Browsing by Author "Oguz, A"

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    Study of heavy metal pollution and speciation in Buyak Menderes and Gediz river sediments
    Akcay, H; Oguz, A; Karapire, C
    In this study, two economically important rivers of Turkey, Gediz and Buyuk Menderes (BM) are studied to determine their environmental pollution levels. An old analytical procedure involving sequential chemical extraction is improved and used for the partitioning of particulate trace metals (Cu, Co, Cr, Mn, Fe, Zn, Pb and Ni). Cationic and anionic Mn and Cr species with different phases are also determined by-using leaching, extraction and ion exchange speciation processes. The sediment samples are analysed using graphic-furnace atomic absorption spectroscopy and differential pulse anodic stripping voltammeter: Experimental results obtained on five replicate samples of fluvial bottom surface sediments at the sampling points demonstrate that the relative standard deviation of the sequential extraction procedure is generally better than +/-10%. The accuracy, determined by comparing total metal concentrations with the sum of the five sequential chemical extractions, is proved to be satisfactory. The detection limits established for three standard deviations of blank for different metals are identical and found to be 0.1 mg/kg for sediment samples and 1 ppb for water samples. The results show that the pollution levels are significant especially for Pb, Cr, Mn and Zn in the Gediz river and Co, Mn, and Zn in the BM river. Comparison between our results and the measurements outlined before industralization and the beginning of the intensive pesticide applications in agricultural fields (In: Broekaert et al., editors, Metal speciation in the environment, vol. 23. 1989. p. 601-11; A research on the environmental pollution in the agricultual fields and watering in the Aegean region, Ege University Research Project, No. 127 1988 (in Turkish); DSI Water Analyses Report, Ankara, 1985 (in Turkish)) show that the pollution in these rivers is probably originated from industrial, agricultural and domestic waste discharges. (C) 2002 Elsevier Science Ltd. All rights reserved.
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    Impact of telephonic interviews on persistence and daily adherence to insulin treatment in insulin-naive type 2 diabetes patients: dropout study
    Yavuz, DG; Bilen, H; Sancak, S; Garip, T; Hekimsoy, Z; Sahin, I; Yilmaz, M; Aydin, H; Atmaca, A; Sert, M; Karakaya, P; Arpaci, D; Oguz, A; Guvener, N
    Objective: The objective of this study is to evaluate the impact of sequential telephonic interviews on treatment persistence and daily adherence to insulin injections among insulin-naive type 2 diabetes patients initiated on different insulin regimens in a 3-month period. Methods: A total of 1,456 insulin-naive patients with type 2 diabetes (mean [standard deviation, SD] age: 56.0 [12.0] years, 49.1% were females) initiated on insulin therapy and consecutively randomized to sequential (n=733) and single (n=723) telephonic interview groups were included. Data on insulin treatment and self-reported blood glucose values were obtained via telephone interview. Logistic regression analysis was performed for factors predicting increased likelihood of persistence and skipping an injection. Results: Overall, 76.8% patients (83.2% in sequential vs 70.3% in single interview group, (P<0.001) remained on insulin treatment at the third month. Significantly higher rate for skipping doses was noted in basal bolus than in other regimens (27.0% vs 15.0% for premixed and 15.8% basal insulin, respectively, P<0.0001). Logistic regression analysis revealed sequential telephonic interview (odds ratio [OR], 1.531; 95% confidence interval [CI], 1.093-2.143; P=0.013), higher hemoglobin A1c levels (OR, 1.090; 95% CI, 0.999-1.189; P=0.049), and less negative appraisal of insulin therapy as significant predictors of higher persistence. Basal bolus regimen (OR, 1.583; 95% CI, 1.011-2.479; P=0.045) and higher hemoglobin A1c levels (OR, 1.114; 95% CI, 1.028-1.207; P=0.008) were the significant predictors of increased likelihood of skipping an injection. Conclusion: Our findings revealed positive influence of sequential telephonic interview, although including no intervention in treatment, on achieving better treatment persistence in type 2 diabetes patients initiating insulin.
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    Adherence to insulin treatment in insulin naive type 2 diabetic patients: results of telephonic intervention
    Yavuz, DG; Bilen, H; Sancak, S; Galip, T; Hekimsoy, Z; Sahin, I; Yilmaz, M; Aydin, H; Atmaca, A; Sert, M; Karakaya, P; Arpaci, D; Oguz, A; Guvener, N
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    33 Questions about Triglycerides and Cardiovascular Effects: Expert Answers
    Çetinkalp, S; Koylan, N; Özer, N; Onat, A; Özgen, AG; Koldas, ZL; Güven, GS; Özdogan, Ö; Karsidag, K; Yigit, Z; Kayikçioglu, M; Tokgözoglu, L; Can, LH; Tartan, Z; Kültürsay, H; Karpuz, B; Kirilmaz, B; Ersanli, M; Ural, D; Erbakan, AN; Oguz, A; Kayikçioglu, ÖR; Temizhan, A; Sansoy, V; Ceyhan, C; Öngen, Z; Bayram, F; Örem, C; Sönmez, A; Beyaz, S; Ükinç, K; Yürekli, BS; Çoker, M; Canda, E; Simsir, IY
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    Effectiveness and Safety of Initiation and Titration of Insulin Glargine 300 U/mL in Insulin-Naive Patients with Type 2 Diabetes Mellitus Uncontrolled on Oral Antidiabetic Drug Treatment in Turkey: The EASE Study
    Çetinarslan, B; Çetinkalp, S; Kaya, A; Ersoy, C; Kebapçi, N; Çömlekçi, A; Tütüncü, NB; Deyneli, O; Oguz, A; Ilkova, H; Yilmaz, T; Hekimsoy, Z; Ünübol, M; Balci, MK; Atmaca, A; Dagdelen, S; Yetkin, I; Güler, S; Ötünç, G; Özhan, L
    Objective: The aim of the study was to evaluate the effectiveness and safety of insulin glargine 300 U/ mL (Gla-300) in insulin-naive patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drug (OADs) treatment in Turkey. Methods: One hundred eight patients from 20 centers enrolled in the study. Starting from baseline, Gla-300 was self-administered subcutaneously and once daily in the evening. The primary outcome was the mean change in glycated hemoglobin A1c (HbA1c) from baseline to week 24. Results: The mean (+/- SD) Hb1Ac level of 9.4% (+/- 0.8) at baseline decreased to 7.5% (+/- 0.9) at week 12 (P < .1) and to 7.3% (+/- 0.9) at week 24 (P < .1). Although none of the patients were within the target Hb1Ac level of <= 7% at baseline, the percentage of patients who achieved the target Hb1Ac level was 30.4% at week 12 and increased to 42.9% at week 24. Gla-300 treatment achieved the Hb1Ac target in 21 (19.4%) patients without experiencing a hypoglycemic event and in 27 (25.0%) patients who experienced at least one hypoglycemic event. For each self-monitoring blood glucose time point, significant improvements were observed as compared to baseline (P < .001). Statistically significant improvement (P < .001) was seen in the treatment satisfaction questionnaire - status version scores between baseline and week 24. Conclusion: This study indicated that Gla-300 is effective to provide a successful glycemic control with low risk of hypoglycemia added to OADs in insulin-naive patients with T2DM, and it has the potential to improve the quality of life of patients.