Browsing by Author "Ocal, R"

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    The effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma
    Ocal, FCA; Kesici, GG; Gurgen, SG; Ocal, R; Erbek, S
    Objective To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma. Methods Twenty-eight rats were divided into four groups: noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups. Results In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma. Conclusion Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment.
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    Eating attitudes of migraine patients in Turkey: a prospective multi-center study
    Ocal, R; Karakurum-Goksel, B; Van, M; Coskun, O; Karaaslan, C; Ucler, S; Gokcay, F; Celebisoy, N; Sirin, H; Ak, AK; Saritas, AS; Sirin, TC; Bayir, BRH; Ekizoglu, E; Orhan, EK; Bayram, D; Tanik, N; Bicakci, S; Ozturk, V; Inan, LE; Metin, KM; Eren, Y; Dora, B; Oguz-Akarsu, E; Karli, N; Celik, EU; Atalar, AC; Celik, RGG; Mutluay, B; Aydinlar, EI; Dikmen, PY; Semercioglu, S; Emre, U; Buldukoglu, OC; Er, B; Kilboz, BB; Ibis, S; Yagiz, S; Koklu, H; Kamaci, I; Aliyeva, G; Ates, BE; Kara, MM; Altunc, FZ; Kaya, I; Sisman, C
    Background Migraine is a disease characterized by headache attacks. The disease is multifactorial in etiology and genetic and environmental factors play role in pathogenesis. Migraine can also be accompanied by psychiatric disorders like neurotism and obsessive compulsive disorder. Stress, hormonal changes and certain food intake can trigger attacks in migraine. Previous studies showed that eating attitudes and disorders are prevalant in patients with migraine. Eating disorders are psychiatric disorders related to abnormal eating habits. Both migraine and eating disorders are common in young women and personality profiles of these patient groups are also similar. A possible relationship which shows that migraine and eating habits are related can lead to a better understanding of disease pathogenesis and subsequently new therapeutic options on both entities. Association of migraine in relation to severity, depression and anxiety and eating habits and disorders were aimed to be investigated in this study.Methods The study was designed as a prospective, multi-center, case control study. Twenty-one centers from Turkey was involved in the study. The gathered data was collected and evaluated at a single designated center. From a pool of 1200 migraine patients and 958 healthy control group, two groups as patient group and study group was created with PS matching method in relation to age, body-mass index, marital status and employment status. Eating Attitudes Test-26 (EAT-26), Beck's Depression Inventory (BDI) and Beck's Anxiety Inventory (BAI) were applied to both study groups. The data gathered was compared between two groups.Results EAT-26 scores and the requirement for referral to a psychiatrist due to symptoms related to eating disorder were both statistically significantly higher in patient group compared to control group (p = 0.034 and p = 0.0001 respectively). Patients with migraine had higher scores in both BDI and BAI compared to control group (p = 0.0001 and p = 0.0001 respectively). Severity of pain or frequency of attacks were not found to be related to eating attitudes (r:0.09, p = 0.055).Conclusions Migraine patients were found to have higher EAT-26, BDI and BAI scores along with a higher rate of referral to a psychiatrist due to symptoms. Results of the study showed that eating habits are altered in migraine patients with higher risk of eating disorders. Depression and anxiety are also found to be common amongst migraine patients.