MCBÜ Açıkerişim Sistemi :: Browsing by Author "Kasap, E"

Browsing by Author "Kasap, E"

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THE ROLE OF ENDOSCOPY-INDEPENDENT GASTROINTESTINAL BLEEDING SCORES IN PREDICTING 30-DAY MORTALITY IN AGED OVER 65
Elbi, H; Vatansever Balcan, M; Buran, T; Kasap, E
Introduction: The aim of this study was to assess the power of clinical findings and scoring systems to predict mortality in patients over 65 years of age with non-variceal upper gastrointestinal bleeding. Materials and Method: Data on demographic profiles and risk estimation scores were retrospectively extracted from electronic hospital medical records and other electronic databases using a standard data extraction form. The AIMS65, pre-Rockall, modified Glasgow-Blatchford, T, and Baylor bleeding scores were calculated to estimate the 30-day mortality risk. The inclusion criteria were patients aged 65 and over who presented with active bleeding symptoms and had been diagnosed with acute upper gastrointestinal bleeding by the gastroenterology department. Results: The mean age was 75.23 years, and 23.6% of the patients died within 30 days. The 30-day mortality was associated with albumin levels, malignancy, and intensive care unit hospitalization. An inverse relationship was found between the albumin level and mortality, whereas the presence of cancer and the need for intensive care were associated with 2.8-fold and 2.2-fold increases in the risk of death, respectively. The AIMS65 score (AUC: 0.794) had the highest discriminative ability to predict 30-day mortality among all risk scores. Conclusion: Albumin levels, malignancy presence, and ICU admission were indicators of mortality risk in elderly patients with upper gastrointestinal bleeding. Calculating all the scores, excluding the Baylor Bleeding score, is beneficial for assessing the risk of mortality associated with upper gastrointestinal bleeding. The AIMS65 score demonstrates the highest discriminative ability. However, using these risk-scoring systems necessitates additional data.
The frequency of sexual-physical abuse history in irritabl bowel syndrome patients and diagnostic relation with major depressive disorder history
Eker, MÇ; Kasap, E; Elbi, H; Bor, S
Objective: IBS is a functional disorder which is one of the most common causes of gastroentrology doctor visits. Besides multiple factors suggested for the etiology of IBS, the co-morbidity of psychiatric illnesses, of which MDD is most the frequent, is also noted. Being exposed to sexual or physical abuse is also considered as a risk factor for the development of IBS. Methods: In this study the differences between IBS patients and non-IBS control cases are evaluated regarding the history of major depressive disorder and sexual or physical abuse. Fiftyfour IBS and thirty control cases (mean age for IBS patients 41 +/- 11; for control group 34 +/- 12 years; p<0.05) were recruited for the study. Results: IBS patients had a history of MDD more frequently than the control cases (69% for the IBS group, n=37; 30% for the control group, n=9; p<0.001]. However, two groups did not differ regarding the history of sexual abuse (20% for the IBS group, n=11; (13% for the control group, n=4; p>0.05) or physical abuse (19% for the IBS group, n=10; 13% for the control group, n=4; p>0.05). Discussion: IBS and MDD are frequently co-morbid and this co-morbidity suggests a possible common point for the etiopathogenesis for both disorders. Nevertheless, the contribution of sexual or physical abuse to the co-morbidity of these disorders seems to be inconclusive. It can be suggested that sexual and physical abuse history do not have fundemental importance for the development of IBS in our patients. (Anatolian Journal of Psychiatry 2010; 11:120-126)
A No-Biopsy Approach for the Diagnosis of Celiac Disease in Adults: Can It Be Real?
Baykan, AR; Cerrah, S; Ciftel, S; Vural, MK; Kasap, E
Background and objective Pediatric guidelines on the diagnosis of celiac disease (CD) have reported that the positivity of anti-endomysium antibodies in the presence of anti-transglutaminase antibodies (TGA) 10 times higher than normal is sufficient for the diagnosis. In this study, we aimed to evaluate whether this diagnostic process for children can also be applied to adult patients. Materials and methods We retrospectively examined patients aged >18 years who were diagnosed with CD. The results of serological tests and endoscopic biopsy were evaluated. Patients with more than one month of duration between celiac serology and endoscopy, those diagnosed with CD before admission, those on a gluten-free diet, and those with selective IgA deficiency were excluded from the study.Results A total of 269 patients were included in the study. TGA value was significantly higher in patients with villous atrophy (p<0.001) and positively correlated with mucosal damage (r=0.60, p<0.01). Considering the cut-off value of 100 U/mL (>10 ULN) for the TGA antibodies, in line with the criteria regulated by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) for the diagnosis of CD, the sensitivity was 71.64%, the specificity was 100%, and the positive predictive value (PPV) was 100%. When the cut-off value was taken as 29.42 U/mL, the sensitivity was 100% and the specificity was 99.5%. For a TGA cut-off value of 52.7 U/mL (5.27 ULN), which determines the presence of partial or complete villous atrophy in the evaluation made considering mucosal damage, the sensitivity was 90%, the specificity was 100%, and the PPV was 100%.Conclusion Based on our findings, TGA titers were highly effective in demonstrating CD-related mucosal damage. This study endorses a biopsy-free strategy in adult patients in line with the ESPGHAN criteria. Local validation of test-specific thresholds will ensure that this approach has a significant impact on adult patients.
GSTP1 Gene Methylation Profiles in Helicobacter pylori (+) and (-) Antral Intestinal Metaplasia and Distal Gastric Tumour Patients in Turkish Population
Asik-Sen, G; Kasap, E; Orenay-Boyacioglu, S; Korkmaz, M; Kahraman, E; Unsal, B; Yüksel-Saritas, E; Yuceyar, H
Background/Aims: Gastric cancer (GC) is the second most common malignancy worldwide, with a high mortality rate. The incidence of GC has declined in the western countries during the last decades. The glutathione S-transferases comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study we aimed at the relationship GSTP-1 methylation in patients with intestinal metaplasia with and without Helicobacter pylori infection, gastric cancer and controls. Methodology: The methylation status of GSTP1 gene was analyzed by methylation specific PCR after bisulfate modification in H. pylori (+) (n=25) and (-) (n=25) intestinal metaplasia (IM) patients, GC (n=25) and control subjects (n=15) between September 2009 to November 2011. Results: During the study period 90 patients who underwent endoscopic examination were included in the study. When we considered the GSTP1 gene methylation profile in all of the groups; 26 (28%) patients had methylated GSTP1 gene, 31 (34%) patients had unmethylated GSTP1 gene and 33 (36%) patients had heterogeneously methylated GSTP1 gene. Conclusions: GSTP1 gene methylation profile is not appropriate for early diagnosis of cases with gastric cancer.
The Importance of Apoptosis in Cancer Development and Treatment
Gökbayrak Atay, IN; Gezer, AH; Kasap, E
Cancer is one of the most important causes of death in our era. Multifactorial causes are involved in the formation of cancer. The reduction of apoptosis is one of these reasons. Failure to activate apoptosis pathways can lead to resistance to the current treatment approaches of cancers. A better understanding of the molecular events that regulate apoptosis in cancers and cancer therapy form the basis of a more rational approach to the development of molecular targeted therapies in the fight against cancer.
Correlation Among Standard Endoscopy, Narrow Band Imaging, and Histopathological Findings in the Diagnosis of Nonerosive Reflux Disease
Kasap, E; Zeybel, M; Asik, G; Ayhan, S; Yüceyar, H
Background and Aims: Gastroesophageal reflux disease (GERD) is caused by the reflux of gastric contents into the esophagus. Narrow band imaging (NBI) facilitates mucosal surface evaluation and may improve the endoscopic diagnosis of GERD. The diagnosis of GERD is based on the combination of clinical symptoms, endoscopic findings, and histological changes. In this study we aimed to show the differences between standard white light endoscopy and the NBI technique in squamo-columnar junction evaluation. We also evaluated the patients with NERD, as determined by standard white light endoscopy, using the NBI technique and histopathological mucosa examination (inflammation or normal mucosa). Methods: A total of 60 subjects were recruited prospectively: 40 with nonerosive reflux disease (NERD) and 20 with erosive reflux disease (ERD). Patients were subjected to esophagogastroduodenoscopy and, in all of them, two biopsies were taken 2 cm above the esophagogastric junction. Results: NBI was more sensitive than standard white light endoscopy in distinguishing normal endoscopic findings. Histopathological findings were more prevalent than the mucosal changes diagnosed by the standard white light endoscopy and NBI. Conclusion: NBI is more sensitive than white light endoscopy in detecting inflammation in NERD patients. However, histopathological evaluation is the most sensitive, therefore taking a biopsy will remain useful.
The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment
Kasap, E; Buran, T; Avcu, AT; Hasdemir, PS; Balcan, E; Aktan, Ç; Korkmaz, M
Background: Gastroesophageal reflux disease is a common condition worldwide. There is no curative treatment for gastroesophageal reflux disease. Endoplasmic reticulum stress leads to the activation of the unfolded protein response and has an important role in inflammation. The aim is to determine the role of endoplasmic reticulum stress in the follow-up of individuals with gastroesophageal reflux disease and the temporal changes of endoplasmic reticulum stress markers with treatment. Methods: Twenty-four subjects in total were recruited prospectively, of whom 15 had nonerosive reflux disease. Two biopsies from 2 cm above the esophagogastric junction, 2 biopsies from gastric antrum mucosa, and 2 biopsies from gastric corpus mucosa were taken. Simultaneously, 2 tubes of venous blood samples were drawn from each individual (1 tube for studying the genetic markers and 1 tube for analyzing the CYP2C19 polymorphism). Results: The mean age was 42.3 +/- 17.6 for women and 34.66 +/- 11.2 for men. Pantoprazole, esomeprazole, rabeprazole, and lansoprazole preparations were used for treatment. There was no significant difference between tissue and blood samples for panel genes ATF-6, XBP-1, DDIT-3, DNAJC-10, and EIF-2-AK before treatment. There was a significant decrease in the level of ATF-6, XBP-1, DNAJC-9, EIF2-AK, and NF-2L-2 genes in blood after treatment. In the comparison of proton pump inhibitors, significant decreases in the expression of the ATF-6, XBP-1, and DNAJC-9 mRNAs were detected in blood from individuals after treatment. Conclusion: Endoplasmic reticulum stress can be for evaluating the clinical improvement and the effectiveness of treatment in gastroesophageal reflux disease.
The efficacy of complete blood count parameters in the diagnosis of tubal ectopic pregnancy
Eskicioglu, F; Özdemir, AT; Turan, GA; Gür, EB; Kasap, E; Genç, M
Objective: Ectopic pregnancy (EP) is the major cause of maternal morbidity and is responsible for maternal mortality in the first trimester In order to reduce undesirable results, it is necessary to find rapid and accurate, non-surgical diagnostic tests for EP The goal of the study was to investigate the differences in complete blood count parameters between tubal EPs and healthy pregnancies in be used in the diagnosis of ectopic pregnancy Study design: White blood cell (WBC), neutrophil, monocyte, lymphocyte, platelet (PLT) counts, mean PLT volume (MPV) and PLT distribution width (POW) levels in the complete blood count samples have been obtained from subjects with diagnosed tubal EP (n=78; study group) and women with healthy intrauterine gestations (n=79; control group). Statistical comparisons between groups were performed using the t test Results: POW levels were found to be significantly higher in the control group than EP (p<0.001). However no differences between the study and control groups with regard to PLT and MPV levels were observed. WBC levels were found to be significantly higher in the EP group as compared to controls (p<0.001). When leukocyte differentials were compared, monocyte counts in the EP group were significantly higher than in controls (p=0.005). No statistically significant differences in neutrophil and lymphocyte values were observed in either group. Conclusion: POW as an indicator of PLT activation is lower in tubal EP than intrauterine pregnancy so, possibly endometrial invasion in the intrauterine pregnancy needs more PLT activation. Monocyte counts are higher in tubal indicating that monocyte activation in the pathophysiology of EP could be effective in the formation of tubal motility and microenvironment regulation.
Treatment of inflammatory bowel disease by leukocytapheresis
Gerçeker, E; Yüceyar, H; Kasap, E; Demirci, U; Ekti, BC; Aydogdu, I; Miskioglu, M
Studies about leukocytapheresis have emerged with the need of search for alternatives to conventional treatment in inflammatory bowel diseases (IBD). Leukocytapheresis is a novel non-pharmacologic approach for active ulcerative colitis (UC) and Crohn's disease (CD), in which leukocytes are mechanically removed from the circulatory system. Patients with active IBD treated with leukocytapheresis using a Cellsorba E column between 2012 and 2015, were enrolled in Turkey. In our experience, the results of leukocytapheresis therapy in 6 patients with CD and 20 patients with active UC were overviewed. Leukocytapheresis (10 sessions for remission induction therapy, 6 sessions for maintenance therapy) was applied to the patients with their concomitant medications. Intensive leukocytapheresis (>= 4 leukocytapheresis sessions within the first 2 weeks) was used in 30% patients with active severe UC. The overall clinical remission rate in patients with UC was 80%, and the mucosal healing rate was 65%. Patients were followed for an average of 24 months. It was observed that clinical remission has continued in 65% of patients with UC. Mild relapse was observed in 3 patients with UC during follow up period. In 5 patients with CD significant clinical remission was achieved except only one patient. Surgical needs were disappeared in 3 patients with obstructive type Crohn's disease, Adverse events were seen in only 4.3% of 416 sessions. Any concomitant medications did not increase the incidence of adverse events. Our results indicate that leukocytapheresis is efficacious in improving remission rates with excellent tolerability and safety in patients with IBD. (C) 2017 Elsevier Ltd. All rights reserved.
Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma
Kasap, E; Boyacioglu, SÖ; Korkmaz, M; Yuksel, ES; Ünsal, B; Kahraman, E; Özütemiz, Ö; Yuceyar, H
Gastroesophageal reflux disease is a risk factor for esophageal adenocarcinoma yet studies that have investigated the relationship between erosive esophagitis and esophageal adenocarcinoma have usually focused on symptom-related evidence or polymorphisms. There are no epigenetic gene expression studies on this topic. In this study, we aimed to evaluate the relationship between erosive esophagitis and esophageal adenocarcinoma to identify whether there is a genetic predisposition for esophageal adenocarcinoma. The Human Epigenetic Chromatin Modification Enzyme RT2 Profiler (TM) PCR array (PAHS-085A) was used to detect the expression of 84 key genes encoding enzymes. This was carried out prospectively for samples from 60 patients (20 patients as a control group, 20 patients with erosive esophagitis and 20 patients with esophageal adenocarcinoma). AURKA, AURKB, NEK6 were expressed at significantly higher levels in esophageal adenocarcinoma compared to the control group. MBD2 was expressed at significantly lower levels in the esophageal adenocarcinoma group compared to the control group. AURKA, AURKC, HDAC9 and NEK6 were expressed at significantly higher levels in erosive esophagitis compared to the control group. There was no difference in unregulated gene expression between the erosive esophagitis and esophageal adenocarcinoma. MBD2 was significantly downregulated in esophageal adenocarcinoma compared to erosive esophagitis. NEK6 and AURKA were significantly unregulated in esophageal adenocarcinoma and erosive esophagitis compared to the control group. This is a novel study on the genetic predisposition for erosive esophagitis and esophageal adenocarcinoma. AURKA and NEK6 are two promising genetic markers for erosive esophagitis and esophageal adenocarcinoma.
Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori
Bor, S; Kitapcioglu, G; Kasap, E
AIM To evaluate the prevalence of gastroesophageal reflux disease (GERD) with additional symptoms, relationship with Helicobacter pylori (H. pylori) of this country-wide study. METHODS Data from 3214 adults were obtained with validated questionnaire. Eight hundred and forty-one subjects were randomized to be tested for H. pylori via the urea breath test. Frequent symptoms were defined heartburn and/or regurgitation occurring at least weekly. RESULTS The prevalence of GERD was 22.8%, frequent and occasional heartburn were 9.3%-12.7%, regurgitation were 16.6%-18.7%, respectively. Body mass index (BMI) <= 18.5 showed a prevalence of 15%, BMI > 30 was 28.5%. The GERD prevalence was higher in women (26.2%) than men (18.9%) (P < 0001). Overall prevalence of H. pylori was 75.7%. The prevalence was 77.1% in subjects without symptoms vs 71.4% in subjects with GERD (chi(2) = 2.6, P = 0.27). Underprivileged with the lowest income people exhibit a higher risk. CONCLUSION GERD is common in Turkey which reflects both Western and Eastern lifestyles with high rate of H. pylori. The presence of H. pylori had no effect on either the prevalence or the symptom profile of GERD. Subjects showing classical symptoms occasionally exhibit more additional symptoms compared with those without classical symptoms.
Molecular analyses of ADAMTS-1,-4,-5, and IL-17 a cytokine relationship in patients with ulcerative colitis
Buran, T; Batir, MB; Çam, FS; Kasap, E; Çöllü, F; Çelebi, HBG; Sahin, M
BackgroundUlcerative colitis (UC) is a chronic inflammatory bowel disease that develops due to the impaired immune response in genetically susceptible individuals, and its etiopathogenesis is not fully elucidated. IL-17 A is a cytokine that is produced by a type of immune cell called Th17 cells and is involved in the immune response and inflammation. On the other hand, ADAMTS-1, -4, and - 5 are enzymes that are involved in the breakdown of extracellular matrix proteins, including proteoglycans, which are important components of the intestinal wall. This study aimed to evaluate the relationship between interleukin 17 (IL-17 A) cytokine, which plays a role in the pathogenesis of ulcerative colitis, and the inflammation-controlled a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1, -4, and - 5 protein members.MethodsBowel tissue samples and blood serum from 51 patients with UC and 51 healthy controls were included in this study. mRNA expression levels of the ADAMTS-1, -4, -5, and IL-17 A were analyzed by RT-qPCR, and immunohistochemical analyses were performed to evaluate ADAMTS-1, -4, -5, and IL-17 A proteins in tissue samples. In addition, ELISA analysis determined serum levels of the ADAMTS-1, -4, -5, and IL-17 A.ResultsRT-qPCR results reveal that the expression of ADAMTS-1, -4, -5, and IL-17 A genes in the UC tissue samples were significantly high according to the control tissue samples. Also, ADAMTS-1, -4, -5, and IL-17 A proteins revealed enhanced expression pattern UC groups according to the control. Also, ADAMTS-1, -4, -5, and IL-17 A protein showed cytoplasmic localization patterns in both control and UC groups. The serum levels of ADAMTS-1,-5, and IL-17 A were significantly higher in UC samples than in the control group.ConclusionsWe observed a positive correlation between the ADAMTS-1, -5 and IL17A cytokine expression in UC samples. These results provide a new understanding of controlling crucial ADAMTS family protein members by IL-17 A cytokines with UC.
Schizophrenia and gastroesophageal reflux symptoms
Kasap, E; Ayer, A; Bozoglan, H; Ozen, C; Eslek, I; Yüceyar, H
Background: Psychological factors and psychiatric disorders play a role in a variety of gastrointestinal illnesses, including esophageal diseases. Aim: The aim of the present study was to evaluate the frequency of gastroesophageal reflux disease symptoms in patients with schizophrenia in Turkey. Patients and Methods: Ninety-eight patients with schizophrenia and one hundred control individuals were enrolled in the study, which was undertaken at the Manisa State Hospital for Mental Health and Neurological Disorders and Celal Bayar University Gastroenterology Department. Case and control subjects alike underwent 30-45 min oral interviews conducted by a designated study coordinator (E.K.). The coordinator gathered information about demographic characteristics, social habits, and a large variety of symptoms suggestive of reflux disease or other gastrointestinal conditions. Results: In terms of reflux symptoms, cough was the only significant association in schizophrenic patients than controls. Heartburn and regurgitation were more frequent in schizophrenic patients who smoked than in controls who were smokers. However, the prevalence of reflux symptoms in cigarette smokers versus nonsmoker patients with schizophrenia was similar. Heartburn and/or regurgitation occurred more frequently in patients with schizophrenic than controls with alcohol use. Conclusions: Psychiatric disorders might indirectly affect esophageal physiology through increased consumption of alcohol and nicotine.
Assessment of inflammatory markers in ulcerative colitis and association with the disease
Baykan, AR; Cerrah, S; Karahan, B; Çiftel, S; Temiz, A; Kasap, E
Aim: In daily routine practice, non-invasive tests are needed in addition to symptoms to determine activation in patients with ulcerative colitis (UC). In this study, it was aimed to compare the results of non-invasive tests used frequently at the time of diagnosis of patients diagnosed with UC with endoscopic severity. Material and Methods: This retrospective cohort study was carried out on 202 patients between 2018 and 2022. The white blood count (WBC), mean platelet volume (MPV), hemoglobin (HB), hematocrit (Hct), C-reactive protein (CRP), albumin, neutrophil-lymphocyte ratio (NLR), CRP-albumin ratio (CAR), platelet-lymphocyte ratio (PLR). and lymphocyte-monocyte ratio (LMR) of the patients were calculated at the time of diagnosis. The severity of UC was assessed via colonoscopy using the Mayo Endoscopic Subscore (Mayo Score). In addition, patients with active UC were re-evaluated during remission to calculate the predictive values of tests in UC activation and severity. Results: There was a significant correlation between the Mayo Subscore and CRP (r: 0.34, P < 0.01), WBC (r: 0.23, P = 0.01). HB (r: -023, P = 0.01), NLR (r: 0.49, P < 0.01), CAR (r: 0.51, P < 0.01), PLR (r 0.32, P < 0.01), and LMR (r: -0.34, P < 0.01). The sub-assessment, taking colon involvement into consideration, showed a correlation between the Mayo Subscore and NLR and CAR with pancolitis, left colon involvement, and distal colitis. The highest area under the curve (AUC) value, found in the tests, was with the CAR (0.919). When the CAR cut-off value was taken as 0.11, the sensitivity was 802%, and the specificity was 94.4%, indicating UC activation. Discussion: Inflammatory markers in UC have adequate sensitivity in indicating activation, and they also aid in the identification of severity of involvement in patients.
CHOLANGITIS OF PANCREATITIS? DOES THE ANGIOTENSIN-CONVERTING ENZYME GENOTYPE FAVOR EITHER?
Kasap, E; Akyildiz, M; Akarca, U
Acute cholangitis and pancreatitis are serious complications of gallstones, with considerable morbidity and mortality. Angiotensin-converting enzyme (ACE) is an exopeptidase that is important in regulating blood pressure, metabolizing bradykinin and in maintaining an inflammatory response. To determine whether the ACE genotype determines occurrence of cholangitis or pancreatitis we examined ACE I/D genotypes in 31 patients who had cholangitis, 44 patients with biliary pancreatitis and 157 healthy individuals. The patients had been hospitalized at the Department and Intensive Care Faculty of Medicine, Ege University, Izmir, Turkey. The patients were recalled 4 years later and their prognosis was evaluated. The ACE II genotype was found at a higher frequency in the cholangitis and biliary pancreatitis patients when compared with the healthy subjects (p < 0.05). There was no significant difference between cholangitis and biliary pancreatitis cases regarding the genotype and allele distribution (p > 0.05). Recurrence of infection occurred more frequently in the patients with the DD genotype, although it was not significant according to the first assessment (p > 0.05). The ACE gene polymorphism did not seem to favor development of either cholangitis or pancreatitis.
ASSOCIATION OF INTERLEUKIN 12B RS3212227 POLYMORPHISM WITH GASTRIC CANCER, INTESTINAL METAPLASIA, AND Helicobacter pylori INFECTION
Orenay-Boyacioglu, S; Kasap, E; Yuceyar, H; Korkmaz, M
Interleukin 12 (IL-12) has a key function in promoting Th1 immune response in the gastrointestinal mucosa. Although cytokine gene polymorphisms are associated with increased risk of gastric cancer (GC), studies on different geographic regions and ethnic groups are not able to draw a consistent result. The current case-control study aims to find out an association between a functional IL-12B rs3212227 polymorphism and the susceptibility and clinical features of the study groups, which are GC, Helicobacter pylori-infected and H. pylori-uninfected intestinal metaplasia (IM). In this study, IL-12B rs3212227 polymorphism was genotyped in 35 GC cases, 25 H. pylori-infected IM patients, 25 H. pylori-uninfected IM patients, and 25 control subjects. PCR-RFLP analysis was performed to find out and compare the polymorphism profiles of case biopsies. There was statistical significance in genotype distributions and allelic frequencies in GC patients with proximal arrest in stomach (p=0.042). The rs3212227 genotypes and allelic frequencies were not correlated with any of the study groups (p>0.05). Other clinical features examined in the GC patients were also not correlated with the rs3212227 genotypes and allelic frequencies (p>0.05). Current findings suggest that IL-12B rs3212227 polymorphism may play a role in GC development.
Upper gastrointestinal endoscopy findings of patients with B12 deficiency
Demirci, U; Kasap, E
Purpose: Vitamin B12 deficiency is highly prevalent. It may be caused by malabsorption or low intake and may trigger macrocytic anemia, neuropsychiatric and clinical symptoms. We aimed to detect the endoscopic evidence for vitamin B12 deficiency in the patients who referred to our clinic. Material and Methods: We retrospectively scanned the patients referred to Celal Bayar University, Faculty of Medicine, Department of Gastroenterology for vitamin B12 deficiency and underwent upper gastrointestinal endoscopy for this reason from May 2014 to May 2016. We examined all other reasons that might cause vitamin B12 deficiency for all patients and excluded those with other pathologies or receiving medication. Results: The patients' mean age was 48.13 and 56.7% of them were female. The control group had a mean age of 48.6. The control group had a mean age of 48.6. Of the patients with vitamin B12 deficiency, 24.3% had no pathology in the stomach or duodenum, while 86.4% presented no pathology in the duodenum. Thirty-four percent of the control group had no pathology in the stomach or duodenum. Eighty-two percent of the cases presented normal duodenal endoscopy findings. Conclusion: Vitamin B12 deficiency is a highly prevalent pathology that may lead to a series of clinical symptoms including neuropsychiatric and hematological symptoms. Treatment provides a notably positive response, and its etiology is important for treatment. The present study found no significant difference between the age-and gender-relevant control group and the patient group in terms of gastritis and duodenal pathologies.
Can the FIB-4 score predict the severity of acute pancreatitis in NAFLD?
Kirdok, K; Yogurtcu, Ö; Buran, T; Kasap, E
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a liver pathology. NAFLD's prevalence is increasing in the world and because of the increase non-invasive methods are gaining importance in diagnosis. The Fibrosis 4 (FIB-4) score is one of the most commonly used non-invasive scoring methods for diagnosing NAFLD today. Acute pancreatitis is a disease with inflammation and high morbidity. There are studies indicating that acute pancreatitis progresses more severely in patients with NAFLD. In our study, it was aimed to define the possible relationship between the FIB-4 score and the severity of acute pancreatitis, which has not been investigated before and contribute to the literature.MethodsOur study was conducted by retrospectively scanning 124 patients diagnosed with acute pancreatitis between 2018 and 2020. The patients were compared with the presence of NAFLD and the FIB-4 score results in those with NAFLD.ResultsThe 48th-hour Ranson score was found to be statistically significantly higher in patients with NAFLD compared to those without NAFLD. In patients with NAFLD, the total billurbin, direct billurbin, AST, ALT, ALP, GGT, and Ranson scores were found to be statistically significantly higher in those with FIB-4 score >= 2.67.ConclusionAs liver fibrosis increases in patients with NAFLD, it is suggested that liver damage accompanying acute pancreatitis increases, and the prognosis of acute pancreatitis worsens. There is a need for further studies to be conducted while centering more on this subject, which has not been investigated before in the literature.
Does Helicobacter pylori eradication improve the symptoms of globus hystericus?
Kasap, E; Ayhan, S; Yüceyar, H
Background/aims: Globus hystericus is a feeling of a tension in the throat, irrelevant of swallowing, persisting for at least 12 weeks. Since the cause of glob us hystericus is not fully described, a controversy exists about the treatment options. We aimed in this study to determine the symptoms of gastroesophageal reflux disease, the upper gastrointestinal endoscopic findings, prevalence of Helicobacter pylori, and the post-treatment symptoms (symptoms of gastroesophageal reflux disease and/or Helicobacter pylori) in patients with a diagnosis of globus hystericus. Materials and Methods: In this study, we retrostectively evaluated the medical records of 123 patients who, after the initial diagnosis of globus sensation (globus hystericus), underwent endoscopic examination in the Department of Gastroenterology and Endoscopy at Celal Bayar University Medical School, and thereafter, were given Helicobacter pylori eradication therapy and were followed in the Gastroenterology outpatient clinic, between January 2009 and August 2010. Results: Helicobacter pylori was positive in seventy-five (60%) of the 123 patients. Heartburn, regurgitation, and inlet patch in the upper esophagus were significantly more frequent in Helicobacter pylori (+) patients than in Helicobacter pylori () patients with globus hystericus. Normal endoscopy findings were significantly more common in Helicobacter pylori (-) patients than in Helicobacter pylori (+) patients with globus hystericus. Of patients with eradicated Helicobacter pylori, 27 (50%) reported that globus symptoms had disappeared, while 12 (17.3%) of them had not observed any regression of the symptoms. Improvement of symptoms had a positive correlation with Helicobacter pylori eradication (p=0,001). Conclusions: Helicobacter pylori prevalence among cases with globus sensation is similar to that in the general population. However, Helicobacter pylori eradication was found to decrease the symptoms of globus.
Does Helicobacter pylori treatment improve the symptoms of globus hystericus?
Kasap, E; Ayhan, S; Yüceyar, H
Background/aims: Globus hystericus is a feeling of tension in the throat, irrelevant of swallowing, persisting for at least 12 weeks. Since the cause of glob us hystericus is not fully described, the treatment is controversial. We aimed in this study to determine the symptoms of gastroesophageal reflux disease, upper gastrointestinal endoscopic findings, prevalence of Helicobacter pylori, and post-treatment symptoms (symptoms of gastroesophageal reflux and/or Helicobacter pylori) in patients with a diagnosis of globus hystericus. Materials and Methods: One hundred twenty three patients were recruited from the archives of the Department of Gastroenterology and Endoscopy at Celal Bayar University Medical School between January 2009 and August 2010. Results: Helicobacter pylori was positive in 75 (60%) of 123 patients with globus hystericus. Helicobacter pylori (+) patients had significantly more heartburn, regurgitation, and inlet patch in upper esophagus than Helicobacter pylori (-) patients. Significantly more Helicobacter pylori (-) patients had normal endoscopy findings when compared to Helicobacter pylori (+) patients. While 27 (50%) of Helicobacter pylori-eradicated patients had regressing globus symptoms, 12 (17.3%) of them did not have any regression in globus symptoms. Improvement in symptoms showed a positive correlation with Helicobacter pylori eradication (p=0.001). Conclusions: Helicobacter pylori rate among cases with glob us sensation was similar to values in the general population. Helicobacter pylori eradication was found to decrease glob us symptoms.

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