Browsing by Author "Ozdemir C."
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Item The impact of co-morbid conditions on the SF-36: A primary-care-based study among hypertensives(Elsevier Inc., 2005) Aydemir O.; Ozdemir C.; Koroglu E.Background. Comorbidities in hypertension complicate the course causing more symptoms and deterioration in a patient's daily life. The aim of this present study is to describe the effect of comorbid conditions on health-related quality of life (HRQL) in hypertensive patients. Methods. The study was carried out in four different regions of Turkey by 156 general practitioners between October 1999 and April 2000. In addition to cardiological evaluation, SF-36 health survey questionnaire was used for quality of life measurement. Diagnosis of comorbid conditions were anamnesis based. Results. The mean age of the group (n = 938) was 58.1 ± 11.2, and 58.6% (n = 550) of the group was female. Total scores of the eight domains of SF-36 were lower than the normal population scores. Age and gender affected every domain of SF-36 scale negatively. Heart failure affected four of the domains, primarily physical domains. Previous transient ischemic attack was responsible for low HRQL in emotional role difficulties, vitality, and mental health, but previous stroke had an impact on physical functioning and emotional role. Previous myocardial infarction affected emotional role difficulties negatively whereas previous CABG surgery had a positive impact on the same domain. Obesity and angina pectoris affected physical functioning negatively, whereas peripheral arterial disease caused low general health perception. Nephropathy, retinopathy and diabetes had no impact on HRQL in hypertension. Conclusions. When the contribution of comorbid conditions is taken into consideration, it can be noticed that the impact of every other condition is similar to the same condition when it is pure. Hypertension per se seems to cause less impairment than expected in HRQL. © 2005 IMSS. Published by Elsevier Inc.Item Morphological and anatomical characteristics of endemic Salvia huberi hedge in Turkey(2005) Ozdemir C.; Altan Y.The morphological and anatomical features of S. huberi an endemic member of the genus Salvia in Turkey have been examined in this study. The characters such as the structure of the vascular bundles of the petiole and the number of pith rays can be helpful to distinguish the species of Salvia from each other. In addition, the differences in the anatomy of hair morphology may be helpful to account for the anatomical knowledge of the genus.Item Severe chronic allergic (and related) diseases: A uniform approach - A MeDALL - GA2 LEN - ARIA position paper(2012) Bousquet J.; Anto J.M.; Demoly P.; Schünemann H.J.; Togias A.; Akdis M.; Auffray C.; Bachert C.; Bieber T.; Bousquet P.J.; Carlsen K.H.; Casale T.B.; Cruz A.A.; Keil T.; Lodrup Carlsen K.C.; Maurer M.; Ohta K.; Papadopoulos N.G.; Roman Rodriguez M.; Samolinski B.; Agache I.; Andrianarisoa A.; Ang C.S.; Annesi-Maesano I.; Ballester F.; Baena-Cagnani C.E.; Basagaña X.; Bateman E.D.; Bel E.H.; Bedbrook A.; Beghé B.; Beji M.; Ben Kheder A.; Benet M.; Bennoor K.S.; Bergmann K.C.; Berrissoul F.; Bindslev Jensen C.; Bleecker E.R.; Bonini S.; Boner A.L.; Boulet L.P.; Brightling C.E.; Brozek J.L.; Bush A.; Busse W.W.; Camargos P.A.M.; Canonica G.W.; Carr W.; Cesario A.; Chen Y.Z.; Chiriac A.M.; Costa D.J.; Cox L.; Custovic A.; Dahl R.; Darsow U.; Didi T.; Dolen W.K.; Douagui H.; Dubakiene R.; El-Meziane A.; Fonseca J.A.; Fokkens W.J.; Fthenou E.; Gamkrelidze A.; Garcia-Aymerich J.; Van Wijk R.G.; Gimeno-Santos E.; Guerra S.; Haahtela T.; Haddad H.; Hellings P.W.; Hellquist-Dahl B.; Hohmann C.; Howarth P.; Hourihane J.O.; Humbert M.; Jacquemin B.; Just J.; Kalayci O.; Kaliner M.A.; Kauffmann F.; Kerkhof M.; Khayat G.; Koffi N'Goran B.; Kogevinas M.; Koppelman G.H.; Kowalski M.L.; Kull I.; Kuna P.; Larenas D.; Lavi I.; Le L.T.; Lieberman P.; Lipworth B.; Mahboub B.; Makela M.J.; Martin F.; Martinez F.D.; Marshall G.D.; Mazon A.; Melen E.; Meltzer E.O.; Mihaltan F.; Mohammad Y.; Mohammadi A.; Momas I.; Morais-Almeida M.; Mullol J.; Muraro A.; Naclerio R.; Nafti S.; Namazova-Baranova L.; Nawijn M.C.; Nyembue T.D.; Oddie S.; O'Hehir R.E.; Okamoto Y.; Orru M.P.; Ozdemir C.; Ouedraogo G.S.; Palkonen S.; Panzner P.; Passalacqua G.; Pawankar R.; Pigearias B.; Pin I.; Pinart M.; Pison C.; Popov T.A.; Porta D.; Postma D.S.; Price D.; Rabe K.F.; Ratomaharo J.; Reitamo S.; Rezagui D.; Ring J.; Roberts R.; Roca J.; Rogala B.; Romano A.; Rosado-Pinto J.; Ryan D.; Sanchez-Borges M.; Scadding G.K.; Sheikh A.; Simons F.E.R.; Siroux V.; Schmid-Grendelmeier P.D.; Smit H.A.; Sooronbaev T.; Stein R.T.; Sterk P.J.; Sunyer J.; Terreehorst I.; Toskala E.; Tremblay Y.; Valenta R.; Valeyre D.; Vandenplas O.; Van Weel C.; Vassilaki M.; Varraso R.; Viegi G.; Wang D.Y.; Wickman M.; Williams D.; Wöhrl S.; Wright J.; Yorgancioglu A.; Yusuf O.M.; Zar H.J.; Zernotti M.E.; Zidarn M.; Zhong N.; Zuberbier T.Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright © 2012 S. Karger AG, Basel.Item Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs(2012) Bousquet J.; Schünemann H.J.; Samolinski B.; Demoly P.; Baena-Cagnani C.E.; Bachert C.; Bonini S.; Boulet L.P.; Bousquet P.J.; Brozek J.L.; Canonica G.W.; Casale T.B.; Cruz A.A.; Fokkens W.J.; Fonseca J.A.; Van Wijk R.G.; Grouse L.; Haahtela T.; Khaltaev N.; Kuna P.; Lockey R.F.; Lodrup Carlsen K.C.; Mullol J.; Naclerio R.; O'hehir R.E.; Ohta K.; Palkonen S.; Papadopoulos N.G.; Passalacqua G.; Pawankar R.; Price D.; Ryan D.; Simons F.E.R.; Togias A.; Williams D.; Yorgancioglu A.; Yusuf O.M.; Aberer W.; Adachi M.; Agache I.; Aït-Khaled N.; Akdis C.A.; Andrianarisoa A.; Annesi-Maesano I.; Ansotegui I.J.; Baiardini I.; Bateman E.D.; Bedbrook A.; Beghé B.; Beji M.; Bel E.H.; Ben Kheder A.; Bennoor K.S.; Bergmann K.C.; Berrissoul F.; Bieber T.; Bindslev Jensen C.; Blaiss M.S.; Boner A.L.; Bouchard J.; Braido F.; Brightling C.E.; Bush A.; Caballero F.; Calderon M.A.; Calvo M.A.; Camargos P.A.M.; Caraballo L.R.; Carlsen K.H.; Carr W.; Cepeda A.M.; Cesario A.; Chavannes N.H.; Chen Y.Z.; Chiriac A.M.; Chivato Pérez T.; Chkhartishvili E.; Ciprandi G.; Costa D.J.; Cox L.; Custovic A.; Dahl R.; Darsow U.; De Blay F.; Deleanu D.; Denburg J.A.; Devillier P.; Didi T.; Dokic D.; Dolen W.K.; Douagui H.; Dubakiene R.; Durham S.R.; Dykewicz M.S.; El-Gamal Y.; El-Meziane A.; Emuzyte R.; Fiocchi A.; Fletcher M.; Fukuda T.; Gamkrelidze A.; Gereda J.E.; González Diaz S.; Gotua M.; Guzmán M.A.; Hellings P.W.; Hellquist-Dahl B.; Horak F.; Hourihane J.O'B.; Howarth P.; Humbert M.; Ivancevich J.C.; Jackson C.; Just J.; Kalayci O.; Kaliner M.A.; Kalyoncu A.F.; Keil T.; Keith P.K.; Khayat G.; Kim Y.Y.; Koffi N'Goran B.; Koppelman G.H.; Kowalski M.L.; Kull I.; Kvedariene V.; Larenas-Linnemann D.; Le L.T.; Lemière C.; Li J.; Lieberman P.; Lipworth B.; Mahboub B.; Makela M.J.; Martin F.; Marshall G.D.; Martinez F.D.; Masjedi M.R.; Maurer M.; Mavale-Manuel S.; Mazon A.; Melen E.; Meltzer E.O.; Mendez N.H.; Merk H.; Mihaltan F.; Mohammad Y.; Morais-Almeida M.; Muraro A.; Nafti S.; Namazova-Baranova L.; Nekam K.; Neou A.; Niggemann B.; Nizankowska-Mogilnicka E.; Nyembue T.D.; Okamoto Y.; Okubo K.; Orru M.P.; Ouedraogo S.; Ozdemir C.; Panzner P.; Pali-Schöll I.; Park H.S.; Pigearias B.; Pohl W.; Popov T.A.; Postma D.S.; Potter P.; Rabe K.F.; Ratomaharo J.; Reitamo S.; Ring J.; Roberts R.; Rogala B.; Romano A.; Roman Rodriguez M.; Rosado-Pinto J.; Rosenwasser L.; Rottem M.; Sanchez-Borges M.; Scadding G.K.; Schmid-Grendelmeier P.; Sheikh A.; Sisul J.C.; Solé D.; Sooronbaev T.; Spicak V.; Spranger O.; Stein R.T.; Stoloff S.W.; Sunyer J.; Szczeklik A.; Todo-Bom A.; Toskala E.; Tremblay Y.; Valenta R.; Valero A.L.; Valeyre D.; Valiulis A.; Valovirta E.; Van Cauwenberge P.; Vandenplas O.; Van Weel C.; Vichyanond P.; Viegi G.; Wang D.Y.; Wickman M.; Wöhrl S.; Wright J.; Yawn B.P.; Yiallouros P.K.; Zar H.J.; Zernotti M.E.; Zhong N.; Zidarn M.; Zuberbier T.; Ang C.S.; Baigenzhin A.K.; Boakye D.A.; Briggs A.H.; Burney P.G.; Busse W.W.; Chuchalin A.G.; Haddad H.; Johnston S.L.; Kogevinas M.; Levy M.L.; Mohammadi A.; Oddie S.; Rezagui D.; Terreehorst I.; Warner J.O.Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified AR as mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. In its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIA World Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children. © 2012 American Academy of Allergy, Asthma & Immunology.Item Studies on the morphology, anatomy and ecology of ophrys lutea cav. subsp. minor (Guss.) O. Danesch & E. Danesch ex Gölz & H.R. Reinhard (orchidaceae) in Turkey(Pakistan Botanical Society, 2014) Durmuskahya C.; Ozdemir C.; Bozdag B.; Öztürk M.In this study, morphological, anatomical and ecological characteristics of Ophrys lutea subsp. minor in Turkey were investigated. The plant material was collected from 30 different populations during 2010-2013. In all 19 morphological and 20 anatomical features were investigated, and habitat characteristics recorded. The soil samples were also collected from the plant sampling sites and subjected to an analysis for 18 characteristics. The minimum plant length was 69 mm and maximum 323 mm, minimum length of underground part was 29 mm, and maximum 49 mm, and the number of leaves varied between 1-10. The ecological characteristics revealed that O. lutea subsp. minor flourishes well from sea level to 800 m, and the most common habitats of O. lutea subsp. minor are rocky limestones, phrygana, macchie, olive gorves, woodland margins.Item Prioritizing research challenges and funding for allergy and asthma and the need for translational research—The European Strategic Forum on Allergic Diseases(Blackwell Publishing Ltd, 2019) Agache I.; Annesi-Maesano I.; Bonertz A.; Branca F.; Cant A.; Fras Z.; Ingenrieth F.; Namazova-Baranova L.; Odemyr M.; Spanevello A.; Vieths S.; Yorgancioglu A.; Alvaro-Lozano M.; Barber Hernandez D.; Chivato T.; Del Giacco S.; Diamant Z.; Eguiluz-Gracia I.; van Wijk R.G.; Gevaert P.; Graessel A.; Hellings P.; Hoffmann-Sommergruber K.; Jutel M.; Lau S.; Lauerma A.; Maria Olaguibel J.; O'Mahony L.; Ozdemir C.; Palomares O.; Pfaar O.; Sastre J.; Scadding G.; Schmidt-Weber C.; Schmid-Grendelmeier P.; Shamji M.; Skypala I.; Spinola M.; Spranger O.; Torres M.; Vereda A.; Bonini S.The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision-makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solutions for the next decade. The Strategic Forum was an upscaling of the EAACI White Paper aiming to integrate the Academy's output with the perspective offered by EAACI's partners. This collaboration is fundamental for adapting and integrating allergy and asthma care into the context of real-world problems. The Strategic Forum on Allergic Diseases brought together all partners who have the drive and the influence to make positive change: national and international societies, patients’ organizations, regulatory bodies and industry representatives. An open debate with a special focus on drug development and biomedical engineering, big data and information technology and allergic diseases and asthma in the context of environmental health concluded that connecting science with the transformation of care and a joint agreement between all partners on priorities and needs are essential to ensure a better management of allergic diseases and asthma in the advent of precision medicine together with global access to innovative and affordable diagnostics and therapeutics. © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.Item Nitric oxide regulates watermelon (Citrullus lanatus) responses to drought stress(Springer Science and Business Media Deutschland GmbH, 2020) Hamurcu M.; Khan M.K.; Pandey A.; Ozdemir C.; Avsaroglu Z.Z.; Elbasan F.; Omay A.H.; Gezgin S.The role of exogenous nitric oxide (NO) application in alleviating drought stress responses by enhancing the antioxidant activities in plants is well established for several species. However, none of the studies reported its role in protecting the watermelon genotypes from drought stress. In this study, we aimed to observe the effect of NO application on the physiological and biochemical responses of the two watermelon (Citrullus lanatus var. lanatus) genotypes grown under drought stress conditions by treating the plants with 15% polyethylene glycol 6000 (PEG 6000) and 100 µM sodium nitroprusside (SNP), which is a NO donor in Hoagland solution. Among the two genotypes, one genotype, KAR 98 was drought tolerant; while another, KAR 147 was drought sensitive. Drought stress showed a decrease in the growth parameters of both the genotypes; however, as expected it was higher in the susceptible genotype, KAR 147. NO application could not prevent the reductions in the growth parameters; however, it reduced the increment in malondialdehyde (MDA) content caused by the drought stress in both watermelon genotypes. Moreover, while drought stress condition reduced the ascorbate peroxidase (APX), catalase (CAT), glutathione reductase (GR), and peroxidase (POX) activities in both genotypes, NO + PEG application increased the APX activity in the tolerant genotype, KAR 98. Though the obtained results does not show the direct involvement of NO in increasing drought tolerance of watermelon plants, the increase in the APX antioxidant enzyme activity on NO application under drought stress confirmed its role in protecting the watermelon genotypes from the oxidative damage caused by the drought stress. Moreover, it can be concluded that the effect of NO application on watermelons’ responses towards drought stress condition may vary according to the specific genotypes. As to date none of the studies reported the effect of NO application on the antioxidant activity of watermelon genotypes under drought stress, the present study may provide information about the mechanisms that can be focused to improve drought stress tolerance of watermelon genotypes. © 2020, King Abdulaziz City for Science and Technology.Item Food-induced anaphylaxis in early childhood and factors associated with its severity(OceanSide Publications Inc., 2021) Aydogan M.; Topal E.; Yakici N.; Cansu H.; Demirkale Z.H.; Arga M.; Uysal P.; Aydemir S.; Simsek I.E.; Tamay Z.; Cekic S.; Cavkaytar O.; Kaplan F.; Kiykim A.; Cogurlu M.T.; Süleyman A.; Yücel E.; Akkelle E.; Hancioglu G.; Yasar A.; Tuncel T.; Nacaroglu H.T.; Aydogmus C.; Güler N.; Cokugras H.; Sapan N.; Yüksel H.; Sancak R.; Erdogan M.S.; Ozdemir O.; Ozdemir C.; Orhan F.Background: Several factors that increase the risk of severe food-induced anaphylaxis have been identified. Objective: We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis. Methods:We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey. Results: The data of 227 patients with 266 food-induced anaphylaxis episodes were included in the study. The median (interquartile range) age of the first anaphylaxis episode was 9 months (6-18 months); 160 of these patients were boys (70.5%). The anaphylaxis episodes were mild in 75 cases (28.2%), moderate in 154 cases (57.9%), and severe in 37 cases (13.9%). The most frequent food allergens involved were cow's milk (47.4%), nuts (16.7%), and hen's egg (15.8%). Epinephrine was administered in only 98 (36.8%) of these anaphylaxis episodes. A logistic regression analysis revealed two statistically significant factors that were independently associated with severe anaphylaxis: the presence of angioedema and hoarseness during the anaphylactic episode. Urticaria was observed less frequently in patients who developed hypotension. In addition, confusion and syncope were associated with 25.9- and 44.6-fold increases, respectively, in the risk of concomitant hypotension. Conclusion: Cow's milk, nuts, and hen's egg caused the majority of mild and moderate-to-severe anaphylaxis episodes. The presence of angioedema and hoarseness in any patient who presents with a history of food-induced anaphylaxis should alert clinicians that the reaction may be severe. In addition, the presence of confusion, syncope, or stridor probably indicates concomitant hypotension. Copyright © 2021, OceanSide Publications, Inc., U.S.A.