Browsing by Author "Keles G."

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    Clinical aspects and risk factors of nosocomial Stenotrophomonas maltophilia bacteremia episodes in a Turkish intensive care unit
    (E.S.I.F.T. srl, 2007) Tunger O.; Vural S.; Cetin C.B.; Keles G.; Borand H.; Gazi H.
    Stenotrophomonas maltophilia is an important nosocomial pathogen with increasing frequency in recent years, especially in immunocompromised and clinically debilitated patients. The aim of this study is to describe the characteristics of 35 episodes of S. maltophilia bacteremia at Celal Bayar University hospital in Turkey over a 3-year period from January 2003 to December 2005. Cases were identified with microbiology laboratory records and clinical data were collected from the medical record of each patient. The source of bacteremia was central venous catheter (CVC) in 65.7% (23) and respiratory tract infection in 2.9% (1) of episodes while the source of bacteremia was unknown in 11 (31.4%) episodes of bacteremia. Factors significantly associated with mortality were age of ≥65 years, APACHE score of ≥16, the presence of the total parenteral nutrition, anemia, low creatinine clearance level and shock. The most sensitive antibiotic was found as trimethoprim-sulfamethoxazole (91.4%) in antibiotic susceptibility testing of the isolates. Susceptibilities of piperacillin-tazobactam and netilmicin which frequently used antibiotics as an empirical therapy were 62.8% and 68.6%, respectively. © E.S.I.F.T. srl.
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    Primary echinococcal cyst in the axillary region
    (Journal of Infection in Developing Countries, 2011) Ozsoy M.; Keles C.; Kahya M.; Keles G.
    Introduction: Human hydatid disease is a parasitic infection caused by the larval form of Echinococcus granulosus. It has worldwide distribution and is endemic in many countries, especially the Mediterranean region. It most commonly affects the liver and lungs although multi-organ involvement has been observed in 20-30% of patients. Case report: A 45-year-old woman presented to a gynaecologist because of a mass in the axillary region. Her mother and her two sisters were undergoing treatment for breast cancer. In her examination, a hard, semi-mobile, painless mass was found that was approximately 3 cm in diameter. Axillary ultrasonography showed lymphadenopathy. No abnormality was found in mammographic examination of either breast, or in abdominal ultrasonography and chest X-ray. Occult breast cancer was suspected but when the mass was excised for pathological examination the biopsy showed a hydatid cyst with germinative membranes. Subsequent lung, abdomen and brain tomography scans, whole body bone scintigraphy and hydatid serology, including indirect haemagglutination and enzyme-linked immunosorbent assay, were negative. For these reasons an isolated axillary hydatid cyst was diagnosed. Conclusion: Parasitic cysts should be considered in endemic areas in patients presenting with a soft tissue mass in the axillary region. Imaging methods should be planned to include this possibility. © 2011 Ozsoy et al.
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    Nanostructured Metal Oxide-Based Electrochemical Biosensors in Medical Diagnosis
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Keles G.; Sifa Ataman E.; Taskin S.B.; Polatoglu İ.; Kurbanoglu S.
    Nanostructured metal oxides (NMOs) provide electrical properties such as high surface-to-volume ratio, reaction activity, and good adsorption strength. Furthermore, they serve as a conductive substrate for the immobilization of biomolecules, exhibiting notable biological activity. Capitalizing on these characteristics, they find utility in the development of various electrochemical biosensing devices, elevating the sensitivity and selectivity of such diagnostic platforms. In this review, different types of NMOs, including zinc oxide (ZnO), titanium dioxide (TiO2), iron (II, III) oxide (Fe3O4), nickel oxide (NiO), and copper oxide (CuO); their synthesis methods; and how they can be integrated into biosensors used for medical diagnosis are examined. It also includes a detailed table for the last 10 years covering the morphologies, analysis techniques, analytes, and analytical performances of electrochemical biosensors developed for medical diagnosis. © 2024 by the authors.