Browsing by Author "Oytun, MG"

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    Contribution of complete response to treatment to survival in patients with unresectable metastatic colorectal cancer: A retrospective analysis
    Bulut, G; Oytun, MG; Almuradova, E; Harman, M; Uslu, R; Karabulut, B
    Background The aim of the study is to reveal the contribution of complete response (CR) to treatment to overall survival (OS) in patients with unresectable metastatic colorectal cancer. In addition, to evaluate progression-free survival (PFS) in patients who attained CR to treatment and to examine the clinicopathologic features of the patient group with CR. Methods This article is a retrospective chart review. Patients diagnosed with metastatic colorectal cancer were divided into two groups. The systemic treatment was compared with the patients who received a full response according to the Response Evaluation Criteria in Solid Tumors (RECIST1.1) and those who did not attain CR (progression partial response and stable response) in terms of both PFS and OS data, and the effect of attaining CR to treatment on prognosis was evaluated. Results A total of 222 patients were included in the study. 202 of 222 patients could be evaluated in terms of complete response. All data from their files were tabulated and analyzed retrospectively. The mean age of diagnosis of the study group was 60.13 12.52 years. The total number of patients who attained CR to treatment was 31 (15.3%); 171 (84.6%) patients did not attain CR. Patients who had a CR had longer median PFS times than patients who did not have a CR (15.2 vs. 7.4 months, P<0.001). Patients who had CR had longer median survival times than patients who did not have a CR (39.2 vs. 16.9 months, P<0.001). In subgroup patients who underwent primary surgery, the number of patients who attained CR was statistically higher compared with the number of patients who did not attain CR (p<0.001). Complete response was less common in the presence of liver metastasis and bone metastasis (p = 0.041 and p = 0.046, respectively), had a negative prognostic effect. In other words, 89.1% of patients with liver metastasis, 100.0% of patients with bone metastasis, and 88.7% of those who died did not have a CR to the treatment. According to multivariate analysis, CR to treatment, primary surgery, first-line chemotherapy (combination compared with fluoropyrimidine), and no bone metastasis were found to be predictors for OS. Conclusion Providing CR with systemic treatment in patients with unresectable metastatic colorectal cancer (mCRC) contributes to prognosis. The primary resection in our secondary acquisitions from the study, the number of metastatic regions and the combination therapy regimens also contributed to the prognosis.
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    Best Practice Recommendations for Geriatric Dysphagia Management with 5 Ws and 1H
    Umay, E; Eyigor, S; Bahat, G; Halil, M; Giray, E; Unsal, P; Unlu, Z; Tikiz, C; Vural, M; Cincin, AT; Bengisu, S; Gurcay, E; Keseroglu, K; Aydeniz, B; Karaca, EC; Karaca, B; Yalcin, A; Ozsurekci, C; Seyidoglu, D; Yilmaz, O; Alicura, S; Tokgoz, S; Selcuk, B; Sen, EI; Karahan, AY; Yaliman, A; Ozkok, S; Ilhan, B; Oytun, MG; Ozturk, ZA; Akin, S; Yavuz, B; Akaltun, MS; Sari, A; Inanir, M; Bilgilisoy, M; Çaliskan, Z; Saylam, G; Ozer, T; Eren, Y; Bicakli, DH; Keskin, D; Ulger, Z; Demirhan, A; Calik, Y; Saka, B; Yigman, ZA; Ozturk, EA
    Background: Dysphagia is a geriatric syndrome. Changes in the whole body that occur with aging also affect swallowing functions and cause presbyphagia. This condition may progress to oropharyngeal and/or esophageal dysphagia in the presence of secondary causes that increase in incidence with aging. However, no study has been published that provides recommendations for use in clinical practice that addresses in detail all aspects of the management of dysphagia in geriatric individuals. This study aimed to answer almost all potential questions and problems in the management of geriatric dysphagia in clinical practice. Methods: A multidisciplinary team created this recommendation guide using the seven-step and three-round modified Delphi method via e-mail. The study included 39 experts from 29 centers in 14 cities. Results: Based on the 5W and 1H method, we developed 216 detailed recommendations for older adults from the perspective of different disciplines dealing with older people. Conclusion: This consensus-based recommendation is a useful guide to address practical clinical questions in the diagnosis, rehabilitation, and follow-up for the management of geriatric dysphagia and also contains detailed commentary on these issues.