Browsing by Author "Kirteke, K"

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    The effect of maternal vitamin D levels on placental shear wave elastography findings in the first trimester
    Artunc-Ulkumen, B; Kirteke, K; Koyuncu, FM
    The aim of this study was to investigate the effect of maternal serum Vitamin D levels on the elasticity of placenta. Seventy-four spontaneously conceived singleton pregnancies in their first trimester were enrolled into this study. Fifty-one of them had Vitamin D deficiency (<20 ng/mL), while 23 pregnancies had Vitamin D levels >= 20 ng/mL. The placental elasticity was measured by the transabdominal Point Shear Wave Elastography (pSWE) method. In each case, the mean of 10 consecutive measurements was accepted as the mean placental elasticity value. The mean pSWE values did not significantly differ between the Vitamin D deficient group and the control group (p > .05). Placental elasticity was not found to be different in the pregnancies with Vitamin D deficiency during the first trimester.IMPACT STATEMENT What is already known on this subject?The pSWE technique provides opportunity to determine the elasticity of any interested tissue. Placental elasticity has been found to be changed in inflammatory and fibrotic conditions such as in preeclampsia, intrauterine growth restriction or diabetes. On the other hand, Vitamin D deficiency is linked with several comorbidities such as autoimmune disorders, cancer and cardiovascular disorders. Vitamin D also plays a role in placental angiogenesis in the first trimester. Maternal Vitamin D levels are shown to be related with adverse pregnancy outcomes. What do the results of this study add?To the best of our knowledge, this study is the first assessing the association between Vitamin D levels and placental elasticity. Placental elasticity was not found to be changed by Vitamin D deficiency. What are the implications of these findings for clinical practice and/or further research?Our pilot study revealed that Vitamin D deficiency does not have any impact on placental elasticity in the first trimester. However, longitudinal studies concerning placental elasticity in subsequent trimesters are needed to support our findings.
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    Comparison of serum neuropeptide-FF and catestatin levels in hypertensive pregnant women
    Günsel, H; Oruç, S; Taneli, F; Sizer, M; Kirteke, K; Sunar, N; Okuyan, E; Yoldas, A
    Aim: We aimed to compare the levels of Neuropeptide-FF and Catestatin in the sera of hypertensive and normotensive pregnant women, to determine the possible changes in hypertensive diseases of pregnancy and to examine the possible place of pregnancy in hypertensive diseases. Material and Methods: We used the quantitative analysis method to test the hypotheses of the research and examine the relationship between variables. Neuropeptide FF and Catestatin levels were analyzed by Enzyme Linked Immunoassay (ELISA) method. Neuropeptide-FF and Catestatin values of patient and control groups were analyzed with Mann -Whitney and Chi-square tests. Results: A higher Catestatin value was determined in the patient group compared to the control group, and this difference was statistically significant(p = 0.000). Catestatin value in the patient group was 31.61 +/- 12.54, and value in the control group was 48.46 +/- 22.45 and the relation was statistically found significant (p <0.05). The neuropeptide-FF was not statistically significant in the patient and control group compared to the control group (p = 0.916). Therefore, the Neuropeptide-FF value in the patient group was 134.30 +/- 93.72; this value was found as 139.49 +/- 96.41 in the control group, but the relation statistically was not found significant (p> 0.05). According to the analysis results of our study, a statistically significant difference was found for Catestatin at the 5% significance level between the patient group and the control group. Discussion: Decreased NPFF expression in the hypothalamus of hypertensive patients may lead to impaired interaction with other neurochemical systems and therefore may play a role in the pathogenesis of hypertensive disease.