Browsing by Author "Ozdemir, A"
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Item INTEGRAL CHARACTERIZATIONS FOR TIMELIKE AND SPACELIKE CURVES ON THE LORENTZIAN SPHERE S13Kazaz, M; Ugurlu, HH; Ozdemir, AV. Dannon showed that spherical curves in E-4 can be given by Frenet-like equations, and he then gave an integral characterization for spherical curves in E-4. In this paper, Lorentzian spherical timelike and spacelike curves in the space time are shown to be given by Frenet-like equations of timelike and spacelike curves in the Euclidean space E-3 and the Minkowski 3-space R-1(3). Thus, finding an integral characterization for a Lorentzian spherical R-1(4)-timelike and spacelike curve is identical to finding it for E-3 curves and R-1(3)-timelike and spacelike curves. In the case of E-3 curves, the integral characterization coincides with Dannon's. Let {T, N, B} be the moving Frenet frame along the curve alpha(s) in the Minkowski space R-1(3). Let alpha(s) be a unit speed C-4-timelike (or spacelike) curve in R-1(3) so that alpha(s) = T. Then, alpha(s) is a Frenet curve with curvature kappa(s) and torsion tau(s) if and only if there are constant vectors a and b so that (i) T'(s)= kappa(s){acos xi(s)+bsin xi(s) + integral(s)(0) cos[xi(s)-xi(delta)]T(delta)kappa(delta)d delta}, T is timelike, (ii) T'(s) = kappa(s) {ae(xi) + be(-xi) + integral(s)(0) cosh (xi(delta)T(delta)kappa(delta)d delta} N is timelike, where xi(s)= integral(s)(0)tau(delta)d delta.Item Performance Evaluation of Learning Styles Based on Fuzzy Logic Inference SystemOzdemir, A; Alaybeyoglu, A; Mulayim, N; Balbal, KFDetermining best convenient learning style in accordance with the individual's capabilities and personalities is very important for learning rapidly, easily, and in high quality. When it is thought that each individual has different personality and ability, it can be recognized that each individual's best convenient learning style will be different. Because of the importance of lifelong learning, many methods and approaches have been developed to determine learning styles of the individuals. In this study, a rule based fuzzy logic inference system is developed to determine best convenient learning styles of the engineering faculty stuffs and the students. During studies, two different learning style models namely Honey&Mumford and McCarthy are used in implementations. This study is carried out with a total number of 60 and 26 engineering faculty students and stuffs, respectively. The personal information form and Learning Style Preference Survey of Honey&Mumford and McCarthy are used to collect the data which are analyzed using the techniques of frequency, percentage, mean, standard deviation, and t-test. While Honey&Mumford learning style classifies engineering faculty students and stuffs as Activist, Reflector, Theorist, and Pragmatist; McCarthy learning style classifies them as Innovative, Analytic, Common Sense, and Dynamic. Gender, age, and department are selected as the metrics for evaluation of the system performance. (C) 2016 Wiley Periodicals, IncItem NUMERICAL COMPARISON OF ANATOMICAL FEATURES IN SOME ALLIUM L.Ozdemir, A; Ozdemir, CIn this study, the anatomical features of some members of the Allium L. (A. karsianum Fomin, A. kunthianum Vved., A. rupestre Steven, Allium armenum Boiss. Et Kotschy and Allium djimilense Boiss. Ex Rege) were compared numerically. The values produced by analysis of the root, stem and leaf anatomical characters are compared both with one another and with those produced by analysis of all characters. The results showed that investigated species also could be distinguished from each other not only by their morphological features but numerical anatomical characters as well.Item Immunolocalization of ERK1/2 and p-AKT in normal endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer and their prognostic significance in malignant groupGungorduk, K; Ertas, IE; Sahbaz, A; Ozvural, S; Sarica, Y; Ozdemir, A; Sayhan, S; Gokcu, M; Yilmaz, B; Sanci, M; Inan, S; Harma, M; Yildirim, YObjective: To analyze the expression patterns of extracellular signal-regulated kinase (ERK1/2) and phosphorylated (p)-AKT in the tissues of non-pathologic endometrium, endometrial hyperplasia, and early and advanced stage endometrioid endometrial adenocancer using indirect immunohistochemistry, and also to investigate the effect of ERK1/2 and p-ART expression patterns on prognosis in endometrioid adenocancer. Study design: Immunolocalization of ERK1/2 and p-Ala was examined in six different types of endometrial tissues: proliferative endometrium (PE; n = 10, 11.2%), secretuar endometrium (SE; n = 10, 11.2%), simple hyperplasia (SH; n = 15,16.9%), complex hyperplasia (CH; n=3, 3.4%) and atypical complex hyperplasia (ACH; n = 10, 11.2%), which were obtained from endometrial biopsies, curettage materials, and hysterectomy specimens and classified as the benign group; and both early stage endometrioid (n = 21, 23.6%) and advanced stage endometrioid adenocancer (AC; n=20, 22.5%), which were obtained from complete surgical staging materials and classified as the malignant group. All specimens were fixed in 10% formalin and processed using routine paraffin protocols. Immunostaining intensities were evaluated as negative or weak (assigned as low expression) and moderate or strong (assigned as high expression). Results: In the malignant group, 23 of 41 patients (56.1%) had high ERK1/2 and p-AKT expression, whereas only three of 48 patients in the benign group (6.3%) had high ERK1/2 and p-ART expression (P < 0.0001 and P < 0.0001, respectively), p-ART expression was significantly higher in women with positive lymph nodes (OR 9.0; 95% CI: 1.2-100.0; P = 0.03). Higher expression of p-Ala was significantly associated with poor progression-free survival (PFS) and overall survival (OS). In contrast, ERK1/2 expression was not associated with PFS or OS. Conclusions ERK1/2 and p-ART can be useful in the differential diagnosis of benign vs. malignant endometrial lesions, as well as early vs. advanced stage endometrioid endometrial adenocancer. Additionally, higher p-ART expression could be used as a marker of poor prognosis in the management of patients with endometrioid endometrial adenocancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Item Luminescence characteristics of Al-and Ca-doped BeO obtained via a sol-gel methodAltunal, V; Guckan, V; Ozdemir, A; Can, N; Yegingil, ZBeO, BeO:Al-1%, BeO:Ca-1%, and BeO:Al-1%, Ca-0.1% ceramics were synthesized by the sol-gel method. The X-ray luminescence was studied, and broad emission peaks located at 230 nm (similar to 5.4 eV) and 300 nm (similar to 4.1 eV) were observed. We investigated thermoluminescence peaks contributing to optically stimulated luminescence (OSL) signals for the ceramics. The thermal quenching of the OSL signals was evaluated, and the quenching energies were estimated as between approximately 0.5 eV and approximately 0.7 eV. To check the feasibility for dosimetry purposes, the dose response, reusability, and dark storage fading of the OSL signals were investigated. The dose response was observed to be linear between 0.1 and 100 Gy. The minimum detectable doses of BeO, BeO:Al-1%, BeO:Ca-1%, and BeO:Al-1%, Ca-0.1% were estimated as approximately 0.9 mGy, approximately 4 mGy, approximately 0.5 mGy, and approximately 0.5 mGy, respectively. Very good reusability was observed over ten cycles, with a maximum deviation of 2%. The results obtained from BeO:Al-1%, Ca-0.1% could be useful for OSL dosimetry, particularly in medical applications.Item Lymphovascular space invasion and cervical stromal invasion are independent risk factors for nodal metastasis in endometrioid endometrial cancerSolmaz, U; Mat, E; Dereli, M; Turan, V; Gungorduk, K; Hasdemir, P; Tosun, G; Dogan, A; Ozdemir, A; Adiyeke, M; Sanci, MAimsThe purpose of this study was to investigate the potential roles of pathological variables in the prediction of nodal metastasis in women with endometrioid endometrial cancer (EC). Materials and MethodsWomen who underwent surgery for endometrioid EC between 1995 and 2012 were retrospectively reviewed. Those who underwent prior neoadjuvant chemotherapy or radiotherapy and inadequate lymphadenectomy as well as those with nonendometrioid histology, synchronous cancers, International Federation of Gynecology and Obstetrics stage IV disease, gross uterine serosal and/or gross adnexal involvement were excluded. Lymph node dissemination was defined as occurring in the following circumstances: (i) when nodal metastasis with pelvic and/or para-aortic (P/PA) lymph node dissection (LND) was performed or (ii) when there was recurrence in the P/PA lymph nodes after a negative LND or when LND was not performed. Univariate and multivariate logistic regression models were used to identify the pathological predictors of lymphatic dissemination. ResultsA total of 827 women with endometrioid EC were assessed; 516 (62.4%) of whom underwent P/PA LND and 205 (24.8%) underwent P LND. Sixty-seven (13%) women in the P/PA LND group and 5 (2.4%) in the P LND group had positive lymph nodes. Multivariate analysis confirmed cervical stromal invasion (OR 4.04, 95% CI 2.02-8.07 (P<0.001)) and lymphovascular space invasion (LVSI) (OR 110.18, 95% CI 38.43-315.87 (P<0.001)) as independent predictors of lymphatic dissemination. ConclusionCervical stromal invasion and LVSI are highly associated with LN metastasis. These markers may serve as a surrogate for nodal metastasis.Item Mobile devices use in analyzing the engineering students attitude towards programming by using a fuzzy logic techniqueOzdemir, A; Balbal, KF; Senel, BCThe aim of this study is to use mobile devices in the determination of engineering students' attitudes towards programming by using a fuzzy logic technique. First of all, a mobile game that is played by engineering students is developed to make learning programming more enjoyable. After that, the proposed fuzzy logic-based attitude determination system which runs on mobile devices comes into play. Student answers and gives points between 1 and 5 to the survey questions which are presented by the developed mobile application. These points are first evaluated in the fuzzification step by using membership functions and then the fuzzied input is given to the rule base step. To get crisp output value, fuzzied output is defuzzified at the last step of the fuzzy logic-based system. Hence the attitude of the student towards programming is inferenced. The developed system is carried out with 100 first-grade students of the software engineering department. Frequency, mean, standard deviation, normality, t test, and analysis of variance (ANOVA) analyses are performed with the obtained data. Results show that the proposed fuzzy logic-based system performs much better than the classical approach. As a result of Article Reliability Analysis of the Attitude Scale Towards Mobile Learning, the scale is found highly reliable. A significant difference is found in favor of fuzzy logic-based attitude score among classical logic-based attitude scores as a result of the paired-samples t test. The results of t test and ANOVA tests according to gender, mother, and father education levels are found not statistically significant.Item MATHEMATICAL MINIMAL SURFACES IN MICROMORPHOLOGICAL STRUCTURES OF PLANTSOzdemir, AIn this study, we determined that some micro morphological structures of plants have a mathematical minimal of surfaces. Minimal surfaces arc defined as surfaces with zero mean curvature. A minimal surface parametrized as x = (u,v,h (u, v)) therefore satisfies Lagrange's equation , (1 + h(v)(2))h(uu) - 2h(u)h(v)h(uv) + (1 + h(u)(2))h(vy) = 0. One of the microscopic structures with a mathematically minimal surface examined in the study is glandular hairs. The glandular hairs are aromatic and often used as herbs, spices, folk medicines and fragrances thanks to their secretions, One of the other microscopic structures with a mathematically minimal surfaces examined is the tracheal elements, which are characterized by the formation of lignified cell wall. They serve for upward conduction of water and dissolved minerals in plants. One of the main objectives of the study is to provide concrete examples by showing minimal surfaces, which are the subject of geometry, in the microscopic structures that cannot be seen with the naked eye of plants, Thus, it is extracted from the theoretical form of mathematical formulas and showing concrete examples in nature,Item GEOMETRIC MODELING AND STATISTICAL COMPARISON OF SOME SAGE GLANDULAR HAIRSOzdemir, AIn this study, we give a geometric description of glandular hairs of some sage which are aromatic and often used as herbs, spices, folk medicines and fragrances thanks to their glandular hairs. Glandular hairs are divided into different types according to geometric shape of the head cells. In the present study we have shown that the glandular hairs of the sage are considered a certain part of surface of revolution about a plane curve alpha(t) = (f(t), g(t)) and alpha: f(y, z) = c. To draw these kind of surfaces we type into the Maple plotting command. The head part of glandular hairs of 18 Salvia L. taxa tried to be defined geometrically and numerical data obtained from anatomical studies were evaluated statistically to compare the examined taxa with each other. The results from numerical and geometrically analysis of the geometric shape of head cell provides a different point of view, therefore creates a new comparing opportunity for the future researchs on the related subjects.Item Fuzzy logic based performance analysis of educational mobile game for engineering studentsOzdemir, A; Balbal, KFThe aim of this study is to examine the effect of an educational android mobile game on the attitude of engineering students. For this purpose, an educational mobile game is developed and a fuzzy logic based attitude determination system is modeled. The study is carried out with 30 students of mechatronic engineering. A mobile game which is called Select Box-Solve Question has been developed in the android studio environment. Besides this; to analyse the performance of the game on the success of education, a fuzzy logic-based attitude determination system, which consists of four number of inputs and outputs, is modeled. These input and output values constitute the factors of the attitude scale. The Triangular Membership Function is used as the Fuzzification step of the Fuzzy Logic Technique. Four different defuzzification methods are used and the results of these methods are compared and analysed.Item Characterization and some fundamental features of Optically Stimulated Luminescence measurements of silver activated lithium tetraborateOzdemir, A; Altunal, V; Guckan, V; Can, N; Kurt, K; Yegingil, I; Yegingil, ZA new lithium tetraborate (Li2B4O7 or abbreviated as LTB) material was produced by adding various concentrations of Ag impurities to allow better luminescent properties using the solution combustion synthesis (SCS) method. The formation of single phase LTB was confirmed using X-ray Diffraction (XRD) data and Scanning Electron Microscopy (SEM) analysis indicated the existence of a tetragonal crystalline domain. Two broad band emissions located at similar to 272 nm (near UV region) and 526 nm (green region) were observed from room temperature photoluminescence (PL) under 205 nm excitation The synthesized material consisted of polycrystalline LTB with 1 wt% Ag (abbreviated herein as LTB: Ag) exhibits considerable thermoluminescence (TL) and Optically Stimulated Luminescence (OSL) which is several times more sensitive to beta radiation than the other concentrations attempted. It was determined that the OSL signal has been a collection of three component signals. A step-preheating procedure to investigate the depth of the trapping centers associated with the OSL signal was carried out. We suggest that the TL peak at 200 degrees C mainly contributes to the OSL signal. It was observed that the total OSL area shows a linear dose response for beta doses ranging from 1 to 100 Gy. The minimum detectable dose (MDD) value was found to be around 3 mGy using the total OSL area. Under optimum conditions (irradiation with beta-rays), the reproducibility of total OSL area was determined with a - 3% deviation at the end of the 9th irradiation-blue light stimulation-readout cycle. The dark storage stability of the total OSL signals was investigated and fading of the total OSL area was found to be approximately 25% after one week. The trap depth corresponding to the OSL signal was found to be 0.99 eV and 0.94 eV using various heating rate and isothermal annealing methods, respectively. Finally, silver doped lithium tetraborate is shown to have promise as an optically stimulated luminescent dosimeter, particularly in medical and personal applications.Item A New Dynamic External Fixation Method in Finger Replantations and Toe-To-Hand TransfersYildiz, K; Kerem, H; Karaaltin, MV; Erdem, A; Ozdemir, A; Ergun, SS; Guneren, EObjective: This study presents a simple and versatile finger fixation method facilitating rehabilitation in the early period and better functional results in replantation and toe-to-hand transfer patients. Methods: In 12 patients, bone fixations were performed by using a dynamic external finger fixator system. The duration of fixations was recorded. The potential complications, such as non-union, pain, joint stiffness, infection of pins, inadequate stabilization, and swelling, were documented. Subjective pain scale was applied on each patient, and the level of satisfaction of patients was examined. Results: All finger transfers and replantations were achieved. The mean time of bone fixation was 11.6 minutes (9 to 20 min.). Nonunion associated with fixation and infection did not occur. Whereas 8 patients were satisfied with the functional results, 3 replantation cases and 1 toe-to-hand transfer patient were dissatisfied. In the assessment of the appearance of the finger, 2 replantation cases and 4 toe-to-hand transfer patients (50% of all cases) were dissatisfied. Conclusion: We are convinced that this dynamic external fixation system, including versatile advantages, such as arranging earlier finger motion, having a simple and quick learning process, reducing the operation time, being able to be used as contributing material in anastomosis, and having fewer complications, can be successfully used in replantations and toe-to-hand transfers.Item Optically Stimulated Luminescence (OSL) dosimetric properties of Li2B4O7:Ag,Gd and its relationship with thermoluminescence (TL) glow-curvesOzdemir, A; Can, N; Kurt, K; Yegingil, ZThe aim of this work was to develop a new lithium tetraborate luminophore with impurities that are strong co-activators for Optically Stimulated Luminescence (OSL) and to investigate its dosimetric properties using OSL method. Li2B4O7:Ag,Gd phosphor consisting of polycrystalline powder was synthesized using Solution Combustion Synthesis method. The structural characterization of the synthesized phosphor was performed using X-Ray Diffraction (XRD) and Scanning Electron Microscope (SEM) methods. OSL dosimetry properties as a function of step-annealing procedure, radiation dose response, reproducibility of response and loss of stored signal in dark were investigated. Thermoluminescence (TL) glow curve of Li2B4O7:Ag,Gd phosphor consists of two separated glow peaks located at similar to 80 and similar to 210 degrees C with a heating rate of 2 degrees C/s. The traps responsible for these two TL peaks in Li2B4O7:Ag,Gd phosphor were found to be optically sensitive. Li2B4O7:Ag,Gd exhibits high OSL sensitivity and a good OSL signal reproducibility to ionizing radiation. The beta dose-response was performed in the range from 0.1 Gy to 500 Gy. The time-integrated total OSL signal intensity increases linearly with increasing dose from -6 Gy to 500 Gy. The minimum detectable dose was found to be -17.1 +/- 0.9 mu Gy. The stored energy increased -6 % within 4 weeks following a strong fading value of 27 % of the initial OSL intensity after 24 h. Indeed, the X-ray Luminescence (XL) emission spectra are the characteristic of the expected f-f transitions. Luminescence spectrum of Gd doped Li2B4O7 exhibits major red emissions (590 nm, 607 nm, 621 nm) and a weak blue emission (450 nm) along with the emission bands from undoped Li2B4O7. These results strongly suggest that the luminescence properties of Li2B4O7:Ag,Gd deserves more attention as possible dosimeter material. Explanations of many TL/OSL phenomena observed in the study of Li2B4O7:Ag,Gd phosphor and improvements based on the better knowledge in the mechanism of TL/OSL in Li2B4O7:Ag,Gd, a boron-based compound were achieved by this study. (C) 2018 Published by Elsevier B.V.Item Caffeine use in preterm neonates: national insights into Turkish NICU practicesUnal, S; Beken, S; Ince, DA; Turan, O; Toygar, AK; Ecevit, A; Akcan, AB; Akin, MA; Aktas, S; Ciftdemir, NA; Altuncu, E; Altunhan, H; Arcagok, BC; Armangil, D; Ozer, EA; Aydin, B; Bezirganoglu, H; Bilgin, L; Calisici, E; Calkavur, S; Celik, K; Celik, Y; Cetinkaya, B; Cetinkaya, M; Demirel, A; Demirel, G; Dogan, NN; Dogan, P; Durukan, M; Engur, D; Ercan, TE; Gokmen, Z; Varal, IG; Gulasi, S; Gunlemez, A; Gursoy, T; Toptan, HH; Hamitoglu, S; Isleyen, F; Iyigun, I; Kader, S; Kahvecioglu, D; Kayki, G; Kostu, M; Kurnaz, D; Mammadaliyev, T; Akin, IM; Narli, N; Okulu, E; Okur, N; Olukman, O; Ovali, F; Ozcan, B; Ozdemir, A; Ozdemir, O; Ozkan, H; Sandal, G; Sarici, D; Sivrikaya, C; Bilgin, BS; Sundus, S; Onay, OS; Simsek, H; Tandircioglu, UA; Tanriverdi, S; Tekgunduz, KS; Terek, D; Tunc, G; Tunc, T; Tutak, E; Tufekcioglu, E; Erdogan, FT; Ulu, E; Isik, DU; Uras, N; Uslu, SI; Unal, I; Yilmaz, FH; Moniri, AObjective: Caffeine is a proven medication used for the prevention and treatment of apnea in premature infants, offering both short- and long-term benefits. International guidelines provide a range of recommendations regarding the preterm population eligible for caffeine prophylaxis, including the timing, dosage, and duration of treatment. Our national guidelines, published prior to the most recent updates of the international guidelines, recommend the use of caffeine citrate starting from the first day after delivery for preterm infants with a gestational age of <28 weeks. For infants up to 32 weeks, if positive pressure ventilation is required, the decision should be made on an individual basis. This study aims to describe the variability in caffeine usage across neonatal intensive care units in our country. Methods: An online survey was sent to neonatologist who are members of the Turkish Neonatology Society to describe the variability in caffeine usage in neonatal intensive care units in our country. Results: We collected responses from 74 units. Prophylactic caffeine usage was observed as; GA <= 27(6/7): 98.6%, GA 28(0/7)-28(6/7): 89.0%, GA 29(0/7)-29(6/7): 75.3%, GA 30(0/7)-31(6/7): 53.4%. 62.2% of units reported administering loading dose within the first two hours. The initial maintenance dose was 5 mg/kg in 64.8% of units, 10 mg/kg in 32.4% of units, and intermediate dose in 5.3% of units. 47.3% of units reported no routine dose adjustment. The postmenstrual age that caffeine treatment was stopped was found to be 34 (min-max; 32-36) weeks for infants without apnea and respiratory support, 36 (min-max; 34-52) weeks for infants without apnea but any respiratory support. The time to discharge after treatment cessation was found as; 1-4 days: 37.8%, 5-7 days: 68.9%. Among the 56 units with multiple responsible physicians, 32.1% reported intra-unit variations. Conclusion: The significant differences in caffeine usage characteristics between and within units highlight the need for clear recommendations provided by standardized guidelines.Item Geographical barriers to timely diagnosis of cystic fibrosis and anxiety level of parents during newborn screening in TurkeyGokdemir, Y; Eyuboglu, TS; Emiralioglu, N; Er, B; Sen, V; Pekcan, S; Ergenekon, AP; Hizal, MG; Eryilmaz, S; Kose, M; Hangul, M; Cakir, E; Cokugras, H; Kilinc, AA; Sasihuseyinoglu, AS; Altintas, DU; Gulen, F; Eski, A; Bingol, A; Ozdemir, A; Topal, E; Gursoy, TR; Girit, S; Ay, P; Yilmaz, OBackground Despite the availability of cystic fibrosis (CF) screening countrywide, diagnostic delay is still a crucial issue. The objectives of this study were to explore the stages of the NBS process, determine the risk factors associated with diagnostic delay and evaluate parent anxiety and experience throughout the process. Methods This is a multicenter cross-sectional study. A questionnaire was completed by parents of newborns diagnosed with CF via NBS in 17 centers. Socio-demographic characteristics, parent knowledge and experiences related to NBS, sweat test availability in the region of residence, and time to the definitive CF diagnosis were assessed through this questionnaire. Parents' anxiety levels were evaluated through the State-Trait Anxiety Inventory scales 1 and 2. Delayed diagnosis (DD) was defined as a definite CF diagnosis beyond the 8th week of life. Predictors of delayed CF diagnosis were evaluated by univariate and multivariate analysis. Results A total of 220 CF patients diagnosed via NBS were enrolled; 82 (37.3%) babies had DD. Multivariable analysis indicated that residence in the Southeast Anatolia region of Turkey (OR = 10.79, 95% CI = 2.37-49.2) was associated with a higher incidence of DD compared with other regions in Turkey. Of the total, 216 (98.1%) of the caregivers regarded the NBS program as useful and 180 (82%) reported high anxiety levels. Conclusion The organization of newborn screening should take into account regional and socio-cultural characteristics to improve the early diagnosis of CF and also reduce the anxiety level of parents.Item Barriers to Timely Diagnosis of Cystic Fibrosis Via Newborn Screening in TurkeyGokdemir, Y; Emiralioglu, N; Sismanlar, T; Er, B; Pekcan, S; Ergenekon, A; Sen, V; Eryilmaz, S; Hizal, MG; Kose, M; Hangul, M; Cakir, E; Cokugras, H; Atabek, A; Sasihuseyinoglu, S; Gulen, F; Bingol, A; Ozdemir, A; Topal, E; Gursoy, TR; Ay, P; Yilmaz, OItem Clinical findings of patients with cystic fibrosis according to newborn screening resultsGursoy, TR; Aslan, AT; Asfuroglu, P; Eyuboglu, TS; Cakir, E; Cobanoglu, N; Pekcan, S; Cinel, G; Dogru, D; Ozcelik, U; Yalcin, E; Sen, V; Ercan, O; Kilinc, AA; Yazan, H; Altintas, DU; Ozturk, GK; Bingol, A; Sapan, N; Celebioglu, E; Tugcu, GD; Ozdemir, A; Harmanci, K; Kose, M; Emiralioglu, N; Tamay, Z; Yuksel, H; Ozcan, G; Topal, E; Can, D; Ekren, PK; Caltepe, G; Kilic, M; Ozdogan, SBackground Cystic fibrosis (CF) is a lethal recessive genetic disease caused by loss of function associated with mutations in the CF trans-membrane conductance regulator. It is highly prevalent (approximately 1 in 3,500) in Caucasians. The aim of this study was to compare demographic and clinical features, diagnostic tests, treatments, and complications of patients with CF whose newborn screening (NBS) with twice-repeated immune reactive trypsinogen testing was positive, normal, and not performed. Methods In this study, 359 of all 1,488 CF patients recorded in the CF Registry of Turkey in 2018, who had been born through the process of NBS, were evaluated. Demographic and clinical features were compared in patients diagnosed with positive NBS (Group 1), normal (Group 2), or without NBS (Group 3). Results In Group 1, there were 299 patients, in Group 2, there were 40 patients, and in Group 3, there were 20 patients. Among all patients, the median age at diagnosis was 0.17 years. The median age at diagnosis was higher in Groups 2 and 3 than in Group 1 (P = 0.001). Fecal elastase results were higher in Group 2 (P = 0.033). The weight z-score was lower and chronic Staphylococcus aureus infection was more common in Group 3 (P = 0.017, P = 0.004, respectively). Conclusions Frequency of growth retardation and chronic S. aureus infection can be reduced with an early diagnosis using NBS. In the presence of clinical suspicion in patients with normal NBS, further analyses such as genetic testing should be performed, especially to prevent missing patients with severe mutations.Item Clinical features and accompanying findings of Pseudo-Bartter Syndrome in cystic fibrosisEyuboglu, TS; Dogru, D; Çakir, E; Cobanoglu, N; Pekcan, S; Cinel, G; Yalçin, E; Kiper, N; Sen, V; Sen, HS; Ercan, O; Keskin, O; Eltan, SB; Alshadfan, L; Yazan, H; Altintas, DU; Sasihuseyinoglu, AS; Sapan, N; Cekic, S; Cokugras, H; Kilinc, AA; Gursoy, TR; Aslan, AT; Bingol, A; Basaran, AE; Ozdemir, A; Kose, M; Hangul, M; Emiralioglu, N; Tugcu, G; Yuksel, H; Yilmaz, O; Orhan, F; Aydin, ZGG; Topal, E; Tamay, Z; Suleyman, A; Can, D; Bal, CM; Caltepe, G; Ozcelik, UBackground Pseudo-Bartter syndrome (PBS) is a rare complication of cystic fibrosis (CF) and there are limited data in the literature about it. We aimed to compare clinical features and accompanying findings of patients with PBS in a large patient population. Methods The data were collected from the Cystic Fibrosis Registry of Turkey where 1170 CF patients were recorded in 2017. Clinical features, diagnostic test results, colonization status, complications, and genetic test results were compared in patients with and without PBS. Results Totally 1170 patients were recorded into the registry in 2017 and 120 (10%) of them had PBS. The mean age of diagnosis and current age of patients were significantly younger and newborn screening positivity was lower in patients with PBS (P < .001). There were no differences between the groups in terms of colonization status, mean z-scores of weight, height, BMI, and mean FEV1 percentage. Types of genetic mutations did not differ between the two groups. Accompanying complications were more frequent in patients without PBS. Conclusion PBS was detected as the most common complication in the registry. It could be due to warm weather conditions of our country. It is usually seen in younger ages regardless of mutation phenotype and it could be a clue for early diagnosis of CF.Item The success of the Cystic Fibrosis Registry of Turkey for improvement of patient careAsfuroglu, P; Eyuboglu, TS; Aslan, AT; Gursoy, TR; Emiralioglu, N; Yalcin, E; Kiper, N; Sen, V; Sen, HS; Altintas, DU; Ozcan, D; Kilinc, AA; Cokugras, H; Baskan, AK; Yazan, H; Erenberk, U; Dogan, G; Unal, G; Yilmaz, AI; Keskin, O; Arik, E; Kucukosmanoglu, E; Irmak, I; Damadoglu, E; Ozturk, GK; Gulen, F; Basaran, AE; Bingol, A; Cekic, S; Sapan, N; Kilic, G; Harmanci, K; Kose, M; Ozdemir, A; Tugcu, GD; Polat, SE; Hangul, M; Ozcan, G; Aydin, ZGG; Yuksel, H; Topal, E; Ozdogan, S; Caltepe, G; Suleyman, A; Can, D; Ekren, PK; Bal, CM; Kilic, M; Cinel, G; Cobanoglu, N; Pekcan, S; Cakir, E; Ozcelik, U; Dogru, DBackground Cystic fibrosis (CF) registries play an essential role in improving disease outcomes of people with CF. This study aimed to evaluate the association of newly established CF registry system in Turkey on follow-up, clinical, growth, treatment, and complications of people with this disease. Methods Age at diagnosis, current age, sex, z-scores of weight, height and body mass index (BMI), neonatal screening results, pulmonary function tests, history of meconium ileus, medications, presence of microorganisms, and follow-up were evaluated and compared to data of people with CF represented in both 2017 and 2019 registry data. Results There were 1170 people with CF in 2017 and 1637 in 2019 CF registry. Eight hundred and fourteen people were registered in both 2017 and 2019 of whom z-scores of heights and BMI were significantly higher in 2019 (p = 0.002, p =0.039, respectively). Inhaled hypertonic saline, bronchodilator, and azithromycin usages were significantly higher in 2019 (p =0.001, p = 0.001, p = 0.003, respectively). The percent predicted of forced expiratory volume in 1 sec and forced vital capacity were similar in 2017 and 2019 (88% and 89.5%, p = 0.248 and 84.5% and 87%, p =0.332, respectively). Liver diseases and osteoporosis were significantly higher, and pseudo-Bartter syndrome (PBS) was significantly lower in 2019 (p = 0.011, p = 0.001, p = 0.001, respectively). Conclusions The z-scores of height and BMI were higher, the use of medications that protect and improve lung functions was higher and incidence of PBS was lower in 2019. It was predicted that registry system increased the care of people with CF regarding their follow-up. The widespread use of national CF registry system across the country may be beneficial for the follow-up of people with CF.