Browsing by Author "Kisabay, AKA"

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    Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol
    Kisabay, AKA; Durmaz, GS; Ataç, C; Duksal, T; Gökçay, F; Çelebisoy, N
    Background: To assess gait and balance in patients with essential tremor (ET), which is the most common tremor disorder characterized by bilateral action tremor of the hands with possible involvement of further tremor locations and to test the efficacy of atenolol on tremor and gait and balance. Methods: In this prospective study, gait and balance were evaluated by static posturography in addition to International Cooperative Ataxia Rating Scale (ICARS) in 22 ET patients without any additional neurologic signs on examination. Tremor severity was assessed by The Essential Tremor Rating Assessment Scale (TETRAS). The efficacy of atenolol 100 mg/day both on tremor and gait and balance was investigated. Posturographic recordings were performed in gender, age-, and height-matched healthy volunteers who constituted the control group. Results: The mean center of gravity sway velocity of the ET patients recorded on firm and foam surfaces with eyes open and closed was not significantly different from the healthy controls but sway velocity on tandem stance was significantly increased (P = 0.032). Gait speed (P = 0.015) was decreased and step width was increased (P = 0.001). An improvement in TETRAS scores was recorded with atenolol treatment (P = 0.046). An improvement not reaching statistical significance was present in ICARS scores (P = 0.059). However, posturographic parameters did not change significantly (P > 0.05). Conclusion: Increased sway velocity on tandem stance, decreased gait speed and increased step width are consistent with midline cerebellar dysfunction in ET patients with no obvious gait and balance deficits on clinical examination. Atenolol seems to be effective on tremor but does not cause a significant improvement in gait and balance deficits.
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    Investigation of Sleep Breathing Disorders in Young Patients (Under 55 years) with Mild Stroke
    Kisabay, AKA; Saritas, AS; Batum, M; Göktalay, T; Horasan, GD; Selcuki, D; Yilmaz, H
    Introduction: Many patients with stroke also have sleep breathing disorders (SBD), most of which is obstructive sleep apnea (OSA). Methods: Sixty patients with a history of stroke aged under 55 years were included in our study. The demographic characteristics (age at stroke, sex, body mass index) of the patients and etiology of stroke was evaluated according to the Trial of Org 10712 in Acute Stroke (TOAST) classification. The National Institute of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS) were used to evaluate functionality. All patients underwent polysomnography (PSG) investigations. Findings: Based on PSG investigations, seven patients were normal, 10 had primary snoring, and 14 had mild, 11 had moderate, and 18 had severe OSA. The demographic characteristics did not differ significantly between the groups. No significant correlation was found between disease severity and NIHSS, MRS or TOAST classifications. Large artery atherosclerosis in the etiology, facial paralysis and dysarthria in the neurological examination, and brain stem involvement in the stroke location were observed to accumulate in the severe OSA group. When the anterior system, posterior system, and association of both were compared for vessel location, no significant difference was found regarding circulatory systems. Conclusions: It is considered that SBD has also a role in the etiology of stroke in patients aged under 55 years, and it should be taken into consideration as much as other risk factors. This is the first study to emphasize the importance of this topic in the literature.
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    Evaluation of predictive factors of idiopathic intracranial hypertension in different clinics
    Karakas, B; Saritas, AS; Kisabay, AKA
    Purpose: Idiopathic Intracranial Hypertension (IIH) is marked by elevated intracranial pressure without an identifiable cause. This study aimed to compare predictive factors between two IIH groups: those experiencing remission (single attack) and those developing migrainous headaches, in order to identify factors influencing the disease's progression. Methods: This retrospective study was conducted after obtaining ethics committee approval. It involved 118 patients diagnosed with IIH who were followed up in the Neuro-ophthalmology outpatient clinic between 2011 and 2023. Data on demographics, clinical history, comorbidities, habits, neurologic and neuro-ophthalmologic findings, cranial imaging features, lumbar puncture opening pressure, and current medical treatments were collected to assess the clinical course and predictive factors. The analyzed parameters were compared between two subgroups: one experiencing remission (single attack) and the other developing migrainous headaches. Statistically significant parameters were subjected to univariate and multivariate analysis. Results: Of the 118 patients, 87 (73.7 %) were in the single-attack group, while 31 (26.3 %) were in the migrainous headache group. Key predictive factors identified between the groups were the presence of allodynia (p < 0.001), neck and back pain (p = 0.042), BMI > 27.8 kg/m(2) (p = 0.002), and a history of migraine (p < 0.001). Conclusions: Allodynia, neck and back pain, a history of migraine, and a BMI > 27.8 kg/m(2) were found to be predictive factors for the development of migrainous headaches in IIH patients. This is the first study in the literature to compare these two patient groups and identify the factors that contribute to the development of migrainous headaches.
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    Coincidental occurance of episodic ataxia and multiple sclerosis: a case report and review of the literature
    Batum, M; Kisabay, AKA; Çetin, G; Celebi, HBG; Çam, S; Mavioglu, H
    Introduction Episodic ataxia is a clinical condition characterized by episodes of balance and coordination problems that last minutes to hours. It can be inherited or sporadic, and it can be seen sporadically in epilepsy, basilar migraine, multiple sclerosis, vertebrobasilar ischaemia, and labyrinth diseases. Methods In this article, we present a case of a patient who had a coincidental occurrence of episodic ataxia type 2 (EA2) and multiple sclerosis (MS) Results: The patient who had a previously unidentified heterozygous mutation in the calcium voltage-gated channel subunit alpha 1 A gene (CACNA1A). Conclusion There is no publication in the literature reporting the co-occurrence of MS and EA2. This combination may be coincidental in this patient, or it may be a relationship that has not yet been scientifically revealed.