Browsing by Author "Oztekin O."

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    Comparative morphological differences between umbilical cords from chronic hypertensive and preeclamptic pregnancies
    (2002) Inan S.; Sanci M.; Can D.; Vatansever S.; Oztekin O.; Tinar S.
    To compare morphological changes in the umbilical cords from chronic hypertensive and preeclamptic patients having normal or pathological umbilical artery Doppler ultrasonographic results. Umbilical cords from 34 normotensive, 31 chronic hypertensive and 70 preeclamptic women with normal and abnormal Doppler flow velocity waveforms (FVW) at 35 40 gestational weeks were studied. Morphological changes in the umbilical cords were examined on formalin-fixed, paraffin-embedded sections. The total umbilical cord area, total vessel area, and wall thickness of umbilical vessels were measured in systematic random samples using unbiased stereology methods. An ANOVA test was used for statistical analysis. In the chronic hypertensive and preeclamptic groups with normal Doppler FVW, the thickness of the umbilical cord vessels remained nearly constant, whereas both the total area and the lumen area were reduced. These changes correlate with the histopathological findings, suggesting a mainly vasoconstrictive effect. By contrast, analysis of the preeclamptic group with pathologic Doppler FVW showed a comparable reduction of all parameters of the umbilical cord. Histopathological findings were related to smaller, contracted smooth muscle cells of the vessel wall, which is suggestive of a predominant hypoplastic mechanism. As a result of reduced uteroplacental perfusion, fetal hypoxia and intrauterine growth retardation become un-avoidable in preeclampsia. The histopathological changes in the umbilical cord between the chronic hypertensive and preeclamptic patients depend on the Doppler results. In conclusion, the umbilical artery Doppler FVW indices provide good values for predicting intrauterine growth retardation in preeclamptic patients.
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    Sarcoidosis with systemic hypertension: Case report
    (2012) Bilgir O.; Bilgir F.; Çalan M.; Balikçi O.; Canbolat S.; Oztekin O.
    Sarcoidosis, which occurs often with the lung involvement and causes significant morbidity, is a multisystem granulomatous disease. This disease manifests itself with signs, and symptoms of neurological disease such as uveitis, blindness or end-stage pulmonary fibrosis, pulmonary hypertension, dysrhythmias, cardiomyopathy, hypercalcemia and renal insufficiency. However, systemic hypertension secondary to hypercalcemia is very rare. We present a 29-year old male patient admitted to the emergency service with complaints of headache and nausea. His arterial blood pressure and calcium level were 220/110 mmHg, and 17.4 mgldl, respectively, and histopathological evaluation after splenectomy confirmed the diagnosis of sarcoidosis..