Browsing by Author "Kocabas, T"

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    Adaptation and Reliability of the Structured Clinical Interview for DSM-5-Disorders - Clinician Version (SCID-5/CV) to the Turkish an Language
    Elbir, M; Alp Topbas, Ö; Bayad, S; Kocabas, T; Zulkif Topak, O; Çetin, S; ÖzdeL, O; Atesçi, F; Aydemir, Ö
    Objective: In this study, we aimed to adapt the Structured Clinical Interview for DSM-5-ClinicianVersion into Turkish and to demonstrate its reliability. Method: A total of 185 patients, both inpatient and outpatient, from two different university hospitals were included. Training sessions on the features and use of SCID-5/CV were held before the data collection. During the study, in order to test the diagnostic agreement and accuracy, two psychiatrists remained present at the evaluation of each participant; alternatively being interviewer and the observer. Cohen's kappa coefficient for inter-rater reliability was calculated for every diagnostic category. Results: The patient group had a mean age of 37.2 (+/- 13.5) years and 55.7% were female. The education status was as follows: 2.7% were illiterate, 1.7% literate with no primary education, 33% had primary education, 23.8% had secondary education and 38.9% had higher education. The calculated kappa value showed excellent agreement for schizophrenia (kappa=0.93), bipolar disorder (kappa=0.96), major depressive disorder (kappa=0.89), dysthymic disorder (kappa=0.82), alcohol use disorder (kappa=0.96), panic disorder (kappa=0.84), agoraphobia (kappa=0.85), social anxiety disorder (kappa=0.95), generalized anxiety disorder (kappa=0.89), obsessive compulsive disorder (kappa=0.87), posttraumatic stress disorder (kappa=0.89), adult attention deficit and hyperactivity disorder (kappa=1.00), specific phobias (kappa=0.82) and very good agreement with adjustment disorder (kappa=0.78) and somatic symptom disorder (kappa=0.65). Conclusion: Similar to the past SCID versions, kappa values were found to be quite high and all were statistically significant. The Turkish version of SCID-5/CV can be reliably used in both clinical practice and clinical studies.
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    Validity and Reliability of the Premorbid Adjustment Scale in a Sample of Turkish Schizophrenic Patients
    Altunsoy, N; Kocabas, T; Bayad, S; Elbir, M; Aydemir,Ö
    Objective: The Premorbid Adjustment Scale (PAS) has gained a reputation as the foremost retrospective assessment tool, although little is known about its reliability and validity. The aim of the study is to examine the psychometric properties of the PAS in a sample of Turkish schizophrenic patients. Methods: The research was carried out with 80 patients with schizophrenia and 50 healthy people. The sociodemographic form and PAS were applied to both groups. In addition, the Disability Assessment Schedule (DAS)-II and Positive and Negative Syndrome Scale were applied to the patients. In the statistical evaluation, the internal consistency coefficient, explanatory factor analysis, and correlation with other scales were calculated. Results: The average age of the schizophrenia group was 39.15 +/- 12.19 and 45.9 +/- 12.18 for control. The average years of education (9.91 +/- 3.79 for the schizophrenia group and 11.08 +/- 4.73 for control) and gender distribution (55% of the schizophrenia group and 46% of the control group were female) were similar. The internal consistency of the PAS was 0.93, and the subscales were between 0.75 and 0.92. Two-factor solution was observed, explaining 72.97% of the total variance. In regard to convergent validity, the correlation coefficients between the total scores of DAS II and PAS and PAS late and early adolescence and childhood were 0.45, 0.53, 0.48, 0.37, and 0.22, respectively (P < .001). The correlation coefficients between the total score of PAS and the total score of DAS 1, DAS 3, DAS 4, DAS 5, and DAS 6 were calculated as 0.46, 0.43, 0.39, 0.48, and 0.44 (P < .001), respectively. The PAS significantly differentiated the schizophrenia group from the control group. Conclusion: The PAS is reliable and valid for Turkish.
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    Adaptation and the Psychometric Properties of Turkish version of the Structured Clinical Interview for the DSM-5-Personality Disorders - Clinician Version (SCID-5-PD/CV)
    Bayad, S; Alp-Topba, Ö; Kocabas, T; Elbir, M; Gökten-Ulusoy, D; Korkmaz, U; Araz, O; Ergüner-Aral, A; Karabekiroglu, A; Aydemir, Ö
    Objective: The aim of this study is to demonstrate the validity and reliability of the Categorical and Dimensional Psychometric Properties of the Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5-PD) after its translation to the Turkish. Method: The study was carried out with 102 volunteers from two university hospitals. The SCID interview was conducted by two experienced psychiatrists who interchanged positions as interviewer and observer; and completed the research forms without discussing the patient. The diagnostic agreement between the interviewers and the Kappa coefficient were calculated. Divergent and convergent validity analyses were carried out for diagnostic validity and the scores obtained from the self-report form as well as the dimensional evaluation scores were used in the statistical analyses. Results: The group mean age for volunteers was 39.6 +/- 11.6 years and 66.7% consisted of females. The Kappa values for personality categories were 0.79 for avoidant personality structure, 0.64 for dependent personality structure, 0.81 for obsessive-compulsive personality structure, 0.76 for paranoid personality structure, 0.49 for schizotypal personality structure, 0.90 for histrionic personality structure, 0.66 for narcissistic personality structure, 0.89 for borderline personality structure and 0.71 for antisocial personality structure. Dimensional evaluation showed significant correlation with the diagnostic agreement between the interviewers and also with the scores of the self-report forms completed by the participants. Conclusion: The results demosntrated that the Turkish version of the Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5-PD-CV-TR) is valid and reliable.
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    Examination of plasma zonulin levels in bipolar I disorder: a case-control study with follow-up
    Aydin, O; Kocabas, T; Sarandöl, A; Tastan, I; Onur, E; Aydemir, Ö; Esen-Danaci, A
    There is an accumulation in studies which strive to reveal zonulin's potential role in mental disorders. To date, one cross-sectional recent study examined zonulin in patients with bipolar disorders (BDs); however, its role still remains vague due to high fluctuation. Our aims are to determine plasma zonulin levels in exacerbation and treatment response periods, and to examine the associations between zonulin and symptom severity in BD. 30 patients with BD type I and 29 healthy controls participated in the current study. Socio-demographic form, Young Mania Rating Scale (YMRS), and Hamilton Depression Rating Scale (HAM-D) were administered. Enzyme-linked immune assay (ELISA) method was used to measure the plasma zonulin levels of the participants. The groups did not differ in plasma zonulin-level comparisons. Plasma zonulin did not alter between the exacerbation and treatment response periods of the patients. Besides, no associations were found between plasma zonulin-level and disease symptoms. Intestinal barrier integrity was not found to be altered among patients with BD type I. The lack of alterations in plasma zonulin level between different periods may be attributable to several factors. One possible factor might be the ELISA method which can detect other proteins (e.g., properdin) rather than zonulin. Therefore, it might fail to indicate direct observation of intestinal permeability. However, future study designs with more accurate estimation of zonulin in a larger sample may provide a different perspective on intestinal permeability's possible role in BD etiology.