Browsing by Author "Mütevelizade, G"

Now showing 1 - 7 of 7
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    Unexpected Metastatic Localizations of Prostate Cancer Determined by 68Ga PSMA PET/CT: Series of Four Cases
    Mütevelizade, G; Sezgin, C; Gümüser, G; Sayit, E
    Prostate-specific membrane antigen (PSMA) is a transmembrane protein with overexpression in most prostate cancer cells. Gallium-68-(Ga-68) PSMA positron emission tomography/computed tomography (PET/CT) imaging is a game-changer in the management of prostate cancer. 68Ga PSMA PET/CT scan is advanced and a promising radioligand has high sensitivity in determining lesions of prostate cancer with a high tumor to background ratio. The most common areas of metastasis are the bone and pelvic lymph nodes. The prognosis of prostate cancer is mainly determined by the status of metastases. The presence and the localization of metastases affects treatment planning. In our cases, we presented some examples of uncommon sites of metastases such as the brain, adrenal glands, penis and orbit. Improvements in imaging techniques, such as Ga-68 PSMA PET/CT have led to the possibility to make more determination of rare metastase sites in prostate cancer patients.
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    Baseline SUV Range for Liver and Blood Pool in Patients Undergoing F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography
    Parlak, Y; Göksoy, D; Mütevelizade, G; Gümüser, G; Sayit, E
    Introduction: The aim of the study was to define the baseline SUVmax range in the liver and blood pool of patients undergoing fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging. Methods: Five hundred and thirty-one patients (264 females, 267 males; mean age: 59.6 dagger 13.4 years) who were admitted to our department for PET/CT imaging before treatment were included in the study. Patient preparation, acquisition parameters and reconstruction protocols were standardized for all patients prior to PET/CT imaging. The mean serum glucose levels and mean age of the patients were calculated. These patients were divided into 10 groups as esophagus, stomach, colon, rectum, larynx, lung, breast, endometrium, ovarian cancers and lymphoma. 2D region of interests were plotted to calculate the mean SUV values in the right lobe of the liver and the aortic arch for the blood pool. Results: Normal Gaussian distributions of mean SUV changes for liver and blood pool were obtained. Mean SUVmax and SUVmean values for liver were 2.73 +/- 0.22 and 2.34 +/- 0.16, respectively, and 1.80 +/- 0.2 and 1.57 +/- 0.14 for blood pool, respectively. Conclusion: It was concluded that the obtained SUV ranges may provide ease of application in the clinic in evaluating qualitative tumor response and comparing tumor/background ratios in cancer patients.
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    Contribution of Open Mouth Technique in 18F-FDG PET/CT Imaging in Patients with Malignant Lip Neoplasm
    Mütevelizade, G; Sezgin, C; Parlak, Y; Gümüser, G; Sayit, E
    Objectives: F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays an important role in evaluating head and neck cancers. However, localization and size evaluation in this region can be rough due to the multitude of the anatomic structures and physiologic uptakes. The aim of this study was to evaluate malignant lip lesions with the contribution of open mouth (OM) imaging technique at PET/CT. Methods: Fifty-six patients with malignant lip neoplasm underwent F-18-FDG PET/CT imaging. Each patient was imaged twice as whole-body PET/CT with routine closed mouth (CM) position; and OM head and neck image, standardized with a special device. Lesion maximum standard uptake value (SUVmax), localization, size, and involvement of lymph nodes were evaluated. Results: Lesion localization was correctly detected in 100% of the OM images. Lesion size in PET/CT was compared with clinical, radiological (magnetic resonance imaging and CT) and/or histopathological results and the size measurement was coherent at 47.1% and 95.6% for CM and OM images, respectively. It was observed that OM acquisition did not contribute additionally in detecting regional lymph node metastasis. Forty-one PET/CT scans with CT artifacts due to dental amalgams were evaluated and 46.3% dimensional and 53.7% localization errors were detected in the CM position. There was no statistically significant difference between OM and CM SUVmax (p>0.05). Conclusion: We concluded that additional OM head and neck imaging is useful and necessary to accurately determine the localization and size of the tumor, thus enhancing the value of PET/CT in staging, treatment response assessment, and restaging of patients with malignant lip cancer with or without dental amalgam.
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    Radiation Exposure to Nuclear Medicine Staff Working with Tc99m Radiopharmaceutical
    Hizli, Y; Parlak, Y; Göksoy, D; Mütevelizade, G; Gümüser, G; Sayit, E
    Introduction: Nuclear medicine technologists are potentially exposed to ionizing radiations while performing a variety of tasks associated with nuclear medicine procedures. We measured the external radiation doses for staff members working with Tc-99m radiopharmaceuticals to assess the annual radiation doses. Methods: Radiation doses for a nuclear medicine physician, a technologist, a nurse, a radiopharmacist, and a cleaning staff were measured by digital dosimeters. We measured the radiation exposure of these five people every day for 1 month. The dosimeters were placed at the waist levels on the anterior surfaces of the bodies. Results: After correction of natural background doses, the mean 1-month radiation dose for the physician, technologist, nurse, radiopharmacist, and cleaning staff were determined as 102.37 +/- 15.16 mu Sv, 110.8 +/- 7.5 mu Sv, 84.67 +/- 8.2 mu Sv, 111.8 +/- 7.1 mu Sv, and 106.5 +/- 12.27 mu Sv, respectively. Discussion: This study showed that effective radiation doses for nuclear medicine department staff members were within the permissible level.
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    Aneurysmal Bone Cyst in a patient with McCune-Albright Syndrome
    Aydin, N; Mütevelizade, G; Gümüser, G; Bilgin, ES
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