Browsing by Author "Ozguven, AA"

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    Neurofibromatosis Type 1 and Diabetes Mellitus: An Unusual Association
    Ozhan, B; Ozguven, AA; Ersoy, B
    Neurofibromatosis type 1 is a multisystemic disease. It may manifest as abnormalities of the nervous tissue, bones, soft tissue, or skin. Autoimmune disease associated with NF1 can be seen. Diabetesmellitus is rarely seen in association with NF1. Here, we report a case with establishedNF1 who also had a diagnosis of diabetes mellitus.
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    Delayed Renal Excretion of Methotrexate After a Severe Anaphylactic Reaction to Methotrexate in a Child With Osteosarcoma
    Ozguven, AA; Uysal, K; Gunes, D; Koroglu, T; Gurcu, O; Olgun, N
    Although methotrexate is an agent widely used in the practice of pediatric oncology, allergic reactions to methotrexate are most unusual. Most of these reactions typically occur after repeated administration. Here, we report it severe anaphylactoid reaction to the first close of high-dose methotrexate infusion in a child with osteosarcoma who has also experienced it delayed excretion of methotrexate. Clinicians must be aware of the possibility of a systemic, near-fatal anaphylactic reactions with methotrexate and patients who experience severe anaphylactic reactions should be followed carefully because of the possibility of delayed methotrexate excretion.
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    Schwannoma Localized Retroperitoneally in a 14-Year-Old Boy
    Cayirli, H; Tanriverdi, HI; Ozguven, AA; Gunsar, C; Ersoy, B; Kandiloglu, AR
    Schwannomas usually occur in adults being between the second and fifth decades, and such neoplasms are extremely rare in a pediatric population. In addition, they are not normally found in the retroperitoneal region. Here, we present a pediatric case of a retroperitoneal schwannoma in an adrenal location where the tumor was not able to be preoperatively differentiated from other benign ormalign adrenal gland tumors. In our opinion, this tumor can be included in the differential diagnosis of a nonfunctioning retroperitoneal adrenal mass in children.
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    Protective effect of ketamine against hemorrhagic cystitis in rats receiving ifosfamide
    Ozguven, AA; Yilmaz, O; Taneli, F; Ulman, C; Vatansever, S; Onag, A
    Objective: To investigate the possible protective effect of a single dose of ketamine and the synergistic effect between ketamine and 2-mercaptoethane sulfonate (mesna) against ifosfamide-induced hemorrhagic cystitis. Materials and Methods: 35 adult female wistar rats were divided into five groups and pretreated with ketamine at 10 mg/kg and/or mesna 400 mg/kg 30 minutes before intraperitoneal injection of IFS (400 mg/kg) or with saline (control group). Hemorrhagic cystitis was evaluated 24 hours after IFS injection according to bladder wet weight (BWW), and microscopic changes, i.e. edema, hemorrhage, cellular infiltration, and urothelial desquamation. The markers of oxidative damage including nitric oxide (NO) and malondialdehyde (MDA) levels and the expressions of tumor necrosis factor alpha (TNF-alpha), interleukin 1-beta (IL-1 beta), inducible nitric oxide synthase (i-NOS) and endothelial nitric oxide synthase (e-NOS) were also assayed in the bladder tissues. Results: Pretreatment with ketamine alone or ketamine in combination with mesna reduced the IFS-induced increase of BWW (58,47% and 63,33%, respectively, P < 0.05). IFS-induced microscopic alterations were also prevented by ketamine with or without mesna (P < 0.05). In addition, also statistically insignificant, the bladder tissue expressions of IL-1 beta were lower in ketamine and/or mesna-receiving groups (P > 0,05). The parameters of oxidative stress, the NO and the MDA contents of the bladder tissues of the study groups were not different. Conclusion: The results of the present study suggest that a single dose of ketamine pretreatment attenuates experimental IFS-induced bladder damage. It is therefore necessary to investigate ketamine locally and systematically with various dosing schedulesin order to reduce the bladder damage secondary to oxazaphosphorine-alkylating agents and these results may widen the spectrum of ketamine.
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