Browsing by Author "Ozsahin D.U."

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    The Use of Fuzzy PROMETHEE Technique in Antiretroviral Combination Decision in Pediatric HIV Treatments
    (Institute of Electrical and Electronics Engineers Inc., 2019) Uzun B.; Yildirim F.S.; Sayan M.; Şanlidaǧ T.; Ozsahin D.U.
    In this study, we analyzed the best treatment options in HIV pediatric cases among many antiretroviral drug combinations and each combination has different properties. Such many combinations can cause confusion for physicians practice. For this aim, we proposed fuzzy PROMETHEE technique, a multi-criteria decision-making technique based on the mutual comparison of the options. The most common antiretroviral drug combinations used in the pediatric HIV treatments (for the infants and for the children aged less than 3 years) were evaluated and compared corresponding to their parameters by PROMETHEE technique. We used the linguistic fuzzy scale for the importance of the weight of the selected parameters according to experts opinion. Integrase inhibitors based drug combinations (RAL; raltegravir + 3TC/ZDV; lamivudin/zidovudin) was found as best preferred regimes. © 2019 IEEE.
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    Determination of Post-Exposure Prophylaxis Regimen in the Prevention of Potential Pediatric HIV-1 Infection by the Multi-criteria Decision Making Theory
    (Institute of Electrical and Electronics Engineers Inc., 2019) Sayan M.; Sultanoglu N.; Uzun B.; Yildirim F.S.; Sanlidag T.; Ozsahin D.U.
    With the use of fuzzy PROMETHEE method, current study analysed and evaluated the preferred and alternative post-exposure prophylaxis (PEP) regimens that can be used in infants and children. PEP is a combination of anti-HIV drugs that can be prescribed after a possible exposure to HIV infection with the aim of preventing infection. The fuzzy PROMETHEE method is a multi-criteria decision maker technique which allows the mutual comparison of different alternatives in a system. Thus, different PEP regimens were evaluated using this technique with their corresponding parameters. The relative importance (weights) of the used parameters for each criterion was determined by expert's opinions and the use of guidelines. Our study indicated that amongst the PEP regimens, raltegravir+tenofovir/emtricitabine (RAL+TDF/FTC) was found to be the most potent PEP regimen that can be applied in infants and children in necessary situations. © 2019 IEEE.
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    Selection of the Most Appropriate Antiretroviral Medication in Determined Aged Groups (≥3 years) of HIV-1 Infected Children
    (Institute of Electrical and Electronics Engineers Inc., 2019) Sultanoglu N.; Uzun B.; Yildirim F.S.; Sayan M.; Sanlidag T.; Ozsahin D.U.
    By using the PROMETHEE technique, we have evaluated the available HIV pediatric antiretroviral drug regimens in three different groups of children which are from ≥3 years to <6 years old, from ≥6 years to <12 years old, and; from ≥ 12 years and older, with sexual maturity rating (SMR) 1-3. This technique is a multi-criteria decision maker that mutually compares the available options. The most frequently used antiretroviral drug regimens were used for determined aged groups and were analysed corresponding to their parameters by PROMETHEE technique. Linguistic fuzzy scale was used in order to evaluate and compare between the antiretroviral drug regimens. This scale consisted of selected parameters that possessed different weights which were determined by the experts' opinions of the field. The result of our study, indicated that the most effective antiretroviral drug regimen for children from ≥3 years to <6 years old was raltegravir + lamivudine/zidovudine (RAL+3TC/ZDV), and for ≥6 years to <12 years old, and from ≥12years old and older with SMR 1-3 were dolutegravir + abacavir/lamivudine (DTG+ABC/3TC). © 2019 IEEE.
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    Evaluating the efficacy of adult hiv post exposure prophylaxis regimens in relation to transmission risk factors by multi criteria decision method
    (Springer, 2020) Sayan M.; Sanlidag T.; Sultanoglu N.; Uzun B.; Yildirim F.S.; Ozsahin D.U.
    There are approximately 39 million people living with the human immunodeficiency virus (HIV) worldwide. Although antiretroviral treatment (ART) has revolutionized the treatment and management of the HIV infection, a cure still remains elusive. In addition to ART’s success at prolonging the lives of the infected individuals, it also has its uses in other cases. For example, post exposure prophylaxis (PEP) ART regimens are used after potential exposure to HIV to prevent the establishment of the HIV infection by up to 80% when administered in a timely manner. There are many guidelines available for these situations; however, they have differences in terms of their content and very few guidelines suggest specific PEP ART regimens for particular risk factors. Our study uses a multi criteria decision making method called Fuzzy PROMETHEE to evaluate the effectiveness of selected PEP ART regimens according to specified transmission risk factors for HIV. The risk factors were the criteria in this study and were weighted according to experts’ opinions in terms of their relative importance. © Springer Nature Switzerland AG 2020.
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    Efficacy evaluation of antiretroviral drug combinations for hiv-1 treatment by using the fuzzy promethee
    (Springer, 2020) Sayan M.; Ozsahin D.U.; Sanlidag T.; Sultanoglu N.; Yildirim F.S.; Uzun B.
    The Human Immunodeficiency Virus (HIV) causes disease by damaging the immune system. If treatment is not initiated, the immune system collapses and this leads to Acquired Immune Deficiency Syndrome (AIDS). The drugs used in the treatment of HIV infection slow or stop the damage caused by the virus to the immune system. In this study, we analyzed the treatment options of HIV since there are many antiretroviral drug combinations available for the treatment and each combination has different properties. The variety of different combinations can cause confusion for physicians in practice. Based on this aim, we proposed the fuzzy PROMETHEE technique, a multi-criteria decision making technique based on mutual comparison of the options. The most common antiretroviral drug combinations used in the HIV treatment were evaluated and compared corresponding to their parameters by the PROMETHEE technique. According to our results, integrase-based inhibitor drug combinations were predominantly preferred. BIC + TAF/FTC (bictegravir + tenofoviralafenamide/ emtricitabine) outranked the other antiretroviral drug combinations with a net flow of 0.0437, followed by DTG + ABC/3TC (dolutegravir + abacavir/ lamivudine) then DTG + TAF/FTC (dolutegravir + tenofoviralafenamide/ emtricitabine). The results obtained with the application of decision-making theories on these option treatment methods will provide significant information for relevant patients, HIV treatment specialists and drug-makers. © Springer Nature Switzerland AG 2020.
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    Comparative Evaluation of the Treatment of COVID-19 with Multicriteria Decision-Making Techniques
    (Hindawi Limited, 2021) Yildirim F.S.; Sayan M.; Sanlidag T.; Uzun B.; Ozsahin D.U.; Ozsahin I.
    Objectives. The outbreak of coronavirus disease 2019 (COVID-19) was first reported in December 2019. Until now, many drugs and methods have been used in the treatment of the disease. However, no effective treatment option has been found and only case-based successes have been achieved so far. This study aims to evaluate COVID-19 treatment options using multicriteria decision-making (MCDM) techniques. Methods. In this study, we evaluated the available COVID-19 treatment options by MCDM techniques, namely, fuzzy PROMETHEE and VIKOR. These techniques are based on the evaluation and comparison of complex and multiple criteria to evaluate the most appropriate alternative. We evaluated current treatment options including favipiravir (FPV), lopinavir/ritonavir, hydroxychloroquine, interleukin-1 blocker, intravenous immunoglobulin (IVIG), and plasma exchange. The criteria used for the analysis include side effects, method of administration of the drug, cost, turnover of plasma, level of fever, age, pregnancy, and kidney function. Results. The results showed that plasma exchange was the most preferred alternative, followed by FPV and IVIG, while hydroxychloroquine was the least favorable one. New alternatives could be considered once they are available, and weights could be assigned based on the opinions of the decision-makers (physicians/clinicians). The treatment methods that we evaluated with MCDM methods will be beneficial for both healthcare users and to rapidly end the global pandemic. The proposed method is applicable for analyzing the alternatives to the selection problem with quantitative and qualitative data. In addition, it allows the decision-maker to define the problem simply under uncertainty. Conclusions. Fuzzy PROMETHEE and VIKOR techniques are applied in aiding decision-makers in choosing the right treatment technique for the management of COVID-19. © 2021 Figen Sarigul Yildirim et al.