Browsing by Author "Oztürk, Z"
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Item Prenatal psychotropic drug exposure, birth outcome and tendency to elective termination of pregnancyOztürk, Z; Olmez, E; Gurpinar, T; Gok, S; Vural, KItem Maternal exposure to contraindicated category X medications: is it really high risk?Oztürk, Z; Olmez, E; Gurpinar, T; Vural, KItem Selenium restores endothelial dysfunction and metabolic profile in type 2 diabetic ratsOztürk, Z; Gurpinar, T; Vural, K; Orenay, S; Korkmaz, M; Var, AItem Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat dietOztürk, Z; Gurpinar, T; Vural, K; Boyacioglu, SÖ; Korkmaz, M; Var, AEndothelial dysfunction develops as a result of oxidative stress and is responsible for diabetic vascular complications. We investigated the effects of selenium on endothelial dysfunction and oxidative stress in type 2 diabetic rats. Male Wistar rats were divided into five groups: controls, untreated diabetics, and diabetics treated with 180, 300, 500 mcg/kg selenium each day. Diabetes was induced by a single intraperitoneal injection of low dose streptozotocin to rats fed a high fat diet. Endothelium-dependent and -independent relaxations were measured in the thoracic aorta. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and endothelial nitric oxide synthase (eNOS) mRNA expressions were analyzed using real-time polymerase chain reaction (RT-PCR). Fasting blood glucose, lipid profile, lipid oxidation, insulin and nitric oxide were measured in blood samples. Malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase levels were measured in liver samples. RT-PCR showed that selenium reversed increased NADPH oxidase expression and decreased eNOS expression to control levels. Selenium also improved the impairment of endothelium-dependent vasorelaxation in the diabetic aorta. Selenium treatment significantly decreased blood glucose, cholesterol and triglyceride levels, and enhanced the antioxidant status in diabetic rats. Our findings suggest that selenium restores a normal metabolic profile and ameliorates vascular responses and endothelial dysfunction in diabetes by regulating antioxidant enzyme and nitric oxide release.Item Drug risk assessment in pregnancy: 5 years' experience in clinical pharmacologyOztürk, Z; Olmez, E; Gurpinar, T; Vural, KItem Evaluation the effects of the olive leaf extract on serum lipid profile, some indicators of atherosclerosis and endothelium-dependent relaxations in cholesterol-fed ratsOlmez, E; Vural, K; Gok, S; Oztürk, Z; Kayalar, H; Ayhan, S; Var, A