Browsing by Author "Kusi, M"

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    Neuroprotective Effects of Hesperidin and Naringin in SK-N-AS Cell as an In Vitro Model for Alzheimer's Disease
    Kusi, M; Becer, E; Vatansever, HS; Yücecan, S
    Objective: Hesperidin and naringin are flavonoids that are found in citrus fruits. Our aim was to create an in vitro model of Alzheimer's disease (AD) and to evaluate the neuroprotective effects of hesperidin and naringin in SK-N-AS and AD model cells. Methods: A beta(25-35) was used to create an AD model in SK-N-AS cells. The cytotoxicity of hesperidin and naringin was evaluated using MTT. beta-amyloid, tau and alpha-synuclein distributions were analyzed using indirect immunoperoxidase staining to investigate the neuroprotective effects of hesperidin and naringin. Results: The AD model was created by 1 mu M of A beta(25-35) for 48 hours after ThT staining. The intensity of beta-amyloid was reduced through both hesperidin and naringin treatment in AD model cells. Both flavonoids significantly decreased the intensity of alpha-synuclein in SK-N-AS and AD model cells. Conclusions: Hesperidin and naringin can be potentially used as neuroprotective agents. Naringin may be more effective than hesperidin in the accumulation of beta-amyloid and tau proteins.
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    Basic approach on the protective effects of hesperidin and naringin in Alzheimer's disease
    Kusi, M; Becer, E; Vatansever, HS
    ObjectivesAlzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment. This situation imposes a great burden on individuals, both economically and socially. Today, an effective method for treating the disease and protective approach to tau accumulation has not been developed yet. Studies have been conducted on the effects of hesperidin and naringin flavonoids found in citrus fruits on many diseases.MethodsIn this review, the pathophysiology of AD is defined, and the effects of hesperidin and naringin on these factors are summarized.ResultsStudies have shown that both components may potentially affect AD due to their antioxidative and anti-inflammatory properties. Based on these effects of the components, it has been shown that they may have ameliorative effects on A beta, alpha-synuclein aggregation, tau pathology, and cognitive functions in the pathophysiology of AD.DiscussionThere are studies suggesting that hesperidin and naringin may be effective in the prevention/treatment of AD. When these studies are examined, it is seen that more studies should be conducted on the subject.