Browsing by Author "Kaya, T"
Now showing 1 - 20 of 21
Results Per Page
Sort Options
Item Imported Cutaneous Leishmaniasis Cases Detected in Truck Drivers in HatayÇulha, G; Çigdem Dogramaci, AC; Kaya, T; Çavus, I; Gülkan, B; Özbilgin, ALeishmaniasis, seen in tropical and subtropical regions, is an infectious disease caused by the protozoan parasite Leishmania species. There are three main forms of leishmaniasis: cutaneous, mucocutaneous and visceral leishmaniasis. Cutaneous leishmaniasis (CL) has become an increasing problem as the number of travels around the world increases and people go to work in endemic areas. Turkey has received great numbers of immigrants in recent years, from its neighboring countries like Iraq, Islamic Republic of Iran, Afghanistan, Turkmenistan and the Syrian Arab Republic because of the political instabilities in these countries as well as the job opportunities caused by large-scale development projects undertaken by Turkey. In this report, imported CL cases detected in five truck drivers transporting from Hatay to Turkmenistan, Syria, Saudi Arabia, Iran and Georgia, Uzbekistan and Azarbaijan countries were presented. The patients admitted to Mustafa Kemal University, Faculty of Medicine Dermatology Policlinic, with wound complaints on their bodies were directed to the Department of Parasitology to obtain smear samples from their wounds. The age range of the patients were 38 to 43 years. Patients with wound trail for a period ranging from one month to one year had a number of lesions varying between 2-7 and in all cases, a smear preparation was prepared from the lesions for diagnostic purposes. Clinical material obtained from five patients with pre-diagnosis of CL was firstly examined with Giemsa stain. Samples taken from the patients were inoculated into modified NNN (Novy-MacNeal-Nicolle) medium for the evaluation of the presence of the promastigotes. Promastigotes obtained from the inoculated medium were also genotyped using the ITS1 region. In all of the slides prepared from the clinical material taken from the patients amastigotes were determined. The growth of promastigotes were observed in only three of the clinical specimen inoculated media. The genotyped three species were Leishmania tropica, Leishmania infantum/donovani and Leishmania major. In this study, the importance of support for the diagnosis of different microbiological methods used in the diagnosis of leishmaniasis infection which occurred during the outbreaks of the disease has been put forward. In addition, it was aimed to draw attention to the importance of imported CL cases in our country diagnosed in five truck drivers making transportation from Hatay to Turkmenistan, Syria, Saudi Arabia, Iran, Georgia, Uzbekistan and Azerbaijan.Item Investigation of impact behavior of reinforced concrete beam to column connection strengthened with carbon fiber-reinforced polymer stripsKaya, T; Aras, M; Yilmaz, T; Çaliskan, Ö; Anil, Ö; Erdem, RTReinforced concrete (RC) members may expose to impulsive dynamic loads due to the reasons such as the explosions occurring in the interior or exterior part of them, rockfall, the vehicle crash to the bridges, the collision of masses with the effects of floods and landslide. Many studies have investigated the effects of impulsive dynamic loads on the beam, column, and slab RC structural elements have been investigated in the literature. However, the authors have not encountered any study focused on the impact behavior of beam to column connections of the frames constructing the bearing system of reinforced concrete structures. Therefore, an experimental study has been planned to investigate RC beam impact behavior to column connections strengthened with carbon fiber-reinforced polymer (CFRP) strips. The concrete compressive strength, shear reinforcement spacing, CFRP strip spacing, and input impact energy applied to test specimens were taken as experimental variables. The time histories of impact load acting on test specimens, accelerations, displacements, and the strains measured from CFRP strips have been recorded in experiments. The experimental variables' effect on dynamic responses of RC beam to column connections strengthened with CFRP strips subjected to impact load has been interpreted in detail. The study's scope and improved numerical analysis procedure have also been introduced to verify experimental results. Good agreement between numerical and experimental results demonstrated that the presented numerical procedures could be safely used for evaluation of impact behavior of RC beam to column connections strengthened with CFRP strips.Item The Toxicity of Essential Oils From Three Origanum Species Against Head Louse, Pediculus humanus capitisArserim, SK; Cetin, H; Yildirim, A; Limoncu, ME; Cinbilgel, I; Kaya, T; Ozbel, Y; Balcioglu, ICPurpose Pediculosis caused by human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae) is a public health problem with a high prevalence, especially among children in school age. Different chemical pediculicides (insecticides) are used against lice but the repeated application of these pediculicides for the treatment of P. humanus capitis infestation in the past decades has resulted in the development of resistance. The plant essential oils have been used as alternative sources of lice treatment agents. Pediculicidal activity of the essential oils of three Origanum species (O. onites, O. majorana and O. minutiflorum) against P. humanus capitis adults was examined in this study. Methods Essential oils from aerial parts of three Origanum species were obtained by hydrodistillation using a Clevenger-type apparatus. P. humanus capitis specimens used were obtained from infested children by combing method at primary schools. Adult lice were exposed to three dilutions (1%, 0.5% and 0.1% w/v) of tested oils for 5 min using the adult immersion test. Results According to the results, all Origanum essential oils at 1% concentration have been shown to significantly decrease the rate of limb, bowel and abdomen movements, producing more than 90% mortality after 12 h. Conclusion Our results indicated that Origanum essential oils can be used for the development of new pediculicides against head louse.Item Experimental investigation of impact behaviour of shear deficient RC beam to column connectionAras, M; Yilmaz, T; Çaliskan, Ö; Anil, Ö; Erdem, RT; Kaya, TReinforced concrete (RC) structures may be subjected to sudden dynamic impact loads such as explosions occurring for different reasons, the collision of masses driven by rockfall, flood, landslide, and avalanche effect structural members, the crash of vehicles to the highway and seaway structures. Many analytical, numerical, and experimental studies focused on the behavior of RC structural elements such as columns, beams, and slabs under sudden dynamic impact loads. However, there is no comprehensive study on the behavior of the RC column-beam connections under the effect of sudden dynamic impact loads. For this purpose, an experimental study was performed to investigate the behavior of RC column-beam connections under the effect of low-velocity impact loads. Sixteen RC beam-column connections with a scale of 1/3 were manufactured and tested under impact load using the drop-weight test setup. The concrete compressive strength, shear reinforcement spacing in the beam, and input impact energy applied to test specimens were taken as experimental variables. The time histories of impact load acting on test specimens, accelerations, and displacements measured from the test specimens were recorded in experiments. Besides, shear and bending crack widths were measured. The effect of experimental variables on the impact behavior of RC beam-column connections has been determined and interpreted in detail. Besides, a finite element model has been established for verification and comparison of the experimental results by using ABAQUS software. It has been demonstrated that concrete strength, shear reinforcement ratio, and impact energy significantly affect the impact behavior of RC column-beam connections.Item An Observational Study from the Perspective of Rheumatology in the Management of Patients with Psoriatic Arthritis in Turkey - LOOP StudyDalkilic, E; Solmaz, D; Kucuksahin, O; Capkin, E; Derin, ME; Arslan, D; Noyan, F; Coskun, NB; Murat, S; Sendur, OF; Melikoglu, MA; Gursoy, S; Kaya, T; Sahin, A; Karkucak, M; Pirildar, T; Terzioglu, ME; Bes, C; Akar, SItem Assessment of the Relationship Between Vitamin D Level and Non-specific Musculoskeletal System Pain: A Multicenter Retrospective Study (Stroke Study Group)Karahan, AY; Hüner, B; Kuran, B; Sezer, N; Çelik, C; Salbas, E; Ordahan, B; Karaca, G; Yilmaz, H; Gündüz, B; Erhan, B; Bugdayci, DS; Bardak, A; Paker, N; Külcü, DG; Yaliman, A; Atalay, NS; Yildiz, N; Icagasioglu, A; Basaran, S; Tikiz, C; Kaydok, E; Kaya, T; Karatas, GK; Baygutalp, F; Celebi, G; Yilmaz, F; Önes, K; Akkus, S; Yumusakhuylu, Y; Durlanik, G; Dogu, B; Öncü, J; Sari, A; Özkan, FÜ; Kaysin, MY; Taskiran, ÖÖ; Erol, AM; Eskiyurt, NObjective: In this study, it was aimed to evaluate the relationship between vitamin D level and pain severity, localization and duration in patients with non-specific musculoskeletal pain. Materials and Methods: Patients who applied to physical medicine and rehabilitation outpatient clinics due to non-specific muscle pain in 19 centers in Turkey were retrospectively screened. Three thousand four hundred fourpatients were included in the study, whose pain level was determined by visual analog scale (VAS) and the painful region, duration of pain and vitamin D level were reached. D group was found to be D deficient (group 1) when 25 (OH) D level was 20 ng/mL or less and group D 2 (vitamin D deficiency) was higher than 30 ng/mL (group 3). The groups were compared in terms of pain duration, localization and severity. In addition, the correlations of pain localization, severity and duration with vitamin D levels were examined. Results: D vitamin deficiency was detected in 2202 (70.9%) of 3 thousand four hundred and four registered patients, and it was found that vitamin D deficiency in 516 (16.6%) and normal vitamin D in 386 (12.4%). The groups were similar in terms of age, body mass index, income level, duration of complaint, education level, family type and working status (p>0.05). There was no statistically significant difference between groups in terms of VAS, pain localization and duration scores (p>0.05). Conclusion: Our study shows that vitamin D deficiency in patients with nonspecific musculoskeletal pain is not associated with the severity and duration of pain.Item Assessment of the Relationship Between Vitamin D Level and Non-specific Musculoskeletal System Pain: A Multicenter Retrospective Study (Stroke Study Group) (vol 23, pg 61, 2017)Karahan, AY; Hüner, B; Kuran, B; Sezer, N; Çelik, C; Salbas, E; Ordahan, B; Karaca, G; Yilmaz, H; Gündüz, B; Erhan, B; Bugdayci, DS; Bardak, A; Paker, N; Külcü, DG; Yaliman, A; Atalay, NS; Yildiz, N; Içagasioglu, A; Basaran, S; Tikiz, C; Kaydok, E; Kaya, T; Karatas, GK; Baygutalp, F; Çelebi, G; Yilmaz, F; Önes, K; Akkus, S; Yumusakhuylu, Y; Durlanik, G; Dogu, B; Öncü, J; Sari, A; Özkan, FU; Kaysin, MY; Taskiran, OO; Erol, AM; Eskiyurt, NItem Management of Rheumatoid Arthritis: Consensus Recommendations From the Turkish League Against RheumatismAtaman, S; Borman, P; Evcik, D; Aydog, E; Ayhan, F; Yildizlar, D; Bodur, H; Altay, Z; Birtane, M; Bütün, B; Duruöz, T; Erdem, HR; Gunendi, Z; Günaydin, R; Gürer, G; Kaçar, C; Kaptanoglu, E; Kaya, T; Ölmez, N; Paker, N; Rezvani, A; Tur, BS; Yener, M; Özgöçmen, SObjectives: Taking new developments in the management of rheumatoid arthritis (RA) and the economic conditions of our country into account, the Turkish League Against Rheumatism (TLAR) aimed to develop national treatment recommendations for the management of RA; thus, they consulted with national experts for their opinions. Materials and methods: Eight rheumatologists and 15 physiatrists experienced in the field contributed to the development of the TLAR recommendations for the management of RA. The expert committee planned to develope Recommendations for the Management of RA in Turkey based on EULAR 2010 recommendations for the management of RA with synthetic and biological disease-modifying antirheumatic drugs (DMARDs) in light of expert opinions. Following the meeting, a systematic literature review was performed by searching the Medline and Cochrane, Embase, and Turkish Medical Index databases between 2009 and 2010 for pharmacological treatment recommendations and between 2007 and 2010 for non-pharmacological treatment recommendations. This was done in addition to the studies included in the EULAR 2010 recommendations. All articles were examined, their contents were summarized, their levels of evidence were determined, and the Delphi process was initiated. Results: Sixteen general recommendations were listed along with five main principles and one non-pharmacological treatment method. A consensus was reached for all recommendations, and their strength levels were voted upon. Conclusion: Recommendations were formed for the management of RA in Turkey. These national recommendations are intended to guide physical medicine and rehabilitation specialists (physiatrists), rheumatologists, and family physicians and should be regularly updated.Item THE FREQUENCY AND ASSOCIATION OF KNEE, HIP, HAND AND SPINE OSTEOARTHRITIS IN TURKISH POPULATION: A PRELIMINARY RE PORT OF MULTICENTER LONGITUDINAL STUDYTuncer, T; Ugur, S; Nur, H; Kacar, C; Akarimak, U; Altan, L; Ayhan, F; Bal, A; Basaran, S; Bilgilisoy, M; Bozbas, G; Cerrahoglu, L; Cevik, R; Coskun, N; Dagli, Z; Durmaz, B; Duruoz, T; Dulgeroglu, D; Gurer, G; Gursoy, S; Hepguler, S; Hizmetli, S; Kaplanoglu, E; Kaya, T; Kocabas, H; Kuran, B; Melikoglu, M; Nas, K; Oncu, J; Ozcakir, S; Ozdolap, S; Saridogan, M; Sarikaya, S; Sindel, D; Sahin, O; Sendur, OF; Tikiz, C; Ugurlu, H; Yilmaz, FItem 2017 update of the Turkish League Against Rheumatism (TLAR) evidence-based recommendations for the management of knee osteoarthritisTuncer, T; Cay, FH; Altan, L; Gurer, G; Kacar, C; Ozcakir, S; Atik, S; Ayhan, F; Durmaz, B; Eskiyurt, N; Genc, H; GokceKutsal, Y; Gunaydin, R; Hepguler, S; Hizmetli, S; Kaya, T; Kurtais, Y; Saridogan, M; Sindel, D; Sutbeyaz, S; Sendur, OF; Ugurlu, H; Unlu, ZIn a Turkish League Against Rheumatism (TLAR) project, evidence-based recommendations for the management of knee osteoarthritis (OA) was developed for the first time in our country in 2012 (TLAR-2012). In accordance with developing medical knowledge and scientific evidence, recommendations were updated. The committee was composed of 22 physical medicine and rehabilitation specialists (4 have rheumatology subspeciality also) and an orthopaedic surgeon. Systematic literature search were applied on Pubmed, Embase, Cochrane and Turkish Medical Index for the dates between January the 1st 2012 and January the 29th of 2015. The articles were assessed for quality and classified according to hierarchy for the level of evidence, and the selected ones sent to committee members electronically. They were asked to develop new recommendations. In the meeting in 2015, the format of the recommendations was decided to be patient-based and considering the grade and the severity of the disease. By the discussion of the each item under the light of new evidences, the final recommendations were developed. Each item was voted electronically on a 10-cm visual analogue scale (VAS) and the strength of recommendation (SoR) was calculated. In the light of evidences, totally 11 titles of recommendations were developed; the first 7 were applicable to each patient in every stages of the disease, remaining were for defined specific clinical situations. The mean SoR value of the recommendations was between 7.44 and 9.93. TLAR-2012 recommendations were updated in a new format. We think that, present recommendations will be beneficial for the physicians who manage, as well as the patients who suffer from the disease.Item THE RADIOLOGICAL, CLINICAL AND FUNCTIONAL PROPERTIES OF HAND OSTEOARTHRITIS AND THEIR RELATION WITH RADIOLOGICAL FINDINGS IN A TURKISH POPULATION: TLAR-OA STUDYDuruöz, MT; Erdem, D; Tuncer, T; Altan, L; Ayhan, F; Bal, A; Cerrahoglu, L; Capkin, E; Cevik, R; Dulgeroglu, D; Gursoy, S; Hizmetli, S; Kacar, C; Kaptanoglu, E; Kaya, T; Kocabas, H; Nas, K; Ozcakir, S; Sindel, D; Sahin, O; Bozbas, GT; Tikiz, C; Ugurlu, HItem Pandemic of the century: COVID-19 in inflammatory rheumatic diseases of a national cohort with 3,532 patientsYurdakul, F; Bodur, H; Çengiz, AK; Durmaz, Y; Duruöz, MT; Kaya, T; Ketenci, S; Cüzdan, N; Güler, T; Günendi, Z; Sarikaya, S; Çapkin, E; Önder, ME; Melikoglu, MA; Gñzel, R; Sen, N; Ayna, AB; Akgül,Ö; Eser, E; Ataman, SObjectives: This study aimed to assess the clinical outcomes and risk factors for severe coronavirus disease 2019 (COVID-19) in patients with inflammatory rheumatic disease (IRD) of a national cohort. Patients and methods: The multicenter cross-sectional study was carried out between July 15, 2020, and February 28, 2021. Data collection was provided from a national network database system, and 3,532 IRD patients (2,359 males, 1,173 females; mean age: 48.7 +/- 13.9 years; range; 18 to 90 years) were analyzed. Demographics, clinics about rheumatic disease, comorbidities, smoking status, being infected with COVID-19, and the course of the infection were questioned by rheumatology specialists. Results: One hundred seventeen patients were infected with COVID-19, the hospitalization rate due to COVID-19 was 58.9%, and the mortality rate was 1.7%. There was no difference between the COVID-19 positive and negative groups in terms of rheumatic disease activities and receiving drugs. It was observed that patients with COVID-19 had worse compliance with isolation rules, and bacillus Calmette-Guerin (BCG) vaccination was less common. The mean age and the rate of smoking of hospitalized COVID-19 patients were higher than those without hospitalization. Conclusion: In this cohort, in which real-life data were analyzed, COVID-19 rates in IRD patients were similar to the general population for the same period. Compliance with the isolation rules and BCG vaccination attracted attention as components that reduce the risk of COVID-19 infection. The risk factors for hospitalization were older age and smoking.Item Management of Psoriatic Arthritis: Turkish League Against Rheumatism (TLAR) Expert OpinionsNas, K; Kiliç, E; Çevik, R; Bodur, H; Ataman, S; Ayhan, F; Akgül, Ö; Akinci, A; Altay, Z; Çapkin, E; Dagli, AZ; Duruöz, T; Gürer, G; Gögüs, F; Garip, Y; Kaçar, C; Kamanli, A; Kaptanoglu, E; Kaya, T; Kocabas, H; Özdemirel, EA; Özel, S; Sezer, I; Sunar, I; Yilmaz, GObjectives: This study aims to establish the first national treatment recommendations by the Turkish League Against Rheumatism (TLAR) for psoriatic arthritis (PsA) based on the current evidence. Materials and methods: A systematic literature review was performed regarding the management of PsA. The TLAR expert committee consisted of 13 rheumatologists and 12 physical medicine and rehabilitation specialists experienced in the treatment and care of patients with PsA from 22 centers. The TLAR recommendations were built on those of European League Against Rheumatism (EULAR) 2015. Levels of evidence and agreement were determined. Results: Recommendations included five overarching principles and 13 recommendations covering therapies for PsA, particularly focusing on musculoskeletal involvement. Level of agreement was greater than eight for each item. Conclusion: This is the first paper that summarizes the recommendations of TLAR as regards the treatment of PsA. We believe that this paper provides Turkish physicians dealing with PsA patients a practical guide in their routine clinical practice.Item Turkish League Against Rheumatism National Recommendations for the Management of Ankylosing SpondylitisBodur, H; Sivas, F; Yilmaz, Ö; Özgöçmen, S; Günaydin, R; Kaya, T; Ataman, S; Altan, L; Altay, Z; Aydog, E; Birtane, M; Borman, P; Bugdayci, DS; Bütün, B; Çakirbay, H; Duruöz, T; Gürer, G; Hepgüler, S; Kamanli, A; Kuru, Ö; Küçükdeveci, A; Nacir, B; Ölmez, N; Rezvani, A; Yanik, BÇObjectives: To develop Turkish League Against Rheumatism (TLAR) National Recommendations for the management of ankylosing spondylitis (AS). Materials and methods: A scientific committee of 25 experts consisting of six rheumatologists and 19 physical medicine and rehabilitation specialists was formed by TLAR. Recommendations were based on the 2006 ASsessment in Ankylosing Spondylitis International Working Group(ASAS)/European League Against Rheumatism (EULAR) recommendations and a systematic review of associated publications between January 2005 and September 2010. A Delphi process was used to develop the recommendations. Twelve major recommendations were constructed for the management of AS. Voting using a numerical rating scale assessed the strength of each recommendation. Results: The 12 recommendations include patient assessment, patient follow-up along with pharmacological and non-pharmacological methods. Some minor additions and changes have been made to the ASAS/EULAR recommendations. All of the recommendations had sufficient strength. Conclusion: National recommendations for the management of AS were developed based on scientific evidence and consensus expert opinion. These recommendations will be updated regularly in accordance with recent developments.Item Evidence-Based Recommendations for the Management of Knee Osteoarthritis: A Consensus Report of the Turkish League Against RheumatismTuncer, T; Çay, HF; Kaçar, C; Altan, L; Atik, OS; Aydin, AT; Ayhan, FF; Yanik, BÇ; Durmaz, B; Eskiyurt, N; Genç, H; Kutsal, YG; Günaydin, R; Hepgüler, S; Hizmetli, S; Kaya, T; Kurtais, Y; Ölmez, N; Saridogan, M; Sindel, D; Tur, BS; Sütbeyaz, S; Sendur, ÖF; Ugurlu, H; Ünlü, ZObjectives: Knee osteoarthritis (OA) is a common disease which causes pain, disability and great socioeconomic burden as a result. Turkish League Against Rheumatism (TLAR) initiated a project to prepare national, evidence-based recommendations for the management of knee osteoarthritis supported by expert-opinion in order to assist the physicians who are interested in knee OA in their daily clinical practice. Materials and methods: The expert committee was composed of 25 academicians, 23 of whom were physical medicine and rehabilitation (PM&R) specialists (three also had rheumatology subspeciality) and two were orthopedic surgeons. At the first meeting, the previous guidelines were discussed, and 2008 Osteoarthritis Research Society International (OARSI) recommendations were decided to be taken as the fundamental template for national recommendations. Databases of the Pubmed, Embase, Cochrane, and Turkish Medical Index were used to search the literature, and this was carried out for the period between 2009-2010 for international publications since studies up to 2009 were present in the 2010 OARSI update. No limit was applied for searching of national publications. The selected relevant publications were graded according to evidence level and quality, and were sent to the members who were then asked to suggest propositions according to their experiences, knowledge, and review of the literature. After amalgamation and editing of new proposals, Delphi rounds were started. After five Delphi rounds, the propositions on which the members were in consensus, were discussed with regard to evidence and the strength of recommendation was determined by measuring on visual analog scale (VAS) for each proposal at the final meeting. Results: Nineteen propositions (one for general principles, nine for non-pharmacologic treatments, seven for pharmacologic treatments, and two for surgical treatments) were accepted as the TLAR Evidence-Based Recommendations for the Management of Knee OA in consensus as a result of Delphi rounds. Conclusion: Evidence-based recommendations for the management of knee OA were developed by TLAR for the first time in our country. The recommendations should be updated regularly according to new evidence and insights. It is expected that physicians who are interested in knee OA will benefit greatly from this report in their daily clinical practice.Item Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary ReportKaptanoglu, E; Sahin, O; Tuncer, T; Hizmetli, S; Altan, L; Ayhan, F; Bal, A; Bilgilisoy, M; Bozbas, G; Cerrahoglu, L; Cevik, R; Duruoz, T; Dulgeroglu, D; Gurer, G; Gursoy, S; Hepguler, S; Kacar, C; Kaya, T; Melikoglu, M; Nas, K; Ozcakir, S; Ozdolap, S; Saridogan, M; Sarikaya, S; Sindel, D; Sendur, OF; Tikiz, C; Ugurlu, HItem The clinical, functional, and radiological features of hand osteoarthritis: TLAR-osteoarthritis multi-center cohort studyDuruöz, MT; Gürsoy, DE; Tuncer, T; Altan, L; Ayhan, F; Bal, A; Bilgilisoy, M; Cerrahoglu, L; Çapkin, E; Çay, HF; Çevik, R; Durmaz, B; Dülgeroglu, D; Gürer, G; Gürsoy, S; Hepgüler, S; Hizmetli, S; Kaçar, C; Kaptanoglu, E; Kaya, T; Ecesoy, H; Melikoglu, MA; Nas, K; Nur, H; Özçakir, S; Saridogan, M; Sarikaya, S; Sezer, I; Sindel, D; Sahin, N; Sahin, Ö; Sendur, ÖF; Bozbas, GT; Tikiz, C; Ugurlu, HObjectives: This study aims to evaluate the clinical, functional, and radiological features of hand osteoarthritis (OA) and to examine their relationships in different geographic samples of the Turkish population. Patients and methods: Between April 2017 and January 2019, a total of 520 patients (49 males, 471 females; mean age: 63.6 +/- 9.8 years) with hand OA were included in the study from 26 centers across Turkiye by the Turkish League Against Rheumatism (TLAR). The demographic characteristics, grip strengths with Jamar dynamometer, duration of hand pain (month), the severity of hand pain (Visual Analog Scale [ VAS]), and morning stiffness were evaluated. The functional disability was evaluated with Duruoz Hand Index (DHI). The Kellgren-Lawrence (KL) OA scoring system was used to assess the radiological stage of hand OA. Results: The DHI had significant correlations with VAS- pain (r= 0.367, p<0.001), duration of pain (r=0.143, p=0.001) and bilateral handgrip strengths (r=-0.228, p=0.001; r=-0.303, p<0.001). Although DHI scores were similar between the groups in terms of the presence of hand deformity (p= 0.125) or Heberden's nodes (p=0.640), the mean DHI scores were significantly higher in patients with Bouchard's nodes (p=0.015). The total number of nodes had no significant correlations with the VAS-pain and DHI score (p>0.05). The differences between the groups of radiological hand OA grades in terms of age (p= 0.007), VAS-pain (p<0.001), duration of pain (p<0.001), and DHI (p<0.001) were significant. There were no significant differences between radiological hand OA grades according to the duration of the stiffness, grip strength, and BMI (p>0.05 for all). Conclusion: In our population, the patients with hand OA had pain, functional disability, and weak grip strength. The functional impairment was significantly correlated with the severity of the pain, and the functional status was worse in high radiological hand OA grades.Item Turkish League Against Rheumatism (TLAR) Recommendations for the Pharmacological management of Rheumatoid Arthritis: 2018 Update Under Guidance of Current RecommendationsAtaman, S; Sunar, I; Yilmaz, G; Bodur, H; Nas, K; Ayhan, FF; Akgül, Ö; Akinci, A; Altay, Z; Birtani, M; Soy Bugdayci, D; Çapkin, E; Çevik, R; Garip Çimen, Y; Duruöz, MT; Elhan, AH; Gürer, G; Kaçar, C; Kamanli, A; Kaptanoglu, E; Kaya, T; Kocabas, H; Kuru, Ö; Alkan Melikoglu, M; Özel, S; Rezvani, A; Sezer, I; Gül Yurdakul, FObjectives: This study aims to report the assessment of the Turkish League Against Rheumatism (TLAR) expert panel on the compliance and adaptation of the European League Against Rheumatism (EULAR) 2016 recommendations for the management of rheumatoid arthritis (RA) in Turkey. Patients and methods: The EULAR 2016 recommendations for the treatment of RA were voted by 27 specialists experienced in this field with regard to participation rate for each recommendation and significance of items. Afterwards, each recommendation was brought forward for discussion and any alteration gaining >= 70% approval was accepted. Also, Turkish version of each item was rearranged. Last version of the recommendations was then revoted to determine the level of agreement. Levels of agreement of the two voting rounds were compared with Wilcoxon signed-rank test. In case of significant difference, the item with higher level of agreement was accepted. In case of no difference, the changed item was selected. Results: Four overarching principles and 12 recommendations were assessed among which three overarching principles and one recommendation were changed. The changed overarching principles emphasized the importance of physical medicine and rehabilitation specialists as well as rheumatologists for the care of RA patients in Turkey. An alteration was made in the eighth recommendation on treatment of active RA patients with unfavorable prognostic indicators after failure of three conventional disease modifying anti-rheumatic drugs. Remaining principles were accepted as the same although some alterations were suggested but could not find adequate support to reach significance. Conclusion: Expert opinion of the TLAR for the treatment of RA was composed for practices in Turkish rheumatology and/or physical medicine and rehabilitation clinics.Item Turkish League Against Rheumatism Consensus Report: Recommendations For Management of Axial SpondyloarthritisBodur, H; Yurdakul, FG; Ataman, S; Garip, Y; Nas, K; Ayhan, FF; Akgül, Ö; Akinci, A; Altay, Z; Birtane, M; Soy Bugdayci, D; Çapkin, E; Çevik, R; Duruöz, T; Gürer, G; Kaçar, C; Kamanli, A; Kaptanoglu, E; Kaya, T; Kocabas, H; Kuru, Ö; Melikoglu, MA; Özdemirel, E; Özel, S; Rezvani, A; Sezer, I; Sunar, I; Yilmaz, GObjectives: This study aims to update 2011 Turkish League Against Rheumatism SpondyloArthritis Recommendations, and to compose a national expert opinion on management of axial spondyloarthritis under guidance of current guidelines, and implantation and dissemination of these international guidelines into our clinical practice. Materials and methods: A scientific committee of 28 experts consisting of 14 rheumatologists and 14 physical medicine and rehabilitation specialists (one of them also has an immunology PhD) was formed. The recommendations, systematic reviews, and meta-analyses including pharmacologic and non-pharmacologic treatment were scrutinized paying special attention with convenient key words. The draft of Turkish League Against Rheumatism opinion whose roof consisted of international treatment recommendations, particularly the Assessment of SpondyloArthritis International Society/European League Against Rheumatism recommendations was composed. Assessment of level of agreement with opinions by task force members was established through the Delphi technique. Voting using a numerical rating scale assessed the strength of each recommendation. Results: Panel compromised on five basic principles and 13 recommendations including pharmacological and nonpharmacological methods. All of the recommendations had adequate strength. Conclusion: Turkish League Against Rheumatism expert opinion for the management of axial spondyloArthritis was developed based on scientific evidence. These recommendations will be updated regularly in accordance with current developments.Item Correlations among enthesitis, clinical, radiographic and quality of life parameters in patients with ankylosing spondylitisRezvani, A; Bodur, H; Ataman, S; Kaya, T; Bugdayci, DS; Demir, SE; Koçyigit, H; Altan, L; Ugurlu, H; Kirnap, M; Gür, A; Kozanoglu, E; Akinci, A; Tekeoglu, I; Sahin, G; Bal, A; Sivrioglu, K; Yazgan, P; Aydin, G; Hepgüler, S; Ölmez, N; Sendur, ÖF; Yener, M; Altay, Z; Ayhan, F; Durmus, O; Duruöz, MT; Günendi, Z; Nacir, B; Öken, Ö; Toktas, H; Delialioglu, SÜ; Evcik, D; Sertpoyraz, FMObjectives. To investigate the relationship between enthesitis and disease activity, functional status, fatigue, joint mobility, radiological damage, laboratory parameter and quality of life in patients with ankylosing spondylitis (AS). Methods. A total of 421 patients with AS (323 male and 98 female) who were included in the Turkish League Against Rheumatism Registry were enrolled in the study. The Bath AS Disease Activity Index (BASDAI), fatigue, the Bath AS Functional Index (BASFI), the Bath AS Metrology Index (BASMI), the Maastricht AS Enthesitis Score (MASES), AS quality of life (ASQoL), the Bath AS Radiology Index (BASRI) and erythrocyte sedimentation rate (ESR) were evaluated. Results. Enthesitis was detected in 27.3% of patients. There were positive correlations between MASES and BASDAI, BASFI and fatigue (p < 0.05). MASES was not correlated with BASRI, BASMI, ASQoL and ESR. The mean MASES score was 1.1 +/- 2.4. The most frequent regions of enthesopathies were right iliac crest, spinous process of L5 and proximal to the insertion of left achilles tendon, respectively. Conclusions. Enthesitis was found to be associated with higher disease activity, higher fatigue, worse functional status and lower disease duration. As enthesitis was correlated with BASDAI, we conclude that enthesitis can reflect the disease activity in patients with AS.