Browsing by Author "Korkmaz F."

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    The protective role of thymoquinone in the prevention of gentamicin ototoxicity
    (W.B. Saunders, 2014) Sagit M.; Korkmaz F.; Gürgen S.G.; Kaya M.; Akcadag A.; Ozcan I.
    Objective To investigate the potential protective effect of thymoquinone in gentamicin-induced ototoxicity through auditory brain stem responses (ABR) testing and histomorphological evaluation of the cochlea.; Methods This study was conducted on 48 adult female Sprague-Dawley rats that were randomized into 4 groups. Group 1 received intraperitoneal gentamicin; group 2 received intraperitoneal gentamicin plus corn oil solution; group 3 received intraperitoneal thymoquinone; and group 4 received intraperitoneal gentamicin plus thymoquinone. All groups received the drugs (once daily) in the above-mentioned protocols over 15 days. After conducting repeated ABR measurements, the rats were sacrificed, and their cochleae were isolated.; Results ABR thresholds were preserved in the gentamicin plus thymoquinone group when compared with the group receiving gentamicin alone. There were fewer TUNEL-positive cells and caspase-3 and caspase-9 expressions were weaker in the inner and outer hairy cells of the organ of Corti in the gentamicin plus thymoquinone group compared with the group receiving gentamicin alone.; Conclusion The ABR values and number of apoptotic cells did not significantly increase in the group receiving gentamicin plus thymoquinone when compared to the group receiving gentamicin alone. Again, the cochlear histomorphological findings were supportive of the auditory findings. In light of these findings, we conclude that gentamicin-induced ototoxicity may be prevented by thymoquinone use in rats. © 2014 Elsevier Inc.
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    N-acetylcysteine prevents gentamicin ototoxicity in a rat model
    (Mediterranean Society of Otology and Audiology, 2015) Somdaş M.A.; Korkmaz F.; Gurgen S.G.; Sagit M.; Akcadağ A.
    OBJECTIVE: The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea. MATERIALS and METHODS: This study is conducted on 36 rats in three groups. Gentamicin, gentamicin plus NAC, and NAC alone were intraperitoneally administered for 15 days. The rats were sacrificed to study the cochleas after testing hearing levels. RESULTS: ABR thresholds and OAEs were attenuated in the gentamicin group, in which apoptosis was detected with histopathological investigation. The group that received NAC in addition to gentamicin had better ABR thresholds and better OAEs. The histopathological evidence of apoptosis in was considerably less in this group. CONCLUSION: Gentamicin ototoxicity can be detected by ABR and OAE testing in rats, and NAC may protect the cochlear cells from apoptosis. © The Mediterranean Society of Otology and Audiology.
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    Quercetine attenuates the gentamicin-induced ototoxicity in a rat model
    (Elsevier Ireland Ltd, 2015) Sagit M.; Korkmaz F.; Gürgen S.G.; Gundogdu R.; Akcadag A.; Ozcan I.
    Objectives: The aim of this study is to evaluate the protective role of quercetin in gentamicin-induced ototoxicity through an auditory brainstem response (ABR) test and a histopathological evaluation of the cochlea. Methods: In this study, 48 female adult Sprague-Dawley rats aged 20-22 weeks and weighing 200-250. g were used. An ABR test was carried out on all rats prior to drug administration, after which, the rats were divided into four groups of 12 animals each. Drug administration was gentamicin 120. mg/kg plus ethanol in group one gentamicin 120. mg/kg plus quercetin 15. mg/kg in group two; quercetin 15. mg/kg in group three; and ethanol in group four. The drugs were administered intraperitoneally once a day for two weeks, and the ABR test was repeated after drug administration. Subsequently, the rats were sacrificed and their cochleae were dissected and examined histopathologically. Results: There was no significant difference between the pre-treatment ABR measurement values of the groups. However, a significant increase was detected in the ABR values in the group of rats that were administered gentamicin plus ethanol, while no statistically significant increase was found in the ABR values in the groups administered with gentamicin plus quercetin; quercetin alone and ethanol alone. The number of TUNEL positive cells in the inner and outer hair cells in the Corti organ was found to be fewer, and Caspase 3 and 9 expressions were found to be weaker in the group receiving gentamicin plus quercetin than in the group receiving gentamicin plus ethanol. Conclusions: Auditory function was detected to be significantly protected and apoptotic cells were found to be decreased when quercetin was administered together with gentamicin. From these results it was concluded that quercetin, a powerful antioxidant, attenuates ABR thresholds and histopathological lesions in the cochlea in gentamicin-induced ototoxicity in rats. © 2015 Elsevier Ireland Ltd.
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    A review on bismuth telluride (Bi2Te3) nanostructure for thermoelectric applications
    (Elsevier Ltd, 2018) Mamur H.; Bhuiyan M.R.A.; Korkmaz F.; Nil M.
    Bismuth Telluride (Bi2Te3) is basically known as an efficient thermoelectric material. Nowadays, it has been attracted a great deal of interest in energy harvesting, chip cooling, chip sensing and other field of material science because of its potential applications. In order to produce Bi2Te3 nanostructure, a number of methods such as solvo and hydro thermal, refluxing, straight forward arc–melting and polyol methods have been employed. Among of them, the solvothermal method has been one of the most common methods to fabricate Bi2Te3 nanostructure in thermoelectric applications. But the development of device–quality material has been a challenging task for the researchers, yet. For this reason, this paper provides a review of current research activities on Bi2Te3 nanostructure growth by several methods and its characterization through theoretical and analytical aspects. Moreover, the paper handles a systematic and intensive research work to develop and understand the materials in nanostructure forms. © 2017 Elsevier Ltd