Browsing by Author "Mutlu F."

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    Comparison of blood brain barrier permeability in normal and ovariectomized female rats that demonstrate right or left paw preference
    (2012) Kutlu N.; Mutlu F.; Vural K.; Cezayirli E.
    We explored the relations among paw preference, cerebral asymmetry and asymmetrical disruption of blood-brain barrier (BBB) permeability in normal and ovariectomized female rats with known paw preference. A high dose of pentylenetetrazol was used to disrupt the BBB and induce acute hypertension. To determine the areas of macroscopic infarct, samples were stained with 2,3,5-triphenyltetrazolium chloride. Histological staining techniques were used to show the areas of infarct microscopically on paraffin sections. Sixty-two percent of the rats demonstrated right paw preference, 24% demonstrated left paw preference and 14% were ambidextrous. Areas of infarct, which indicated destruction of the BBB, were determined microscopically and macroscopically in rats that demonstrated right and left paw preference. We found a relation between permeability of the BBB and paw preference. There may be a relation between paw preference, cerebral asymmetry and asymmetrical destruction of the BBB in rats. Asymmetrical destruction of the BBB in experimental rats was similar to the control group, which had asymmetrically disrupted BBB with respect to paw preference. Like the control rats, asymmetrical areas of infarct consistent with cerebral asymmetry were observed in ovariectomized rats. © 2012 The Biological Stain Commission.
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    Distribution of paw preference in female and male rats: Assessed by a modified version food-reachıng test; [Erkek ve dişi sıçanlarda modifiye besine uzanma test yöntemi ile pençe tercih daǧılımı]
    (Veteriner Fakultesi Dergisi, 2012) Kutlu N.; Bayazit T.O.; Mutlu F.
    We re-studied the distribution of paw preference in male and female rats using a new food-reaching test. Paw preference was assessed using a modified new version of food reaching task in quadrupedal position. Of the total sample (N=165). Of 165 rats, 86 (52.12%) were right-handed, 72 (43.64%) were left-handed, and 7 (4.24%) were mixed-handed. Of the in male (N=74) 36 (48.65%) were right-handed, 35 (47.30%) were left-handed, and 3 (4.05%) were mixed-handed. The right-minus left paw reaches fitted to gaussian data with two prominent peaks due to right-and left preference. In female (N=91) 50 (54.94%) were right-handed, 37 (40.66%) were left-handed, and 4 (4.40%) were mixed-handed. The female right-preference showed a right-bais compared to males. The males left-preference were more than female left-preference.The distribution of right minus left paw reach was not U-shaped, it was J-shaped like in humans. The results indicate that the distribution of paw preference in rats is similar to that of other animals and to human handedness. It was concluded that there is a right-bias in paw rats, which is caused by the female right-preference under the influence of a biological factor. The right-pawed males were found to be least lateralized than the male left-preference, and female right-and left preference. The brain is in general more lateralized than the female brain.