Browsing by Author "Ozcan I."

Now showing 1 - 5 of 5
  • No Thumbnail Available
    Item
    The effects of different intensity walking programs on serum blood lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2 in premenopausal women; [Effets de programmes de marche de différentes intensités sur les lipides sériques, la protéine C réactive ultrasensible et la phospholipase A2 associée à une lipoprotéine chez des femmes pre]
    (2010) Buyukyazi G.; Ulman C.; Taneli F.; Esen H.; Gozlukaya F.; Ozcan I.; Tikiz H.
    Aim: This study examined the effects of 12 weeks of walking programs on serum lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2. Methods: Twenty-six pre-menopausal women (30-49 years) completed 12 weeks of walking programs either at moderate or high intensity (50-55%, 70-75% maximum heart rate reserve, respectively). Estimated maximal oxygen consumption was assessed with a 2-km walking test; body composition, blood lipids, high-sensitive C-reactive protein, and lipoprotein-associated phospholipase A2 were measured before and after the study. Results: Maximal oxygen consumption increased, favoring high-intensity group; body weights, percent body fat (p<0.01) and body mass index (p<0.05) decreased in both exercise groups. There were no significant changes in the measured blood lipids in any of the groups, except for a significant reduction in low-density lipoprotein-cholesterol in high-intensity group (p<0.05). High-sensitive C-reactive protein and lipoprotein-associated phospholipase A2 levels reduced significantly in high-intensity (p<0.01) and moderate-intensity (p<0.05) groups, which were also different from the changes in the control group. Conclusion: Walking programs with different intensity result in favorable changes; however, for protective effects against cardiovascular diseases, high-intensity walking may be advised due to greater reductions in low-density lipoprotein-cholesterol, and high-sensitive C-reactive protein and lipoprotein-associated phospholipase A2. © 2010 Elsevier Masson SAS.
  • No Thumbnail Available
    Item
    The protective role of thymoquinone in the prevention of gentamicin ototoxicity
    (W.B. Saunders, 2014) Sagit M.; Korkmaz F.; Gürgen S.G.; Kaya M.; Akcadag A.; Ozcan I.
    Objective To investigate the potential protective effect of thymoquinone in gentamicin-induced ototoxicity through auditory brain stem responses (ABR) testing and histomorphological evaluation of the cochlea.; Methods This study was conducted on 48 adult female Sprague-Dawley rats that were randomized into 4 groups. Group 1 received intraperitoneal gentamicin; group 2 received intraperitoneal gentamicin plus corn oil solution; group 3 received intraperitoneal thymoquinone; and group 4 received intraperitoneal gentamicin plus thymoquinone. All groups received the drugs (once daily) in the above-mentioned protocols over 15 days. After conducting repeated ABR measurements, the rats were sacrificed, and their cochleae were isolated.; Results ABR thresholds were preserved in the gentamicin plus thymoquinone group when compared with the group receiving gentamicin alone. There were fewer TUNEL-positive cells and caspase-3 and caspase-9 expressions were weaker in the inner and outer hairy cells of the organ of Corti in the gentamicin plus thymoquinone group compared with the group receiving gentamicin alone.; Conclusion The ABR values and number of apoptotic cells did not significantly increase in the group receiving gentamicin plus thymoquinone when compared to the group receiving gentamicin alone. Again, the cochlear histomorphological findings were supportive of the auditory findings. In light of these findings, we conclude that gentamicin-induced ototoxicity may be prevented by thymoquinone use in rats. © 2014 Elsevier Inc.
  • No Thumbnail Available
    Item
    Quercetine attenuates the gentamicin-induced ototoxicity in a rat model
    (Elsevier Ireland Ltd, 2015) Sagit M.; Korkmaz F.; Gürgen S.G.; Gundogdu R.; Akcadag A.; Ozcan I.
    Objectives: The aim of this study is to evaluate the protective role of quercetin in gentamicin-induced ototoxicity through an auditory brainstem response (ABR) test and a histopathological evaluation of the cochlea. Methods: In this study, 48 female adult Sprague-Dawley rats aged 20-22 weeks and weighing 200-250. g were used. An ABR test was carried out on all rats prior to drug administration, after which, the rats were divided into four groups of 12 animals each. Drug administration was gentamicin 120. mg/kg plus ethanol in group one gentamicin 120. mg/kg plus quercetin 15. mg/kg in group two; quercetin 15. mg/kg in group three; and ethanol in group four. The drugs were administered intraperitoneally once a day for two weeks, and the ABR test was repeated after drug administration. Subsequently, the rats were sacrificed and their cochleae were dissected and examined histopathologically. Results: There was no significant difference between the pre-treatment ABR measurement values of the groups. However, a significant increase was detected in the ABR values in the group of rats that were administered gentamicin plus ethanol, while no statistically significant increase was found in the ABR values in the groups administered with gentamicin plus quercetin; quercetin alone and ethanol alone. The number of TUNEL positive cells in the inner and outer hair cells in the Corti organ was found to be fewer, and Caspase 3 and 9 expressions were found to be weaker in the group receiving gentamicin plus quercetin than in the group receiving gentamicin plus ethanol. Conclusions: Auditory function was detected to be significantly protected and apoptotic cells were found to be decreased when quercetin was administered together with gentamicin. From these results it was concluded that quercetin, a powerful antioxidant, attenuates ABR thresholds and histopathological lesions in the cochlea in gentamicin-induced ototoxicity in rats. © 2015 Elsevier Ireland Ltd.
  • No Thumbnail Available
    Item
    Protective role of lycopene in experımental allergic rhinitis in rats
    (Elsevier Ireland Ltd, 2021) Polat H.; Sagıt M.; Gurgen S.G.; Yasar M.; Ozcan I.
    Objective: We investigate whether lycopene has a protective effect in an experimental rat model of allergic rhinitis. Methods: Experimental animals (65 rats) were randomized to 7 groups (Sham-Control, Lycopene 10 mg/kg/day, Lycopene 20 mg/kg/day, Intranasal lycopene drops, Intranasal steroid, Corn oil, Allergic Rhinitis). Rats were sensitized by administering of ovalbumin intraperitoneally and intranasally. In addition to ovalbumin; lycopene, corn oil and steroids were given to the relevant groups. Nasal symptom scores of the rats were recorded throughout the study. At end of the study, after intracardiac blood sample collection, all rats were sacrificed, and nasal tissues were examined histopathologically. Serum total immunoglobulin E (IgE) and ovalbumin (OVA) specific IgE were studied from all rats before and after the study. Results: There was a statistically significant increase (p < 0.05) in OVA specific IgE values measured before and after the study in all groups except the sham group. In serum total IgE values; there was a statistically significant increase after treatment in allergic rhinitis, corn oil, lycopene 10 mg and intranasal lycopene drops group, but other groups did not show any significant change. Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) expression found that lycopene suppresses inflammation with both nasal administration and increased dose. Nasal symptom scores were observed to decrease significantly in all lycopene and steroid groups compared to allergic rihinits and corn groups. Conclusion: It was determined that lycopene were effective in the treatment of allergic rhinitis, and this effect was found to be stronger with increasing doses of lycopene. © 2021 Elsevier B.V.
  • No Thumbnail Available
    Item
    Investigating the physical and quality characteristics and rheology of mayonnaise containing aquafaba as an egg substitute
    (Elsevier Ltd, 2023) Ozcan I.; Ozyigit E.; Erkoc S.; Tavman S.; Kumcuoglu S.
    This paper aimed to examine the effect of using aquafaba in different ratios (25%, 50%, 75%, 100%) as an egg yolk substitute on the physical, structural, and rheological properties of mayonnaise. Large amplitude oscillatory shear analysis (LAOS) parameters (ηL′, ηM′, G'L, G'M, e3, e1, v3, v1) were evaluated to determine the rheological properties of mayonnaise samples. The droplet size of samples significantly increased and the stability of the emulsion decreased after 50% substitution ratio. The density of mayonnaise significantly increased with increased aquafaba substitution. According to Lissajous curves, egg yolk substitution with aquafaba leads to a decrease in stress values. Aquafaba affected the microstructure of samples and decreased the dissipated and stored energies. The LAOS parameters showed that the sample's behavior is strain stiffening and shear thinning in the nonlinear region. Textural parameters decreased with increased ratio of aquafaba. Significant differences were observed for L*, a*, b* and ΔE values. © 2022 Elsevier Ltd