Browsing by Author "Laçin, S"

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    Effects of oestrogen replacement therapy on pattern reversal visual evoked potentials
    Yilmaz, H; Erkin, E; Mavioglu, H; Laçin, S
    As a result of a regression in the ovarian functions, oestrogen level in circulation during the menopause drops to 1/50 of its value in the normal reproductive cycle. Excitatory oestrogen increases the sensitivity of the central nervous system to catecholamines by changing the opening frequency of voltage-related L-type calcium channels and augmenting the effect of glutamate; in addition it inhibits the formation of gamma-amino butyric acid (GABA) by the inhibition of glutamate decarboxylase enzyme. It is argued that oestrogen increases transmission in the optic pathways and that oestrogen is responsible for the shorter latency values and higher amplitudes of visual evoked potentials in women. We recorded the monocular pattern reversal visual evoked potentials (PRVEP) of both eyes of 54 post-menopausal women before treatment and of 30 of them after replacement therapy with Tibolon, and of 24 women receiving placebo treatment. The explicit values of P-100 latency of right and left eyes before treatment were 98.8 +/- 3.5 and 99.0 +/- 3.3 ms, respectively. The explicit values of P-100 latency of right and left eyes after placebo treatment were 98.6 +/- 3.7 and 98.8 +/- 4.0, respectively. The explicit values of P-100 latency of right and left eyes after replacement treatment were 94.6 +/- 3.7 and 94.8 +/- 4.0, respectively. We found a statistically significant decrease in the mean PRVEP latencies and a statistically significant increase in mean amplitudes after replacement treatment (P < 0.001) compared with those before treatment and those after placebo treatment, We attributed the changes in PRVEP values after replacement treatment to the action of Tibolon, which acted as a natural sex steroid and speeded the visual transmission time via the widespread receptors in the central nervous system. It is concluded that PRVEP is an objective electrophysiological assessment method in evaluating the efficiency of hormone replacement therapy in post-menopausal women.
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    The role of selectins in the first trimester pregnancy loss
    Eskicioglu, F; Laçin, S; Özbilgin, K; Köse, C
    Objective: There are no well-defined findings about reasons for first trimester abortion in some pregnancy cases. Selectins are cell adhesion proteins which are important for blastocyst implantation in the decidua. The goal of the study was to investigate the role of selectins in first trimester pregnancy loss by immunohistochemistry Study design: Decidual and placental tissue samples have been obtained from the women with unwanted pregnancy as the control group (n=40) and missed abortion (n=40) as the study group. Immunohistochemistry technique has been used to compare P, L and E-selectin expression of the fibroblast and the decidual cells in uterine decidual stroma; and fibroblasts and mesenchymal cells in placental villous stroma. Immunostaining for P,L,E-Selectin has been evaluated semiquantitatively by HSCORE analysis. Results: Decidual cells, for E and L-selectin showed stronger staining in the study group than controls, and the difference was statistically significant (p = 0.001, p = 0.001). P-selectin showed stronger staining in the control group, but the difference was not as significant as the E and L-selectins (p=0.04). In the placenta, cytotrophoblasts and syncytiotrophoblasts showed stronger staining for P,E,L-selectins for the control group (p<0.001, p=0.001 and p<0.001, respectively). Conclusion: Strong expression of each of the three investigated selectins in healthy pregnancy villi shows their contribution to implantation and strong placentation. There is a need for better understanding of the functions of adhesive molecules in these events to reveal unknown causes for pregnancy loss.
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    Immunohistochemical staining of IGF-I, IGF-binding proteins-1 and-3, and transforming growth factor beta-3 in the umbilical cords of preeclamptic patients
    Inan, S; Vatansever, S; Kuscu, NK; Laçin, S; Ozbilgin, K; Koyuncu, F
    Background. To detect the immunoreactivity of insulin-like growth factor-I, insulin-like growth factor-binding proteins-1 and -3 and transforming growth factor beta-3 in the umbilical cords of normal and preeclamptic patients. Methods. Umbilical cords were obtained from 15 normal and 15 preeclamptic patients. Immunoreactivities were determined using either indirect immunofluorescence or immunoperoxidase techniques on formalin-fixed, paraffin-embedded sections. Staining intensity was graded by a semiquantitative scoring method. The results were compared by Mann-Whitney U -test. Results. The umbilical cords were thinner and the vessels were hypoplastic in the preeclamptic group. Moderate staining intensity for insulin-like growth factor-I, insulin-like growth factor binding protein-1 and -3 and transforming growth factor-beta 3 was observed in normal patients. The preeclamptic group had mild and strong intensities for insulin-like growth factor-I and insulin-like growth factor binding protein-1, respectively, and intensity for insulin-like growth factor binding protein-3 did not change, but diffuse and increased intensity was observed for transforming growth factor-beta 3. Conclusion. Changes in the intensity of insulin-like growth factor-I and its major binding protein and the transformation of growth factor-beta 3 may play a role in the pathogenesis of preeclampsia by altering the structure and responsiveness of the umbilical cord
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    Rupture of rudimentary horn pregnancy at the 15th week of gestation
    Kuscu, NK; Laçin, S; Kartal, Ö; Koyuncu, F
    A patient with acute abdomen at 15th week of gestation underwent an emergency laparatomy. A ruptured rudimentary horn pregnancy was diagnosed. and the rudimentary part including the fetus and the accessories was resected. The mother survived without any complications. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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    Collagenase treatment of sore nipples
    Kuscu, NK; Koyuncu, F; Laçin, S
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    Clomiphene citrate does not adversely affect endometrial leukemia inhibitory factor levels
    Kuscu, NK; Koyuncu, FM; Var, A; Laçin, S; Uyanik, BS; Ceylan, E
    The aim of this study was to compare endometrial leukemia inhibitory factor (LIF) levels in spontaneous and clomiphene citrate (CC)-induced cycles of patients with unexplained infertility. The patients were followed in two consecutive cycles. Endometrial samples were obtained 7 days after ultrasonographic evidence that ovulation has occurred during the spontaneous cycle, then the patients were induced with CC from day 5 to day 9 during the subsequent cycle with 50 mg/day, and ovulation monitoring and endometrial biopsy were performed in the same manner. The samples were obtained using a Pipelle biopsy device without using local anesthesia, and kept in formaldehyde solution until the day of measurement, Then they were homogenized in phosphate buffered distilled water, and LIF levels were detected in the homogenized fluid by ELISA method, Endometrial LIF levels were 4 70 +/- 52 and 501 +/- 45 pg/1 gram wet tissue in spontaneous and CC-induced cycles respectively, revealing no significant difference. Ovulation induction with CC did not adversely affect endometrial LIF levels.
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    Assessment of the effectiveness of postmenopausal tibolone therapy on neural functions by measuring visual evoked potentials
    Laçin, S; Oruç, S; Karaca, S; Kusçu, K; Koyuncu, F; Uyar, Y; Çaglar, H
    Objective: To assess the effect of hormone replacement therapy on neural transmission in postmenopausal women using tibolone by a non-invasive, objective way. Study design: In a randomised, 3 cycle, placebo-controlled study, neurovisual transmission in optic pathways were evaluated by measuring visual evoked potentials (VEP). After neuroophtalmologic examination, eligible subjects were randomised into two groups. Treatment group (n = 38) were given tibolone 2.5 mg daily continuously for 3 months and control group (n = 20) were treated with placebo. A baseline VEP measurement before the treatment and then at the end of first, second and third month were obtained by the EMG-evoked system in the Department of Neurology, University of Celal Bayar, Manisa, Turkey. Results: Data from 31 women from treatment group and 16 from control group were available for evaluation. The mean P(100) latency values, which indicate the transition time period between the optic stimuli and electrical change recorded on the occipital area by the skin electrodes, have showed a significant decrease for the study group (from 100.39 +/- 0.58 to 97.90 +/- 0.65 ms, P < 0.01) at the end of the first month of treatment according to the baseline values. This difference between two groups has remained constant during the study period. Conclusion: The change in latency measurements of VEP, reflecting the functional status in optic pathways from retina to occipital cortex were significantly different in the treatment group than in that of control. We concluded that a facilitating effect of tibolone was observed on neurovisual transmission. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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    Parental Attitude in Women with Hyperprolactinemia: a Controlled Cross-Sectional Study
    Ulman, C; Aydemir, Ö; Taneli, F; Aksun, S; Öztin, A; Safak, C; Laçin, S
    Objective: Prolactin hormone affects the brain, attitude and mood. Secretion of prolactin may be stimulated by environmental factors. The aim of this study was to demonstrate any possible effect of poor child-parent relationship on hyperprolactinemia. We hypothesize that women with hyperprolactinemia may have been subjected to poor child-parent relationship and neglect. Method: The present study was designed in a maternity hospital and included women with gynecologic complaints referred from the gynaecology outpatient clinic for serum prolactin assessments. An 85-item, self-rated EMBU Scale questionnaire (a scale for perceived parental attitude) was applied. Fifty women were enrolled over a period of 5 months. Results: Women with hyperprolactinemia (prolactin levels above 26 ng/ml) constituted the patient group (Group 1) (n=34) and those with normal serum prolactin levels (below 26 ng/ml) served as the controls (Group 2) (n=16). The mean +/- SD levels of prolactin for group 1 and 2 were 57.25 +/- 38.7 ng/ml and 18.81 +/- 4.4 ng/ml, respectively. Group 1 patients believe that their parents did not show enough emotional warmth and had rejective behavior. Emotional warmth parameters of patients' mothers and fathers were significantly lower (p=0.002 and p=0.01, respectively) than those of the control group. We also found that the patients believed that their mothers and fathers both had rejective behaviors (p=0.008 and p=0.009, respectively). Conclusion: Prolactin secretion is regulated by the dopaminergic system and since dopamine is responsible of pleasure and satisfaction sensations, the negative affection of both mothers and fathers in childhood may play a role in the etiology of chronic low-grade hyperprolactinemia in women.