Browsing by Author "Kaya, E"
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Item Parental Acceptance/Rejection Perceptions and Attachment Styles of Men With Online Gambling DisorderKaya, E; Deveci, AOnline gambling disorder has recently emerged as a significant public health issue. Family dynamics play an important role in the development of online gambling disorder. In this research, the aimed to compare the parental acceptance/rejection and attachment styles of individuals with online gambling disorder with a healthy control group. Also, the relationship between parental acceptance/rejection and attachment styles was examined in individuals with online gambling disorder. The study group consisted of 53 male patients with online gambling disorder and 57 healthy controls. The individuals with online gambling disorder perceived more rejection from mothers but especially from fathers than the individuals in the control group. Paternal hostility/aggression and indifference/neglect are determinants of online gambling behavior. The individuals with online gambling disorder had lower levels of secure attachment and higher levels of dismissive and fearful attachment than the individuals in the control group. Both secure attachment style and dismissive attachment style are thought to be determinants of gambling behavior. Mother-father rejection and insecure attachment are important in terms of creating risk for online gambling. Assessment of the effects of maternal and especially paternal rejection in online gambling disorder will be beneficial within the scope of preventive mental health.Item Evaluation of silicosis in ceramic workersSakar, A; Kaya, E; Çelik, P; Gencer, N; Temel, O; Yaman, N; Sepit, L; Yildirim, ÇA; Dagyildizi, L; Coskun, E; Dinç, G; Yorgancioglu, A; Çimrin, AHThis study is aimed to evaluate the incidence of silicosis and the relation of it with personal and work-related factors among workers exposed to silica in ceramic factory. Workers were evaluated by respiratory symptoms, physical examination, pulmonary function and radiological findings. Occupational and Enviromental Pulmonary Disease Evaluation Questionnaire of the Turkish Thoracic Society Enviromental and Occupational Pulmonary Diseases Working Group was used. 365 of 626 workers had exposure to silica and the rest 261 were concerned as control group. There was no difference between mean age, duration of work and smoking pack year among the groups (p> 0.05). Cough and sputum rates were higher in silicosis group FEV1 and FVC values were lower in silica group but this was not statistically significant. When the two subgro-ups of silica group (the workers in high dust concentration and the ones in low concentration) were compared, the high concentrated group had significantly more sputum but the other symptoms and pulmonary functional parameters were not different significantly. 24 workers had parenchymal densities adjusted with pneumoconiosis. The workers with the pneumoconistic finding, had a higher mean age and longer duration of work. As a conclusion, ceramic industry has risk for silicosis. And the risk increase by time and age.Item Reliability and Validity of the Turkish Version of the Social Adaptation Self-Evaluation Scale (SASS)Akkaya, C; Sarandöl, A; Danaci, AE; Sivrioglu, EY; Kaya, E; Kirli, SObjective: SASS is a new self-evaluation scale that assesses the level of social functioning in depressed patients for clinical research purposes. The aim of this study was to investigate the validity and reliability of the Turkish version of SASS. Method: Data were obtained from 2 different sample groups that hod no physical disturbances that could impair social functioning; healthy participants between the ages of 18 and 65 years (n = 66) and patients (n = 227) diagnosed with major depressive disorder (MDD). Assessment tools used in the study were SASS, Hamilton Depression Rating Scale, 17-item version, and Global Assessment of Functioning Scale. Results: In the reliability analysis of both groups combined and the MDD group Cronbach's alpha values for the internal consistency of the scale were 0.90 and 0.87, respectively. Item-total score correlations were between 0.22 and 0.66 for both groups combined, and between 0.21 and 0.59 for the MDD group. The correlation coefficient of the scale's test-retest reliability was 0.770 (P < 0.0001) and the SASS value rose from 29.4 +/- 8.1 to 37.8 +/- 8.1 following treatment of depression (P < 0.0001). Four factors with Eigen values > 1 were obtained from the factor analysis. Factor 1, with an Eigen value of 7.169 explained 35.8% of the total variance and represented the entire scale alone. Conclusions: The Turkish version of SASS, as the original scale, demonstrated adequate validity and reliability for the measurement of loss of social functioning in MDD patients and demonstrated that scores changed in accordance with treatment for depression.Item Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, TurkeyDeveci, A; Taskin, O; Dinc, G; Yilmaz, H; Demet, MM; Erbay-Dundar, P; Kaya, E; Ozmen, EThere is not a wide agreement upon rate of conversion disorder within Turkish population. The aim of this study was to determine the prevalence of conversion disorder with pseudoneurological symptoms or deficits and related risk factors in a city. In total, 1,086 people, aged 15-65 years old, were selected from the city of Manisa, Turkey to take part in the study. We applied sociodemographic and health information questionnaires and the Composite International Diagnostic Interview (CIDI) Somatization Subscales to the samples. The likelihood that an individual might have conversion disorder with pseudoneurological symptoms or deficits was found to be 5.6% (n = 61). The prevalence of conversion disorder with pseudoneurological symptoms or deficits was significantly higher among women (p < 0.0001), 15-24 year old women (p = 0.011) and 25-34 year old women (p = 0.003), people who live as squatters (p = 0.03), those with a history of psychiatric disorder (p < 0.0001) and those having a mother with a psychiatric disorder (p = 0.04). This study has shown the conversion disorder with pseudoneurological symptoms or deficits is inadequately frequent in the population.Item Correlation of Alexithymia with Grief and Depression Symptom Severity in Persistent Complex Bereavement DisorderKaya, E; Aydemir, ÖThis study aimed to compare the depression and grief levels between patients with persistent complex bereavement disorder who have alexithymia and those who do not have alexithymia. This study also aimed to examine the correlations between these variables. A total of 80 patients with persistent complex bereavement disorders were included and divided into two groups: alexithymia (n = 45) and nonalexithymia (n = 35). Each patient was evaluated using the Toronto Alexithymia Scale, the Inventory of Complicated Grief and the Beck Depression Inventory. Individuals with alexithymia who have symptoms of complicated grief may experience more severe depression and grief than patients without alexithymia. Among individuals with alexithymia, the difficulty identifying feelings dimension may be a predictor of complicated grief, and the externally oriented thinking dimension appears to be significant in terms of masking depressive symptoms.Item The effects of residual affective symptoms on cognitive and social functioning in remitted bipolar patientsKaya, E; Aydemir, O; Selçuki, DObjective: In bipolar disorder, both cognitive and social functioning is impaired during remission. It is not well documented whether residual affective symptoms cause impairment in cognitive and social functions or cognitive impairment per se is the source of psychosocial dysfunction during remission. In this work, the effects of subsyndromal residual affective symptoms on cognitive and social functioning in remitted bipolar patients are studied. Materials and Methods: The study was carried out with 43 patients diagnosed as bipolar I disorder with a remission for at least 6 months. The mean age of the patients was 38.1 +/- 13.5 and 55.8% (n=24) were male. The mean duration of illness was 12.1 +/- 10.2 years and the mean number of previous episodes was 6.6 +/- 6.0. As healthy controls, 22 volunteers without any lifetime psychiatric and medical diagnosis or treatment were invited to the study. In the assessment Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS), Stroop Test, Auditory Verbal Learning Test (AVLT), increased latency positive-evoked potentials (P300), Global Assessment of Functioning Scale (GAF), and Social Functioning Scale (SFS) were used. In statistical analyses, linear regression analysis was performed. Results: HAM-D scores significantly affected cognitive functions such as P300 amplitude, immediate recall, verbal learning, delayed recall, recognition, retrieval, Stroop effect, and social functions such as social engagement, interpersonal behavior, prosocial activities, recreation, independence-performance and competency and employment. YMRS scores affected only verbal learning. Cognitive functions do not have any effect on mood symptoms or social functions. Discussion and Conclusion: Subsyndromal residual depressive symptoms seem to affect functioning in remitted bipolar patients. In order to improve the functioning of the bipolar patients, it will be helpful to implement strategies for these depressive symptoms. (Anatolian Journal of Psychiatry 2009; 10: 124-130)Item The effects of residual affective symptoms on cognitive and social functioning in remitted bipolar patientsKaya, E; Aydemir, O; Selcuki, DItem Residual symptoms in bipolar disorderKaya, E; Aydemir, Ö; Selcuki, DIn this study it is aimed to assess interepisode residual symptoms in remitted bipolar disorder patients with a hypothesis that the last episode recovered has implications on residual symptomatology. The study was carried out with 23 bipolar patients diagnosed as mania (BP-M) and 20 bipolar patients diagnosed as depression (BP-D) in their last episode, and with 22 healthy controls in a university hospital clinic. All patients were in remission for at least 6 months. In the assessment Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS), Stroop Test, Auditory Verbal Learning Test (AVLT), increased latency positive-evoked potentials (P300), Global Assessment of Functioning Scale (GAF), and Social Functioning Scale (SFS) were used cross-sectionally. In affective symptomatology, the BP-M group had higher YMRS scores, and the BP-D group had higher HAM-D scores compared to the controls. P300 test results revealed low amplitude in the 13P-D group. In the AVLT, verbal learning and delayed recall were significantly lower in the two bipolar groups. The Stroop tasks were not different in the groups. Concerning the SFS, social withdrawal was impaired in the two bipolar groups, whereas dependency-competency was impaired in the BP-M and employrnent/occupation was impaired in the BP-D group. As a conclusion, bipolar patients recovering from depressive episode may experience more impairment in daily functioning due to residual depressive symptoms and impairment of attention and memory. (c) 2007 Elsevier Inc. All rights reserved.Item The prevalence of asthma and allergic symptoms in Manisa, Turkey (A western city from a country bridging Asia and Europe)Sakar, A; Yorgancioglu, A; Dinc, G; Yuksel, H; Celik, P; Dagyildizi, L; Coskun, E; Kaya, E; Ozyurt, B; Ozcan, CThe aim of this study was to determine the prevalence of asthma and allergic symptoms in Manisa city center, Turkey, to evaluate the determinants effective on those values, and to review the prevalence rates reported from different parts of the country. Data were collected from 610 households and complete interviews were conducted with 1,336 adults over 18 years of age by using European Community Respiratory Health Survey-ECRHS questionnaire. The prevalences of current asthma, cumulative asthma and asthma-like symptoms were found in 1.2, 1.0 and 25.0%, respectively, of the 20-44 years age group and the prevalences of allergic rhinitis, allergic dermatitis and family atopy were found in 14.5, 10.9, and 15.2%, respectively, in all age group. Wheezing with breathlessness, wheezing without cold, woken up with shortness of breath and woken up with cold were reported by 9.1%, 6.9%, 6% and 16.1% of the study population, respectively. Gender, age, active or passive smoking, family atopy and home condition effect on prevalence of asthma and allergic symptoms. In this study prevalence of asthma correlated with the studies reporting low prevalence rates of Turkey.Item Evaluation of Thyroid Function Tests In Chronic Obstructive Pulmonary DiseaseKaya, E; Coskun, E; Celik, P; Sakar, A; Yorgancioglu, A; Özyurt, BAbnormal thyroid function test (TFT) levels were reported in chronic obstructive pulmonary disease (COPD) patients. We aimed to investigate the relationship between COPD and TFT in our study. Ninety three stable COPD patients and 17 healthy adults as a control group were evaluated. Physical examination, pulmonary function tests, and arterial blood gas analysis were performed in COPD patients. To evaluate the thyroid functions, fT3, fT4, TSH levels were measured. Mean age was 65,8 +/- 9,0 for the COPD group consisting of 9 (% 10) female and 84 (% 90) male, and 44,6 +/- 9,2 for the control group. When COPD and control groups were compared, TSH levels were found to be lower in the COPD group (p= 0.03). There is no relationship between age and TFT levels. In the COPD group, there was a negative correlation between fT4 and PEF (r=-0,21); and a positive correlation between sT4 and pH (r= 0,27). In conclusion, TFT levels are considered to be affected in COPD which is a systemic disorder, thyroid hormone levels decreased in severe COPD, and TFT levels low in all COPD patients, and correlations between TFT and some PFT levels are suggested.Item What Does the Subjective Assessment of Cognitive Functioning Measure in Bipolar Disorder? Correlation with the Objective Assessment of Cognitive FunctioningAydemir, Ö; Kaya, EObjective: Even in remission, cognitive deficits are frequently observed in bipolar disorder Because these deficits are assessed with complex and comprehensive tests, they seem to be neglected in routine daily practice, however assessing them with short self-rated questionnaires could be beneficial. This study aimed to investigate the correlation between objective and subjective cognitive assessment in bipolar disorder. Method: The study included 38 patients with bipolar disorder that were in remission for at least 6 months and 19 healthy controls. The Stroop Test and Auditory Verbal Learning Test were used for the objective assessment of cognitive functioning, and the cognitive functioning subscale of the Bipolar Disorder Functioning Questionnaire was used for the subjective assessment of cognitive functioning. Mood symptoms were assessed using the Hamilton Depression Rating Scale and Young Mania Rating Scale. Results: Based on objective assessment there were significant differences in all domains of the Auditory Verbal Learning Test between the bipolar patients and healthy controls, whereas there weren't any significant difference in Stroop Test results. Based on subjective assessment there were significant differences between the bipolar patients and healthy controls in terms of cognitive functioning subscale total score and first item score, but not in terms of the other items. When the correlation between the objective and subjective cognitive assessments was investigated, total score of the cognitive functioning subscale and 2 items-1. to run simple calculations in one's mind and 2. gathering and performing what one is asked to do-were moderately to weakly correlated with immediate recall, verbal learning, recognition, retrieval, and reading shape color No correlation was observed between the other items of the cognitive functioning subscale. Conclusion: Based on subjective assessment of cognitive functioning, the bipolar patients tended to over-estimate themselves. Furthermore, bipolar patients tended to report more deficits correlated with objective cognitive assessment when they had to display active performance, whereas they did not report cognitive deficits at this level when such a condition was not present.Item Prevalence of Asthma and Allergic Symptoms in ManisaSakar, A; Yorgancioglu, A; Dinç, G; Yüksel, H; Çelik, P; Dagyildizi, L; Coskun, E; Kaya, E; Özyurt, B; Özcan, CThe aim of this study was to determine the prevalence of asthma and allergic symptoms in Manisa city centre (Turkey), to evaluate the data obtained and to review the prevalences reported from different parts of our country. Data were collected from 610 home visits and complete interviews were conducted with 1336 adults over the age of 18. The questionnaire was consisted of sociodemographic questions and European Community Respiratory Health Survey (ECRHS) questionnaire. The prevalences of current asthma, cumulative asthma, asthma-like symptoms were found as 1.2, 1.0, and 25.0% respectively in 20-44 years age group and allergic rhinitis, allergic dermatitis, family atopy were found as 14.5, 10.9, and 15.2% respectively in the overall group. Wheezing with breathlessness, wheezing in the absence of upper respiratory tract infection, waking up with shortness of breath and waking up with cough were detected in 9.1, 6.9, 6, and 16.1% of the study population respectively. Gender, age, active or passive smoking, familial history of atopy and in-house conditions are the factors that effect the prevalence of asthma and allergic symptoms. In this study, the prevalence of asthma in Manisa was found to be consistent with the low prevalence rates reported from different parts of our country.Item Unusual foreign body aspirationÇelik, P; Kaya, E; Sakar, A; Yorgancioglu, ATracheobronchial foreign body aspiration in adults is rare when compared to children. In this case report, 76 years old female patient who aspirated a screw of tracheostomy canula which was taken out by fiberoptic bronchoscopy (FOB) was presented. This case showed us that education of patients about stoma care is important. The FOB can be used safely to get foreign body from distal airways.Item Lung Cancer and the Relationship Between Lung Cancer - Human MetapneumovirusKaya, E; Coskun, AS; Akçali, S; Çelik, P; Sanlidag, T; Yorgancioglu, AIt is aimed to investigate the prevelance of human metapneumovirus (hMPV) in bronchial lavage and blood samples of patients with lung cancer and the relationship between hMPV and lung cancer. Seventy patients with lung cancer and 30 healthy controls were included in the study. Bronchial lavage from patients with lung cancer and blood samples from patients with lung cancer and healthy controls were investigated for presence of hMPV with PCR. The mean age of 65 (93%) male and 5 (7%) female cases was 61.44 +/- 9.65 (44-81) in lung cancer patients. In control group the mean age of 20 (67%) male and 10 (33%) female cases was 51 (40-55). There were 54 (77%) nonsmall cell lung carcinoma (NCCLC) and 16 (23%) small cell lung carcinoma (SCLC). Nine (54%) patients with SCLC were staged as limited disease. Diagnosis of patients with NSCLC were 22 (41%) squamous cell carcinoma, 14 (26%) adenocarcinoma, 2 (4%) others. In 16 (29%) patients, histological type of the cancer was not identified. The number of patients with NSCLC was 2 (4%) in stage I, 1 (1%) in stage II, 2 (4%) in stage IIIA, 27 (50%) in stage IIIB, and 16 (30%) in stage IV. hMPV was not found in bronchial lavage and blood samples in patients with lung cancer and blood samples in controls with PCR method. Although it is estimated that the study population is at risk for hMPV presence because of old age, immune deficiency and smoking, no relationship between hMPV and lung cancer was observed. This may be a result of the small number of study population, absence of symptoms or methodological problems.Item The prevalence of suicide ideation and suicide attempts in Manisa city centreDeveci, A; Taskin, EO; Dündar, PE; Demet, MM; Kaya, E; Özmen, E; Dinç, GObjective: Suicide attempts are a major public health problem. This study aimed to investigate the lifetime prevalence of suicide ideation and suicide attempts in Manisa city centre. Risk factors related to suicide ideations and attempts were also studied. Method: This study was carried out in Manisa city centre. Using cluster and systematic samples, data were collected from 1086 persons 15-65 years old. Separate questions were asked about the lifetime occurrence of suicide ideation (Have you ever seriously thought about committing suicide?), and suicide attempts (Have you ever attempted suicide?). A form for suicide attempters was used to determine the characteristics of the attempts. Results: The lifetime prevalences of suicide ideation and suicide attempts were 6.6% (n=72) and 2.3% (n=25), respectively. Marital problems were the most common stressor in suicide attempts (44%, n=11). Approximately two thirds of the suicide attempters used a drug overdose for suicide. Of all the suicide attempters, 24% (n=6) had made previous attempts. The essential risk factors for suicide ideation were being female (p=0.012), smoking (p=0.001), consuming alcohol (p=0.028), having a previous psychiatric disorder (p < 0.0001), and a family history of psychiatric disorders (p=0.021). The essential risk factors for suicide attempts were smoking (p=0.005), having a previous psychiatric disorder (p < 0.0001), and a family history of psychiatric disorders (p=0.029). Conclusion: The results of the present study suggest that suicide attempts must be carefully evaluated in subjects with previous psychiatric disorders, previous suicide attempts and a family history of psychiatric disorders. It is necessary to know the clinical and demographic features related to suicide attempts.Item Brucella Pleurisy (Case report)Kaya, E; Yildirim, Ç; Akin, MBrucellosis is a chronic disease with systemic manifestations caused by the Brucella type bacteria. The disease is more frequently seen in populations consuming fresh milk products and working as farmers. Pulmonary system involvement reveals pleural effusion, hiliary lymphadenopathy and nodular pulmonary lesions. Pleural manifestation is relatively rare. In this article, we present in the light of current literature a case of a 24 year old male with pleural brucellosis and pleural effusion which was proven both serologicly and culture positivity.Item Demographic and clinical characteristics of inpatient stroke patients in TurkeyKülcü, DG; Kuran, B; Karahan, AY; Özgirgin, N; Basaran, S; Yaliman, A; Savas, S; Tikiz, C; Aktas, I; Bardak, A; Tuncer, T; Yilmaz, F; Erhan, B; Sirzai, H; Çelik, B; Durlanik, G; Dogu, B; Öncü, J; Hüner, B; Öztürk, G; Eskiyurt, N; Akpinar, FM; Özkan, FU; Paker, N; Bugdayci, DS; Gündüz, B; Satir, Ö; Atalay, NS; Yildiz, N; Altindag, Ö; Demir, SE; Kaya, E; Uçar, D; Sari, A; Karatas, GK; Taskiran, ÖÖObjectives: This study aims to assess the stroke rehabilitation facilities provided by university hospitals (UHs) and training and research hospitals (TRHs) and to evaluate the geographical disparities in stroke rehabilitation. Patients and methods: Between April 2013 and April 2014 a total of 1,529 stroke patients (817 males, 712 females; mean age: 61.7 +/- 14.0 years; range, 12 to 91 years) who were admitted to the physical medicine and rehabilitation clinics in 20 tertiary care centers were retrospectively analyzed. Demographic, regional and clinical characteristics, details of rehabilitation period, functional status, and complications were collected. Results: The median duration of stroke was five (range, 1 to 360) months. The ratio of the patients treated in the TRH in the Marmara region was 77%, but only 25% of the patients were living in the Marmara region. Duration of hospitalization was longer in the TRHs with a median of 28 days compared to those of UHs (median: 22 days) (p<0.0001). More than half of the patients (55%) were rehabilitated in the Marmara region. Time after stroke was the highest in the Southeast region with a median of 12 (range, 1 to 230) months and the lowest in the Aegean region with a median of four (range, 1 to 84) months. Conclusion: This study provides an insight into the situation of stroke rehabilitation settings and characteristics of stroke patients in Turkey. A standard method of patient evaluation and a registry system may provide data about the efficacy of stroke rehabilitation and may help to focus on the problems that hinder a better outcome.Item Efficacy and safety of ruxolitinib in patients with myelofibrosis: a retrospective and multicenter experience in TurkeySoyer, N; Ali, R; Turgut, M; Haznedaroglu, IC; Yilmaz, F; Aydogdu, I; Pir, A; Karakus, V; Özgür, G; Kis, C; Ceran, F; Ilhan, G; Özkan, M; Aslaner, M; Ince, I; Yavasoglu, I; Gediz, F; Sönmez, M; Güvenç, B; Özet, G; Kaya, E; Vural, F; Sahin, F; Töbü, M; Durusoy, R; Saydam, GBackground/aim: The aim of this study is to assess the efficacy and safety of ruxolitinib in patients with myelofibrosis. Materials and methods: From 15 centers, 176 patients (53.4% male, 46.6% female) were retrospectively evaluated. Results: The median age at ruxolitinib initiation was 62 (28-87) and 100 (56.8%) of all were diagnosed as PMF. Constitutional symptoms were observed in 84.7%. The median initiation dose of ruxolitinib was 30 mg (10-40). Dose change was made in 69 (39.2%) patients. Forty seven (35.6%) and 20 (15.2%) of 132 patients had hematological and nonhematological adverse events, respectively. The mean spleen sizes before and after ruxolitinib treatment were 219.67 +/- 46.79 mm versus 199.49 +/- 40.95 mm, respectively (p < 0.001). There was no correlation between baseline features and subsequent spleen response. Overall survival at 1-year was 89.5% and the median follow up was 10 (1-55) months. We could not show any relationship between survival and reduction in spleen size (p = 0.73). Conclusion: We found ruxolitinib to be safe, well tolerated, and effective in real-life clinical practice in Turkey. Ruxolitinib dose titration can provide better responses in terms of not only clinical benefit but also for long term of ruxolitinib treatment.Item Primary central nervous system lymphoma in daily practice and the role of autologous stem cell transplantation in relapsed disease: A retrospective multicenter studyErkurt, MA; Berber, I; Tekgunduz, E; Dogu, MH; Korkmaz, S; Demir, C; Yilmaz, M; Akay, OM; Pala, C; Bilen, Y; Kaya, E; Sari, I; Sencan, M; Kuku, I; Altuntas, F; Dal, MS; Aydogdu, IWe investigated the course of 54 patients presenting with primary central nervous system lymphoma, who were treated in daily practice. The patients were treated with chemotherapy and/or radiotherapy and/or intrathecal chemotherapy. At a median follow-up period of 23 months (range 1-71), median relapse-free survival (RFS) and overall survival (OS) were not reached. Estimated 2-year RFS and OS rates were 42% and 48%, respectively. Ten relapsed PCNSL patients underwent ASCT. Complete remission rate of these patients was 40%, with 20% treatment-related mortality. Estimated 2-year RFS and OS rates were 37% and 40%, respectively. The prognosis of patients with PCNSL, who received off-study treatment, is still dismal. (c) 2016 Elsevier Ltd. All rights reserved.Item Genetic diversity of Lilium candidum natural populations in Türkiye evaluated with ISSR and M13-tailed SSR markersTokgöz, HB; Çetin, Ö; Kaya, HB; Akkale, C; Yildirim, H; Pirhan, AF; Kaya, E; Altan, FThe Liliaceae family includes the perennial, herbaceous, monocotyledonous plant Lilium candidum (L. candidum). The cosmetics, fragrance, and pharmaceutical industries regularly use L. candidum. It has been widely used in traditional medicine for wound healing, and its anti-inflammatory, antidiabetic, antimicrobial, and anticancer effects have been demonstrated in various studies. Natural populations of L. candidum are significantly affected by biotic and abiotic factors such as anthropological pressure, diseases, pathogen attacks, fossil fuel pollution, and climate change. Overcollection and destruction of its habitat put L. candidum into the endangered category. Therefore, it is of great importance to preserve this plant's genetic diversity, which plays a crucial role in adapting to different conditions, preserving evolutionary potential, and breeding studies. Molecular markers are essential in breeding and evolution studies to conserve genetic resources. Because of its economic and medical importance, various DNA markers have been used to evaluate the genetic diversity of L. candidum accessions. In this study, the genetic diversity of L. candidum, which is native to Turkiye, was determined with ISSR and SSR molecular markers among accessions collected from seven different cities and 76 accessions (Mugla, Izmir, Aydin, Antalya, Balikesir, Denizli, and Manisa). Genetic distances and phylogenetic analysis were carried out using the software TASSEL 5.2.63. The assessment of genetic diversity was visualized through a UPGMA dendrogram. The resulting phylogenetic tree revealed two distinct groups. The closest and farthest accessions were determined according to the genetic distance matrix. It was determined that the highest genetic distance value was between 19 (Balikesir, Kepsut) and 76 (Mugla, Ula) accessions (0.5390946) and the lowest genetic distance value was between 53 (Mugla, Marmaris) and 54 (Mugla, Marmaris) accessions (0.1069968).