Browsing by Author "Kayikçioglu, ÖR"

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    Unintentional Staining of the Anterior Vitreous With Trypan Blue During Cataract Surgery
    Kayikçioglu, ÖR; Mayali, H; Dogruya, S; Alp, S; Yilmazlar, AA; Kurt, E
    During phacoemulsification and intraocular lens (IOL) implantation surgery, the trypan blue dye used to stain the anterior capsule passed into vitreous cavity and stained the anterior capsule and anterior vitreous in 6 patients. There was history of trauma in 2 patients, uveitis in 1 patient, mature cataract in 1 patient, and no risk factors in the other patients. IOL was implanted in-the-bag without problem in 5 patients. In the patient with iris and zonular defects due to trauma, a sutured IOL was implanted in the same session. The migration of trypan blue into the vitreous cavity through damaged or intact lens zonules is a rare but important complication that makes subsequent surgical steps substantially more difficult.
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    Comparison of Icare Pro Tonometry and Icare one Tonometry Measurements in Healthy Eyes
    Mayali, H; Sarigül, Ç; Kurt, E; Kayikçioglu, ÖR; Ilker, SS
    Objectives: To compare intraocular pressure (IOP) measurements obtained with the Icare Pro tonometer used in clinical practice and the Icare One self-tonometer. Materials and Methods: Fifty-two eyes of 52 healthy, right-handed individuals with no prior intraocular surgery or ocular trauma, structural ocular pathology, or systemic disease were evaluated. IOP was first measured using the Icare Pro tonometer. The participants were then told how to use the Icare One tonometer and asked to measure their own IOP The results were analyzed statistically using SPSS v.24. Results: Of the 52 healthy participants, 16 (30.7%) were male and 36 (69.3%) were female. Their mean age was 31.6 +/- 6.3 (23-47) years. Mean IOP measured with the Icare Pro was 17.10 +/- 6.2 (11.5-25.2) mmHg, and the mean self-measured IOP with Icare One was 14.01 +/- 3.4 (7-24) mmHg. When the two methods were compared using Levene's t-test, there was a significant mean difference of -3.08 +/- 0.6 (95% confidence interval: -4.39 -1.78; p<0.001). Conclusion: In this study, there was a significant difference between the IOP measurements we made using the Icare Pro and the participants' self-measured IOP using the Icare One, with the latter being relatively lower. This may be related to the fact that the participants were unfamiliar with using the Icare One. Although the Icare One is a promising tool for glaucoma patients to self-monitor their IOP, further studies are needed.
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    Expression of Nitric Oxide Synthase in Primary and Recurrent Pterygium
    Emre, S; Vatansever, SH; Türköz, E; Kayikçioglu, ÖR
    Purpose: The aim of this study was to investigate the expression of different nitric oxide synthases (NOSs) in primary and recurrent pterygia and to investigate the probable role of any nitric oxide synthase on pterygium recurrence. Materials and Method: Specimens of 40 primary pterygia and 10 recurrent pterygia excised during pterygium surgery were included in the study. Also, 15 normal conjunctiva of medial limbus obtained from patients free of pterygia and removed during other ophthalmologic surgeries formed the control group. Specimens were stained with hematoxylin and eosin for general histological and morphologic evaluation. The distribution of n-NOS, e-NOS and i-NOS were analyzed using indirect immunoperoxidase staining. Results: Histological evaluation of specimens revealed that the epithelium in primary and recurrent pterygia groups was thicker compared to that in the control group. Immunohistochemical analysis revealed that in both primary pterygium and control groups, immunoreactivity was positive for all NOSs in both epithelium and connective tissue. For recurrent pterygium group, NOS immunoreactivity could be detected moderately for n-NOS in the epithelium and weakly for e-NOS in both epithelium and connective tissue. However, in recurrent pterygium samples, i-NOS immunoreactivity was lacking in both epithelium and connective tissue. Discussion: These data are the first to demonstrate that NOS expression may differ between primary and recurrent pterygia. Meanwhile, continuous expression of n-NOS with suppression of i-NOS and e-NOS may be an important step in the recurrence process of pterygia.
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    Evaluation of the Effect of Body Position on Intraocular Pressure Measured with Rebound Tonometer
    Mayali, H; Tekin, B; Kayikçioglu, ÖR; Kurt, E; Ilker, SS
    Objectives: It is important to determine variables that influence intraocular pressure (IOP) measurement. This study aimed to evaluate the effect of body position on IOP. Materials and Methods: The study included 52 right eyes of 52 patients who presented to the ophthalmology department of our hospital and had no ocular disease except refractive errors. IOP was measured with an Icare PRO tonometer while patients were in sitting, standing, and supine positions, with intervals of 10 minutes between the positions. Correlations between the results were evaluated using Spearman's correlation analysis and Wilcoxon tests. Results: Thirty-six of the 52 patients were female, 16 were male. Mean age was 31.65 +/- 6.30 (23-47) years. Mean IOP values in the sitting, standing, and lying positions were 17.76 +/- 3.41 (12.70-25.60) mmHg, 17.10 +/- 3.27 (11.50-25.20) mmHg, and 18.46 +/- 4.67 (10.50-29.40) mmHg, respectively. There were no statistically significant differences between measurements taken in the different positions (p=0.112, p=0.472, p=0.071). We observed that there was no relationship between age and body position (p>0.45, p>0.79, p>0.77) or between gender and position (p>0.59, p>0.69, p>0.54). Conclusion: Gender and age had no effect on IOP measured in different body positions. There were also no significant differences between IOP values measured in the different positions. Therefore, we believe the portable Icare PRO tonometer can be used for patients who are confined to bed and will provide IOP measurements that are concordant with values obtained while sitting.
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    Effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma
    Erkin, EF; Tarhan, S; Kayikçioglu, ÖR; Deveci, H; Güler, C; Göktan, C
    PURPOSE. To evaluate the effects of betaxolol and latanoprost on ocular blood flow and visual fields in patients with primary open-angle glaucoma (POAG) by means of an observer-masked, prospective clinical study. METHODS. Thirty-two patients with newly diagnosed POAG were included in the study. The patients were randomized into two groups. The first group was treated with betaxolol 0.50% twice daily and the second group with latanoprost 0.005% once daily. Baseline and posttreatment examinations on the first and third months of treatment included intraocularpressure (IOP) measurement, automated visual field testing, and ocular blood flow assessment. For evaluation of visual fields, mean defect and pattern standard deviation indices were used. Ocular blood flow was assessed by means of color Doppler imaging of the central retinal artery (CRA) and the temporal short posterior ciliary artery (PCA). For each vessel, peak systolic (PSV) and end-diastolic (EDV) blood flow velocities were measured and resistivity index (RI) calculated. RESULTS. After exclusion of one noncompliant patient, the study was completed with 31 eyes of 31 patients. Both drugs significantly reduced IOP (p<0.05). The mean IOP lowering effect of latanoprost was significantly higher than that of betaxolol (p=0.03). Visual field indices exhibited no significant changes in either group (p>0.05). There were no significant changes in PSV or EDV measurements of CRA or PCA in either group (p>0.05). RI decreased in both CRA and PCA with both drugs. The mean changes between baseline and 3 month blood flow measurements were not significantly different between betaxolol and latanoprost (p>0.05). CONCLUSIONS. Over a treatment period of 3 months, both betaxolol and latanoprost tended to improve ocular blood flow without one of them being superior to the other The results suggest that the direct (non IOP-dependent)influence on ocular circulation is better for betaxolol than for latanoprost. In addition, neither drug caused significant generalized improvements in visual fields during this period.
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    Comparison of Induced Astigmatism After Trabeculectomy and Deep Sclerectomy+Trabeculectomy Surgeries with Vector Analysis
    Kayikçioglu, ÖR; Emre, S; Mayali, H; Baser, EF
    Purpose: The aim of this study is to compare the changes in surgically induced astigmatism with time among two different glaucoma surgery techniques that have been used in cases of progressive glaucomatous optic nerve damage. Material and Method: The study group was composed of eyes which have been operated on with classical trabeculectomy (group 1) or deep sclerectomy+trabeculectomy (group 2). Each group consisted of 13 eyes of 12 patients. All eyes were examined preoperatively and postoperatively at 1. week, 1., 3. and 6. month. At these examinations, except intraocular pressure (IOP), corneal power was recorded with keratometer and corneal topographer. The magnitude of absolute astigmatism, and induced astigmatism were determined by vector analysis at each visit and were statistically compared between the study groups. Results: The mean (+/-SD) age of the patients was 56.2+/-24.0 and 52.5+/-24.3 in group 1 and 2, respectively. Preoperatively, IOP were 30.77+/-10.30 and 27.54+/-11.28 mmHg, and at 6 month of surgery decreased to 12.38+/-4.13 and 12.08+/-5.73 mmHg in groups 1 and 2, respectively. At all postoperative visits, a significant decrease in IOP was observed compared to the preoperative measurements (p< 0.05). Postoperatively at 1. week of surgery, the mean induced astigmatism values were 1.50+/-2.16 and 2.60+/-2.65D in group 1, and 1.66+/-1.32 and 2.01+/-1.95D in group 2, with keratometer and corneal topographer, respectively. The difference between the groups was not significant (p>0.05). At following visits, surgically induced astigmatism decreased in both groups with both methods and the difference never reached significant levels with time. Discussion: Glaucoma surgeries, particularly in the early period, are likely to be the reason for the changes in the corneal power. It seems that the addition of deep sclerectomy to trabeculectomy does not cause any significant change in surgically induced astigmatism.
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    Short-term results of surgical treatment in large idiopathic macular hole cases
    Dogruya, S; Karabacak, DD; Altinisik, M; Delibay, Y; Kayikcioglu, OC; Kayikçioglu, ÖR
    Purpose To evaluate results of the surgical treatment for large stage (Stage 3 and 4) idiopathic macular hole cases with and without ILM flap technique. Methods Sixty eyes of 60 patients diagnosed with idiopathic macular hole (MH) were included in the study. Complete ophthalmologic examination and SD-OCT examination were performed in all eyes. MH stages, MH base diameter, height and closest distance were measured quantitatively. Postoperative and 3 months visits were evaluated. Results The mean age of the cases was 65.0 +/- 8.0 (range 30-84) years, there were 31 (51.7%) female and 29 (48.3%) male patients with a mean follow-up period of 18.1 +/- 16.7 (range 3-63) months. The mean best corrected visual acuity recorded at preoperative and third month control visits were 0.89 +/- 0.40(preoperative) logMAR, 0.82 +/- 0.60(3 month) logMAR (p < 0.05). The mean MH index was 0.48 +/- 0.16, the closest hole distance was 517.86 +/- 210.89 m and mean basal diameter of holes was 947.78 +/- 361.90 mu m and the average height was 448.93 +/- 79.80 microns. There was no statistically significant difference between anatomic results of macular hole surgery with (n = 22) and without (n = 38) flap in terms of hole closure (86.4% vs. 92.1% p > 0.05). In 90% (54 cases) of the cases, closure was observed after the first surgery. Two eyes that failed macular hole surgery were reoperated. In one of these eyes, anatomical success was obtained with macular hole massage and mechanical cytumulation. However, anatomical success could not be achieved in the other eye. Conclus & imath;on In the treatment of large macular holes, pars plana vitrectomy, internal limiting membrane peeling with/without flap and gas tamponade demonstrated high anatomical and functional success.
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    33 Questions about Triglycerides and Cardiovascular Effects: Expert Answers
    Çetinkalp, S; Koylan, N; Özer, N; Onat, A; Özgen, AG; Koldas, ZL; Güven, GS; Özdogan, Ö; Karsidag, K; Yigit, Z; Kayikçioglu, M; Tokgözoglu, L; Can, LH; Tartan, Z; Kültürsay, H; Karpuz, B; Kirilmaz, B; Ersanli, M; Ural, D; Erbakan, AN; Oguz, A; Kayikçioglu, ÖR; Temizhan, A; Sansoy, V; Ceyhan, C; Öngen, Z; Bayram, F; Örem, C; Sönmez, A; Beyaz, S; Ükinç, K; Yürekli, BS; Çoker, M; Canda, E; Simsir, IY