Browsing by Author "Mutevelizade, G"
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Item The effect of sodium iodide symporter protein on ablation success in patients with differentiated thyroid cancerMutevelizade, G; Kocer, NE; Reyhan, MObjective This study aimed to investigate immunohistochemical staining of sodium iodide symporter (NIS) and its effect on response to I-131 therapy in differentiated thyroid carcinoma patients. Methods We evaluated NIS expression, the intracellular distribution of NIS, iodine-131 uptake in residual tissues on post-ablation I-131 whole body scan, and the ablation status after 100 mCi I-131 therapy. We also investigated NIS expression and localization in tumoral paraffin-embedded tissues. Results In this retrospective study, 35 patients (mean age 44.17 +/- 12.9 years, 27 female, 8 male) were studied. Twenty-one of these patients responded to radioiodine therapy, and 14 did not. NIS expression and iodine-131 uptake in residual tissues post-ablation I-131 whole body scan were not statistically significant. When we compared the patients who responded to radioiodine therapy and the poor responder group, NIS expression and iodine-131 uptake in residual tissues did not demonstrate statistically significant difference [(p = 0.308) (p = 0.985) respectively]. 47.6% of the patients in the successful ablation group and 85.7% in the unsuccessful ablation group had intracellular NIS immunostaining. The difference was not statistically significant (p = 0.139). 52.4% of the patients in the successful ablation group and 7% in the unsuccessful ablation group had NIS immunostaining at the basolateral membrane. The difference was statistically significant (p < 0.05). Conclusions In conclusion, we did not find any significant difference between successful and unsuccessful ablation groups in terms of NIS expression; however, we concluded that the intracellular (cytoplasmic) localization of NIS is one of the leading causes of ablation failure regardless of NIS expression in DTC patients.Item The Effect of Sodium Iodine Symporter Protein on Ablation Success in Patients With Differentiated Thyroid CancerMutevelizade, G; Kocer, NE; Reyhan, MItem Predicting Treatment Response in Esophageal Cancer Patients Using 18F FDG PET/CT Texturel Features ParametersMutevelizade, G; Duran, O; Aydin, N; Erdugan, M; Suner, A; Bilgin, ESItem A Comprehensive Analysis of Volumetric 68 Ga-PSMA PET/CT Parameters, Clinical and Histopathologic Features: Evaluation of the Predictive RoleMutevelizade, G; Parlak, Y; Arikbasi, CS; Guemüser, G; Sayit, EObjectives: To evaluate the relationships between volumetric 68 Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/ computed tomography (PET/CT) parameters, Gleason score (GS), prostate-specific antigen (PSA) levels, histopathological data, and metastatic status in newly diagnosed prostate cancer (PCa) patients and to assess the predictive factors for progression despite treatment. Methods: A total of 78 newly diagnosed patients with PCa who had 68 Ga-PSMA PET/CT scans were included. Clinical parameters, histopathological data, and metastatic status were documented, and volumetric parameters of primary prostate lesions were measured. All obtained data were compared statistically. Results: Primary prostate tumor maximum standardized uptake value (SUV max ) and GS were significantly related to serum PSA levels (p<0.05). PSA levels and SUV max values were significantly higher in patients with lymph node metastases than in those without. GS was found to be significantly increased in metastatic patients. PSMA-derived tumor volume (PSMA-TV) and total lesion PSMA of the primary lesion had a significant relationship with PSA value, GS, and regional lymph node metastases. Receiver operating characteristic analysis, conducted in patients with metastatic and localized disease, identified the cutoff value for SUV max as 10.85. According to the results of the logistic regression analysis, PSMA-TV was found to be a predictive factor for progression despite treatment. Conclusion: 68 Ga-PSMA PET/CT remains an invaluable imaging modality that should be considered first in PCa staging because of its superior compatibility with clinical and histopathologic data. The importance of this method goes beyond diagnostic accuracy; it also extends into the predictive domain, where the PSMA-TV value of primary prostate lesions is a potential predictor of treatment efficacy. This information is valuable for personalizing patient treatment, improving prognostic accuracy, and predicting clinical outcomes.Item Splenosis imaging with 99mTc nano-colloid as a different mimicker in a lymphoma patient on 18F-FDG PET/CTSezgin, C; Parlak, Y; Mutevelizade, G; Gumuser, G; Sayit, EFluorodeoxyglucose (FDG) 18F-FDG PET/CT plays an important role in lymphoma staging and evaluation of treatment response. Mimics should be considered when evaluating 18F-FDG PET/CT images to perform correct staging and correct treatment response evaluation. Splenosis is one of the causes that may cause misinterpretation by mixing with lymph nodes in lymphoma patients. In our case report, we visualized splenosis mimicking lymph node in a 50-year-old lymphoma patient with 99mTc nano-colloid scintigraphy.Item Body Mass Index Assessment In PET/CT Imaging PatientsMutevelizade, G; Parlak, Y; Sezgin, C; Sayit, E; Gumuser, GItem Primary pleural synovial sarcoma with diffuse pleural involvement: A case reportMutevelizade, G; Sayit, ESynovial sarcoma (SS) is a mesenchymal tumor which generally affects the soft tissues of the extremities. Primary pleural synovial sarcoma (PPSS) is a very rare and aggressive subtype of SS. A 73-year-old male patient presented with chest-back pain and dyspnea. Hypermetabolic diffuse pleural lesions were detected in 18F-FDG PET/CT performed after pleural nodular thickenings were observed on CT. As the result of the molecular analysis performed in the excisional biopsy, SYT-SSX mutation was detected and the patient was diagnosed as SS. Pazopanib treatment was commenced. We are reporting a very rare case of PPSS with diffuse pleural involvement. @ 2023 Elsevier Masson SAS. All rights reserved.Item The Relationship Between Four Parameters: 68Ga PSMA PET/CT, Gleason Score, PSA Levels and MetastasisSezgin, C; Mutevelizade, G; Parlak, Y; Gumuser, G; Sayit, EItem Effect of Reconstruction Parameters on Lu-177 SPECT ImagingParlak, Y; Goksoy, D; Sezgin, C; Mutevelizade, GItem Contribution of open mouth technique in F-18 FDG PET/CT imaging of patients with malignant lip neoplasmMutevelizade, G; Sezgin, C; Sayit, E; Gumuser, GItem Influence of Arm Movement on Lesion Detection in PET/CT Imaging: Case ReportParlak, Y; Mutevelizade, G; Gumuser, G; Sayit, EArm movement after the CT scan is a common artifact in PET/CT scanning. Motion artifacts may lead to difficulties in interpreting PET/CT images accurately. We report a 66 year old male patient with gastric cancer who underwent PET/CT for primary staging. He had a previous history of papillary thyroid cancer. In PET scan, there were striking cold artifacts at the level of arms. This is a classical sign of an accidental arm motion. A second scan was performed with the arms down due to the history of papillary thyroid cancer. The results were discussed.Item Inguinoscrotal Bladder Hernia Mimicking Testicle TumorSezgin, C; Duzgun, F; Mutevelizade, G; Gumuser, G; Sayit, EBladder hernias usually begin asymptomatically and are discovered incidentally at the time of discovery. Preoperative diagnosis of bladder hernias is important to reduce the risk of bladder injury during surgery. Although F-18 FDG PET/CT is applied for oncological purposes, benign conditions should also be taken into account when evaluating the implants. In this article, a case of bladder hernia, which can be confused with pathological cancer involvement, with the diagnosis of F-18 FDG PET/CT performed in a 73-year-old male patient with renal cell carcinoma is presented.Item Effective half-life, excretion and radiation exposure of 177Lu-PSMAParlak, Y; Mutevelizade, G; Sezgin, C; Goksoy, D; Gumuser, G; Sayit, EThe study aims to evaluate the radiation safety conditions by detecting the patient's urine excretion rate, calculating the effective half-life, and determining the retention of Lu-177-PSMA in the body. Urine samples of patients were collected for 24 hours (6, 12, 18, and 24 hours) following the infusion, excretion rate and retention of Lu-177-PSMA in the body of patients were calculated. The measurements of dose rate were performed. Effective half-life calculated from dose rate measurements was found as 18.5 +/- 11 h within the first 24 h and 48.1 +/- 22.8 h between 24 and 72 h. Excreted activity in urine was found as 33.8 +/- 20.7, 40.4 +/- 20.3, 46.1 +/- 22.4, and 53.3 +/- 21.5% of total doses at 6, 12, 18, and 24 h after administration, respectively. External dose rates for 4 h and 24 h were 24.51 mu Sv/h, 16.14 mu Sv/h, respectively. Our results showed that Lu-177-PSMA treatment was suitable for outpatient treatment in terms of radiation safety.Item Evaluation of SUL measurements in 68Ga-DOTATATE PET/ CT ImagingParlak, Y; Mutevelizade, G; Goksoy, D; Gumuser, G; Sayit, EItem Effects on Lesion Detection of Arm Movement in PET/CT Imaging: Case ReportParlak, Y; Mutevelizade, G; Gumuser, F; Sayit, EItem An Innovative Approach with Ga-68 PSMA PET/CT: The PRIMARY Scoring SystemAydin, N; Mutevelizade, G; Bozdemir, BC; Bilgin, ESItem Innovative Approaches in Prostate Cancer Management: The Efficacy of Ga-68 PSMA PET/CT in Detecting Bone MetastasesBozdemir, B; Mutevelizade, G; Aydin, N; Gumuser, G; Bilgin, ESItem How the Correction of Data Entry Errors Effect F18-FDG PET/CT ImagesParlak, Y; Goksoy, D; Mutevelizade, G; Sayit, E; Gumuser, FItem 18F-FDG PET/CT in the Presence of Truncation Artifacts, A Phantom StudyParlak, Y; Goksoy, D; Yesil, F; Mutevelizade, G; Gumuser, F; Sayit, EItem Retrospective correction of false data entry on the PET/CT ImagingParlak, Y; Goksoy, D; Mutevelizade, G; Gumuser, F; Sayit, E