Browsing by Author "Olgun N."

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    Delayed renal excretion of methotrexate after a severe anaphylactic reaction to methotrexate in a child with osteosarcoma
    (2009) Ozguven A.A.; Uysal K.; Gunes D.; Koroglu T.; Gurcu O.; Olgun N.
    Although methotrexate is an agent widely used in the practice of pediatric oncology, allergic reactions to methotrexate are most unusual. Most of these reactions typically occur after repeated administration. Here, we report a severe anaphylactoid reaction to the first dose of high-dose methotrexate infusion in a child with osteosarcoma who has also experienced a delayed excretion of methotrexate. Clinicians must be aware of the possibility of a systemic, near-fatal anaphylactic reactions with methotrexate and patients who experience severe anaphylactic reactions should be followed carefully because of the possibility of delayed methotrexate excretion. © 2009 Lippincott Williams & Wilkins Inc.
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    Successful use of inhaled steroids for the management of radiation pneumonitis in an infant: Case repot; [Radyasyon pnömonisinin tedavisinde i̇nhale steroidlerin bir süt çocuǧunda başarı ile kullanımı]
    (Turkiye Klinikleri, 2010) Mutafoǧlu Uysal K.; Uzuner N.; Çetingöz R.; Özgüven A.A.; Babayiǧit A.; Ölmez D.; Güneş D.; Olgun N.
    Radiation pneumonitis and subsequent pulmonary fibrosis are among the serious complications of thoracic irradiation and can have severe implications on patients' quality of life. Systemic corticosteroids are commonly used agents to treat radiation pneumonitis. However, the potential adverse effects of systemic corticosteroids, particularly in growing children, are consid-erable. An infant with lung metastatic Ewing sarcoma developed severe radiation pneumonitis following chemoradiotherapy. Systemic prednisolone was started first. However, due to the prolonged need for corticosteroid therapy, inhaled budesonide was administered with reduced systemic corticosteroid dose in an attempt to avoid the adverse effects of systemic corticosteroid treatment. The treatment was then continued exclusively with budesonide with a good clinical response. To our knowledge, this is the first pediatric case reported to benefit from inhaled steroids for severe radiation pneumonitis. This response suggested that inhaled steroids might serve as a adjunct or even an alternative to systemic corticosteroids in radiation pneumonitis. © 2010 by Türkiye Klinikleri.
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    Cross-sectional study: Long term follow-up care for pediatric cancer survivors in a developing country, turkey: Current status, challenges, and future perspectives
    (Turkiye Klinikleri, 2020) İncesoy Özdemir S.; Taçyildiz N.; Varan A.; Kebudi R.; Zülfikar B.; Celkan T.; Şahin G.; Çorapçioğlu F.; Keskin Yildirim Z.; Pinarli F.G.; Olgun N.; Sari N.; Dağdemir A.; Özyörük D.; Eren T.; Çakir F.B.; Adakli Aksoy B.; Bozkurt C.; Güler E.; Özgüven A.A.; Erbey F.; Berber M.; Dinçaslan H.; Ünal E.; Kantar M.
    Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at the pediatric oncology outpatient clinic. Of these centers, 17 (80.9%) reported difficulty in transition from the pediatric clinic to the adult clinic, 14 (66.6%) reported insufficient care providers, and 12 (57.1%) reported insufficient time and transportation problems. As neglected late effects, 16 (76.1%) centers reported psychosocial and getty job problems and 11 (52.3%) reported sexual and cognitive problems. None of the centers had their own LTFU guidelines for their daily LTFU practice. Conclusion: This study was the first to gain an overview of the needs of POCs and the gaps in survivorship services in Turkey. The results from this study will help to develop a national health care system and national guidelines for pediatric cancer survivors. © TÜBİTAK.