Browsing by Author "Ozgur Akgul"

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    Turkish Compliance and Adaptation of EULAR 2013 Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-Modifying Antirheumatic Drugs: Expert Opinion of TLAR
    (2015) gülcan gurer; Ozgur Akgul; Cahit KAÇAR; Figen AYHAN; Zühre SÜRMELİ SARI; Erhan ÖZDEMİREL; aylin rezvani; Ece KAPTANOĞLU; İsmihan Sunar; Şebnem ATAMAN; Taciser Kaya; Ayşen AKINCI; ZUHAL ALTAY; Erhan ÇAPKIN; Hilal KOCABAŞ; Rezzan GUNAYDIN; zafer günendi; Peyman YALÇIN; Hatice BODUR; Nesrin Şen; Kemal NAS; Mehmet Tuncay DURUÖZ; Ömer Faruk ŞENDUR; Murat BİRTANE; AJDA BAL HASTÜRK; LALE ALTAN İNCEOĞLU; AYŞE BEYHAN LALE CERRAHOĞLU; Derya BUĞDAYCI SOY; Nurdan KOTEVOĞLU
    Objectives: This study aims to report Turkish League Against Rheumatism s assessment on the compliance of European League Against Rheumatism 2013 treatment recommendations for rheumatoid arthritis with practices in Turkish rheumatology clinics and adaptations for Turkey. Patients and methods: Members of Turkish League Against Rheumatism and one rheumatoid arthritis patient voted for the 2013 recommendations of the European League Against Rheumatism for treatment of rheumatoid arthritis in two sessions. An item was changed and voted again only if at least 70% of participants wanted a change. Strength of recommendations was calculated for the items. Strength of recommendations for the changed items in the first and second voting rounds was compared by Wilcoxon signed-rank test. In case of significant difference, the item with higher strength of recommendation was accepted. In case of no difference, the changed item was selected. Results: Three overarching principles and fourteen recommendations were assessed among which the three overarching principles were changed emphasizing the importance of physiatrists as well as rheumatologists for taking care of the patients. Third item was changed by adding composite indices for assessing disease activity. In the ninth recommendation, rituximab was suggested as a first line drug independent of situations like latent tuberculosis or lymphoma, etc. In the 11th recommendation, unlike European League Against Rheumatism, our committee did not suggest any thought about tofacitinib, as then it had not been approved in Turkey. Remaining principles were accepted as the same. Conclusion: Expert opinion of Turkish League Against Rheumatism for treatment of rheumatoid arthritis patients was formed for practices in Turkish clinics. Conflict of InterestThe authors declared no conflicts of interest with respect to the authorship and/or publication of this article. Financial DisclosureThe authors received no financial support for the research and/or authorship of this article.
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    Real-life data on the comorbidities in spondyloarthritis from our multicenter nationwide registry: BioStar
    (2023) Hasan Fatih Çay; Meltem Alkan Melikoğlu; Fatma Yurdakul; Hatice Bodur; sebnem ataman; erhan capkin; gülcan gurer; Ilhan Sezer; Mehmet Tuncay Duruöz; aylin rezvani; Ilker Yagci; Feride Gogus; Ayhan KAMANLI; REMZİ ÇEVİK; Ozgur Akgul
    Objectives: Considering that the comorbid situations during the management of Spondyloarthritis (SpA) have been underlined in several recommendations, the main objective of this study was to evaluate the comorbid conditions of Turkish patients with SpA. Patients and methods: This cross-sectional observational study was conducted with 1,242 SpA patients (844 males, 398 females; mean age: 43.9±11.0 years; range, 19 to 81 years) diagnosed according to the modified New York criteria for ankylosing spondylitis or the Assessment of SpondyloArthritis International Society (ASAS) criteria. The patient data were collected from the Biologic and targeted Synthetic antirheumatic drugs Registry (BioStar) between February 1, 2019, and December 29, 2020. Clinical and demographic data, including, age, sex, disease duration, body mass index (BMI), pain, patient’s global assessment, physician’s global assessment, Bath Ankylosing Spondylitis Disease Activity Index, Ankylosing Spondylitis Disease Activity Score, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, and Maastricht Enthesitis Score, were recorded. Comorbid conditions were recorded by filling out a questionnaire according to the clinical history or medical records. Charlson Comorbidity Index and Rheumatic Disease Comorbidity Index scores were calculated from the gathered comorbidity information. Results: Nine hundred thirteen patients had radiographic axial SpA, 153 had nonradiographic axial SpA, and 176 had peripheral SpA. The most common comorbidities were hypertension (HT) (n=167, 13.4%), diabetes mellitus (DM) (n=83, 6.7%), thyroid disorders (n=64, 5.6%), and depression (n=61, 4.9%). The comorbidities and the calculated comorbidity indices were significantly higher in females, in those with a BMI >25 kg/m2, and those over 60 years of age. No relationship was found between smoking and alcohol use and comorbidities. A significantly higher prevalence of HT and DM in peripheral SpA patients and a lower prevalence of thyroid disorders in radiographic axial SpA patients were observed. Conclusion: The most commonly reported comorbidities were HT, DM, thyroid disorders, and depression in SpA patients according to the BioStar database. The frequency of comorbidities and composite comorbidity scores were higher among females, older (>60 years) patients, and overweight (BMI >25 kg/m2) patients.
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    Hemoptizi ile Başvuran Hasta, Hughes-Stovin Sendromlu Bir Olgu
    (2023) kezban ARMAGAN; Ozgur Akgul
    Hughes-Stovin sendromu (HSS), pulmoner ve/veya bronşiyal arterlerde tromboflebit ve çoklu anevrizma varlığı olarak tanımlanan, çok nadir görülen bir otoimmün klinik bozukluktur. Patogenezi hala bilinmemektedir, ancak bu sendrom sıklıkla Behçet hastalığının bir varyantı olarak düşünülmektedir. Burada masif hemoptizi nedeniyle başvuran 59 yaşında bir erkek hastayı sunduk. HSS, görüntülemede pulmoner arter anevrizmaları görülmesi ve alt ekstremite tromboz öyküsü temelinde konuldu. İleri yaş bir olguda bu nadir sendromun görülmesi açısından farklılık göstermektedir. Yüksek mortalitesi olan bu sendromda tedavisi hemen başlandığında sonuçlar yüz güldürücü olmaktadır.
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    Pandemic of the century: COVID-19 in inflammatory rheumatic diseases of a national cohort with 3,532 patients
    (2024) Fatma Yurdakul; Hatice Bodur; ahmet kivanc cengiz; Yunus Durmaz; Mehmet Tuncay Duruöz; Taciser Kaya; sertaç ketenci; nihan cüzdan balta; Tuba Güler; zafer günendi; Selda Sarıkaya; erhan capkin; Mustafa Erkut Onder; Meltem Alkan Melikoglu; Rengin Guzel; Nesrin Şen; Ata Bora Ayna; Ozgur Akgul; ERHAN ESER; sebnem ataman
    Objectives: This study aimed to assess the clinical outcomes and risk factors for severe coronavirus disease 2019 (COVID-19) in patients with inflammatory rheumatic disease (IRD) of a national cohort. Patients and methods: The multicenter cross-sectional study was carried out between July 15, 2020, and February 28, 2021. Data collection was provided from a national network database system, and 3,532 IRD patients (2,359 males, 1,173 females; mean age: 48.7±13.9 years; range; 18 to 90 years) were analyzed. Demographics, clinics about rheumatic disease, comorbidities, smoking status, being infected with COVID-19, and the course of the infection were questioned by rheumatology specialists. Results: One hundred seventeen patients were infected with COVID-19, the hospitalization rate due to COVID-19 was 58.9%, and the mortality rate was 1.7%. There was no difference between the COVID-19 positive and negative groups in terms of rheumatic disease activities and receiving drugs. It was observed that patients with COVID-19 had worse compliance with isolation rules, and bacillus Calmette-Guérin (BCG) vaccination was less common. The mean age and the rate of smoking of hospitalized COVID-19 patients were higher than those without hospitalization. Conclusion: In this cohort, in which real-life data were analyzed, COVID-19 rates in IRD patients were similar to the general population for the same period. Compliance with the isolation rules and BCG vaccination attracted attention as components that reduce the risk of COVID-19 infection. The risk factors for hospitalization were older age and smoking.