Browsing by Author "Ozden M.G."

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    Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity
    (Blackwell Publishing Ltd, 2021) Özkur E.; Karadağ A.S.; Üstüner P.; Aksoy B.; Eşme P.; Çalışkan E.; Akoğlu G.; Kalkan G.; Demirseren D.D.; Polat M.; Ozden M.G.; Kılınç F.; Yalçınkaya İyidal A.; Kıvanç Altunay İ.; Türkmen M.; Uğurer E.; Baysak S.; Fettahlıoğlu Karaman B.; Mammadlı K.; Baykal Selçuk L.; Türkoğlu Z.; Atcı T.; Didar Balcı D.; Adışen E.; Temel B.; Aktan Ş.; Kaçar N.; Gündüz K.; Türel Ermertcan A.; Özdemir M.; Ünal Çakıter A.; Çölgeçen E.; Uçmak D.; Kelekçi H.; Ataseven A.; Durmaz K.; Kaya Özden H.; Engin B.; Yazıcı S.; Alpsoy E.
    Background: Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim: In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods: In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results: The mean age of disease onset was 26.2 ± 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 ± 8.4 years with a delay in diagnosis of 5.8 ± 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions: Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity. © 2020 British Association of Dermatologists
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    Relationship of psoriatic arthritis with nail and scalp involvement in Turkish psoriasis patients: Multicentered cross-sectional study
    (Lippincott Williams and Wilkins, 2024) Askin O.; Engin B.; Ozdede A.; Kartal S.P.; Ugurlu S.; Akbulut T.O.; Ekinci A.P.; Aydogdu İ.H.; Ozden M.G.; Kok H.; Dogan S.; Ozturkcan S.; Borlu M.; Baskan E.B.; Yilmaz N.; Ak T.; Topkarci Z.; Serdaroglu S.
    Psoriasis is a common multisystem inflammatory disease, and arthritis is an essential component of the disorder, requiring early diagnosis and prompt treatment for successful management. In this study, we aimed to investigate the relationship between nail and scalp involvement and other covariates with psoriatic arthritis (PsA). This cross-sectional study, conducted from June 2021 through December 2021, included 763 patients from 11 different centers in Turkey. The severity of involvement was evaluated using psoriasis area severity index (PASI), nail psoriasis severity index (NAPSI), and psoriasis scalp severity index (PSSI) scores. Predictors for PsA were evaluated using univariate and multivariate logistic regression models. PsA (n = 155, 21.5%) was significantly more common in patients having a family history of psoriasis (43.2% vs 30.9%, P = .004), nail involvement (68.4% vs 52.3%, P < .001), and coexistence of nail and scalp involvement (53.7% vs 39.6%, P = .002). Furthermore, patients with PsA had considerably higher PASI (7 vs 5.6, P = .006), NAPSI (5 vs 2, P < .001), and PSSI scores (7 vs 4, P = .002) and longer disease duration (months) (126 vs 108, P = .009). In multivariate analysis, female gender [OR: 3.01, 95% CI (1.861-4.880), P < .001], nail involvement [OR: 2.06, 95% CI (1.293-3.302), P = .002)], and body mass index (BMI) [OR: 1.06, 95% CI (1.017-1.100), P = .005] were identified as independent predictors for PsA. Female gender, nail involvement, and high BMI are significant predictors for PsA and warrant detailed rheumatological assessment. Notably, being female is the strongest predictor of increased risk of PsA in our survey. Scalp involvement appears not to be associated with PsA. Also, the presence of PsA seems related to a more severe skin involvement phenotype. Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.