 2011 and 2023. Data on demographics, clinical history, comorbidities, habits, neurologic and neuro-ophthalmologic findings, cranial imaging features, lumbar puncture opening pressure, and current medical treatments were collected to assess the clinical course and predictive factors. The analyzed parameters were compared between two subgroups: one experiencing remission (single attack) and the other developing migrainous headaches. Statistically significant parameters were subjected to univariate and multivariate analysis. Results: Of the 118 patients, 87 (73.7 %) were in the single-attack group, while 31 (26.3 %) were in the migrainous headache group. Key predictive factors identified between the groups were the presence of allodynia (p < 0.001), neck and back pain (p = 0.042), BMI > 27.8 kg/m(2) (p = 0.002), and a history of migraine (p < 0.001). Conclusions: Allodynia, neck and back pain, a history of migraine, and a BMI > 27.8 kg/m(2) were found to be predictive factors for the development of migrainous headaches in IIH patients. This is the first study in the literature to compare these two patient groups and identify the factors that contribute to the development of migrainous headaches.