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Browsing by Author "Müezzinoglu, T"

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Mediterranean Diet and Overactive Bladder
Bozkurt, YE; Temeltas, G; Müezzinoglu, T; Üçer, O
Purpose: The relationship between nutrition and overactive bladder (OAB) has yet to be elucidated. 'therefore, this study investigated the relationship between the Mediterranean diet and OAB. Methods: The 14-item Mediterranean Diet Adherence Screener (MeDAS) and Overactive Bladder-Validated 8-question Screener (OAB-V8), validated in Turkish, were administered to 500 patients over the age of 18 who presented to outpatient clinics other than urology outpatient clinics. Of those patients, 174 with chronic diseases and urinary tract infections (based on urinalysis and a detailed medical history) were excluded. Therefore, 326 patients' data were analyzed. Results: There was a negative correlation between the MeDAS and OAB-V8 scores. High OAB-V8 scores were associated with obesity (body mass index >= 30 kg/m(2)), being single, and a low education level. Conclusions: Dietary patterns represent a broader perspective on food and nutrient consumption and may therefore be more predictive of disease risk. The Mediterranean type should be recommended in the first-line treatment of patients with OAB symptoms. It is easily possible to determine the compliance of patients with this diet by using the 14-item MeDAS.
Asymptomatic Giant Renal Calculi: Single-Session Percutaneous Nephrolithotomy-Images
Bozkurt, YE; Temeltas, G; Üçer, O; Müezzinoglu, T
In a 55-year-old woman patient with a body mass index of 27 kg/m(2), a giant staghorn kidney stone (10 x 6.4 x 8 cm) was detected in the right kidney on computed tomography, then the patient was treated with a single-session percutaneous nephrolithotomy, and there were no complications afterwards.
Obstructive Uropathy in Advanced Prostate Cancer
Erbatu, O; Müezzinoglu, T
Objective: The incidence of advanced prostate cancer increases in proportion to new treatment options and prolonged life expectancy. Especially in advanced disease, prostate cancer is a progressive disease that can cause obstructive uropathy. This study investigated the relationship between the characteristics of advanced prostate cancer and obstructive uropathy.Materials and Methods: This study retrospectively evaluated the data of prostate adenocarcinoma patients admitted to the Urology Clinic of Manisa Celal Bayar University Hospital between 2017 and 2021. Of them, 48 were advanced prostate cancer patients, and they were all included. All patients in the study received hormonal therapy along with chemotherapy for prostate cancer treatment. The relationship between hydronephrosis and patient age, creatinine and prostate -specific antigen (PSA) values, urinary tract infections, prostate volume, pathological features of cancer, and castration resistance was evaluated.Results: Parameters that we found to be associated with obstructive uropathy (OU) are as follows: high creatinine level at the time of diagnosis of cancer (p<0.001), increase in creatinine at follow-up (p=0.001), urinary infection at the time of diagnosis of cancer (p=0.002) and at follow-up (p=0.003), development of castration resistance during treatment (p=0.038) and high PSA values at the time of diagnosis of prostate cancer (p=0.011).Conclusion: Renal functions should be observed very carefully in advanced prostate cancer patients who develop or are at risk of developing OU. High PSA values and/or castration resistance should be approached carefully in terms of the patients prognosis. It should not be forgotten that their significant relationship with OU has been demonstrated.
Dermoscopy of scalp cutaneous metastasis of sarcomatoid renal cell carcinoma
Çetinarslan, T; Ermertcan, AT; Temiz, P; Evrenos, MK; Müezzinoglu, T
Experimental animal models for bladder cancer
Tombul, ST; Müezzinoglu, T
Bladder cancer is one of the most common cancers of urinary system. A number occupational and environmental carcinogens have well known role in etiology of bladder cancer. Its high recurrence rate and progression is another charecteristic feature of bladder cancer. For this reason many preclinical studies related with carcinogenesis, preventive and curative treatments of bladder tumors have been published so far. From these preclinical studies, experimental animal models for bladder cancer were reviewed in this paper.
Assessment of Quality of Life of Partners of Patients with Benign Prostate Hyperplasia: Does Benign Prostate Hyperplasia Disturb Female Partners?
Müezzinoglu, T; Çam, K; Kayikçi, A; Lekili, M
Objective: Benign prostate hyperplasia (BPH) is a common health problem throughout the world. The aim of the study was to evaluate the consequence of BPH on partners by using Turkish version of a specific quality of life (QoL) scale for partners of BPH patients. Material and Methods: The study group consisted of partners of 300 BPH patients who were admitted to urology outpatient departments of two university hospitals (Duzce University and Celal Bayar University) with lower urinary tract symptoms. BPH patients were asked to fill out International Prostate Symptom Score (IPSS) form, while female partners were separately requested to complete the specific QoL questionnaire. Results: The mean age of patients with BPH was 63.8 +/- 7.2 years and it was 56.3 +/- 6.5 years for female partners. The results of the specific questionnaire showed that QoL of partners were significantly affected. Particularly, most of the the partners had the fear of cancer development and possibility of surgery for their husbands, 77% (231/300 partners) and 79% (237/300 partners), respectively. At night majority of partners woke up frequently because of their husbands, however mostly of them declared no or little disturbance in terms of being tired during the day. On the other hand, it was revealed that there was a significant correlation between QoL degrees of partners and IPSS values of BPH patients (p< 0.001; correlation coefficient 0.664). Conclusion: BPH significantly impairs the QoL of female partners. This negative impact correlates with the IPSS values of BPH patients. Therefore, the physicians should also consider burden of the female partners in the management of BPH patients.
The effect on the sensitivities of PSA and PSA-age volume score of IPSS and nocturia in predicting positive prostate biopsy findings
Üçer, O; Müezzinoglu, T; Çelen, I; Temeltas, G
Objective: The PSA-age volume (PSA-AV) score was calculated by multiplying the age and prostate volume and then dividing the total by the prebiopsy PSA level. The aim of this study was to evaluate the effect on the sensitivities of PSA and PSA-AV score of International Prostate Symptom Score (I-PSS) and nocturia in predicting positive prostate biopsy findings. Subjects and methods: A total of 1302 biopsies data were divided into two groups according to presence/absence of nocturia. Of these biopsies, 452 biopsies data with I-PSS were also divided into three groups according to severity of I-PSS. The sensitivities, specificities, positive and negative predictive values of the PSA-AV and PSA in all the groups were calculated separately. Results: Although the sensitivities of PSA and PSA-AV were similar in the patients with nocturia (94.1% and 95.8%, respectively), the sensitivity of PSA-AV (99.2%) was higher than PSA (91.8%) in the patients without nocturia. The sensitivities of PSA in mild, moderate and severe I-PSS group were found to be 100%, 92.9% and 95%, respectively (the sensitivities of PSA-AV were 100%, 94.4% and 88.2%, respectively). While severity of I-PSS was decreasing, although sensitivity of PSA-AV increased regularly, sensitivity of PSA was variable. Conclusions: All our data shows that if we remove most of the factors which effect PSA such as age, prostate volume, prostatitis and BPH, we may increase the sensitivity of PSA for predicting positive prostate biopsy. Further PSA formulas contain of result of some tests (I-PSS, uroflowmetry or postvoiding residue urine) as well as age and prostate volume should increase the sensitivity and specificity of PSA for detecting prostate cancer. (C) 2016 Pan African Urological Surgeons' Association. Production and hosting by Elsevier B.V.
How affected Active Surveillance the quality of life in low-risk localized prostate cancer?
Çelen, I; Çitgez, S; Müezzinoglu, T
Active surveillance (AS) is emerging as an alternative approach to limit the risk of overtreatment and impairment of quality of life (QoL) in patients with low-risk localised prostate cancer. Patients with prostate cancer may be distressed by the idea of living with untreated cancer. However, most of them report high levels of QoL. We aimed to assess quality of life of the patients in AS with low-risk localised prostate cancer.
Sexual function in ankylosing spondylitis
Pirildar, T; Müezzinoglu, T; Pirildar, S
Purpose: We evaluated sexual function in male patients with ankylosing spondylitis (AS) using the validated International Index of Erectile Function (IIEF). We also assessed the frequency and association of erectile dysfunction with patient age, disease duration, morning stiffness, laboratory activity, disease severity, depression status and medication use in this patient group. Materials and Methods: We evaluated sexual function, in particular erectile dysfunction (ED), using the IIEF in male patients with AS followed regularly at the outpatient clinic of rheumatology and compared results with those in healthy controls. Patient age, disease duration, morning stiffness, laboratory activity, disease severity and medication use were obtained by reviewing the medical record. Affective patient and control states were measured by the Beck Depression Inventory. The Bath AS Functional Index was used to measure functional status in AS cases. Results: To our knowledge this is the first study of the frequency of ED in men with AS (8 of 65 or 12%). Compared to healthy controls patients with AS had significantly lower erectile function, orgasmic function, intercourse satisfaction and overall satisfaction scores according to the IIEF, whereas sexual desire scores were also lower, although not significantly. According to self-reported patient data ED was a prominent characteristic of our population. We were not able to relate any clinical features or laboratory findings to ED except the duration of morning stiffness. The 22 men with a high degree of morning stiffness (greater than 4 hours) had lower erectile function scores compared to the 12 with AS and a low degree of morning stiffness (less than 2 hours) (18.3+/-1.6 vs 26.5+/-2.4, p<0.05). Of 65 patients with AS 25 (38%) were depressed in our study group according to the Beck Depression Inventory, while no healthy controls were depressed when a score of greater than 13 was used as the cutoff. Conclusions: ED can be seen in the course of AS. The pathogenesis of ED in patients with AS is thought to be multifactorial with disease and treatment related factors. Thus, male patients with AS, in particular those with a high degree of morning stiffness, should be encouraged to talk about their sexuality.
Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey
Uçer, O; Yücetas, U; Çelen, I; Toktas, G; Müezzinoglu, T
Objectives: To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey. Materials and Methods: PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies. Results: The population's average age was 63.71 +/- 7.63 years, the mean PSA level was 9.73 +/- 17.01ng/mL, the mean prostate volume was 44.46 +/- 23.88 cm(3). Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA-AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-off of 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-off of 700 in patients over 60 years was similar to the PSA cut-off of 4ng/mL and the age-adjusted PSA, in patients < 60 years, its sensitivity was higher. While the sensitivities of a PSA-AV cut- off of 700 in patients with low prostate volume was higher than a PSA cut-off of 4ng/mL, the sensitivities of both methods with moderate prostate volumes were similar. Conclusions: Considering all the biopsies, the sensitivity and specificity of a PSA-AV of 700 for predicting positive biopsy findings were similar to a PSA of 4ng/mL. We suggest the PSA-AV cut-off of 700 should only be used in patients younger than 60 with low prostate volumes (<20cm(3)).
Histopathological effects of sildenafil citrate on rat corpus cavernosum
Gümüs, B; Vatansever, HS; Müezzinoglu, T; Müftüoglu, S; Kaymaz, F; Büyüksu, C
Sildenafil citrate (Viagra) is widely used for the treatment of erectile dysfunction with various etiologies. The aim of the present study was the investigation of histopathotogical effects of sildenafil citrate on, rat corpus cavernosum using light and electron microscopical techniques. Twenty mate rats were divided into two groups. The first group (n = 10) was used as a Control and the second group (n = 10) was treated with sildenafil citrate. Penile tissue was collected, fixed with formalin and embedded in paraffin for light microscopy, or fixed with gluteraldehyde and osmium tetroxide and embedded in Epon for electron microscopy. Light microscopical analysis showed that the corpus cavernosum was elongated and the number of blood vessels was increased. The amount of connective tissue in the penis was increased and dense collagen and smooth muscle fibers were observed in treated rats. electron microscopical analysis showed that stromal. structures of the corpus cavernosum (collagen fibers and number of cellular elements) were increased in treated rats. Fibroblasts showed signs of activation and the number of other stromal cells was increased. Immature newly synthesized collagen fibers were observed and penetrated endothelial basement membranes. In addition, endothelial cells also showed signs of activation such as cytoplasmic granules in treated rats, whereas the surface area of blood vessels was increased and basement membranes were thickened. These histopathological changes due to treatment with sildenafil citrate indicate that prolonged use of sildenafil citrate may increase the risk of fibrosis in the penis. (C) 2003 Elsevier GmbH. All rights reserved.
The effect of trace elements in prostate cancer
Çelen, I; Senol, F; Müezzinoglu, T
Prostate cancer is the sixth prevailing cancer type seen all over the world. It is also the third most common cancer type among men. The aim of this study is to investigate the effects of exposure to trace elements in prostate cancer etiology and to evaluate the latest data in literature about the clinical consequences of the deposition of trace elements in prostate tissues. There is a variety of factors in prostate cancer etiology including age, ethnogenesis, family history, androgens and hormonal factors, food and environmental exposures. Nowadays it is believed that trace elements take part in the development of prostate cancer as a result of environmental pollution and exposure to carcinogenic materials. Trace elements participate in biological systems as components of enzymes or as catalysts carrying out some chemical reactions in living cells so it is known that excessive or inadequate intakes of many trace elements lead to a variety of diseases including cancer. The methods to measure the extent of exposure to trace elements include vocational history, measurements in existing pollution and air and personal survey signs. However it is difficult to compare these results with each other as result of the measurement differences in these methods. The capability of the methods used to determine the trace elements in biological and environmental systems depends on the type of the specimen (blood, urine, hair, nail) and the preparation of the specimen for the analysis. Cumulative exposure is very important in cancer etiology. Measurements in serum and plasma indicate short term exposure whereas measurements in toenails and red blood cells indicate long term exposure. Apart from that automatic analysis methods have been developed and commercial systems providing fast and numerous data with very little contribution of the user have been produced to meet the increasing needs. There is a variety of recent studies in literature on the determination of trace elements in tissues. However it is obvious that we need studies evaluating the exposures to trace elements together with their depositions in human tissues.
Simultaneous Partial Nephrectomy and Radiofrequency Ablation in a Solitary Kidney Patient
Albaz, AC; Mammadzada, M; Müezzinoglu, T; Üçer, O; Temeltas, G
Renal cell carcinomas, which comprise the majority of primary kidney tumors, present diverse challenges in treatment planning. This case report explores the application of simultaneous partial nephrectomy and radiofrequency (RF) ablation in a patient with a solitary kidney, emphasizing the significance of specific interventions. A 52-year-old female patient who underwent radical nephrectomy presented with right flank pain and hematuria. Contrast-enhanced computed tomography revealed exophytic and calyceal system-extending lesions in the right kidney. A multidisciplinary approach involving interventional radiology and nephrology facilitated preoperative preparation. The patient underwent simultaneous partial nephrectomy and RF ablation in a single session, resulting in favorable outcomes. This meta- analysis highlighted radical nephrectomy's association with chronic kidney disease, emphasizing the need for specialized treatment approaches. Ablative treatment was associated with superior perioperative outcomes, whereas partial nephrectomy exhibited higher urological complication rates. Minimally invasive techniques are crucial, especially for solitary kidney cases and small renal tumors. Simultaneous partial nephrectomy and RF ablation are effective for managing exophytic and calyceal system-extending masses in solitary kidneys. The preservation of renal function is of paramount importance, prompting consideration of ablative treatment alongside partial nephrectomy. Despite limited evidence, ablative therapies offer a viable alternative for frail and comorbid patients, ensuring long-term oncological durability and superior preservation of renal function.
Cutaneous Metastasis of Hormone Therapy-Resistant Prostate Adenocarcinoma to the Inguinal Region
Çetinarslan, T; Ermertcan, AT; Temiz, P; Müezzinoglu, T
Sorafenib-induced erythema multiforme in metastatic renal cell carcinoma
Bilaç, C; Müezzinoglu, T; Ermertcan, AT; Kayhan, TÇ; Temeltas, G; Öztürkcan, S; Temiz, P
Sorafenib is a new therapeutic agent being used in metastatic renal cell carcinoma, hepatocellular carcinoma, and malignant melanoma. The most frequently seen cutaneous side effects due to sorafenib are erythema, exfoliative dermatitis, acne vulgaris, and flushing. Folliculitis, eczema, and erythema multiforme are other, rare side effects of sorafenib. A 59-year-old man underwent left radical nephrectomy due to renal cell carcinoma 8 months ago, and after the operation he received immunochemotherapy and then sorafenib. On the third day of sorafenib therapy his lesions occurred. His dermatologic examination revealed multiple erythematous papules on his neck, arms, and legs and bullae and iris lesions on his palms and soles. He was diagnosed as having erythema multiforme. In the literature we found only 1 other erythema multiforme case due to sorafenib. We present this interesting case to show and discuss cutaneous side effects of sorafenib, especially erythema multiforme as a very rare cutaneous side effect.
Comparison of the nuclear matrix protein 22 with voided urine cytology in the diagnosis of transitional cell carcinoma of the bladder
Lekili, M; Sener, E; Demir, MA; Temeltas, G; Müezzinoglu, T; Büyüksu, C
Several urinary markers for transitional cell carcinoma have been investigated, including urine cytology, bladder tumor antigen, autocrine motility factor receptor and fibrin degradation products. Unfortunately, they have poor overall sensitivity. The United States Food and Drug Administration have recently approved nuclear matrix protein (NMP 22) for the detection of occult or rapidly recurring disease after transurethral resection of bladder tumor. The objective of the current study was to assess the sensitivity of NMP 22 for the detection of bladder carcinoma, as well as to correlate the NMP 22 values with multiplicity of tumor, tumor size, configuration, stage and grade respectively. A total of 78 patients (38 with bladder cancer) provided a urine sample which was divided into appropriate aliquots for each of urine cytology and NMP 22. Comparative results demonstrate a clear superiority of NMP 22 in bladder cancer detection (52.6% vs 31.6% sensitivity), while specificity was in favor of urine cytology (100% vs 82.5%). For superficial tumors, sensitivity was 78.5% for NMP 22 and 41.6% for cytology and for invasive cancers, sensitivity was 90% for NMP 22 and 60% for cytology. Urinary NMP 22 levels were significantly correlated with tumor grade and were significantly higher in large tumors than small tumors. NMP 22 test results showed sufficient sensitivity in comparison with urine cytology for the detection of transitional cell carcinoma. However, we do not think that it is a useful tool as a substitute for endoscopic examination for the detection and surveillance in bladder cancer.
The Effect of Transurethral Resection and BCG Therapy on Cytokine Levels in Non-Muscle Invasive Bladder Cancer
Üçer, O; Temeltas, G; Müezzinoglu, T; Ari, Z; Kosova, F
Objective: The present study investigated the effect of treatment on interleukin (IL)-1, IL-6, IL-8, and neopterin levels in patients with non-muscle invasive bladder cancer (NMIBC). Materials and Methods: Thirty patients with NMIBC and 30 age-matched controls were included in the study. Preoperative, postoperative first control [at two weeks after second transurethral resection of bladder tumor (TURBT)] and the second control (at the end of intravesical immunotherapy) blood samples were analyzed using ELISA to determine IL-1, IL-6, IL-8, and neopterin levels. The mean cytokine levels of the patients were statistically compared and comparing the patients' and controls' levels. Results: There were no statistically significant differences between the mean IL-1, IL-6, IL-8, and neopterin levels of the patient and control groups before initial TURBT. In the patient group, there were no statistically significant differences in the IL-6 and IL-8 levels after both TURBT and intravesical Bacillus Calmette-Guerin (BCG) therapy. The mean of preoperative IL-1 and neopterin levels significantly decreased after TURBT (p<0.05). However, this reduction does not continue after intravesical BCG instillation. Conclusion: The findings of this study showed that the IL-1, IL-6, IL-8, and neopterin levels of the patients with NMIBC were similar to the levels of healthy controls. IL-1 and neopterin levels significantly decreased after TURBT. But these reduction did not continue after intravesical BCG instillation. These findings demonstrate that IL-1 and neopterin levels decrease after TURBT due to the reduction in tumor weight or tumor removal.
Effects of Treatment on Angiogenic (Vascular Endothelial Growth Factor-2 and Matrix Metalloproteinase-2) and Antiangiogenic (Endostatin and Thrombospondin-1) Factors in Non-muscle Invasive Bladder Carcinoma
Temeltas, G; Kosova, F; Üçer, O; Müezzinoglu, T; Ari, Z
Objective: We aimed to investigate possible effects of treatment on angiogenic [vascular endothelial growth factor-2 (VEGF-2) and matrix metalloproteinase-2 (MMP-2)] and antiangiogenic [ endostatin (ES) and thrombospondin-1 (TSP-1)] factors in non-muscle invasive bladder carcinoma (NMIBC). Materials and Methods: Thirty NMIBC patients and 30 age-matched controls were included in the study. For the above-mentioned markers, peripheral blood samples were drawn at three time points to be studied by enzyme-linked immunosorbent assay: before transurethral resection of bladder tumor (TURBT), at first control (20 days after the operation) and second control (at the end of intravesical immunotherapy). The mean blood levels obtained in the three measurements and those in patients and controls were compared statistically. Results: The mean levels of VEGF-2 and MMP-2 in patients before TURBT were found to be statistically significantly higher than in controls (p=0.04 and p=0.01, respectively), while no significant differences were obtained between the mean ES and TSP-1 levels (p=0.95 and p=0.99, respectively). It was also found that the VEGF-2 and MMP-2 levels were significantly decreased after TURBT (p=0.03 and p=0.01, respectively), but the tendency of these decrease was not found to be statistically significant between the first and second controls. Conclusion: Elevated VEGF-2 and MMP-2 levels in patients with NMIBC were significantly decreased after and probably due to the TURBT, which leads to a conclusion that these angiogenic markers may be used for follow-up of NMIBC.
What is the Color of Cancer?
Tatli, V; Üçer, O; Müezzinoglu, T
Objective: To investigate the colors that evokes cancer in the patients with prostate, lung and breast cancer, and in healthy controls. Materials and Methods: A visual card in one of the 9 colors (white, red, orange, yellow, green, blue, purple, navy, black) was shown to totally 210 patients diagnosed with lung cancer (LC), prostate cancer (PC) or breast cancer (BC) and 200 healthy participants and the question of What is the color of cancer? was asked to them. Disease information of the cancer patients were also recorded. Results: The mean ages of the patient and control groups were 61.54 and 20.49, respectively (p<0.001). While the most preferred color was yellow (24.8%) in the patient group, it was red (39%) in the control group. The patients were divided into three groups according to both type and stage of cancer. While the patients with PC and BC selected yellow color, the patients with LC selected black color. The patients without recurrent and residual diseases preferred yellow, patients with local recurrence preferred red and patients with distant metastasis preferred black colors. Conclusion: While cancer patients selected yellow color which represents positive emotions, the healthy young individuals selected red color which represents negative emotions. However, progressive or aggressive cancer patients selected red and black colors which is associated with negative emotions.
Long term follow-up results of ablation treatment for patients with small renal mass
Gümüs, BH; Albaz, AC; Düzgün, F; Üçer, O; Temeltas, G; Müezzinoglu, T; Tarhan, S
Objective The aim of this study is to evaluate the outcome of ablation therapy in our clinic for the treatment of patients with a small renal mass Materials and Methods: We retrospectively evaluated the technic and follow-up data of 30 patients with 36 tumours who underwent Radiofrequency Ablation (RFA) and Microwave Ablation (MWA) in our clinic. Demographic data, ablation type, tumour characteristics, peroperative and postoperative complications and treatment success of the patients were evaluated. Results A total of 36 tumours who underwent ablation treatments, 23 were treated with RFA, 13 with MWA. The mean tumour size was 28.9 +/- 6.92 mm in RFA and 29.3 +/- 7.70 mm in MWA. The mean follow-up period was 49.6 +/- 24.7 months in patients with RFA and mean follow-up was 16 +/- 8.05 months in MWA treatments. The overall success in MWA administration was calculated as 76.9%, while the overall success in RFA was 80%. Conclusion Long-term oncologic efficacy of RFA appears to be successful in the treatment of T1a renal carcinomas. Further studies can be conducted to elucidate the influence of MWA on long-term oncological outcomes.

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