Browsing by Author "Kutlu N."
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Item The effect of FAD on erythrocyte glutathione reductase activity in undialyzed uremic patients and healthy subjects(1997) Ari Z.; Uyanik B.S.; Yigitoglu M.R.; Kutlu N.; Pirim I.The erythrocyte glutathione reductase (GSSG-R) activity with and without FAD supplementation (Act. A and Act. B, respectively) was studied in 24 undialyzed uremic patients and 25 healthy subjects. Mean erythrocyte GSSG-R activity from normal subjects was 5.39 ± 1.43 U/g Hb (the active form). After the addition of FAD to the hemolysates, this increased to 7.79 ± 1.07 U/g Hb, an increase of 1.88 ± 0.84 U/g Hb (the inactive from) (p < 0.001). In patients with FAD supplementation, erythrocyte GSSG-R activity increased from 9.26 ± 1.19 U/g Hb to 10.06 ± 1.06 U/g Hb, an increase of 0.80 ± 0.76 U/g Hb (p < 0.01). In addition, there were significant positive correlations between the enzyme activities and plasma urea level, and negative correlations between the enzyme activities and hemoglobin concentrations in patients, but not in the controls. It was concluded that further cross-sectional in vivo studies should be made to determine whether riboflavin administration may or not be useful in preventing renal anemia.Item Does chronic exercise alter immune parameters in postmenopausal women?(2002) Karadeniz G.; Buyukyazi G.; Gunduz T.; Kutlu N.; Ozbakkaloglu B.The aim of this study was to determine the effect of chronic exercise on immune functions. Eighteen postmenopausal women were included in the study: nine were undertaking chronic exercise (exercise group) and the other nine were sedentary (control group). The exercise group had been training for 7.2 h per week for 19.9 years. The subjects were chosen among postmenopausal women to eliminate any effects of menstrual cycle on the immune system. The subjects were paired and reported to the Human Performance Laboratory twice a week between 8:00 and 10:00 a.m. In the first visit, body composition and aerobic capacity were measured. In the second visit, their blood samples were drawn and screened immediately. VO2max was significantly higher in the exercise group. The leukocyte and lymphocyte subset data comparions demonstrated no significant difference between the exercise group and the control group. Only IgA was significantly higher in the exercise group than in the control group (p = 0.005). The results of this investigation indicate that chronic exercise training does not significantly alter concentrations of T and B lymphocytes or T lymphocyte subsets. However, a significant increase in IgA levels may occur, leading to changes in immune response.Item Nurses' knowledge regarding patients with intravenous catheters and phlebitis interventions(Mosby Inc., 2003) Karadeniz G.; Kutlu N.; Tatlisumak E.; Özbakkaloǧlu B.This study was planned and applied in 2 stages. Stage I was applied to determine the knowledge of nurses working in the internal medicine, surgery, obstetrics and gynecology, pediatrics, and other services in Celal Bayar University Hospital about using intravenous catheter and intravenous fluid treatment, and the symptoms and treatment procedure for phlebitis. Stage II consisted of observation of all patients who had intravenous catheters for symptoms of phlebitis for 5 days and the interventions the nurses used for the patients who had phlebitis. In stage I, questionnaires were used to determine the knowledge of the nurses; in stage II, 2 investigators observed the patients. Results were evaluated using SPSS software with χ2 statistical analysis. Nurses were found to have high knowledge levels, but their practices were not suitable to their knowledge levels. Of the patients who participated in the study, 67.24% showed symptoms of phlebitis. We found that there was a significant relationship (P < .05) between the selection of the vein and the occurrence of phlebitis in patients who had an intravenous catheter. We also found that the relationships between the age groups of the patients and phlebitis and the relationships between the diagnosis and phlebitis were statistically significant (P < .05).Item Serum testosterone, growth hormone, and insulin-like growth factor-1 levels, mental reaction time, and maximal aerobic exercise in sedentary and long-term physically trained elderly males(2004) Ari Z.; Kutlu N.; Uyanik B.S.; Taneli F.; Buyukyazi G.; Tavli T.The aim of the study was to investigate the effect of regular exercise on maximum oxygen uptake capacity (VO2max), reaction time (RT), testosterone (T), growth hormone (GH), insulin-like growth factor-I (IGF-1) in athletes compared to sedentary controls. VO2max RT, T, GH, and IGF-I levels were 31.2 ± 6.2 ml/min/kg, 106.7 ± 23.2 s, 8.3 ± 1. 3 ng/mL 1.6 ± 0.7 ng/mL, 106.5 ± 27.0 ng/mL in master athlete group and 18.8 ± 5.1 ml/min/kg, 148.3 ± 39.3 s, 5.4 ± 1.7 ng/mL, 0.8 ± 0.3 ng/mL, 90.2 ± 23.8 ng/mL in sedentary control group, respectively. The differences between regularly exercising males and the control group of sedentary males were found to be statistically significant. The results showed that long-term exercise decreased RT and increased VO 2max, T, and GH in elderly males; elevated serum T and GH levels may be advantageous for brain functions.Item Differences in the cellular and humoral immune system between middle-aged men with different intensity and duration of physically training(2004) Buyukyazi G.; Kutukculer N.; Kutlu N.; Genel F.; Karadeniz G.; Ozkutuk N.Aim. The effects of acute exercise on immune system and serum magnesium and iron have been investigated in recent years. However, data related to the comparisons of long-term physical training with different intensity and duration are limited. Methods. The association between long-term physical training and cellular (lymphocyte phenotyping) and humoral immune parameters (serum immunoglobulins) and serum magnesium and iron values in the middle-aged men was investigated. Eleven male master athletes (MA) performing high intensity and long duration training, 11 male recreational athletes (RA) performing moderate intensity and duration training (>10 years) participated. Eleven male sedentary individuals were enrolled as control group (CG). Results. The percentages of total CD3+ T cells, CD4+ T helper, CD8+ T suppressor/cytotoxic, CD19+ B cells, natural killer cells, HLA-DR+ active T cells and CD4/CD8 ratios did not show any significant difference among 3 groups. In MA, VO2max values showed a significant negative correlation with CD4+ T helper cells. There were no significant differences among MA, RA and CG in terms of IgG, IgA, and IgM concentrations. There was a significant correlation between VO 2max and IgG in RA. Iron, iron binding capacity and ferritin were found similar in all groups, but serum magnesium level in MA was significantly lower than RA and CG. Conclusion. No exact data to support immunosuppression or immunostimulation could be obtained except a significant negative correlation between CD4+ T helper cells and VO2max values in MA and a positive correlation between serum IgG and VO2max ivalues in RA. These findings may be the indirect markers of cellular immune system suppression by intensive exercises and stimulation of IgG production by moderate exercises.Item Personality traits and DRD4, DAT1, 5-HT2A gene polymorphisms in risky and non risky sports participation; [Riskli ve risksiz sporlara katılımda kişilik özellikleri ile DRD4, DAT1, 5-HT2A gen polimorfizmleri](Turkiye Klinikleri, 2010) Çam F.S.; Çolakoǧlu M.; Tok S.; Tok I.; Kutlu N.; Berdeli A.Objective: Relationships amongst Big Five personality traits and DRD4, DAT1 and 5-HT2A gene polymorphisms were investigated in 193 college students participating in risky and non-risky sports. Material and Methods: Personality traits were assessed by Five Factor Personality Inventory (FFPI) and gene polymorphisms were analyzed by polymerase chain reaction. Results: In order to examine whether signifant Big Five personality trait differences existed between DAT1 gene polimorphisms, independent sample t-test was used. Results showed that only Agreeableness dimension revealed significant difference indicating that individuals with non-10/10 genotype had higher agreeableness scores when compared to individuals with 10/10 genotype. ANOVA results showed that Big Five personality dimensions scores differed significantly amongst 5-HT2A genotypes. Individuals with CC genotype had lower emotional stability scores when compared to individuals with TC genotype, and CC genotype individuals had greater openness to experience scores when compared to TT genotype individuals. Openness to experience scores were also significantly different among DRD4 genotypes. Individuals with ll genotype had greater openness to experience scores when compared to individuals with ss genotype. No 5-HT2A and risky sport participation (RSP) interaction effect was found on emotional change score. Conclusion: DAT1 was not associated with RSP. It was concluded that DRD4 and 5-HT2A were not directly associated with RSP but may be used as indirect predictors of it. © 2010 by Türkiye Klinikleri.Item Comparison of blood brain barrier permeability in normal and ovariectomized female rats that demonstrate right or left paw preference(2012) Kutlu N.; Mutlu F.; Vural K.; Cezayirli E.We explored the relations among paw preference, cerebral asymmetry and asymmetrical disruption of blood-brain barrier (BBB) permeability in normal and ovariectomized female rats with known paw preference. A high dose of pentylenetetrazol was used to disrupt the BBB and induce acute hypertension. To determine the areas of macroscopic infarct, samples were stained with 2,3,5-triphenyltetrazolium chloride. Histological staining techniques were used to show the areas of infarct microscopically on paraffin sections. Sixty-two percent of the rats demonstrated right paw preference, 24% demonstrated left paw preference and 14% were ambidextrous. Areas of infarct, which indicated destruction of the BBB, were determined microscopically and macroscopically in rats that demonstrated right and left paw preference. We found a relation between permeability of the BBB and paw preference. There may be a relation between paw preference, cerebral asymmetry and asymmetrical destruction of the BBB in rats. Asymmetrical destruction of the BBB in experimental rats was similar to the control group, which had asymmetrically disrupted BBB with respect to paw preference. Like the control rats, asymmetrical areas of infarct consistent with cerebral asymmetry were observed in ovariectomized rats. © 2012 The Biological Stain Commission.Item Distribution of paw preference in female and male rats: Assessed by a modified version food-reachıng test; [Erkek ve dişi sıçanlarda modifiye besine uzanma test yöntemi ile pençe tercih daǧılımı](Veteriner Fakultesi Dergisi, 2012) Kutlu N.; Bayazit T.O.; Mutlu F.We re-studied the distribution of paw preference in male and female rats using a new food-reaching test. Paw preference was assessed using a modified new version of food reaching task in quadrupedal position. Of the total sample (N=165). Of 165 rats, 86 (52.12%) were right-handed, 72 (43.64%) were left-handed, and 7 (4.24%) were mixed-handed. Of the in male (N=74) 36 (48.65%) were right-handed, 35 (47.30%) were left-handed, and 3 (4.05%) were mixed-handed. The right-minus left paw reaches fitted to gaussian data with two prominent peaks due to right-and left preference. In female (N=91) 50 (54.94%) were right-handed, 37 (40.66%) were left-handed, and 4 (4.40%) were mixed-handed. The female right-preference showed a right-bais compared to males. The males left-preference were more than female left-preference.The distribution of right minus left paw reach was not U-shaped, it was J-shaped like in humans. The results indicate that the distribution of paw preference in rats is similar to that of other animals and to human handedness. It was concluded that there is a right-bias in paw rats, which is caused by the female right-preference under the influence of a biological factor. The right-pawed males were found to be least lateralized than the male left-preference, and female right-and left preference. The brain is in general more lateralized than the female brain.Item Asymmetry, handedness and auricle morphometry; [Asimetría, lateralidad y morfometría de la oreja](Universidad de la Frontera, 2015) Tatlisumak E.; Yavuz M.S.; Kutlu N.; Asirdizer M.; Yoleri L.; Aslan A.The aims of this study were to determine various morphometric measurements of auricle, to investigate asymmetry and its relation with handedness in both sexes. Main morphometric measurements of both auricles and hand preferences were determined on 200 male and 200 female healthy university students. All measurements of the auricles were larger in males than the corresponding ones in females and all the differences except earlobe widths were statistically significant. All measurements of left and right auricles were statistically significantly different in both sexes except earlobe length in males, and distance from the highest point of the auricle to the bottom of the intertragic notch and earlobe length in females. Auricle length and distance from the highest point of the auricle to the bottom of the intertragic notch had higher values at the left side and all other measurements were larger at the right side. There was no significant difference between the measurements of the corresponding auricles of the righthanded and lefthanded subjects. All measurements were larger at the right side except auricle length and distance from the highest point of the auricle to the bottom of the intertragic notch in righthanded and lefthanded subjects and all differences except earlobe length were significantly different in righthanded subjects as in the total population but in lefthanded subjects the difference of the auricle width was not significant, either. There was an apparent asymmetry of right and left auricles of normal people in the current study which should be taken in to consideration in plastic surgeries of the external ear, designing the ear devices and forensic applications of earprints. © 2015, Universidad de la Frontera. All rights reserved.Item Significance of using a nonlinear analysis technique, the lyapunov exponent, on the understanding of the dynamics of the cardiorespiratory system in rats(Turkiye Klinikleri Journal of Medical Sciences, 2016) Zeren T.; Özbek M.; Kutlu N.; Akilli M.Background/aim: Pneumocardiography (PNCG) is the recording method of cardiac-induced tracheal air flow and pressure pulsations in the respiratory airways. PNCG signals reflect both the lung and heart actions and could be accurately recorded in spontaneously breathing anesthetized rats. Nonlinear analysis methods, including the Lyapunov exponent, can be used to explain the biological dynamics of systems such as the cardiorespiratory system. Materials and methods: In this study, we recorded tracheal air flow signals, including PNCG signals, from 3 representative anesthetized rats and analyzed the nonlinear behavior of these complex signals using Lyapunov exponents. Results: Lyapunov exponents may also be used to determine the normal and pathological structure of biological systems. If the signals have at least one positive Lyapunov exponent, the signals reflect chaotic activity, as seen in PNCG signals in rats; the largest Lyapunov exponents of the signals of the healthy rats were greater than zero in this study. Conclusion: A method was proposed to determine the diagnostic and prognostic values of the cardiorespiratory system of rats using the arrangement of the PNCG and Lyapunov exponents, which may be monitored as vitality indicators. © TÜBITAK.Item Therapeutic effects of Lacosamide in a rat model of traumatic brain injury: A histological, biochemical and electroencephalography monitoring study(Elsevier Ltd, 2021) Mete M.; Alpay S.; Aydemir I.; Unsal U.U.; Collu F.; Özel H.F.; Duransoy Y.K.; Kutlu N.; Tuglu M.İ.Objective: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI can be classified based on severity, mechanism or other features. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophys-iological mechanisms underlying neuronal loss after TBI. Lacosamide (LCM) is an anticonvulsant compound approved for the adjunctive treatment of partial-onset seizures and neuropathic pain. This study aimed to investigate possible neuroprotective effects of LCM in a rat model of TBI. Material and methods: Twenty-eight adult male, Wistar albino rats were used. The rats were divided into 4 groups. Group 1 was the control group (n=7). Group 2 was the trauma group (n=7) where rats were treated with 100 mg/kg saline intraperitoneally (IP) twice a day. Groups 3 and 4, rats were treated with 6 (group 3, n=7) or 20 (group 4, n=7) mg/kg Lacosamide IP twice a day. For each group, brain samples were collected 72 hours after injury. Brain samples and blood were evaluated with histopathological and biochemical methods. In addition, electroencephalograpy monitoring results were compared. Results: The immunoreactivity of both iNOS and eNOS (oxidative stress markers) were decreased with LCM treatment compared to trauma group. The results were statistically significant (***P<0.001). The treatments of low (56,17±9,69) and high-dose LCM (43,91±9,09) were decreased the distribution of HIF-1α compared to trauma group (P<0.01). The number of apoptotic cells were decreased with LCM treatment the difference between the trauma group and 20mg/kg LCM treated group (9,55±1,02) was statistically significant (***P<0.001). Malondialdehyde level was reduced with LCM treatment. MDA level was significantly higher in trauma group compared to LCM treated groups (***P<0.001). The level of Superoxide dismutase in the trauma group was 1,86 U/ml, whereas it was 36,85 U/ml in 20mg/kg LCM treated group (***P<0.001). Delta strength of EEG in 20mg/kg LCM treated group were similar to control group values after LCM treatment. Conclusion: No existing study has produced results suggesting that different doses of LCM has therapeutic effect against TBI, using EEG recording in addition to histological and biochemical evaluations in rats. © 2021 Elsevier LtdItem Histologic and physiologic analysis of the relationship between the dorsal nerve of the penis and the corpus cavernosum on a rat model. A complementary pathway on the innervation of penile erection?(John Wiley and Sons Inc, 2022) Kozacioglu Z.; Vatansever H.S.; Onal T.; Kutlu N.; Ozel F.; Gunlusoy B.; Gumus B.H.Aim: The dorsal nerve of the penis (DNP) is the terminal branch of the pudendal nerve which is responsible for the somatic innervation of the penis. This study aims to outline any direct role of the DNP in the hemodynamics of erection histologically and physiologically. Materials and Methods: Fifteen Wistar albino rats were sorted into the electrical activity (n = 6), intracavernous pressure (n = 4), and control (n = 5) groups. The dorsal nerve was electrostimulated and the simultaneous changes in intracavernous pressure and smooth muscle activity were recorded. Penile tissues were collected, fixed, and sectioned, the slides were stained with either hematoxylin-eosin for morphological evaluation or using the indirect immunoperoxidase technique to analyze the distributions of eNOS, iNOS, and nNOS. Results: During electrostimulation, there was a simultaneous statistically significant decrease in the electrical activity inside the corpora in electromyography and an increase in intracavernous pressure. eNOS and iNOS immunoreactivities were higher in the study group than in the control group. nNOS immunoreactivity was moderate in both study and control groups. Conclusion: Some fibers in the dorsal nerve of penis continue into the corpora cavernosa through the tunica albuginea and have an active, direct role in the hemodynamic process of erection, which may be complementary to the main route of innervation. © 2021 Wiley Periodicals LLC.Item Histological and electroencephalographic demonstration of probiotic effect for reduce of oxidative stress and apoptosis in experimental traumatic brain injury; [Deneysel travmatik beyin hasarında oluşan oksidatif stres ve apoptozun azalmasında probiotik etkisinin histolojik ve elektroensefalografik gösterilmesi](2023) Karakayalı E.M.; Kocamaz E.; Alpay Ş.; Önal T.; Öztatlıcı M.; Duruşma R.; Özel H.F.; Mete M.; Barutcuoglu M.; Kutlu N.; Tuğlu M.İ.BACKGROUND: The gut microbiota modulates nervous system function. In the literature, it has been shown that this modula-tion is used in many nervous system injuries through oxidative stress (OS) and apoptosis mechanisms. In this study, it was aimed to investigate the neuroprotective effects of probiotic (PB) treatment in a rat traumatic brain injury (TBI) model with histological and electroencephalographic (EEG) data. METHODS: Forty male Wistar albino rats were divided into four groups. Group 1 was the control group (CONTROL, n=10) and no trauma was applied. Group 2 was the trauma group with the weight-drop technique (TBH, n=10). Group 3 was the sham group (SHAM), (TBH+sterile saline [SS], n=10) rats were given 500 µL of SS per day by oral gavage. Group 4 was the PB treatment group, (TBH+PB, n=10) rats were treated daily for 7 days with 500 µL of PB oral gavage. Brain samples were collected 7 days after trauma. Histopathological evaluation of brain samples was done with HE. OS with Endothelial nitric oxide synthase, vascularization with Vas-cular Endothelial Growth Factor, gliosis with S100, and apoptosis with caspase 3 were evaluated immunohistochemically. Apoptotic index was determined with TUNEL. In addition, EEG and somatosensory evoked potential (SEP) recording findings were compared. RESULTS: It was determined by HE staining that there was a significant (P<0.001) damage in the TBI and sham groups compared to the control group. It was found that PB treatment provided a significant (P<0.01) improvement in the damage created. While OS (P<0.01), gliosis (P<0.01), and apoptosis (P<0.05) decreased with PB treatment, angiogenesis (P<0.01) increased. In support of these findings, in the software-mediated EEG and SUP examination; Delta wave power and theta/alpha ratio increased with TBI and de-creased with PB treatment. CONCLUSION: The results showed that PB treatment provided a significant improvement in rats by reducing OS, apoptosis, and gliosis and increasing vascularity. To the best of our knowledge in the literature, it was shown for the 1st time that histological results for the treatment of PB were supported by software-mediated EEG and SEP analysis.Item Effects of Ketamine/Xylazine and Urethane Anesthesia on Compound Muscle Action Potential Latency of Gastrocnemius Muscle in Rats(Wolters Kluwer Medknow Publications, 2023) Mentese B.; Özel H.F.; Özbek M.; Kutlu N.Objective: Anesthetic agents, which are used in appropriate doses for the application of the experimental procedure in animals, relieve pain when applied in sufficient amounts as well as muscle relaxation. However, many anesthetics can alter the dynamics of neuromuscular systems. We aimed to compare the effects of two frequently used anesthetic agents on electromyographic parameters in rats. Materials and Methods: This study was performed on male Wistar albino rats aged 22-24 months. The animals were divided into two groups: urethane (1.5 gkg-1, i.p; n = 6) and ketamine+xylazine (K+X) (80 mg/kg, i.p; n = 6). Under general anesthesia, rats were electrically stimulated with bipolar hook electrodes from both legs, and compound muscle action potential (CMAP) was recorded from the needle electrode of the gastrocnemius muscle. Motor nerve action potential latency (MNAPL) was measured from the sciatic nerve of the rats. Results: The results of electrodiagnostic findings related to two different anesthetics in the animals were compared, and CMAP parameters were found to differ between the groups. MNAPL in both the right and left legs was significantly reduced in the urethane group compared to the K+X group (P < 0.05). Conclusion: Urethane anesthesia may be a better choice than K+X anesthesia to evaluate nerve and muscle functions in animal electromyography studies. © 2023 Neurological Sciences and Neurophysiology.Item Individual and interactive effect of ultrasound pre-treatment on drying kinetics and biochemical qualities of food: A critical review(Elsevier B.V., 2023) Pandiselvam R.; Aydar A.Y.; Kutlu N.; Aslam R.; Sahni P.; Mitharwal S.; Gavahian M.; Kumar M.; Raposo A.; Yoo S.; Han H.; Kothakota A.One of the earliest and most prevalent processing methods to increase the shelf-life of foods is drying. In recent years, there has been an increased demand to improve product quality while lowering processing times, expenses, and energy usage in the drying process. Pre-treatments are therefore effectively used before drying to enhance heat and mass transfer, increase drying efficiency, and lessen degradation of final product quality. When food is dried, changes are expected in its taste, color, texture, and physical, chemical, and microbial properties. This has led to the need for research and development into the creation of new and effective pre-treatment technologies including high-pressure processing, pulsed electric field, ultraviolet irradiation, and ultrasound. Sound waves that have a frequency >20 kHz, which is above the upper limit of the audible frequency range, are referred to as “ultrasound”. Ultrasonication (US) is a non-thermal technology, that has mechanical, cavitational, and sponge effects on food materials. Ultrasound pre-treatment enhances the drying characteristics by producing microchannels in the food tissue, facilitating internal moisture diffusion in the finished product, and lowering the barrier to water migration. The goal of ultrasound pre-treatment is to save processing time, conserve energy, and enhance the quality, safety, and shelf-life of food products. This study presents a comprehensive overview of the fundamentals of ultrasound, its mechanism, and how the individual effects of ultrasonic pre-treatment and the interactive effects of ultrasound-assisted technologies affect the drying kinetics, bioactive components, color, textural, and sensory qualities of food. The difficulties that can arise when using ultrasound technology as a drying pretreatment approach, such as inadequate management of heat, the employment of ultrasound at a limited frequency, and the generation of free radicals, have also been explained. © 2022 The AuthorsItem Menstrual cycle phases, sex hormones and hand preference modulate nerve conduction velocity in healthy subjects(Elsevier Inc., 2023) Mentese B.; Kutlu N.The aim of the present study was to investigate the relationship between hand preference and electrophysiological parameters in women menstrual cycle phases and men. Our study was conducted on 25 healthy, naturally cycling females and 30 healthy males between the ages of 18 and 25 who participated voluntarily. The female participants completed three test sessions (early follicular phase, the late follicular phase, and the luteal phase). We measured sex hormone concentrations in blood samples collected. Nerve conduction velocity was calculated using electromyography by stimulating the median nerves of the left and right hands of both the male and female participants. The median nerve conduction velocities of the dominant hands of both the males and females were higher than those of the non-dominant hands. The median nerve conduction velocity during the follicular phase of both the right-handed and left-handed females was higher than in the right-handed and left-handed males, while the latency was shorter. When we evaluated the nerve conduction velocities of the participants, we observed the effects of sexual dimorphism and lateralization. The findings suggested that nerve conduction velocity was found to be affected during the phases of the menstrual cycle in healthy female volunteers. © 2022 Elsevier Inc.Item Lateralization of the Fine Motor Skills in Right - and Left-handed Men and Women(Wolters Kluwer Medknow Publications, 2024) Mentese B.; Kutlu N.Introduction: Motor performance is an important feature that can be measured to observe the development of the central and peripheral nervous system. Fine motor skill assessed by Morische-Leistungs-Serie (MLS) was studied in normal male and female right-handers and left-handers considering familial sinistrality and writing hand. Evaluations were conducted by measuring fine motor performance through the use of a modern computerized model. Materials and Methods: Hand preference was assessed by the Edinburgh Handedness Inventory Geschwind score (GS). Fine motor skills were measured by the MLS in the computerized Vienna Test System. Results: Left-handed volunteers had a significantly higher fine motor skills in both dominant and nondominant hands compared to right-handed volunteers. Conclusions: These results suggest that the contributions of the right and left cerebral hemispheres to the motor output of the brain depend on sex and more importantly, hand preference. It was determined that left handed subjects were more skillfull than right-handed subjects when dominant hands or weak hands were compared. © 2024 Journal of Integrative Nursing All rights reserved.