Browsing by Author "Oncu-Oner T."

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Meta-analysis of the relationship between Toxoplasma gondii and schizophrenia
    (Polish Parasitological Society, 2022) Oncu-Oner T.; Can S.
    Toxoplasma gondii (T. gondii), which is an obligate intracellular protozoan parasite, could infect a wide range of hosts including humans. It infects approximately one-third of the entire human population. Infection with T. gondii can lead similar psychotic symptoms of schizophrenia. Starting from this information, numerous studies have revealed that maternal, acute and chronic T. gondii infections predispose to schizophrenia. The aim of this work was to evaluate the relationship between T. gondii and schizophrenia with a meta-analysis study using current data. 112 studies were reached using PubMed, Google Scholar and Council of Higher Education (YÖ̈K) Thesis Center databases. 15 studies which included a proportion of seropositive schizophrenia patients and controls were further examined in a meta-analysis. Among these studies, 13 of them showed a positive association between higher anti-T. gondii IgG level and patients with schizophrenia in the experimental groups whereas the remaining 2 studies showed a negative correlation. According to the random effects model, it was seen lower limit of 0.180 and upper limit of 0.490 with a standard error of 0.279 and a 95% confidence interval. The average effect size value was calculated as 0.335. This result having positive average effect size indicated that there was a positive association between T. gondii infection with a higher IgG level and the presence of schizophrenia. © 2022 Polish Parasitological Society.
  • No Thumbnail Available
    Item
    Exploring genetic diversity and population structure of a large grapevine (Vitis vinifera L.) germplasm collection in Türkiye
    (Frontiers Media S.A., 2023) Kaya H.B.; Dilli Y.; Oncu-Oner T.; Ünal A.
    Grapevine (Vitis Vinifera L.) has been one of the significant perennial crops in widespread temperate climate regions since its domestication around 6000 years ago. Grapevine and its products, particularly wine, table grapes, and raisins, have significant economic importance not only in grapevine-growing countries but also worldwide. Grapevine cultivation in Türkiye dates back to ancient times, and Anatolia is considered one of the main grapevine migration routes around the Mediterranean basin. Turkish germplasm collection, conserved at the Turkish Viticulture Research Institutes, includes cultivars and wild relatives mainly collected in Türkiye, breeding lines, rootstock varieties, and mutants, but also cultivars of international origin. Genotyping with high-throughput markers enables the investigation of genetic diversity, population structure, and linkage disequilibrium, which are crucial for applying genomic-assisted breeding. Here, we present the results of a high-throughput genotyping-by-sequencing (GBS) study of 341 genotypes from grapevine germplasm collection at Manisa Viticulture Research Institute. A total of 272,962 high-quality single nucleotide polymorphisms (SNP) markers on the nineteen chromosomes were identified using genotyping-by-sequencing (GBS) technology. The high‐density coverage of SNPs resulted in an average of 14,366 markers per chromosome, an average polymorphism information content (PIC) value of 0.23 and an expected heterozygosity (He) value of 0.28 indicating the genetic diversity within 341 genotypes. LD decayed very fast when r2 was between 0.45 and 0.2 and became flat when r2 was 0.05. The average LD decay for the entire genome was 30 kb when r2 = 0.2. The PCA and structure analysis did not distinguish the grapevine genotypes based on different origins, highlighting the occurrence of gene flow and a high amount of admixture. Analysis of molecular variance (AMOVA) results indicated a high level of genetic differentiation within populations, while variation among populations was extremely low. This study provides comprehensive information on the genetic diversity and population structure of Turkish grapevine genotypes. Copyright © 2023 Kaya, Dilli, Oncu-Oner and Ünal.
  • No Thumbnail Available
    Item
    COVID-19 in early 2023: Structure, replication mechanism, variants of SARS-CoV-2, diagnostic tests, and vaccine & drug development studies
    (John Wiley and Sons Inc, 2023) Polatoğlu I.; Oncu-Oner T.; Dalman I.; Ozdogan S.
    Coronavirus Disease-19 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome-coronaviruses-2 (SARS-CoV-2), a highly pathogenic and transmissible coronavirus. Most cases of COVID-19 have mild to moderate symptoms, including cough, fever, myalgias, and headache. On the other hand, this coronavirus can lead to severe complications and death in some cases. Therefore, vaccination is the most effective tool to prevent and eradicate COVID-19 disease. Also, rapid and effective diagnostic tests are critical in identifying cases of COVID-19. The COVID-19 pandemic has a dynamic structure on the agenda and contains up-to-date developments. This article has comprehensively discussed the most up-to-date pandemic situation since it first appeared. For the first time, not only the structure, replication mechanism, and variants of SARS-CoV-2 (Alpha, Beta, Gamma, Omicron, Delta, Epsilon, Kappa, Mu, Eta, Zeta, Theta, lota, Lambda) but also all the details of the pandemic, such as how it came out, how it spread, current cases, what precautions should be taken, prevention strategies, the vaccines produced, the tests developed, and the drugs used are reviewed in every aspect. Herein, the comparison of diagnostic tests for SARS-CoV-2 in terms of procedure, accuracy, cost, and time has been presented. The mechanism, safety, efficacy, and effectiveness of COVID-19 vaccines against SARS-CoV-2 variants have been evaluated. Drug studies, therapeutic targets, various immunomodulators, and antiviral molecules applied to patients with COVID-19 have been reviewed. © 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.
  • No Thumbnail Available
    Item
    Algae in Biomedicine
    (Springer, 2024) Inam A.; Oncu-Oner T.; Deniz I.
    Algae, which live in marine or freshwater, are photosynthetic organisms. They vary greatly in size, morphology, and degree of complexity of their body structures. Algae are generally divided into two main groups, microalgae, which are small in size, and macroalgae, which are larger in size. These aquatic organisms have rich and valuable compounds including sterols, polysaccharides, pigments, fatty acids, proteins, enzymes, minerals, and vitamins that could be used in different application fields due to their bioactive functions. In recent years, algae and their components have attracted interest in biomedicine and health applications as their bioactive components could show antioxidant, anticancer, anti-inflammatory, antiviral, antiangiogenic, antidiabetic, antiobesity, immunostimulatory, vaccine adjuvant, and hypolipidemic activities. In this chapter, these activities and bioactive components underlying these properties are reviewed. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.