Browsing by Author "Kazandi M."

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    Evaluation of VEGF in placental bed biopsies from preeclamptic women by immunohistochemistry
    (2007) Cirpan T.; Akercan F.; Terek M.C.; Kazandi M.; Ozcakir H.T.; Giray G.; Sagol S.
    Objective: The aim of the study was to determine VEGF protein with immunohistochemical staining in placental bed biopsies of preeclamptic pregnancies in comparison to normal controls. Design: Prospective cohort study. Methods: The placental bed biopsies were obtained from 12 patients with preeclapmsia and ten patients for a control group at the time of cesarean delivery. Tissue samples of the placental bed were examined for VEGF protein distribution with avidin-biotin-peroxidase immunohistochemistry. Two blinded histopathologists were asked to score each sample for the intensity of staining and the number of cells stained in a randomly selected HPF of each sample. The resulting "H-score" was computed as a product of intensity and percent of cells stained. Results: VEGF expression was significantly lower in both the myometrium and stroma of the preeclamptic group compared to the control group (77.2 ± 25.4 vs 134 ± 44.3, p = 0.007; 194.1 ± 20.7 vs 170.2 ± 17, p = 0.017, respectively). Conclusion: VEGF expression is significantly lower in placental bed biopsies of preeclamptic pregnancies.