Browsing by Author "Ozdogan, F"

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    Investigation of the cochlear effects of intratympanic steroids administered following acoustic trauma
    Ozdogan, F; Ensari, S; Cakir, O; Ozcan, KM; Koseoglu, S; Ozdas, T; Gurgen, SG; Dere, H
    Objectives/Hypothesis: To electrophysiologically and histomorphologically demonstrate the effects of intratympanic corticosteroids administered following an acoustic trauma on cochlear hair cells. Methods: The trial was performed on 16 Wistar albino rats. The rats underwent distortion product otoacoustic emissions (DPOAE) measurement before the acoustic trauma, and subsequently rats were exposed to noise. Following acoustic trauma, the otoacoustic emission measurement was repeated. The rats were divided into two groups, a study group and a control group. The study rats were injected with methylprednisolone via the intratympanic route throughout the study. In the control group, the rats were injected daily with saline. After performing repeated otoacoustic emission measurements, one rat in each of the groups was sacrificed and their cochleae isolated. Results: The histological investigation performed after the 1st week revealed a statistically significantly higher rate of apoptotic cells in the inner and particularly the outer hair cells of the rat cochleae in the control group compared to the study group. Early measurement of DPOAE within the 1st week demonstrated significantly better amplitudes in the study group compared to controls. The otoacoustic emission assessment performed on the 14th day demonstrated statistically similar DPOAE values between the two groups. Conclusions: Intratympanic methylprednisolone injection administered following an acoustic trauma appears to reduce cochlear outer hair cell loss. The impact on hearing loss is less certain. Early measurement of DPOAE within the 1st week shows significantly better amplitudes in the study group compared to controls. However at 2 weeks, there is no statistically significant difference in DPOAE amplitudes between the study and control group.
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    Turkish Guideline for Diagnosis and Treatment of Allergic Rhinitis (ART)
    Ecevit, MC; Özcan, M; Can, IH; Tatar, EC; Özer, S; Esen, E; Atan, D; Göde, S; Elsurer, C; Eryilmaz, A; Coskun, BU; Yazici, ZM; Dinç, ME; Ozdogan, F; Gunhan, K; Bilal, N; Korkut, AY; Kasapoglu, F; Türk, B; Server, EA; Çelebi, ÖÖ; Simsek, T; Kum, RO; Adali, MK; Eren, E; Aslier, NGY; Bayindir, T; Çetin, AC; Göker, AE; Güvenç, IA; Köseoglu, S; Özler, GS; Sahin, E; Yilmaz, AS; Güne, C; Yildirim, GA; Öca, B; Durmusoglu, M; Kantekin, Y; Özmen, S; Kubat, GO; Sanal, SK; Altuntas, EE; Selçuk, A; Yazici, H; Baklaci, D; Yaylaci, A; Hanci, D; Dogan, S; Fidan, V; Uygur, K; Keles, N; Cingi, C; Topuz, B; Çanakçioglu, S; Önerci, M
    Object: To prepare a national guideline for Oto-rhinolaryngologist who treat allergic rhinitis patients Methods: The study was conducted by three authors, namely the writing support team. The support team made the study plan, determined the writing instructions, chose the subgroups including the advisory committee, the advisors for authors and the authors. A workshop was organized at the very beginning to explain the details of the study to the team. Advisors took the chance to meet their coworkers in their subgroups and determined the main headings and subheadings of the guideline, together with the authors. After key words were determined by the authors, literature search was done in various databases. The authors keep in touch with the advisors and the advisors with the advisory committee and the support group at every stage of the study. National and International published articles as well as the abstracts of unpublished studies, imperatively presented in National Congresses, were included in this guideline. Only Guideline and meta-analyses published in last seven years (2013- 2017) and randomized controlled studies published in last two years (2015- 2017) were included. After all work was completed by the subgroups, support team brought all work together and edited the article. Results: A detailed guideline about all aspects of allergic rhinitis was created. Conclusion: The authors believe that this guideline will enable a compact and up-to-date information on allergic rhinitis to healthcare professionals. This guideline is the first in the field of Otolaryngology in Turkey. It should be updated at regular intervals.