Browsing by Author "Onaǧ A."

Now showing 1 - 7 of 7
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    Should children with infection be tested for lipid, lipoprotein and apolipoprotein?
    (1998) Işcan A.; Yiǧitoǧlu R.; Onaǧ A.; Vurgun N.; Ari Z.; Ertan P.; Şengil A.Z.
    The lipid profile is known to alter in patients with infection, but there has not been a study of the apolipoprotein levels in serum of otherwise healthy children during infection. Lipids, lipoproteins, apolipoproteins A-1 and B and lipoprotein (a) were evaluated prospectively in 31 consecutive children, aged 4-15 years, who were admitted to the hospital with bacterial pharyngitis. The degree of dyslipidemia associated with bacterial pharyngitis was assessed using each child as his/her own control and by comparison with 79 healthy children who had not had an infection during the past 3 months. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-1 and apolipoprotein B levels were significantly decreased during the symptomatic phase of the disease, whereas the serum triglyceride level was slightly elevated. Serum lipoprotein (a) concentration did not change significantly. In conclusion, it is suggested that serum lipids, lipoproteins and apolipoproteins should not be assessed during infection because of the possible transient changes of these parameters during infection or inflammation.
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    Environmental exposure to cadmium and lead in the pediatric age group
    (1998) Onaǧ A.; Oksel F.; Taneli B.; Hakerlerler H.
    Lead additives in automotive fuel, smog from a nearby industrial center warranted an investigation on cadmium and lead in Manisa, a city of tabacco processing. Hundred and one children were screened in view of lead and cadmium exposure. In 23 children between the ages of 0-2 years the mean (±SEM) serum lead level was 7.15 ± 0.10 μg/dl, in 28 between the ages of 3-6 years was 7.20 ± 0.10 μg/dl and in 50 between the ages of 7-15 years was 7.20 ± 0.10 μg/dl, respectively, with no significant differences. Serum cadmium levels in the same groups of children was 0.066 ± 0.008 ng/ml, 0.078 ± 0.008 ng/ml 0.088 ± 0.006 ng/ml, respectively. The difference in cadmium levels between the age groups of 0-2 years and 7-15 years was significant (p<0.038). This significant increase in blood cadmium level is also shown by simple linear regression analysis: Cadmium (ng/ml) = 0.049 + 0.005 (age), and p<0.0001, F Ratio = 50.578, coefficient of correlation = 0.581. Our study revealed that lead is not a serious environmental contaminant for children, yet; however, the increasing trend seen in exposure to cadmium warrants serious consideration and urgant preventive measures.
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    The use of intermittant dose azithromycin in children with sinusitis; [Çocukluk çaǧinda akut si̇nüzi̇t tedavi̇si̇nde i̇ntermi̇ttant doz azi̇tromi̇si̇n kullanimi]
    (2001) Yüksel H.; Coşkun Ş.; Demir E.; Ikizoǧlu T.; Yilmaz D.; Onaǧ A.; Tanaç R.
    Aim: Antibiotic selection and the duration of its use are two of the most important factors that affect the prognosis of children with sinusitis. New effective antibiotherapy strategies with higher dose and short usage interval in children with sinusitis are needed because compliance to drug usage is difficult in childhood. In this study we aimed to compare 'single dose intermittent usage' of azithromycin (AZT) therapy and 'two doses per day for 15 days usage' of amoxisilin-clavunate (AMK) in the treatment of children with acute maxillary sinusitis. Material and Method: Sixty-one children diagnosed as having maxillary sinusitis (between 5 and 14 years old) were enrolled into study. Twenty-nine children were treated using single daily dose of AZT for five days. After a treatment- free period for 5 days, the drug was readministered for five days. Thirty-two children were treated using two doses of AMK for fifteen days. Clinical signs, symptom scores of sinusitis and compliance to the therapy were followed up for two weeks. Results: At the end of the first week, the mean symptom score of the AZT group was significantly lower than that of the AMK group (p<0.05). Although it was lower in AZT group, the symptom scores at the end of the second week were not significantly different between the two groups. Recovery rate from sinusitis was 93% in the AZT and 91% in the AMK group. Seven percent of the AZT group patients failed to use the total recommended dose and also 3% stopped the therapy earlier. In the AMK group, these were 24% and 15% respectively, and the difference between two groups was statistically significant (p<0.05). Satisfaction from using the drug was significantly higher in the AZT group than the AMK group. Conclusion: The therapy regimen with a single dose - intermittant usage of AZT for five days is as effective as two doses of AMK therapy for fifteen days. Furthermore, it was shown that intermittant dose AZT reduced symptom scores of sinusitis earlier. Thus, an intermittant dose of AZT recommendation may be a new, more compliant and effective therapy regiment in the treatment of children with sinusitis.
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    Evaluation of the location of the anus by a modified technique in the neonate
    (2002) Genç A.; Taneli C.; Tansuǧ N.; Kasirga E.; Yilmaz D.; Küçükoǧlu T.; Onaǧ A.
    Purpose: The aim of the current study was to bring to notice the anterior displacement of the anus and to recommend the measurement of anal position index in the neonate by a modified method. Methods: Sixty newborns (34 girls and 26 boys) were taken into study, and the anal position index (API), which is the ratio of anus-fourchette (scrotum) distance to coccyx fourchette (scrotum) distance, was measured. To obtain the measurement, a transparent adhesive tape was placed along the midline on the long axis, covering the anus. The upper and lower tips and the center of the anal circle was marked and measured using a caliber. Results: API was found as 0.46 (SD ± 0.08) and 0.53 (SD ± 0.05) in female and male neonates, respectively. Because an index of 0.34 in girls and 0.46 in boys are considered abnormal, the 3 female babies in the study group with API indices of 0.18, 0.28, and 0.33 were subjected to further examination. The abnormality was seen not to be rare in the Aegean region. Conclusions: An abnormal index alone cannot be the sole cause of constipation mentioned in the literature and therefore not an indication for operation. Anal position index in the neonates could be measured more accurately by the current modified method. If an anterior location of the anus is found early in infancy the baby should undergo follow-up accordingly. © 2002 Elsevier Science Ltd. All rights reserved.
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    Serological levels of zinc, copper and iron elements among Giardia lamblia infected children in turkey
    (2002) Ertan P.; Yereli K.; Kurt Ö.; Balcioǧlu I.C.; Onaǧ A.
    Background: Giardiasis, an intestinal protozoan infection caused by Giardia lamblia, is common in Turkey, especially among children aged between 2- and 14-years-old. Effects of giardiasis on serological levels of zinc, copper and iron elements were assessed in this study. Methods: A total of 45 children, aged between 2- and 14-years-old, who were admitted to the Pediatrics Department of Celal Bayar University Medical School with gastrointestinal complaints and diagnosed as having giardiasis by stool examinations in the Parasitology Department, were enrolled as the study group (SG). The control group (CG) consisted of 45 age-matched healthy children. Serological levels of zinc, copper and iron were measured by atomic absorption spectrophotometer in all samples. Results: As a result of the study, serum zinc levels were 67.43 ± 17.72 μg/dL and 145.20 ± 9.13 μg/dL, copper levels were 198.45 ± 39.14 μg/dL and 150 ± 21.14 μg/dL and iron levels were 87.98 ± 18.31 μg/dL and 160.45 ± 45.40 μg/dL, in SG and CG, respectively. When compared separately as SG and CG, there was a statistically significant difference between the serological levels of all these elements. Conclusion: These results revealed that giardiasis increased the serological levels of copper, like other infectious agents. However, zinc and iron levels decreased during giardiasis due to malabsorption.
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    Increased transaminase levels coexistent with pseudo-obstruction; [Çölyak hastaliǧinda transaminaz yüksekliǧi ile psödo-obstrüksiyonun birlikteliǧi]
    (2003) Polat M.; Kasirga E.; Ersoy B.; Abay I.; Onaǧ A.
    Celiac disease is an intestinal reaction towards gluten which causes a defect in the digestive system. Although celiac disease presents with typical malabsorption symptoms, it can also cause atypical gastrointestinal system symptoms (discomfort). Among case reports in the literature related with atypical celiac disease, there has been no celiac disease case who presented with pseudo-obstruction and increased liver enzymes. In this paper, we report a nine-year-old celiac patient who presented with pseudo-obstruction symptoms and increased aminotransferase level.
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    A child with cervical Castleman's disease mimicking nasofaringeal carcinoma: Case report; [Nazofarenks karsinomunu taklit eden servikal Castleman hastaliǧi tanili bir çocuk olgu]
    (2010) Neşe N.; Özgüven A.A.; Onaǧ A.; Yücetürk A.V.
    Castleman's disease (CD) is an uncommon benign disease that causes progressive lymph node enlargement. Most observations of CD have focused on adult patients and it rarely occurs in children. It usually arises as a solitary mass and is commonly found in the mediastinum and abdomen and less commonly in the head, neck and axilla.The diagnosis of CD is histopathological. We report a child of CD in the neck region who also had a mass at the nasopharenx mimicking nasofaringeal carcinoma and review the published child cases with CD that involved neck region. This report emphasizes that CD should be considered in the differential diagnosis of children presented with neck mass. Copyright © 2010 by Türkiye Klinikleri.