Browsing by Author "Martin, F"

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    Spelling Changes and Fluorescent Tagging With Prime Editing Vectors for Plants
    Wang, L; Kaya, HB; Zhang, N; Rai, R; Willmann, MR; Carpenter, SCD; Read, AC; Martin, F; Fei, ZJ; Leach, JE; Martin, GB; Bogdanove, AJ
    Prime editing is an adaptation of the CRISPR-Cas system that uses a Cas9(H840A)-reverse transcriptase fusion and a guide RNA amended with template and primer binding site sequences to achieve RNA-templated conversion of the target DNA, allowing specified substitutions, insertions, and deletions. In the first report of prime editing in plants, a variety of edits in rice and wheat were described, including insertions up to 15 bp. Several studies in rice quickly followed, but none reported a larger insertion. Here, we report easy-to-use vectors for prime editing in dicots as well as monocots, their validation in Nicotiana benthamiana, rice, and Arabidopsis, and an insertion of 66 bp that enabled split-GFP fluorescent tagging.
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    Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA2LEN - ARIA Position Paper
    Bousquet, J; Anto, JM; Demoly, P; Schünemann, HJ; Togias, A; Akdis, M; Auffray, C; Bachert, C; Bieber, T; Bousquet, PJ; Carlsen, KH; Casale, TB; Cruz, AA; Keil, T; Carlsen, KCL; Maurer, M; Ohta, K; Papadopoulos, NG; Rodriguez, MR; Samolinski, B; Agache, I; Andrianarisoa, A; Ang, CS; Annesi-Maesano, I; Ballester, F; Baena-Cagnani, CE; Basagaña, X; Bateman, ED; Bel, EH; Bedbrook, A; Beghé, B; Beji, M; Ben Kheder, A; Benet, M; Bennoor, KS; Bergmann, KC; Berrissoul, F; Jensen, CB; Bleecker, ER; Bonini, S; Boner, AL; Boulet, LP; Brightling, CE; Brozek, JL; Bush, A; Busse, WW; Camargos, PAM; Canonica, GW; Carr, W; Cesario, A; Chen, YZ; Chiriac, AM; Costa, DJ; Cox, L; Custovic, A; Dahl, R; Darsow, U; Didi, T; Dolen, WK; Douagui, H; Dubakiene, R; El-Meziane, A; Fonseca, JA; Fokkens, WJ; Fthenou, E; Gamkrelidze, A; Garcia-Aymerich, J; van Wijk, RG; Gimeno-Santos, E; Guerra, S; Haahtela, T; Haddad, H; Hellings, PW; Hellquist-Dahl, B; Hohmann, C; Howarth, P; Hourihane, JO; Humbert, M; Jacquemin, B; Just, J; Kalayci, O; Kaliner, MA; Kauffmann, F; Kerkhof, M; Khayat, G; N'Goran, BK; Kogevinas, M; Koppelman, GH; Kowalski, ML; Kull, I; Kuna, P; Larenas, D; Lavi, I; Le, LT; Lieberman, P; Lipworth, B; Mahboub, B; Makela, MJ; Martin, F; Martinez, FD; Marshall, GD; Mazon, A; Melen, E; Meltzer, EO; Mihaltan, F; Mohammad, Y; Mohammadi, A; Momas, I; Morais-Almeida, M; Mullol, J; Muraro, A; Naclerio, R; Nafti, S; Namazova-Baranova, L; Nawijn, MC; Nyembue, TD; Oddie, S; O'Hehir, RE; Okamoto, Y; Orru, MP; Ozdemir, C; Ouedraogo, GS; Palkonen, S; Panzner, P; Passalacqua, G; Pawankar, R; Pigearias, B; Pin, I; Pinart, M; Pison, C; Popov, TA; Porta, D; Postma, DS; Price, D; Rabe, KF; Ratomaharo, J; Reitamo, S; Rezagui, D; Ring, J; Roberts, R; Roca, J; Rogala, B; Romano, A; Rosado-Pinto, J; Ryan, D; Sanchez-Borges, M; Scadding, GK; Sheikh, A; Simons, FER; Siroux, V; Schmid-Grendelmeier, PD; Smit, HA; Sooronbaev, T; Stein, RT; Sterk, PJ; Sunyer, J; Terreehorst, I; Toskala, E; Tremblay, Y; Valenta, R; Valeyre, D; Vandenplas, O; van Weel, C; Vassilaki, M; Varraso, R; Viegi, G; Wang, DY; Wickman, M; Williams, D; Wöhrl, S; Wright, J; Yorgancioglu, A; Yusuf, OM; Zar, HJ; Zernotti, ME; Zidarn, M; Zhong, N; Zuberbier, T
    Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel
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    Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs
    Bousquet, J; Schünemann, HJ; Samolinski, B; Demoly, P; Baena-Cagnani, CE; Bachert, C; Bonini, S; Boulet, LP; Bousquet, PJ; Brozek, JL; Canonica, GW; Casale, TB; Cruz, AA; Fokkens, WJ; Fonseca, JA; van Wijk, RG; Grouse, L; Haahtela, T; Khaltaev, N; Kuna, P; Lockey, RF; Carlsen, KCL; Mullol, J; Naclerio, R; O'Hehir, RE; Ohta, K; Palkonen, S; Papadopoulos, NG; Passalacqua, G; Pawankar, R; Price, D; Ryan, D; Simons, FER; Togias, A; Williams, D; Yorgancioglu, A; Yusuf, OM; Aberer, W; Adachi, M; Agache, I; Aït-Khaled, N; Akdis, CA; Andrianarisoa, A; Annesi-Maesano, I; Ansotegui, IJ; Baiardini, I; Bateman, ED; Bedbrook, A; Beghé, B; Beji, M; Bel, EH; Ben Kheder, A; Bennoor, KS; Bergmann, KC; Berrissoul, F; Bieber, T; Jensen, CB; Blaiss, MS; Boner, AL; Bouchard, J; Braido, F; Brightling, CE; Bush, A; Caballero, F; Calderon, MA; Calvo, MA; Camargos, PAM; Caraballo, LR; Carlsen, KH; Carr, W; Cepeda, AM; Cesario, A; Chavannes, NH; Chen, YZ; Chiriac, AM; Pérez, TC; Chkhartishvili, E; Ciprandi, G; Costa, DJ; Cox, L; Custovic, A; Dahl, R; Darsow, U; De Blay, F; Deleanu, D; Denburg, JA; Devillier, P; Didi, T; Dokic, D; Dolen, WK; Douagui, H; Dubakiene, R; Durham, SR; Dykewicz, MS; El-Gamal, Y; El-Meziane, A; Emuzyte, R; Fiocchi, A; Fletcher, M; Fukuda, T; Gamkrelidze, A; Gereda, JE; Diaz, SG; Gotua, M; Guzmán, MA; Hellings, PW; Hellquist-Dahl, B; Horak, F; Hourihane, JO; Howarth, P; Humbert, M; Ivancevich, JC; Jackson, C; Just, J; Kalayci, O; Kaliner, MA; Kalyoncu, AF; Keil, T; Keith, PK; Khayat, G; Kim, YY; N'Goran, BK; Koppelman, GH; Kowalski, ML; Kull, I; Kvedariene, V; Larenas-Linnemann, D; Le, LT; Lemière, C; Li, J; Lieberman, P; Lipworth, B; Mahboub, B; Makela, MJ; Martin, F; Marshall, GD; Martinez, FD; Masjedi, MR; Maurer, M; Mavale-Manuel, S; Mazon, A; Melen, E; Meltzer, EO; Mendez, NH; Merk, H; Mihaltan, F; Mohammad, Y; Morais-Almeida, M; Muraro, A; Nafti, S; Namazova-Baranova, L; Nekam, K; Neou, A; Niggemann, B; Nizankowska-Mogilnicka, E; Nyembue, TD; Okamoto, Y; Okubo, K; Orru, MP; Ouedraogo, S; Ozdemir, C; Panzner, P; Pali-Schöll, I; Park, HS; Pigearias, B; Pohl, W; Popov, TA; Postma, DS; Potter, P; Rabe, KF; Ratomaharo, J; Reitamo, S; Ring, J; Roberts, R; Rogala, B; Romano, A; Rodriguez, MR; Rosado-Pinto, J; Rosenwasser, L; Rottem, M; Sanchez-Borges, M; Scadding, GK; Schmid-Grendelmeier, P; Sheikh, A; Sisul, JC; Solé, D; Sooronbaev, T; Spicak, V; Spranger, O; Stein, RT; Stoloff, SW; Sunyer, J; Szczeklik, A; Todo-Bom, A; Toskala, E; Tremblay, Y; Valenta, R; Valero, AL; Valeyre, D; Valiulis, A; Valovirta, E; Van Cauwenberge, P; Vandenplas, O; van Weel, C; Vichyanond, P; Viegi, G; Wang, DY; Wickman, M; Wöhrl, S; Wright, J; Yawn, BP; Yiallouros, PK; Zar, HJ; Zernotti, ME; Zhong, N; Zidarn, M; Zuberbier, T
    Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified ARas mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIAWorld Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children. (J Allergy Clin Immunol 2012;130:1049-62.)